• IMMUNE NETWORK
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• v.21 no.3
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• pp.18.1-18.13
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• 2021

TLR signaling is critical for broad scale immune recognition of pathogens and/or danger molecules. TLRs are particularly important for the activation and the maturation of cells comprising the innate immune response. In recent years it has become apparent that several different TLRs regulate the function of lymphocytes as well, albeit to a lesser degree compared to innate immunity. TLR2 heterodimerizes with either TLR1 or TLR6 to broadly recognize bacterial lipopeptides as well as several danger-associated molecular patterns. In general, TLR2 signaling promotes immune cell activation leading to tissue inflammation, which is advantageous for combating an infection. Conversely, inappropriate or dysfunctional TLR2 signaling leading to an overactive inflammatory response could be detrimental during sterile inflammation and autoimmune disease. This review will highlight and discuss recent research advances linking TLR2 engagement to autoimmune inflammation.

• Proceedings of the KIEE Conference
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• 1998.11c
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• pp.941-943
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• 1998

Exploitation of equipment with cross linked polyethylene (XLPE) insulation requires its condition monitoring and diagnostic. Traditionally diagnostics of insulation is carried out by means of partial discharge detection. Many researchers have developed a lot of methods to identify the defect by the PD form. However, such identification of a defect, for example, void, inclusion or treeing, does not say about its danger from a point of view of full insulation gap breakdown and insulation construction failure. The information about the form and size of formed upon high voltage treeing is necessary for prediction of the remained resource of XLPE insulation. For this purpose we carry out experimental research for determination of the dependencies between PD characteristics in XLPE upon time and three dimension PD patterns of corresponding treeing. The investigations were carried out by means of electrical measurement of PD current and simultaneous optical recording of treeing image. Test results show that the PD patterns can be applied for detecting tree growth well.

• Journal of information and communication convergence engineering
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• v.7 no.1
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• pp.7-12
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• 2009

The advanced computer network and Internet technology enables connectivity of computers through an open network environment. Despite the growing numbers of security threats to networks, most intrusion detection identifies security attacks mainly by detecting misuse using a set of rules based on past hacking patterns. This pattern matching has a high rate of false positives and can not detect new hacking patterns, making it vulnerable to previously unidentified attack patterns and variations in attack and increasing false negatives. Intrusion detection and prevention technologies are thus required. We proposed a network based hybrid Probe Intrusion Detection model using Fuzzy cognitive maps (PIDuF) that detects intrusion by DoS (DDoS and PDoS) attack detection using packet analysis. A DoS attack typically appears as a probe and SYN flooding attack. SYN flooding using FCM model captures and analyzes packet information to detect SYN flooding attacks. Using the result of decision module analysis, which used FCM, the decision module measures the degree of danger of the DoS and trains the response module to deal with attacks. For the performance evaluation, the "IDS Evaluation Data Set" created by MIT was used. From the simulation we obtained the max-average true positive rate of 97.064% and the max-average false negative rate of 2.936%. The true positive error rate of the PIDuF is similar to that of Bernhard's true positive error rate.

• Biomolecules & Therapeutics
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• v.31 no.4
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• pp.395-401
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• 2023

Innate immunity is a first line defence system in the body which is for sensing signals of danger such as pathogenic microbes or host-derived signals of cellular stress. Pattern recognition receptors (PRR's), which present in the cell memebrane, are suspect the infection through pathogen-associated molecular patterns (PAMP), and activate innate immunity with response to promote inflammation via inflammatory cells such as macrophages and neutrophils, and cytokines. Inflammasome are protein complexes which are part of innate immunity in inflammation to remove pathogens and repair damaged tissues. What is the important role of inflammation in disease? In this review, we are focused on the action mechanism of NLRP3 inflammasome in inflammatory diseases such as asthma, atopic dermatitis, and sepsis.

• Molecules and Cells
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• v.44 no.11
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• pp.830-842
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• 2021

When perceiving microbe-associated molecular patterns (MAMPs) or plant-derived damage-associated molecular patterns (DAMPs), plants alter their root growth and development by displaying a reduction in the root length and the formation of root hairs and lateral roots. The exogenous application of a MAMP peptide, flg22, was shown to affect root growth by suppressing meristem activity. In addition to MAMPs, the DAMP peptide PEP1 suppresses root growth while also promoting root hair formation. However, the question of whether and how these elicitor peptides affect the development of the vascular system in the root has not been explored. The cellular receptors of PEP1, PEPR1 and PEPR2 are highly expressed in the root vascular system, while the receptors of flg22 (FLS2) and elf18 (EFR) are not. Consistent with the expression patterns of PEP1 receptors, we found that exogenously applied PEP1 has a strong impact on the division of stele cells, leading to a reduction of these cells. We also observed the alteration in the number and organization of cells that differentiate into xylem vessels. These PEP1-mediated developmental changes appear to be linked to the blockage of symplastic connections triggered by PEP1. PEP1 dramatically disrupts the symplastic movement of free green fluorescence protein (GFP) from phloem sieve elements to neighboring cells in the root meristem, leading to the deposition of a high level of callose between cells. Taken together, our first survey of PEP1-mediated vascular tissue development provides new insights into the PEP1 function as a regulator of cellular reprogramming in the Arabidopsis root vascular system.

• Journal of the Society of Disaster Information
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• v.18 no.3
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• pp.495-506
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• 2022

Purpose: When a serious disaster occurred in East Japan on March 11, 2011, some evacuees in shock failed to avoid danger to the best of their ability. Why did they hesitate and waste their time? And why didn't they choose correct escaping routes? This study attempts to classify human behavior through psychological point of view and cognitive science and to interpret behavioral patterns based on animal behaviors from the field of biology. Method: This study first conceptually categorized walking behavior into intellectualization, automaticity and instinct based on the existing literature and matched these with empirical data. Result: The actual walking patterns observed failed to be compatible with these categories and consequently, this study suggests the following five categories: normal, busy, fast & straight, freezing and tizzy. This new classification of walking behavior is based on speed, variation of speed and change of direction. Conclusion: The method used in this study and the results can be applied to simulations of walking behavior and analysis of behavior in emergency situations.

• IMMUNE NETWORK
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• v.8 no.1
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• pp.1-6
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• 2008

Apoptosis signal-regulating kinase 1 (ASK1), a mitogen- activated protein kinase kinase kinase, plays pivotal roles in stress responses. In addition, ASK1 has emerged as a key regulator of immune responses elicited by pathogen-associated molecular patterns (PAMPs) and endogenous danger signals. Recent studies have demonstrated that reactive oxygen species (ROS)-dependent activation of ASK1 is required for LPS-stimulated cytokine production as well as extracellular ATP-induced apoptosis in immune cells. The mechanism of ROS-dependent regulation of ASK1 activity by thioredoxin and TRAFs has been well characterized. In this review, we focus on the molecular details of the activation of ASK1 and its involvement in innate immunity.

• Proceedings of the Korean Society for Emotion and Sensibility Conference
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• 1999.03a
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• pp.221-230
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• 1999

Automobile horn's psychoacoustic characteristic and significance as a anturalistic signal of danger makes it a valuable auditory stimulus to study such psychophysiological responses as startle, orienting and defense reactions. However, comparison and differentiation of physiological responses to commercially available horns is a complicated task due to small contrast of technical features of horns and influence of such processes as habituation on physiological outcome with increased number of auditory stimulation trials. In the study on 10 college students we performed comparative analysis of tonic and phasic reactivity of physiological responses mediated by autonomic nervous system in order to identify role of habituation and decrement of autonomic responsivity, as well as possibility o differentiate subjectively most and least preferred and subjectively more appropriate horns according to physiological manifestations. It was showed that electrodermal and cardiovascular reactivity have concurrent patterns of adaptation to repeated stimulation, namely skin conductance variables habituated, cardiac reactivity failed to show signs of habituation, while vascular component of response were facilitated demonstrating marked sensitization. Differentiation of Physiological responses to horns with respect to their subjective rating scores was possible, however electrodermal reactivity was effective only at the first block of trials, while phasic and tonic cardiovascular reactivity differentiate responses during whole course of experiment. There are discussed possible autonomic mechanisms involved in mediation of observed results.

• Journal of Satellite, Information and Communications
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• v.10 no.4
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• pp.77-82
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• 2015

This paper proposed an accident prediction model in order to prevent accidents in mountain areas using a big data analysis. Data of accidents in mountain areas are shown as graphs. We have analyzed cases: the number of accidents per year, day of week, time of day to find patterns of the negligent accident in mountain areas. The proposed prediction model consists of weighted variables of the accident in mountain through visualized big data analysis. The model of danger index performance is demonstrated by showing accident-prone areas with weighted variables.

• Journal of the Korean Society of Safety
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• v.13 no.1
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• pp.98-104
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• 1998

Recently, industrial accidents have occurred in various patterns due to the diversity of industries and the integration of facilities. Especially, the major accidents affect broad area and result in huge loss of lives and properties. Domestic researches on techniques for keeping away from such hazardous danger have been actively performed but their activities are limited in some institutes and universities. In advanced countries, integrated management systems like Seveso Directive of EU and OSHA(Occupational Safety and Health Act) of U.S.A. have been legislated along with the systematic research activities. In Korea, the integrated safety management systems called SMS(Safety Management System) and PSM(Process Safety Management) have been applied to major industries. These systems made chemical industries manage the process safety information by collecting and arranging safety data by themselves. In order to implement the system successfully, it is urgently required to prepare a tool for searching and accumulating process safety data systematically. In this study, a computerized prototype of Risk Assessment System which is essential to SMS and PSM was developed as a main system and data base as subsystem to handle safety information.