• Journal of Pharmaceutical Investigation
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• v.31 no.4
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• pp.225-232
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• 2001

The present study was carried out to observe the effect of liposome dispersed gel formulation (Lipogel) on topical delivery of ascorbyl palmitate (AsP). Neutral and negatively charged MLV liposomes containing AsP were prepared with dimyristoylphosphadtidylcholine (DMPC) and dicetyl phosphate (DCP), and dispersed to poloxamer gel matrix. In the hydrolysis study in rat's skin homogenates, AsP hydrolyzed to ascorbic acid (AsA) according to the first-order kinetics with the rate constant of $2.46{\times}10^{-2}\;min^{-1}$. In the passive skin penetration study using Franz diffusion cell, lipogel systems exhibited the greater values in the flux $(J_s)$ and the amount penetrated $(Q_p)$ compared to control hydrogels containing diethyleneglycol monoethyl ether $(Transcutol^{\circledR})$ as a solubilizing agent and a penetration enhancer for AsP. The total amount penetrated $(Q_{Total})$, which is expressed as a summation of $Q_P\;and\;Q_L$, for lipogel system was about 1.4 times higher in average than that of control hydrogel. However the amount localized in the skin $(Q_L)$ was similar in both formulations. As a result, lipogel system enhanced the skin penetration of AsP, possibly due to the increase in local concentration of AsP by preferential adsorption of liposome to the skin and the enhancing effect of phospholipid in liposome composition. Moreover it was expected that the penetrated AsP would generate AsA during skin penetration by the skin esterase. In conclusion, lipogel formulation was considered as a good candidate for topical delivery of AsP.

• Korean Journal of Food Science and Technology
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• v.7 no.4
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• pp.208-211
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• 1975

Round muscle of Korean cattle treated with papain were examined the tenderness relation by use of penetrometer which results were indicated as follows. 1. Measuring method of tenderness effect in bovine muscle was acknowledged that there are correlation by using penetrometer (p<.05) 2. Penetration value were also proportional increased according to increasing of enzyme concentration. 3. It was acknowledged as considerable difference in penetration value cf longitudinal and cross section against muscle fiber. 4. In the case of 0.05% enzyme addition, there are extremely high increasing rate of tenderness in longitudinal and cross section but it was not acknowledged as significant difference in 0.1% of enzyme concentration.

• Journal of Pharmaceutical Investigation
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• v.29 no.1
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• pp.29-36
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• 1999

Aceclofenac is an non-steroidal antiinflammatory drug which has been used in the treatment of rheumatoidal rthritis and osteo-arthritis. In order to decrease the gastric ulcerogenic effects and contol the plasma level of aceclofenac, we have developed the transdermal delivery system of aceclofenac plaster, which were formulated employing matrix polymers of acrylates and penetration-enhancers such as $Lauroglycol^{\circledR}$, $Transcutol^{\circledR}$, oleic acid and linoleic acid. Using Franz diffusion cells mounted with a rat skin, transdermal penetration characteristics of the formulations were evaluated by the HPLC assay of aceclofenac and diclofenac, an active metabolite, in the receptor compartment of pH 7.2 phosphate buffered solution. Skin penetration was increased when the content of aceclofenac increased, showing the flux $(J,\;{\mu}g/cm^2/hr)$ of 0.37 and 2.50 for 2% and 6.75% of the content, respectively. The flux$(J,\;{\mu}g/cm^2/hr)$ from plasters made of $Durotak^{\circledR}$ 87-2074, $Durotak^{\circledR}$ 87-2510 and $Durotak^{\circledR}$ 87-2097 were 2.50, 2.77 and 4.39, respectively. $Durotak^{\circledR}$ 87-2074 showed the lowest penetration due to the carboxylic acid group in the polymer, which might form a strong hydrogen bonding with a secondary amine of aceclofenac. Although both $Durotak^{\circledR}$ 87-2510 and $Durotak^{\circledR}$ 87-2097 are amine-resistant adhesives, $Durotak^{\circledR}$ 872510 showed lower penetration than $Durotak^{\circledR}$ 87-2097 because of the hydroxyl group in $Durotak^{\circledR}$ 87-2510, which might form a weak hydrogen bonding with aceclofenac. These results reveal that the functional group in acrylic polymers would greatly affect the release of aceclofenac from the matrix, which is the rate-limiting step in the penetration of aceclofenac through rat skins. The penetration of aceclofenac from plasters using different penetration-enhancers increased in the following order: Transcutol < linoleic acid < oleic acid. And the flux from the plasters containing oleic acid as a penetrationenhancer was 2.22 times greater than that of creams, which suggest that a newly deveolped aceclofenac plaster could be used in the treatment of rheumatoidal arthritis and osteo-arthritis as an advanced transdermal delivery system.

• Preventive Nutrition and Food Science
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• v.20 no.1
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• pp.60-66
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• 2015

The aim of this study was to determine the heat-penetration characteristics using stationary and rotary retorts to manufacture Kimchi soup. Both heat-penetration tests and computer simulation based on mathematical modeling were performed. The sterility was measured at five different positions in the pouch. The results revealed only a small deviation of $F_0$ among the different positions, and the rate of heat transfer was increased by rotation of the retort. The thermal processing of retort-pouched Kimchi soup was analyzed mathematically using a finite-element model, and optimum models for predicting the time course of the temperature and $F_0$ were developed. The mathematical models could accurately predict the actual heat penetration of retort-pouched Kimchi soup. The average deviation of the temperature between the experimental and mathematical predicted model was 2.46% ($R^2=0.975$). The changes in nodal temperature and $F_0$ caused by microbial inactivation in the finite-element model predicted using the NISA program were very similar to that of the experimental data of for the retorted Kimchi soup during sterilization with rotary retorts. The correlation coefficient between the simulation using the NISA program and the experimental data was very high, at 99%.

• Journal of ILASS-Korea
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• v.15 no.3
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• pp.115-123
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• 2010

The purpose of this study is to compare and to investigate spray characteristics of dimethyl ether (DME) and diesel fuel in the various injection pressures, ambient pressures, and the energizing durations. For the analysis of the spray characteristics, the spray visualization system including the high speed camera and the spray image analyzer is installed. The spray characteristics such as the spray development process, spray tip penetraion and the spray cone angle are analyzed from the spray images. It was revealed that the spray characteristics of DME and diesel fuels are mainly affected by the injection conditions. However, in the region after the end of the injection, the spray tip penetration was affected by the fuel properties such as the fuel density, the surface tension, and the viscosity. DME fuel has generally a short tip penetration and a wide cone angle. In the elevating conditions of the ambient gas pressure, the spray cone angle of DME fuel converged to high value when comparing diesel fuel in advance. Also, the increasing rate of the spray tip penetration in DME fuel is significantly decreased from 0.7 ms of the energizing duration (diesel : 0.9 ms).

• Transactions of the Korean Society of Automotive Engineers
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• v.11 no.2
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• pp.56-62
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• 2003

Spray characteristics of conventional diesel fuel and bio-diesel fuel(methyl-ester of soybean oil) were compared, in terms of spray tip penetration and spray angle, by using a commercial high pressure common rail injection system for light-duty DI Diesel engines. The experiments were carried out under the non-evaporating condition at ambient density(8.8, $15.6 kg/\textrm{m}^3$) and injection pressure(75, 135 MPa). The experimental method was based on a laser sheet scattering technique. Spray tip penetrations of bio-diesel fuel were longer, on the whole, than those of conventional diesel fuel, except for lower injection pressure(75 MPa) under lower ambient density$(8.8 kg/\textrm{m}^3)$. But spray near angle and spray far angle of bio-diesel fuel were smaller than those of conventional diesel fuel, implying spray angle is related to the growth rate of spray tip penetration. The experimental results of spray tip penetration agreed well with the calculated values by the Wakuri et al.'s correlation based on the momentum theory.

• Structural Engineering and Mechanics
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• v.72 no.3
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• pp.367-382
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• 2019

This paper presents experimental and analytical investigations on additional fixed-end rotations resulting from the strain penetration of high-strength reinforcement in reinforced concrete (RC) beam-column connections under monotonic loading. The experimental part included the test of 18 interior beam-column connections with straight long steel bars and 24 exterior beam-column connections with hooked and headed steel bars. Rebar strains along the anchorage length were recorded at the yielding and ultimate states. Furthermore, a numerical program was developed to study the effect of strain penetration in beam-column connections. The numerical results showed good agreement with the test results. Finally, 87 simulated specimens were designed with various parameters based on the test specimens. The effect of concrete compressive strength ($f_c$), yield strength ($f_y$), diameter ($d_b$), and anchorage length ($l_{ah}$) of the reinforcement in the beam-column connection was examined through a parametric study. The results indicated that additional fixed-end rotations increased with a decrease in $f_c$ and an increase in $f_y$, $d_b$ and $l_{ah}$. Moreover, the growth rate of additional fixed-end rotations at the yielding state was faster than that at the ultimate state when high-strength steel bars were used.

• Korean Journal of Metals and Materials
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• v.46 no.5
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• pp.296-303
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• 2008

Hydrogen permeation through dense palladium-based membranes has attracted the attention of many scientists largely due to their unmatched potential as hydrogen-selective membranes for membrane reactor applications. Although it is well known that the permeation mechanism of hydrogen through Pd involves various processes such as dissociative adsorption, transitions to and from the bulk Pd, diffusion within Pd, and recombinative desorption, it is still unclear which process mainly limits hydrogen permeation at a given temperature and hydrogen partial pressure. In this study, we report an all-electron density-functional theory study of hydrogen permeation through Pd membrane (using VASP code). Especially, we focus on the variation of the energy barrier of the penetration process from the surface to the bulk with hydrogen coverage, which means the large reduction of the fracture stress in the brittle crack propagation considering Griffith's criterion. It is also found that the penetration energy barrier from the surface to the bulk largely decreases so that it almost vanishes at the coverage 1.25, which means that the penetration process cannot be the rate determining process.

• Journal of Electrochemical Science and Technology
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• v.12 no.4
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• pp.440-452
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• 2021

Enhancement of durability and reduction of maintenance cost of concrete, with the implementation of various approaches, has always been a matter of concern to researchers. The integration of pozzolans as a substitute for cement into the concrete is one of the most desirable technique. Silica fume (SF) and colloidal nanosilica (CS) have received a great deal of interest from researchers with their significant performance in improving the durability of concrete. The synergistic role of the micro and nano-silica particles in improving the main characteristics of cemented materials needs to be investigated. This work aims to examine the utility of partial substitution of cement by SF and CS in binary and ternary blends in the improvement of the durability characteristics linked to resistance for electrochemical corrosion using electrical resistivity and half-cell potential analysis and chloride penetration trough rapid chloride penetration test. Furthermore, the effects of this silica mixture on the compressive strength of concrete under normal and aggressive environment have also been investigated. Based on the maximum compression strength of the concrete, the optimal cement substituent ratios have been obtained as 12% SF and 1.5% CS for binary blends. The optimal CS and SF combination mixing ratios has been obtained as 1.0% and 12% respectively for ternary blends. The ternary blends with substitution of cement by optimal percentage of CS and SF exhibited decreased rate for electrochemical corrosion. The strength and durability studies were found in consistence with the microstructural analysis signifying the beneficiary role of CS and SF in upgrading the performance of concrete.

• Journal of Environmental Science International
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• v.13 no.7
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• pp.645-653
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• 2004

Indoor air quality is affected by source strength of pollutants, ventilation rate, decay rate, outdoor level, and so on. Although technologies measuring these factors exist directly, direct measurements of all factors are not always practical in most field studies. The purpose of this study was to develop an alternative method to estimate these factors by application of multiple measurements. For the total duration of 30 days, daily indoor and outdoor $NO_2$ concentrations were measured in 30 houses in Brisbane, Australia, and for 21 days in 40 houses in Seoul, Korea, respectively. Using a box model by mass balance and linear regression analysis, penetration factor (ventilation divided by sum of air exchange rate and deposition constant) and source strength factor (emission rate divided by sum of air exchange rate and deposition constant) were calculated, Sub-sequently, the ventilation and source strength were estimated. In Brisbane, the penetration factors were $0.59\pm0.14$ and they were unaffected by the presence of a gas range. During sampling period, geometric mean of natural ventilation was estimated to be $l.l0\pm1.5l$ ACH, assuming a residential $NO_2$ decay rate of 0.8 hr^{-1}$ in Brisbane. In Seoul, natural ventilation was $1.15\pm1.73$ ACH with residential $NO_2$ decay rate of 0.94 hr^{-1}$ Source strength of $NO_2$ in the houses with gas range $(12.7\pm9.8$ ppb/hr) were significantly higher than those in houses with an electric range $(2.8\pm2,6$ ppb/hr) in Brisbane. In Seoul, source strength in the houses with gas range were $l6.8\pm8.2$ ppb/hr. Conclusively, indoor air quality using box model by mass balance was effectively characterized.