• Korean Journal of Medicinal Crop Science
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• v.26 no.4
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• pp.271-280
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• 2018

Background: Astragalus membranaceus is a well known oriental medicinal herb. The polysaccharides of the aboveground parts (AMA) and the radix (AMR) of A. membranaceus are the most important functional constituents. Methods and Results: The aim of this study was to determine the effects of AMA and AMR on the oxidative damage induced in the skeletal muscle of rats subjected to exhaustive exercise. Sprague-Dawley rats were randomly divided into exercise and non-exercise groups; in the groups receiving the test compounds, AMA and AMR were administered orally for 30 days. Skeletal muscle samples were collected from each rat after running to exhaustion on a treadmill to determine the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) and the concentation of malondialdehyde (MDA). The antioxidant enzyme activities of SOD and GSH-Px of skeletal muscle of AMA- and AMR-treated groups were significantly higher than those of the control and commercial sports drink (SPD)-treated groups in exhaustive exercise rats. In addition, MDA concentrations in the skeletal muscle of the AMA- and AMR-treated groups were significantly lower than those of the control and SPD-treated groups. In the present study, the effects of AMA and AMR on exercise endurance capacity were also evaluated in mice subjected to a swimming exercise test. AMA and AMR supplementation prolonged the swimming time of mice and enhanced exercise endurance capacity. AMA and AMR possess the ability to retard and lower the production of blood lactate, and prevent the decrease of serum blood glucose. Conclusions: These results showed that, AMR and AMA exerted beneficial effect in mice, increasing the activity of the antioxidant systems and inhibiting oxidative stress induced by exhaustive exercise. The compounds improved exercise performance and showed anti-fatigue effects against exhaustive exercise.

• Journal of Preventive Medicine and Public Health
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• v.35 no.4
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• pp.282-286
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• 2002

Objectives : The level of 4-hydroxyproline (4-Hyp) in human urine was measured using high performance liquid chromatography (HPLC) with a fluorescence detector. This method is useful for medical examinations and investigating the radicals induced by physical, chemical, mental stresses. This method is superior to many published several methods in terms of its low cost and ability to analyze many samples. Methods : The urine from workers in a tire manufacturing company (22 male pre- and post-shift workers) and 18 office-workers as controls were analyzed. Data concerning age, the cumulative drinking amount and the cumulative smoking amount was collected with a questionnaire. The optimum applied amount of dansyl-Cl, the optimum reaction temperature and time, the recoveries and the optimum pH of the eluent and buffer were determined.4-Hyp from human urine was derivatized with dansyl-Cl (dimethylamino-naphthalene-1-sulfonyl chloride) after removing the a-amino acid by a treatment with phthalic dicarboxaldehyde (OPA) and cleaned with Bond Elut C18 column. The 4-Hyp derivatives were separated on a reversed phase column by gradient elution with a phosphate buffer (5 mmol, pH 8.0) and acetonitrile, and detected by fluorescence measurements at 340 nm (excitation) and 538 nm (emission). Results : The detection limit for the urinary free 4-Hyp was $0.364{\mu}mol/l$. The recovery rate of 4-Hyp was 99.7%, and the effective pH of the phosphate buffer and borate buffer were 3.0 and 8.0, respectively. From statistical analysis, age, drinking and smoking did not affect the urinary free 4-Hyp in both the controls and workers. The range of urinary 4-Hyp in the controls, pre-shift, and post-shift workers were 0.33-16.44, N.D-49.06, and $0.32-56.27{\mu}mol/l$. From the pared-sample t-test, the urinary 4-Hyp levels in post-shift workers ($11.82{\pm}6.73\;nmmol/mg\;Cre$) were 2-fold higher than in pre-shift workers ($5.36{\pm}5.53\;nmol;/mg\;Cre$) and controls ($4.91{\pm}4.89\;nmol;/mg\;Cre$). Conclusions : This method was developed with high sensitivity, accuracy, and precision. The present method was effectively applied to analyze the urinary free 4-Hyp in both controls and workers.

• Molecules and Cells
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• v.40 no.2
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• pp.133-142
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• 2017

Previous studies have shown that bone marrow mesenchymal stromal cell (MSC) transplantation significantly improves the recovery of neurological function in a rat model of intracerebral hemorrhage. Potential repair mechanisms involve anti-inflammation, anti-apoptosis and angiogenesis. However, few studies have focused on the effects of MSCs on inducible nitric oxide synthase (iNOS) expression and subsequent peroxynitrite formation after hypertensive intracerebral hemorrhage (HICH). In this study, MSCs were transplanted intracerebrally into rats 6 hours after HICH. The modified neurological severity score and the modified limb placing test were used to measure behavioral outcomes. Blood-brain barrier disruption and neuronal loss were measured by zonula occludens-1 (ZO-1) and neuronal nucleus (NeuN) expression, respectively. Concomitant edema formation was evaluated by H&E staining and brain water content. The effect of MSCs treatment on neuroinflammation was analyzed by immunohistochemical analysis or polymerase chain reaction of CD68, Iba1, iNOS expression and subsequent peroxynitrite formation, and by an enzyme-linked immunosorbent assay of pro-inflammatory factors (IL-$1{\beta}$ and TNF-${\alpha}$). The MSCs-treated HICH group showed better performance on behavioral scores and lower brain water content compared to controls. Moreover, the MSC injection increased NeuN and ZO-1 expression measured by immunochemistry/immunofluorescence. Furthermore, MSCs reduced not only levels of CD68, Iba1 and pro-inflammatory factors, but it also inhibited iNOS expression and peroxynitrite formation in perihematomal regions. The results suggest that intracerebral administration of MSCs accelerates neurological function recovery in HICH rats. This may result from the ability of MSCs to suppress inflammation, at least in part, by inhibiting iNOS expression and subsequent peroxynitrite formation.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.10
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• pp.655-665
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• 2016

Considering the importance of SMEs, which account for 88% of employment and 99% of domestic businesses, the government has implemented informatization policy support. On the other hand, due to budget limitations and the ability of the private market, it is time to transition to the new policy of the informatization support paradigm. This study evaluated the informatization policy support of SMBA by a comparison with the stage model to determine the future direction. The informatization development model is a step model divided into five levels ranging from the informatization initiation level to the strategic innovation level. The informatization policy of SMBA was focused on the development of automation and in-house integration, and business-to-business integration and strategic innovation step was found to be lacking. Based on these results, there are three implications for the informatization policy of the next SMEs. First, there is a need for a movement of the center of the support in the informatization step to the strategic innovative step. Second, by establishing an informatization road map, it is necessary to develop their own informatization capabilities according to the road map. Finally, it is important to improve the effectiveness of informatization support based on performance rather than policy providers.

• Current Research on Agriculture and Life Sciences
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• v.5
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• pp.12-18
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• 1987

This study was performed to investigate the creeping habit in top-cross progeny, and to determine the relationship among the major agronomic characters in the top-cross progeny testing based on the The The conclusions of simple correlation coefficients. the study were summarized as follows ; The creeping type crossed with the non-creeping tester was the greatest in width and seed yield. For all three characters, the creeping type crossed with the non-creeping tester and the non-creeping type crossed with the creeping tester were greater than any other combination. The top-cross method was desirable for the study of general and specific combining ability. The sensitivity of the tester to differentiate the creeping and non-creeping types was better when a non-creeping tester was used.

• Journal of the Korea Computer Industry Society
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• v.3 no.1
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• pp.95-104
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• 2002

This paper presents some studies on the Internet TCP/IP(Transmission Control Protocol-Internet Protocol) traffic over ATM(Asynchronous Transfer Mode) UBR(Unspecified Bit Rate) and ABR(Available Bit Rate) classes of service. Fuzzy logic prediction has been used to improve the efficiency and fairness of traffic throughput. For TCP/IP over UBR, a novel fuzzy logic based cell dropping scheme is presented. This is referred to as fuzzy logic selective cell drop (FSCD). A key feature of the scheme is its ability to accept or drop a new incoming packet dynamically based on the predicted future buffer condition in the switch. This is achieved by using fuzzy logic prediction for the production of a drop factor. Packet dropping decision is then based on this drop factor and a predefined threshold value. Simulation results show that the proposed scheme significantly improves TCP/IP efficiency and fairness. To study TCP/IP over ABR, we applied the fuzzy logic ABR service buffer management scheme from our previous work to both approximate and exact fair rate computation ER(Explicit cell Rate) switch algorithms. We then compared the performance of the fuzzy logic control with conventional schemes. Simulation results show that on zero TCP packet loss, the fuzzy logic control scheme achieves maximum efficiency and perfect fairness with a smaller buffer size. When mixed with VBR traffic, the fuzzy logic control scheme achieves higher efficiency with lower cell loss.

• The Korean Journal of Emergency Medical Services
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• v.12 no.1
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• pp.17-26
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• 2008

Purpose : With a view to providing basic data to develop basic cardiopulmonary resuscitation education suitable for female college students, the basic cardiopulmonary resuscitation education was conducted to grasp students' knowledge, skill accuracy and the attitude change before and after the education. Methods : Convenience sampling was made on first graders(total-38 students) of K college located in K city, Chungcheongnam-do, and this was a preliminary research designed before and after choosing a single group. In terms of methods, the researchers as specified ; 1) Handed out questionnaires to students directly to make them fill in firsthand and collected the questionnaires. 2) Utilized Power Point materials based on 2005 AHA guideline and used Anne/Skill Reporter$^{(R)}$ torso produced by Leardal Inc, and Little Anne$^{(R)}$ to conduct practical education individually. 3) Asked students to give Anne/Skill Reporter$^{(R)}$ torso basic cardiopulmonary resuscitation five times with the ratio of 30:2, and then one of researchers filled in the evaluation sheet individually. 4) Evaluated the accuracy of students' ability to perform the resuscitation based on the record of Anne/Skill Reporter$^{(R)}$ integrated printer(which was the objective tool to grasp students' skills accuracy). 5) Gave out questionnaires to make students fill them in and then collected them, after completing the practical evaluation. Results : 1) In case of the attitude(confidence) about basic cardiopulmonary resuscitation, students' confidency rose from 14%(before the education) to 55.5%(after the education)- which was a positive change. 2) In case of the attitude(educational necessity) about basic cardiopulmonary resuscitation, students' confidency rose from 94.7%(before the education) to 100%(after the education)- which was a positive change. 3) As a result of the education, some female college students' scored knowledge about basic cardiopulmonary resuscitation. The average point also reached 88.95%(after the education), jump from 63.51%(before the education), which was the rise of 25.44%. 4) Regarding skill accuracy, pressure accuracy(%)($M{\pm}SD=91.37{\pm}14.16$) was higher than respiration accuracy(%)($M{\pm}SD=61.55{\pm}26.13$). Conclusion : The result showed that students' attitude(confidence, on basic cardiopulmonary resuscitation changed positively, and meaningful difference(p= .000) existed in the change of students' knowledge. Anne/Skill Reporter$^{(R)}$ performance showed that the accuracy of mouth-to-mouth resuscitation was lower than that of chest compression.

• The Journal of the Korea Contents Association
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• v.19 no.10
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• pp.315-324
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• 2019

In this research, one of five Hofstede's cultural dimension, Long term orientation (LTO) was selected to examine its influence on individual's change oriented organizational citizenship behavior with emotional regulation mediating. East Asian countries and Korea especially received higher score on LTO cultural dimension, meaning it valued harmony, long term relations and saving for future. Also, in today's hyper competitive and evolving global climate, the ability to adapt quickly and also to be able to control one's emotion is highly valued individual competency. Previous research on Hofstede's cultural dimensions were conducted at mostly national or large group levels. However, in this study, Yoo's CVSCALE which allowed for individual level analysis on Hofstede's cultural dimensions were used to analyze multinational company's employees's long term orientations' influence on emotional regulation and change oriented organizational citizenship behavior. The survey conducted from 200 employees from major electronic company based in S city in Korea for two weeks period and the results indicated long term orientation positively influenced change oriented organizational citizenship behavior. Also emotional regulation mediated between long term orientation felt by individuals and change oriented organizational citizenship behavior. Such results validated previous studies that indicated emotional regulation as possible antecedents of individual proactive behaviors such as change organizational citizenship behavior and long term oriented view as another potential antecedent of change oriented organizational citizenship behavior in multinational corporation setting.

• Journal of Convergence for Information Technology
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• v.8 no.3
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• pp.175-181
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• 2018

The purpose of this study is to explore the educational needs of learning supporting program on the students' perception of current competencies and important competencies. The data was collected by using the online type (e-mail survey) and the offline type (printed survey) with survey instrument developed by researcher. Survey instrument was composed of 3 categories and 10 competencies. Collected data was analyzed using the SPSS 21.0 for Windows statistical package. And 159 cases were analyzed finally. The paired t-test was conducted to analyze the difference between importance-performance of students' competencies. The educational needs of learning supporting program were calculated by using the Borich's formula. The findings were as follows: The first, 3 categories and 10 competencies were significant difference exists statistically. The second, The high ranks of the educational needs of learning supporting program were 'Major field knowledge', followed by 'Creativity', 'Problem solving ability', 'Global capability', 'Technology capability' in sequence. The results of this study reflected the authentic needs of students will be used a basic data to establish the curriculum for learning supporting program.

• Journal of Convergence for Information Technology
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• v.9 no.12
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• pp.1-7
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• 2019

As the cloud environment has become more prevalent among large companies, small and medium-sized companies are also trying to utilize various technologies (IoT, blockchain, etc.) that use cloud services as a way to coexist with large companies. In this paper, a blockchain-based IoT information collection model is proposed to efficiently handle large volumes of IoT data produced by small businesses in order to improve information efficiency of SMEs. The proposed model allowe d small businesses to improve their production efficiency by independently creating groups of the same information so that data that could be generated at the endpoints of small businesses can be block-chained and forwarded to the data center for analysis. In addition, the proposed model's performance assessment was assumed to handle the production throughput of data processed in IoT for small and medium businesses, not large enterprises, so the link between large volumes of data processed in the proposed model could be maintained evenly. One of the biggest features of the proposed model is the ability to expand processes to efficiently control the information of prod ucts produced, as well as the productivity of small and medium enterprises.