• Asian Pacific Journal of Cancer Prevention
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• 제16권11호
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• pp.4525-4530
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• 2015

Background: The MTHFR C677T polymorphism is a genetic alteration affecting an enzyme involved in folate metabolism, but its relationship to host susceptibility to prostate cancer remains uncertain. The aim of this study was to investigate the association between MTHFR C677T polymorphism and prostate cancer by performing a meta-analysis. Materials and Methods: Pubmed and Web of Science databases were searched for case-control studies investigating the association between MTHFR C677T polymorphism and prostate cancer. Odds ratios (OR) and 95% confidence intervals (95%CI) were used to assess any link. Results: A total of 22 independent studies were identified, including 10,832 cases and 11,993 controls. Meta-analysis showed that there was no obvious association between MTHFR C677T polymorphism and risk of prostate cancer under all five genetic models. There was also no obvious association between MTHFR C677T polymorphism and risk of prostate cancer in the subgroup analyses of Caucasians. In contrast, MTHFR C677T polymorphism was associated with increased risk for prostate cancer in Asians with the allele model (C vs G: OR=1.299, 95 %CI =1.121-1.506, P=0.001, $P_{heterogeneity}=0.120$, $I^2=45%$), additive genetic model (CC vs TT: OR =1.925, 95 % CI= 1.340-2.265, P=0.00, $P_{heterogeneity}=0.587$, $I^2=0.00%$), recessive model (CC vs TT+TC: OR= 1.708, 95 % CI=1.233-2.367, P=0.001, $P_{heterogeneity}=0.716$, $I^2=0.00%$), and heterozygote genetic model (CT vs TT: OR=2.193, 95 % CI =1.510-3.186, P=0.000, $P_{heterogeneity}=0.462$, $I^2=0.00%$). Conclusions: These results suggest that the MTHFR C677T polymorphism does not contribute to the risk of prostate cancer from currently available evidence in populations overall and Caucasians. However, the meta analysis indicates that it may play a role in prostate cancer development in Asians.

• 대한간호학회지
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• 제24권4호
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• pp.678-695
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• 1994

The purpose of this study was to investigate knowledge, attitudes and practices of women toward breast self-examination and to identify factors that may influence compliance with breast examination. The subjects for this study were 282 women in three hospitals located in In-Chun. Data were collected during the period from October 15 to 30, 1993 by means of a structured questionnaire. The data were analyzed using the SAS program and include descriptive statistics, 1-test, ANOVA, Pearson correlation coefficient and stepwise multiple regression. The results of study are as follows : 1. The mean knowledge score for the total sample was 13.58. Factors affecting the women's knowledge of breast cancer and BSE were : age, level of education, experience with breast cancer patients, experience in learning BSE, information about BSE, self-practice of BSE, level of intention to perform BSE, and participation in a BSE class. 2. Elements related to attitude included : (a) perceived feeling of susceptibility to breast cancer, and (b) belief about the effectiveness of BSE. The mean perceived susceptibility score was 1.62 and the mean effectiveness score was 4.22. Factors affecting the women's perceived susceptibility to breast cancer were exercise for health, level of intention to perform BSE , intention to recommend to others and self-practice of BSE. The relation between the womens' belief about effectiveness of BSE and level of intention to perform BSE and intention to recommend to others were statistically significant. 3. The mean self-practice score for the total sample was 4.01. Factors affecting the women's practice were experience with breast cancer patients, information about BSE, experience in learning BSE, enlisting the help of significant peers, and level of intention to perform BSE. Results indicated 35.8% of the total sample practiced BSE. The most frequent reason women gave for not performing BSE was “Didn’t knew about BSE technique”, “Didn’t think do it”. 4. No relation was found between knowledge and attitudes and practices. 5. When all the variables were examined for their contribution to the variance in the practice of BSE, it was found that confidence in ability to detect a mass by BSE, knowledge about breast cancer and BSE, and experience with breast cancer patients were significant variables and explained 35.8% of the variance. From the results of this study it can be said that women need to be taught proper BSE technique so they can become more proficient in detecting breast abnormalities.

• 벤처창업연구
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• 제15권1호
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• pp.269-284
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• 2020

본 연구는 한국의 바이오메디컬 산업을 중심으로 창업가의 배태조직과 창업경험이 형성하는 창업기업의 핵심경영자원을 탐색적으로 살펴보았다. 이를 위해 바이오메디컬 분야의 창업가 13인을 대상으로 심층 인터뷰를 수행하였다. 선행연구를 바탕으로 창업기업의 핵심 경영자원을 크게 기술 역량, 조직관리 역량, 네트워크 역량, 시장개척 역량 등 4가지로 분류하고 이를 중심으로 반구조화된 질문지를 구성하였다. 인터뷰 내용을 정리한 결과, 창업가의 배태조직 및 창업경험이 형성하는 창업기업의 핵심경영자원을 18가지 세부요인으로 구분할 수 있었다. 특히 기존의 실증연구들이 잘 다루지 않던 요인들을 발견할 수 있었는데, 기술 역량을 구성하는 요인들 중'기술개발 자신감'과 'R&D 수행방식', 조직관리 역량을 구성하는 요인들 중'조직문화', 네트워크 역량을 구성하는 요인들 중 '정신적 지원', 시장개척 역량을 구성하는 요인들 중 '시행착오를 통한 학습'과 '명성자원' 등이 이에 해당한다. 본 연구는 창업가의 배태조직 및 창업경험의 역할을 다룬 질적 연구로서 희소성이 있을 뿐 아니라 이 경험들이 형성하는 기업의 핵심경영자원을 4가지로 유형화하고 있어 향후 연구에서 유용하게 활용될 것으로 기대된다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권8호
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• pp.3917-3925
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• 2012

Background: The relationship between postmenopausal hormone therapy (HT) and invasive breast cancer has been extensively investigated, but that with breast carcinoma in situ (BCIS) has received relatively little attention. The aim of our present study was to review and summarize the evidence provided by longitudinal studies on the association between postmenopausal HT use and BCIS risk. Methods: A comprehensive literature search for articles published up to May 2012 was performed. Prior to performing a meta-analysis, the studies were evaluated for publication bias and heterogeneity. Relative risk (RR) or odds ratio (OR) values were calculated using 14 reports (8 case-control studies and 6 cohort studies), published between 1986 and 2012. Results: There was evidence of an association between ever postmenopausal estrogen use and BCIS based on a random-effects model (RR = 1.25, 95% confidence interval (CI) = 1.01, 1.55). However, we found no strong evidence of an association between ever postmenopausal estrogen combined with progesterone use and BCIS using a randomeffects model (RR = 1.55, 95% CI = 0.95, 2.51). Furthermore, our analysis showed a strong association between "> 5 years duration" of estrogen or estrogen combined with progesterone use and BCIS. Furthermore, current use of any HT is associated with increased risk of BCIS in cohort studies. Additional well-designed large studies are now required to validate this association in different populations.

• 한국과학교육학회지
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• 제32권2호
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• pp.331-345
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• 2012

이 연구는 중등 과학영재교육에서 초임 교사의 수업 전문성 제고 전략으로써의 멘토링 적용에 관한 사례연구로, 멘토링 과학영재수업의 특징을 수업 계획, 수업 진행, 수업 평가, 멘토링 적용 후 단계로 나누어 분석했다. 한 명의 멘토와 두 명의 멘티를 선정한 후, 멘티별로 중등 과학영재수업 중에서 총 3회에 걸친 9차시의 수업에 대해 멘토링을 실시했다. 모든 수업을 관찰했고, 수업 촬영 동영상과 수업 자료, 멘토링 및 면담 녹음 자료, 참관 노트 등을 분석했다. 연구 결과, 멘토링 과학영재수업의 특징으로 수업 계획 단계에서는 좀 더 체계적인 과학영재수업 구성, '과학영재수업=약간 어려운 실험수업'이라는 도식의 탈피와 다양한 교수전략 도입, 과학영재교육 프로그램 개발에 대한 심리적 부담감에 영향, 과학영재수업 준비 시간의 증가 등이 나타났다. 수업 진행 단계의 특징으로는 과학 영재수업의 질 향상, 수업 진행에 대한 심리적 부담감에 영향, 수업 진행의 혼선 초래 등이 있었다. 수업 평가 단계의 특징은 수업에 대한 심도 깊은 반성 기회제공, 실제적인 수업 개선의 동력 제공으로 분류할 수 있었다. 멘토링 적용 후 단계의 특징으로는 멘티의 과학영재수업에 대한 자신감 증가, 멘토의 수업 전문성 및 멘토링 기술 일부 향상 등이 나타났다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권2호
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• pp.847-853
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• 2014

There is a lot of debate on the relationship between vitamin D receptor polymorphisms and risk of breast cancer. Herein, we quantitatively analyzed the published case-control studies on this relationship by meta-analysis, performing a bibliographic search from Pubmed and CNKI up to July 31, 2013. The included case-control studies for Fok1, Bsm1, Taq1, Apa1, Cdx2 and Poly-A were 16, 19, 20, 10, 4, 6, respectively. Crude and adjusted odd ratios and 95% confidence intervals were calculated to present and compare the strength of any associations. The results of combined analyses indicated that Fok1, Bsm1, Apa1, Cdx2 and Poly-A were not significantly associated with the risk of breast cancer. In contrast, the tt genotype of Taq1 was a modest risk factor for breast cancer development (tt vs. TT: OR = 1.21, 95% CI: 1.01-1.44). To further confirm the above results, adjusted effects for the six polymorphisms were pooled based on adjusted ORs reported in the original studies. Adjusted ORs of Fok1, Apa1, Cdx2 and Poly-A were similar to the crude ORs. However, Bsm1 and Taq1 showed inconsistent results. For Bsm1, OR for BB vs. bb was 0.85, 95% CI: 0.74-0.98; for Taq1, OR for tt vs. TT was 1.03, 95% CI: 0.92-1.15, and not associated with risk. Subgroup analyses for crude ORs showed some association between Bsm1, Taq1 and breast cancer in Caucasians only, but for adjusted ORs, no associations were found. This meta-analysis suggests that the roles that Fok1, Apa1, Cdx2 and Poly-A polymorphisms play in breast cancer risk are negligible, with Bsm1 and Taq1 as possible exceptions. To be conservative, we still assumed that they may play a modest role in determining breast cancer risk. Further studies are needed to validate our findings.

• 한국산학기술학회논문지
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• 제14권4호
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• pp.1709-1717
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• 2013

본 연구는 119 구급대의 1급 응급구조사에 의한 심장 마비 환자에 대한 전문기도유지술 실시횟수의 관련 요인을 파악하였다. 광주소방 본부의 1급 응급구조사 95명을 대상으로 구조화된 설문지를 이용하여 일반적 특성, 직업관련 특성, 자기효능감, 전문기도유지술을 시행하는데 저해요인을 조사하였고, 2010년 1월 1일부터 2011년 6월 30일까지 전문기도유지술 실시한 자료는 광주 소방본부에서 제공받았다. 본 연구의 결과로, 전문기도유지술 관련 특성과 실시횟수와 상관관계를 분석한 결과, 필요를 느낀 횟수(r=0.397, p<0.01)와 자기효능감(r=0.419, p<0.01)이 상관관계를 보였고, 저해요인과 실시횟수와 상관관계를 분석한 결과 자신감(r=-0.036, p<0.01)과 경험문제(r=-0.405, p<0.01)가 상관관계가 있었다. 결론적으로, 전문기도유지술의 필요성을 제대로 인식하도록 하고, 자기효능감을 향상시킬 수 있도록 현장위주의 교육 프로그램과 인적자원관리에 대한 대책 마련이 필요할 것이다.

• 한국산학기술학회논문지
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• 제21권9호
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• pp.32-38
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• 2020

화차 제동은 공기 제동관의 압력변화를 이용해 제동 체결과 완해를 반복적으로 작동하여 수행한다. 화차 공기 제동 완해 불량은 기관사의 제동완해 취급 후에 제동 제어밸브의 오작동으로 인해 부분적인 제동체결상태를 의미한다. 이 현상은 화차 주행 동안 차륜 찰상과 열손상을 발생시킴으로서, 차륜파손 또는 열차 탈선사고를 일으킨다. 따라서 화차의 운행 지연 및 사고방지를 위해서는 공기제동 완해불량을 방지하는 체계적인 연구가 중요하다. 이를 해결하기 위하여 본 연구에서는 철도운영기관의 제작과 기능요구사항을 고려하여 완해불량 방지밸브를 개발하였다. 또한 본 밸브의 내구성 시험은 화차제동성능 시뮬레이터 성능시험기를 이용하였으며, 이의 작동성능은 반복적인 제동과 완해불량 조건하에 공압이력으로부터 평가하였다. 본 밸브의 보증수명은 화차 주행동안 제동횟수를 고려하여 무고장 시험기법에 준하여 12개 시제품에 대하여 총 16만회 성능시험을 수행하였다. 내구성 시험동안 본 밸브의 공압 입력 시간과 출력시간 및 출력속도의 차이는 거의 일정하였다. 본 밸브의 보증수명은 신뢰수준 95%에서 59,860회이며, 화차 대차에 본 밸브를 설치할 경우에 요구조건인 4년간 고장없이 운용될 수 있음을 의미한다.

• 한국환경농학회지
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• 제31권2호
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• pp.129-136
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• 2012

BACKGROUND: The changes in the climatic conditions have brought potentially significant new challenges, most critical are likely to be its impact on local livelihoods, agriculture, biodiversity and environments. Water induced disasters such as landslides, floods, erratic rain etc., are very common in developing countries which lead to changes in biological, geophysical and socioeconomic elements. The extent of damages caused by natural disasters is more sever in least developing countries. However, disasters affect women and men differently. In most of the cases women have to carry more burden as compared to their male counterpart during the period of disasters. METHODS AND RESULTS: This study examines the impact of disasters on the local livelihood especially agriculture and income generating activities of women in three districts of Nepal. The study uses the primary data collected following an exploratory approach, based on an intensive field study. The general findings of the study revealed that women had to experience hard time as compared to their male counterpart both during and after the disaster happen. Women are responsible for caring their children, collecting firewood, fetching water, collecting grass for livestock and performing household chores. Whereas, men are mainly involved in out-migration and remained out-side home most of the time. After the disaster occurred, most of the women had to struggle to support their lives as well as had to work longer hours than men during reconstruction period. Nepal follows patriarchal system and men can afford more leisure time as compared to women. During the disaster period, some of the households lost their agricultural lands, livestock and other properties. These losses created some additional workload to women respondent, however at the same time; they learn to build confidence, self-respect, self-esteem, and self-dependency.Although Nepal is predominantly agriculture, majority of the farmers are at subsistence level. In addition, men and women have different roles which differ with the variation in agro-production systems. Moreover women are extensively involved in agricultural activities though their importances were not recognized. Denial of land ownership and denial of access to resources as well as migration of male counterparts are some of the major reasons for affecting the agricultural environments for women in Nepal. CONCLUSION: The shelter reconstruction program has definitely brought positive change in women's access to decision making. The gradual increase in number of women respondent in access to decision making in different areas is a positive change and this has also provided them with a unique opportunity to change their gendered status in society.Furthermore, the exodus out-flow of male counterparts accelerated the additional burden and workload on women.

• Journal of Ginseng Research
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• 제44권5호
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• pp.697-703
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• 2020

Background: GS-3K8 and GINST, both of which are modified ginseng extracts, have never been examined in terms of their effectiveness for the prevention of acute respiratory illness (ARI) in humans. We conducted a pilot study to assess the feasibility of performing a large-scale, randomized, controlled trial. Methods: This study was a randomized, double-blind, placebo-controlled, pilot study at a single center from October 2014 to March 2015. The 45 healthy applicants were randomly divided into the GS-3K8 (n = 15), GINST (n = 15), and placebo groups (n = 15). The study drug was administered as a capsule (500 mg/cap and 3000 mg/day). GS-3K8 contained 6.31 mg/g of Rg1, 15.05 mg/g of Re, 30.84 mg/g of Rb1, 15.02 mg/g of Rc, 12.44 mg/g of Rb2, 6.97 mg/g of Rd, 1.59 mg/g of Rg3, 3.25 mg/g of Rk1, and 4.84 mg/g of Rg5. GINST contained 7.54 mg/g of Rg1, 1.87 mg/g of Re, 5.42 mg/g of Rb1, 0.29 mg/g of Rc, 0.36 mg/g of Rb2, 0.70 mg/g of Rd, and 6.3 mg/g of compound K. The feasibility criteria were the rates of recruitment, drug compliance, and successful follow-up. The primary clinical outcome measure was the incidence of ARI. The secondary clinical outcome measures were the duration of symptoms. Results: The rate of recruitment was 11.3 participants per week. The overall rate of completed follow-up was 97.8%. The mean compliance rate was 91.64 ± 9.80%, 95.28 ± 5.75%, and 89.70 ± 8.99% in the GS-3K8, GINST, and placebo groups, respectively. The incidence of ARI was 64.3% (9/14; 95% confidence interval [CI], 31.4-91.1%), 26.7% (4/15; 95% CI, 4.3-49.0%), and 80.0% (12/15; 95% CI, 54.8-93.0%) in the GS-3K8, GINST, and placebo groups, respectively. The average days of symptoms were 3.89 ± 4.65, 9.25 ± 7.63, and 12.25 ± 12.69 in the GS-3K8, GINST, and placebo groups, respectively. Conclusion: The results support the feasibility of a full-scale trial. GS-3K8 and GINST appear to have a positive tendency toward preventing the development of ARI and reducing the symptom duration. A randomized controlled trial is needed to confirm these findings.