• Korean journal of applied entomology
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• v.23 no.2 s.59
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• pp.102-108
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• 1984

These researches were carried out to investigate the morphology of different species of Trichoderma and the possibilities of differentiation of the species of Trichoderma by electrophoretic methods. Variations between the isolates of a species of Trichoderma indicate the genetical differences, also isozyme and protein patterns will be useful to investigate genetical variations betweens the isolates. It might be possible that distinct bands of isozymes of esterase, phosphotase, catalase, catalase differentiate species of Trichoderma.

• Korean Institute of Interior Design Journal
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• v.15 no.1 s.54
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• pp.30-38
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• 2006

The new aspect of contemporary architectural design is the computer simulation of morphogenesis and evolution of the organic body. Morphogenesis and evolution is the kind of emergence that is the process of complex pattern formation from simpler rules in complex system. The development comprises the sequence of pattern formation, differentiation, morphogenesis, growth. This study analyzes the application methodology of various biomorphism in contemporary architecture. The methods of generative application by computation in architecture are self-organization, differentiation, growth algorithm via MoSS. And the methods of evolution by computation are genetic algorithm, multi-parameter in environments, phylogenetic cross-over, competing as natural selection, mutation+external constraints, generative algorithm+genetic algorithm via Genr8.

• International Journal of Stem Cells
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• v.7 no.2
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• pp.108-117
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• 2014

Background and Objectives: Genomic imprinting is an inheritance phenomenon by which a subset of genes are expressed from one allele of two homologous chromosomes in a parent of origin-specific manner. Even though fine-tuned regulation of genomic imprinting process is essential for normal development, no other means are available to study genomic imprinting in human during embryonic development. In relation with this bottleneck, differentiation of human embryonic stem cells (hESCs) into specialized lineages may be considered as an alternative to mimic human development. Methods and Results: In this study, hESCs were differentiated into three lineage cell types to analyze temporal and spatial expression of imprinted genes. Of 19 imprinted genes examined, 15 imprinted genes showed similar transcriptional level among two hESC lines and two human induced pluripotent stem cell (hiPSC) lines. Expressional patterns of most imprinted genes were varied in progenitors and fully differentiated cells which were derived from hESCs. Also, no consistence was observed in the expression pattern of imprinted genes within an imprinting domain during in vitro differentiation of hESCs into three lineage cell types. Conclusions: Transcriptional expression of imprinted genes is regulated in a cell type- specific manner in hESCs during in vitro differentiation.

• Proceedings of the Korean Society of Applied Pharmacology
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• 2007.11a
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• pp.49-54
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• 2007

• Applied Microscopy
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• v.16 no.2
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• pp.75-91
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• 1986

Differentiation of the rat testis was studied by light and electron microscope from the fetal stage up to the newborn or adult stage. The purpose of the present study is to investigate the ultrastructural changes of seminiferous tubules and interstitial tissue during the developmental process. The results were as follows: the seminiferous tubule diameter began to increase from birth and was fully developed at 30 to 40 days of age through intratubular cell proliferations. Basement membrane and myoid cells lining the seminiferous tubules were differentiated at 17 days gestation. At the fetal stage, seminiferous tubules were primarily composed of Sertoli cells and the differentiation of Sertoli and germ cells progressed from the newborn stage. Spermatids and immature spermatozoa are appeared at 40 days of age, so from this time, spermatogenesis occurred actively until the adult stage. Sertoli cells aided germ cell differentiation and phagocytosed the parts of the spermatid cytoplasm. Leydig ce]] development follows a biphasic pattern: a fetal phase and then an adult phase from 20 days of age. In conclusion, the rat testis is already developed to some extent by the fetal stage and is functional after 50 days of age. Therefore, these findings indicate that differentiation of Sertoli and Leydig cells precedes the onset of spermatogenesis.

• Journal of Microbiology and Biotechnology
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• v.15 no.5
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• pp.971-976
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• 2005

In a 30-1 bioreactor culture, whole differentiation occurred from 48 h, and then proceeded rapidly. As swollen hyphal fragments and arthrospores increased, cephalosporin C (CPC) production increased exponentially to $1.85\;g/1^{-1}$ at 72 h. To explain the morphological changes of Cephalosporium acremonium M25 more quantitatively, specific differentiation rates and fractal analysis were employed. Specific differentiation rates of morphological factors varied greatly during the period of culture time from 48 h to 72 h, when CPC production increased significantly. Changes of fractal dimensions showed a pattern similar to that of the specific rate of arthrospores. Furthermore, it was inversely related to the specific rate of tips. Overall, it was suggested that the fractal dimension had potential for a new morphological parameter of fungal morphology, showing complex differentiation patterns.

• Journal of Korean Medical classics
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• v.27 no.4
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• pp.133-151
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• 2014

Objectives : In this study, the changes of concept of Bianzheng(辨證)[syndrome differentiation] in the traditional medical history are investigated for the purpose of understanding conditions of Korean Medicine in modern times. Methods : The concepts of Zheng(證)[syndrome] and Bianzheng[syndrome differentiation] in Sanghanron(傷寒論) and many important medical literatures were selected and analyzed to overview the historical changes of those. Results : To the modern ages, the concept of Zheng had included the two kinds of concepts, that is, symptom/sing and syndrome with slight changes of meaning. As a abstract meaning of syndrome, Zheng(證) has been systematized and complicated with the times, that means changes of syndrome differentiation. The concept of Zheng has been recognized as the symbol that expresses the characteristics of Traditional Medicine since the modern age that concepts of sign and symptom have flowed from Western Medicine into Traditional Medicine. Conclusions : One of the main key of studies about Bianzheng(辨證) in future would have been harmonizing the balance between the two trends of modern Traditional Medicine, ideation and objectification.

• Knowledge Management Research
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• v.12 no.3
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• pp.1-25
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• 2011

This research empirically examined the determinants of competitive advantages and performance of Korean film industry from 1996 to 2003 over a sample of 396 movies. Especially, the effects of knowledge-based resources, social capital, product differentiation strategy, and market entry strategy on a film performance were hypothesized and empirically tested. Findings of this study are as follows; First, confirming the importance of knowledge-based resources in film industry, both the superior business track records of producers and the superior artistic track records of directors and actors had positive effects on film performance. Second, supporting social capital hypotheses, while the strong ties between directors and producers had positive effects, the strong ties between directors and actors had negative effects on film performance. Third, confirming the importance of product differentiation strategy, genre differentiation against competing films had positive effects on film performance. Finally, confirming the importance of market entry timing, the number of competing films released following a film opening within a week had negative effects on film performance. The findings of this research suggest that producers, directors, and actors are not only the critical knowledge-based resources to create competitive advantages indeed, but the pattern of relationships among them also systematically influences the film performance. Moreover, it is suggested that film performance may be improved by the proper genre differentiation and opening day selection.

• Journal of the Korean Home Economics Association
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• v.41 no.8
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• pp.139-158
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• 2003

This study investigated the effects of Korean parents' family-of-origin experiences, marital conflict, open or dysfunctional communication with their children, children's coping behaviors on their behavior problems as a function of a child's sex. Theoretical models for both sexes were constructed based on the results. Two hundred and nine boys and one hundred and ninety six girls of 4th and 5th grades from two elementary schools filled out the questionnaires to assess their communication with the parents, their problem-focused coping behaviors, and their internalizing and externalizing behavior problems. Four hundred five parents of these children answered the questionnaires to assess differentiation for the family-of-origin and the marital conflict. The results were as follows. Boys' path pattern showed that the fathers' differentiation from the family-of-origin effected their sons' internalizing and externalizing behavior problems through parent-child dysfunctional communication. Girls' path exhibited two different patterns. One is that the mothers' differentiation from the family-of-origin effected their daughters' internalizing and externalizing behavior problems through parent-child dysfunctional communication. Another one is that the mothers' differentiation from the family-of-origin influenced children's internalizing behavior problems through daughters' problem-focused coping behaviors as well as parent-child dysfunctional communication.

• The Journal of Korean Medicine
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• v.21 no.3
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• pp.51-56
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• 2000

To assess the relationship between the severity of stenosis in MCA territory and the differentiation of syndromes in oriental medical aspects, the general characteristics, the scores of stroke-pattern identification, and the findings of MRA were compared in 18 acute cerebral infarction patientshospitalized in Dept. of Internal Medicine, Pundang CHA Oriental Medicine Hospital from 1998 sep. 1 to 1999 sep. 31. We compared the scores of stroke-pattern identification with the severity of stenosis by Kruskall-Wallis test, and analyzed the relationship by Pearson correlation test. The P value under 0.05 was regarded as significant. The results are as follows: The incidence of stenosis(mild to complete occlusion) was 83.3%. There were significant difference of the mean scores according to the severity of stenosis in Yin deficiency pattern. We could also observe a strong relationship between the severity of stenosis and Yin deficiency pattern, whose Pearson correlation coefficient was 0.655 (P<0.05). These results showed that Yin deficiency pattern could be a major cause of cerebral infarction.