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http://dx.doi.org/10.17480/psk.2016.60.1.46

Injectable Sustained Release Gel as a Local Drug Delivery for Periodontal Diseases  

Kim, Ki-jun (College of Pharmacy, Kyungsung University)
Shin, Young-hee (College of Pharmacy, Kyungsung University)
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YAKHAK HOEJI / v.60, no.1, 2016 , pp. 46-50 More about this Journal
Abstract
The purpose of this study was the development of sustained-release lyogel of chlorhexidine in the treatment of periodontal diseases. A sustained-release chlorhexidine lyogel (CHX-G) was formulated, based on Eudragit$^{(R)}$ (1~3%), polyvinyl pyrrolidone (PVP) (0~10%), triacetin (20~40%), hydroxy ethyl cellulose (HEC) (1%) and glycerin. In vitro studies were performed to determine the release rate of chlorhexidine from CHX-Gs using dialysis tube. Our results suggest that the release rate of chlorhexidine from lyogel could be controlled by changing the lyogel compositions.
Keywords
chlorhexidine; sustained-release; lyogel; periodontal diseases;
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