• 보건의료산업학회지
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• 제13권4호
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• pp.229-241
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• 2019

Objectives: This study analyzed the relationship between dietary behavior and health-related characteristics and experiences of major oral disease symptoms using online raw data on adolescent health behavior. Methods: Using the raw data on 61,858 adolescents collected through the 13th Adolescent Health Behavior Online Survey, a complex samples logistic regression analysis was conducted to assess risks of major oral diseases. Results: The less one consumes sweet drinks and the more one eats vegetables per day, the less likely one is to experience symptoms of tooth decay and periodontal diseases. Undergoing scaling and oral health education help prevent major oral diseases. Brushing after school lunch prevents periodontal diseases and foul breath, and using dental floss and interdental brush also help prevent periodontal diseases. Conclusions: To minimize experiences of oral diseases during adolescent years, it is necessary to periodically scale teeth and provide knowledge regarding the personal management of dental plaque through school oral health education.

• 한국치위생학회지
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• 제12권4호
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• pp.817-825
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• 2012

Objectives : This study was to examined the degree of oral health knowledge, attitude of periodontal diseases and dental health behaviors and to examine the relationship among variables in 12-year-old adolescents. Method : Participants were 2,196 adolescents who live in Seosan with an average age of 12.2. Data was collected using a self administrated questionnaire from April 10 through June 10, 2011. Results : The knowledge of periodontal disease of the subjects was $2.46{\pm}1.52$ and the attitude was $1.88{\pm}1.11$. It appears that knowledge and attitude concerning periodontal and dental health among young Korean 12-year-old adolescents living in Seosan city are in need of improvement. The knowledge and attitude were significantly higher in high group than low group of income. The knowledge and attitude toward periodontal and dental health was positively related to dental health behaviors. Conclusion : Based on the findings, dental health behaviors are strongly associated with knowledge and attitude toward periodontal and dental health. This result suggest that the implementation of oral health promotion should be considered for various factors related to attitude of oral health in adolescents.

• 치위생과학회지
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• 제13권4호
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• pp.393-402
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• 2013

본 연구는 국민건강영양조사 제5기 1차년도(2010) 원시 자료를 활용하여 비타민 D와 치주질환의 관계를 파악하고자 하였다. 주요변수의 결측 및 당뇨와 골다공증 유병자를 제외하고 최종 1,327명을 연구대상자로 PASW Statistics 18.0 프로그램을 이용하여 분석하였으며, 다음과 같은 결론을 얻었다. 1. 전체(50세 이상) 대상자에서, 비타민 D와 치주질환의 관계는 유의하지 않은 것으로 나타났다. 2. 폐경(양측난소절제술 포함) 여성에서, 비타민 D 결핍 그룹1 (<10)은 충분 그룹(${\geq}30$)에 비해서 치주질환에 걸릴 가능성이 6.66배 높게 나타났다(OR, 6.66; 95% CI, 1.004~44.19). 이상의 결과로 보아 비타민 D와 치주질환은 폐경여성(양측난소절제술 받은 여성 포함)에서 유의미한 음의 상관관계를 갖는 것으로 확인된 바, 치주질환 예방 및 관리 시 이러한 점이 고려되어야 할 것으로 생각된다.

• 치위생과학회지
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• 제12권2호
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• pp.115-121
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• 2012

본 연구는 치주질환의 자각증상과 삶의 질과의 관련성을 분석하여 성인의 전반적인 삶의 질 향상 방안을 제시하고자 시행하였다. 2010년 1월 7일부터 3월 14일까지 서울 및 경기지역에 거주하는 35세 이상에서 65세 미만의 성인 중 치과의료기관에 방문한 경험이 있는 성인 450명을 대상으로 설문조사를 실시하였으며 다음과 같은 결론을 얻었다. 1. 연구대상자가 인식한 치주질환 자각증상 중 '양치질시 잇몸에서 피가 난다'가 294명(65.8%)으로 가장 많았으며, '흔들리는 치아가 있다'가 84명(18.8%)으로 가장 적었다. 2. 사회 인구학적 특성, 구강건강행동에 따라 치주질환의 자각증상을 분석한 결과 남자는 여자보다 치은출혈, 구취 및 치아통증을 더 많이 인식하고 있었다. 연령이 증가할수록 치간공간과 치아동요 및 치아통증을, 교육수준이 낮아질수록 치간공간과 치아동요를 더 많이 인식하였다. 월 평균 가정 총수입이 400만원 미만인 집단은 그 이상인 집단보다 치은부종과 치간공간을 더 많이 인식하였다(p<0.01). 정기적으로 구강검진을 시행하지 않는 집단은 시행하는 집단보다 치은출혈을 더 많이 인식하였고, 정기적으로 치석제거를 시행하지 않는 집단에서 치은출혈과 구취를 더 많이 인식하였다(p<0.05). 3. 치주질환 자각증상에 따라 OHIP-14 하위요인의 수준을 분석한 결과 치주질환의 자각증상을 인식한 집단은 인식하지 않은 집단에 비해 기능적 제한, 신체적 동통, 정신적 불편과 다양한 영역의 능력저하 및 사회적 불리에 대한 경험이 더 많았다(p<0.001). 4. OHIP-14와 사회 인구학적 특성, 구강건강행동, 치주질환 자각증상과의 관련성을 분석한 결과 남자와 치은출혈, 치은부종 및 구취를 인식한 집단은 대조군보다 삶의 질이 더 낮은 것으로 나타났다(p<0.05). 이상의 결과로 볼 때 치주질환 자각증상의 감소는 기능제한과 통증경험, 신체적 능력저하 등의 다양한 부정적 경험을 줄여 삶의 질을 향상시키는데 중요한 역할을 할 것으로 사료된다.

• 약학회지
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• 제60권1호
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• pp.46-50
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• 2016

The purpose of this study was the development of sustained-release lyogel of chlorhexidine in the treatment of periodontal diseases. A sustained-release chlorhexidine lyogel (CHX-G) was formulated, based on Eudragit$^{(R)}$ (1~3%), polyvinyl pyrrolidone (PVP) (0~10%), triacetin (20~40%), hydroxy ethyl cellulose (HEC) (1%) and glycerin. In vitro studies were performed to determine the release rate of chlorhexidine from CHX-Gs using dialysis tube. Our results suggest that the release rate of chlorhexidine from lyogel could be controlled by changing the lyogel compositions.

• International Journal of Oral Biology
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• 제47권2호
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• pp.25-31
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• 2022

Lysophosphatidic acid (LPA) is a bioactive lipid messenger involved in the pathogenesis of chronic inflammation and various diseases. Recent studies have shown an association between periodontitis and neuroinflammatory diseases such as Alzheimer's disease, stroke, and multiple sclerosis. However, the mechanistic relationship between periodontitis and neuroinflammatory diseases remains unclear. The current study found that lysophosphatidic acid receptors 1 (LPAR1) and 6 (LPAR6) exhibited increased expression in primary microglia and astrocytes. The primary astrocytes were then treated using medium conditioned to mimic periodontitis through addition of Porphyromonas gingivalis lipopolysaccharides, and an increased nitric oxide (NO) production was observed. Application of conditioned medium from human periodontal ligament stem cells with or without LPAR1 knockdown showed a decrease in the production of NO and expression of inducible nitric oxide synthase and interleukin 1 beta. These findings may contribute to our understanding of the mechanistic link between periodontitis and neuroinflammatory diseases.

• 한국치위생학회지
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• 제1권1호
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• pp.111-123
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• 2001

Objectives : The purpose of this study was to investigate distribution of periodontal status and treatment need between smokers and nonsmokers. Methods : Interview and measurement was completed by 82 smoker students and 59 nonsmoker students in Taegu Health College from April 1 to 31, 2001. The community periodontal index of treatment needs(CPITN) was analyzed by percentage. Results : In distribution of CPITN by age, almost all subjects had periodontal diseases except for aged 20~24 years nonsmokers(4%). Smoking 5 cigarettes per a day, up to 10, and above 10 increased 5.3%. 7.1%. and 9.5% in 4 score of CPITN, respectively. In years of smoking, smokers who had above 5 years(13.5%) were higher than below those(6.7%), 20% for smoker who take tooth brushing once per a day had higher than 8.3%(or three in depth of pocket above 6mm. In treatment need, all subjects should take education(or oral health except for aged 20~24 years nonsmokers(4%), 96% of smokers and nonsmokers were need scaling. Conclusion : This study indicated that treatment needs for periodontal diseases and scaling in smoker were higher than nonsmoker those.

• 치위생과학회지
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• 제23권2호
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• pp.169-175
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• 2023

Background: Although microbial infection is direct cause of periodontal disease, various environmental factors influence the disease severity. Aging is considered a risk factor for oral diseases, with the prevalence of periodontal diseases increasing with age. Moreover, senescence-associated secretory phenotype (SASP) expressed in age-related diseases is a key marker of chronic inflammation and aging phenotypes. Therefore, this study aimed to understand the relevance of senescent cells to periodontal health and disease, investigate the possibility of regulating the expression of aging- and osteolysis-related factors in gingival fibroblasts, and investigate the effect of senescence induction in gingival fibroblasts on osteoclast differentiation in mouse bone marrow-derived macrophages (BMMs). Methods: After stimulation with 400 nM hydrogen peroxidase, human gingival fibroblasts (HGFs) were examined for senescence-associated β-galactosidase. Western blot and enzyme-linked immunosorbent assays were performed to assess the expression of SASP. Osteoclast formation was assessed in BMMs using a conditioned medium (CM) from hydrogen peroxide-stimulated HGFs. Osteoclastic differentiation was investigated using tartrate-resistant acid phosphatase (TRAP) staining and activity. Data analysis was performed using SPSS version 25.0. Results: The expression of senescence-related molecules, including p53, p16, and p21, and the expression of osteolytic factors, including IL-6, IL-8, and IL-17, were found to be significantly higher in the hydrogen peroxide-stimulated HGF than in the control group. Regarding the indirect effects of senescent gingival cells, the number of osteoclasts and TRAP activity increased according to the differentiation of BMM cultured in CM. Conclusion: Our results on the of between osteolytic factors and cellular senescence in gingival fibroblast cells helped to reveal evidence of pathological aging mechanisms. Furthermore, our results suggest that the development of novel therapies that target specific SASP factors could be an effective treatment strategy for periodontal disease.

• 한국치위생학회지
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• 제22권1호
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• pp.29-36
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• 2022

Objectives: This study aimed to examine the association between age at menarche and two major oral diseases. Methods: Data from the 7th Korean National Health and Nutrition Examination Survey (2016-2018) were used. The participants included girls and women aged 12 years and above. Thedataofa total of 7,420 participants were analyzed. Statistical analyses were performed using complex samples cross-tabulation analysis and complex samples general linear model. Results: The average age at menarche of those aged 12 to 80 years was 13.81 years. The age at menarche was found to be associated with decayed-missing-filled teeth (DMFT) (p<0.05). When the age at menarche was nine years, DMFT was 4.20 when it was 19 years, DMFT was 10.80. The age at menarche was found to be associated with periodontal tissue state (p<0.05). The group with early menarche age had healthier periodontal tissues (17.1%), whereas the group with late menarche age had more unhealthy periodontal tissues (17.9%) (p<0.001). Conclusions: The age at menarche was associated with two major oral diseases. Therefore, it is necessary to provide women with oral hygiene care and oral health education to prevent major oral diseases before their secondary sex characteristics appear.

• 대한간호학회지
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• 제46권5호
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• pp.653-662
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• 2016

Purpose: The purpose of this study was to identify the influences of oral health behaviors, depression, and stress on periodontal disease in pregnant women. Methods: The participants in this study were 129 pregnant women. Data were collected using questionnaires which included individual characteristics, oral health care behaviors, the Center for Epidemiological Studies-Depression scale (CES-D), a global measure of perceived stress, and pregnancy stress. A dentist measured periodontal probing depth and classified stages of periodontal disease according to the Community Periodontal Index (CPI). Data were analyzed using descriptive statistics, Pearson correlation, and multiple regression. Results: Periodontal disease had significant correlations with oral health care behaviors (r=-.56, p <.001), perceived stress (r=.44 p <.001), pregnancy stress (r=.37 p <.001), diet (r=-.33, p <.001) and depression (r=.18 p =.046). Factors influencing periodontal disease for these pregnant women were being in the 2nd (${\beta}=.27$, p <.001) or 3rd trimester (${\beta}=.45$, p <.001), having a pregnancy induced disease (${\beta}=.20$, p =.002), performing higher oral health behaviors (${\beta}=-.30$, p <.001), and having higher perceived stress (${\beta}=.17$, p =.028). The explanation power of this regression model was 61.6% (F=15.52, p <.001). Conclusion: The findings of this study indicated that periodic assessment of periodontal disease is essential for pregnant women who are in 2nd or 3rd trimester and have pregnancy induced diseases. Enhancing oral health care behaviors and reducing perceived stress are indicated as effective strategies to reduce periodontal disease in pregnant women.