• Journal of The Korean Association For Science Education
• /
• v.42 no.2
• /
• pp.201-214
• /
• 2022

The purpose of this study is to examine the characteristics of model of the experiment in students' open inquiry. The research is a reinterpretation of the data collected from the performance of a three-year research project under the theme of 'school science inquiry' the perspective of model of the experiment. The inquiry activities of a focus group made up of four students have been recorded seven times. The recorded files and transcribed copies were analyzed according to interpretive methods. Students' activities were divided into three modeling of the experiment units, considering the modeling unit that includes the process of starting from the problem until it gets solved. The results of the study include illuminating the dynamic process and characteristics of modeling of the experiment and discussing its educational meaning as a distributed cognitive system at each modeling unit. First, students, instruments, and the primitive form of calculation represented by the interaction between them turned out to be important factors in the distributed cognitive system that constitutes model of the experiment. Second, in the early stages, non-verbal activities were carried out in which students became familiar with instruments, and verbal quantitative signs were created when the activities were sufficiently carried out. The generated quantitative signs became a source of data and confidence that can be referenced in subsequent activities. Third, the specialization of instrumentalization occurred, and factors that were important in inquiry, such as variable control, appeared. The results of the study provide new implications for science education research and education, which have been centered on explanatory models, by unfolding the characteristics of model of the experiment that have not been noticed in science education through students' inquiry.

• Journal of agricultural medicine and community health
• /
• v.47 no.1
• /
• pp.14-26
• /
• 2022

Objectives: Handwashing is one of the most effective methods to prevent the spread of infectious diseases. This study assessed the related factors and reasons for not practicing handwashing at school among adolescents. Methods: We analyzed data collected from 57,303 adolescents who participated in the 15th Korea Youth Risk Behavior Survey 2019. Results: The proportions of not washing hands "before meals at school" and "after using the toilet at school" were 15.9% and 4.4%, respectively. The adjusted odds ratio for not washing hands before meals at school was significantly higher in girls (Odds Ratio [OR]=1.52, 95% Confidence Intervals [CI]=1.42-1.63), metropolitan city (OR=1.32, 95% CI=1.11-1.56), city (OR=1.29, 95% CI=1.08-1.54), higher grade, higher academic performance, lower economic status, not handwashing at home (OR=14.36, 95% CI=13.37-15.42), and without annual personal hygiene education (OR=1.41, 95% CI=1.33-1.49). Reasons for not washing hands at school among adolescents who do not wash their hands before meals at school included 'it is bothersome (52.3%)', 'there is no soap or hand sanitizer (13.8%)', and 'I do not feel the need (9.5%)'. Conclusions: Improving handwashing before meals at school among adolescents requires raising awareness of the importance of handwashing before meals and establishing a suitable environment and handwashing-encouraging culture.

• KIPS Transactions on Computer and Communication Systems
• /
• v.11 no.5
• /
• pp.147-156
• /
• 2022

Industrial control systems that manage and maintain various industries were mainly operated in closed environment without external connection, but with the recent development of the Internet and the introduction of ICT technology, the access to the industrial control system of external or attackers has become easier. Such incorrect approaches or attacks can undermine the availability, a major attribute of the industrial control system, and violation of availability can cause great damage. In this paper, when issuing commands in an industrial control system, a verification group is formed using a random list to verify and execute commands, and a trust score technique is introduced that applies feedback to the verification group that conducted verification using the command execution result. This technique can reduce overhead generated by random generation in the process of requesting command verification, give flexibility to the verification process, and ensure system availability. For the performance analysis of the system, we measured the time and gas usage when deploying a smart contract, gas usage when verifying a command. As a result, we confirmed that although the proposed system generates a random list compared to the legacy system, there was little difference in the time when it took to deploy smart contract and that the gas used to deploy smart contract increased by about 1.4 times in the process of generating a random list. However, the proposed system does not perform random operations even though the operation of command verification and confidence score technique is performed together during the command verification process, thus it uses about 9% less gas per verification, which ensures availability in the verification process.

• Journal of Korean Neurosurgical Society
• /
• v.65 no.5
• /
• pp.751-757
• /
• 2022

Objective : Tumours of the brain are a rare occurrence accounting for approximately 2% of all neoplasms in adults. Few studies have been done in Nigeria on the profile of brain tumours. The aim of this study is to determine the profile of brain tumours in general and determine the change in Kanofsky Performance Score (KPS) after treatment. Methods : This is a prospective hospital-based study in Kaduna. All consecutive patients over 18 years of age with diagnosis of brain tumours from January 2016 to December 2019 were included in the study. Demographic and clinical data was collected using a proforma during the study. Patients who received treatment were followed up for 12 months. The primary outcome data was the difference in the quality of life as measured by KPS at the point of first contact and at 1-month after treatment and at 12-month follow up. Data obtained was analysed with SPSS version 25.0 for Windows. Descriptive statistics was done to determine the profile. Paired t-test at 95% confidence interval was done to check for significant correlation between the mean KPS. Results : A total of 39 consecutive patients were included in the study. There was a slight male preponderance with a M : F of 1.17 : 1. Meningioma and metastasis were more common in females while gliomas and pituitary tumours were more common in males. The mean age of patients was 49.8 years and standard deviation of 11.8 years. Pituitary tumours were the most common tumours. The most common location of the tumour was frontal lobe followed by the pituitary gland. The mean duration of symptoms before neurosurgical consultation was 38 weeks. The most common presenting symptoms of patient with brain tumour was headache. The quality of life improve compare to the baseline in 81% of patient at discharge and at 1 year follow up. The overall mortality rate was 25.6%. Conclusion : The most common brain tumour in our study is pituitary tumour. Most patients present late. The most common presenting symptoms is headache. There is significant improvement in the KPS of patients following treatment. The overall mortality rate at 1-year post treatment is 25.6%.

• Journal of the Korea Organic Resources Recycling Association
• /
• v.29 no.4
• /
• pp.33-40
• /
• 2021

In this study, the physico-chemical and biological characteristics of anaerobic granular sludge at different heights of a full-scale UASB reactor (UASBr) were investigated. Granular sludge was taken from 1 m, 2 m, and 3 m above the ground level in the UASBr. The morphological analysis showed that the upper part had bigger granules and the lower part had rounder granules. The ANOVA test confirmed that the mean size and the roundness of the granules had statistically significant difference along the height at 95% confidence level, and there was a significant negative linear relationship between the size and roundness (r=-0.40, p<0.05). A SMA test using acetic, propionic and butyric acids showed that granules from 2 m height had the highest specific methanogenic activity. The EPS contents were also unequal to each height, with 2 m showing the highest content. These findings could be helpful to understand the different characteristics of stratified anaerobic granules in full-scale UASBr and maintain the reactor performance.

• Analytical Science and Technology
• /
• v.22 no.1
• /
• pp.101-108
• /
• 2009

The bioequivalence of two pioglitazone tablets, Actos$^{(R)}$ tablet (Takeda Chemical Industries, reference drug) and Pioglitazone tablet (Boryung Company, test drug) was evaluated according to the guidelines of Korea Food and Drug Administration. Twenty-eight healthy male Korean volunteers received each medicine (pioglitazone dose of 30 mg) in a $2{\times}2$ crossover study with one week washout interval. After drug administration, blood samples were collected at specific time intervals from 0-36 hours. The plasma concentrations of pioglitazone were determined by high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS). The total chromatographic run time was 5 min and calibration curves were linear over the concentration range of 5-2000 ng/mL for pioglitazone. The method was validated for selectivity, sensitivity, linearity, accuracy and precision. The pharmacokinetic parameters were determined from the plasma concentration-time profiles of both formulations. The primary calculated pharmacokinetic parameters were compared statistically to evaluate bioequivalence between the two preparations. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for Pioglitazone tablet and Actos$^{(R)}$ tablet were log0.9422~log1.1040 and log0.9200~log1.1556, respectively. Based on the statistical considerations, we can conclude that the test drug, Pioglitazone tablet was bioequivalent to the reference drug, Actos$^{(R)}$ tablet.

• 한국노년학
• /
• v.39 no.2
• /
• pp.241-259
• /
• 2019

The purpose of this study was to study the performance of volunteer work for the elderly from the perspective of self-efficacy and self-extension of the elderly, not from successful aging or productive aging. Through this, the research aims to confirm the expansion of internal growth and self-sufficiency that can occur in old age, and to provide an opportunity to re-examine one's life in old age. In order to verify the purpose of this research, questionnaires were distributed to 300 senior citizens who participated in volunteer activities at the City Hall and the District Office of Busan Metropolitan City over a period of three months from September to November 2018 and used the data from 266 questionnaires for the study, excluding the 34questionnaire answered unfaithfully. The results of the study are as follows. First, the motivation for volunteering activities (value function, social function, understanding function) of the elderly has a positive effect on self-efficacy. Second, the motivation for volunteering activities (value functions, social functions, understanding functions) have a positive effect on self-extension. Third, it has been shown that the elderly's sense of self-efficacy (self-regulation efficacy, confidence) has a positive effect on their self-extension. Fourth, it was found that self-efficacy has a mediated effect on the motivation of the elderly to participate in volunteer activities and the relationship of self-extension. This study identified the relevance of the motivation for volunteering activities of the elderly to influence their effectiveness and self-extension. In particular, the research suggests practical and policy measures for the revitalization of volunteer activities of the elderly by providing a new perspective on the welfare of the elderly by utilizing parameters of self-efficacy, a psychological and social concept for the elderly.

• Journal of Digestive Cancer Research
• /
• v.6 no.1
• /
• pp.25-31
• /
• 2018

Background: In Korea, stomach cancer is the second most common malignancy and the third leading cause of cancer-related deaths. the time of diagnosis is very important for treatment so early detection and surgery are currently considered the mainstay of treatment, when diagnosed advanced with tumor extension through the gastric wall and direct extension into other organs, with metastatic involvement. Recently, new drugs, drug combinations, and multimodal approaches have been used to treat this disease and In cancers over expressing or amplifying HER2, the combination of cisplatin-fluoropyrimidine-trastuzumab is considered to be the treatment of reference. but At present, the choice of treatment schedule for HER2-negative tumors is based on the medical institution's preferences and adverse effects profile. The aim of this study was to evaluate the effectiveness and safety of using FOLFOX regimen as a first-line therapy or a salvage therapy in the patients with HER2-negative advanced or metastatic gastric cancer. Methods: We retrospective reviewed the patient medical record from March 2012 to July 2017. This study evaluated 113 patients. Sixty-eight patients were treated with the FOLFOX regimen for the first time (first-line group) and 45 patients were treated with the FOLFOX regimen as a second (35 patients) or third (10 patients) chemotherapy (salvage group). Results: In the first-line group, the response rate was 54.9%. In the salvage therapy group, the response rate was 24.4% and The difference was statistically significant (p=0.205). The median TTP of the first-line group was 10.7 months (95% confidence interval [95% CI], 7.8-13.7 months) and that of salvage line group was 6.1 months (95% CI, 3.8-8.4 months). The median OS of the first-line group was 15.8 months (95% CI, 12.7-18.9 months) and that of the salvage therapy group was 10.2 months (95% CI, 8.2-11.9 months). drug toxicity was similar andtolerable between two groups. Conclusion: In patients with unresctable metastatic gastric cancer, after failing to respond to first-line therapy, most patients have no alternative other than second-line therapy because the disease is highly progressive. if the performance status of the patient is good enough to be eligible to treatments beyond best supportive care. FOLFOX regimen can be a considerable therapeutic option for salvage treatment.

• Education of Primary School Mathematics
• /
• v.26 no.4
• /
• pp.333-348
• /
• 2023

Clear analysis and diagnosis of various characteristic factors of individual students is the most important in order to realize individual customized teaching and learning, which is considered the most essential function of math artificial intelligence-based digital textbooks. In this study, analysis factors and tools for individual customized learning diagnosis and construction models for data collection and analysis were derived from mathematical AI digital textbooks. To this end, according to the Ministry of Education's recent plan to apply AI digital textbooks, the demand for AI digital textbooks in mathematics, personalized learning and prior research on data for it, and factors for learner analysis in mathematics digital platforms were reviewed. As a result of the study, the researcher summarized the factors for learning analysis as factors for learning readiness, process and performance, achievement, weakness, and propensity analysis as factors for learning duration, problem solving time, concentration, math learning habits, and emotional analysis as factors for confidence, interest, anxiety, learning motivation, value perception, and attitude analysis as factors for learning analysis. In addition, the researcher proposed noon data on the problem, learning progress rate, screen recording data on student activities, event data, eye tracking device, and self-response questionnaires as data collection tools for these factors. Finally, a data collection model was proposed that time-series these factors before, during, and after learning.

• Journal of Yeungnam Medical Science
• /
• v.40 no.4
• /
• pp.388-393
• /
• 2023

Background: Differentiating between bacterial and nonbacterial colitis remains a challenge. We aimed to evaluate the value of serum procalcitonin (PCT) and C-reactive protein (CRP) in differentiating between bacterial and nonbacterial colitis. Methods: Adult patients with three or more episodes of watery diarrhea and colitis symptoms within 14 days of a hospital visit were eligible for this study. The patients' stool pathogen polymerase chain reaction (PCR) testing results, serum PCT levels, and serum CRP levels were analyzed retrospectively. Patients were divided into bacterial and nonbacterial colitis groups according to their PCR. The laboratory data were compared between the two groups. The area under the receiver operating characteristic curve (AUC) was used to evaluate diagnostic accuracy. Results: In total, 636 patients were included; 186 in the bacterial colitis group and 450 in the nonbacterial colitis group. In the bacterial colitis group, Clostridium perfringens was the commonest pathogen (n=70), followed by Clostridium difficile toxin B (n=60). The AUC for PCT and CRP was 0.557 and 0.567, respectively, indicating poor discrimination. The sensitivity and specificity for diagnosing bacterial colitis were 54.8% and 52.6% for PCT, and 52.2% and 54.2% for CRP, respectively. Combining PCT and CRP measurements did not increase the discrimination performance (AUC, 0.522; 95% confidence interval, 0.474-0.571). Conclusion: Neither PCT nor CRP helped discriminate bacterial colitis from nonbacterial colitis.