• Journal of Dental Anesthesia and Pain Medicine
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• v.15 no.4
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• pp.241-245
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• 2015

A majority of patients who sustain injuries to the peripheral sensory nerves of the face and jaws experience a slow but gradual return of sensation that is functional and tolerable, if not the same as before the injuries. However, long-term effects of such injuries are aggravating for many patients, and a few patients experience significant suffering. In some of these patients, posttraumatic symptoms become pathological and are painful. The predominant painful components are (1) numbing anesthesia dolorosa pain, (2) triggered neuralgiaform pain, (3) burning and aching causalgiaform pain, and (4) phantom pain. This is a case report of conservative management of traumatic neuralgia and neuritis as part of posttraumatic pain syndromes in geriatric patients who have undergone the teeth extraction and alveoloplasty.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.1
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• pp.22-27
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• 2004

Seop-Gye divided up the constitution's strength and weakness, and so he cured disease by the 'cold and heat'. 'deficiency and excessiveness' means on the basis of the YINㆍYANG of constitution. He classified constitution with pathogenesis grounding in body formal distinction, flesh hardness and softness, face color and form, skin color. Therefore he grasped the rule of constitution connected with physiological function and pathological distinction, applied the rule of constitution in the diagnosis and cure of the chronic & epidemic febrile disease.

• Journal of fish pathology
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• v.34 no.1
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• pp.63-70
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• 2021

As a part of research to elucidate the pathogenesis of so called Soft Tunic Syndrome(STS), that caused mass mortalities in the cultured sea squirts, Halocynthia roretzi, the epidemiological and pathological analysis were done to both clinically normal and diseased groups of the farms of Tongyoung and Geoje coastal areas in southeast sea from February to July, 2008. In the histological finding of the tunic, most of individuals showed tunic softness syndromes that included the disarrangement and destruction of tunic fiber with the simultaneous presence of flagellates-like cells, recently suspected as main agents of tunic softness syndromes. Simultaneously, the intensive degenerative changes of the skeletal muscle of diseased sea squirts were recognized. The changes were characterized with the hyalinization and condensation of muscle fibril and hemocytic infiltration in the muscle fibers. Those were thought to be a kind of typical Zenker's necrosis as in the skeletal muscle of higher vertebrates. Besides of the diseased sea squirts, Zenker's necrosis of skeletal muscles were seen in the normal ones. Epidemiological inquiry for diseased groups revealed that the higher incidences of tunic softness syndrome were recorded in the fast growing groups and in the sites presuming the organic pollution. And Higher malondialadehyde(MDA) and glutathione peroxidase(GPx) activity were detected in the groups showing STS. Those results suggested that Zenker's necrosis of body muscles was a kind of"nutritional myopathy" by oxidative stress. Conclusively, it was considered that Zenker's necrosis of body muscles gives an important clue for elucidating pathogenesis of STS of cultured squirts. And it seems that the necrosis were caused by the oxidative stress to body muscle during abnormal rapid growth of sea squirts.

• Journal of Sasang Constitutional Medicine
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• v.11 no.1
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• pp.79-102
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• 1999

1. Purpose : This studied Cold and Heat syndromes about Four-form Constitutional Physicalogy. It is for help the comprehension, diagnosis and treatment of physicalogy and pathology about each type. 2. Method : I studied the conception of Cold and Heat sydrome in the existing Oriental Medicine before Constitutinal Medicine, through a few symptoms(constipation, diarrhea, sweat, urine, vomiting) and physicalogy, pathology in Dongyi-Soose-Bowon. 3. Results & Conclusion : In the viewpoint of Pathological Disease and a Chapter Name, Shaoyin has the Exterior-Febrile and Interior-Cold Disease, as the constitutional primary cause of the Interior-Cold Disease, Shaoyang has the Exterior-Cold and Interior-Febrile Disease, as the Interior-Febrile Disease, accoreing to the process of the promote incomings and outgoings of food stuffs of the Spleen and Kidney. By the way, Taiyin is classified into 'One who had had the Cold Disease Primarily and the Febrile', Taiyang has the nature of 'No Cold, No Heat' that is not tendency to The Cold or Heat sydromes, according to promote the respiration of air and fluid of the Liver and Lung. In the viewpoint of a few symptoms(constipation, diarrhea, sweat, urine, vomiting), we are known that cold and heat connception of the each symptome is fixed, according to nature of cold and heat in each type. These express the methood of 'constitutional demonstration'.

• Journal of Sasang Constitutional Medicine
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• v.9 no.2
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• pp.67-94
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• 1997

The main purpose of this study is to arrange the diseases, principal medicinal substances and the prescriptions for the Soumin's Sinsooyul-Pyoyul-Byung(少陽人 腎受熱表熱病) by historical examination in the viewpoint of the Constitutional Medicine(四象醫學). In this study, first I collected the original texts of the diseases and priscriptions in Dongyi-Soose-Bowon(東醫壽世保元), and described the development process of the Soumin(少陽人)'s diseases and priscriptions by comparing with the contents in Dongyi-Soose-Bowon(東醫壽世保元). Next, I collected the efficacy of the medicinal substances and priscriptions by the examination of successive literatures referred it, and tried to explain the efficacy of each medicinal substances in the viewpoint of the Constitutional Medicine(四象醫學) by the analysis of successive literatures. As a result, the conclusions could be summarized as follows. 1. The Differentiation of Syndromes(辦證) in the Existing Medicine(旣存醫學) was formed according to the Eight Principal Syndromes(八綱), the Five Elements(五行), the Merdian system(經絡), therefore there were many confusions with the changes of the times. The differentiation of Syndromes(辦證) in the Constitutional Medicine(四象醫學) was formed according to the pathological change of Ascending and Descending Yin Yang(陰陽升降) in the Four Internal Organs(四臟), therefore, there was the consistency in the recognition of diseases. 2. The classification of the Soumin's Pyoyul-Byung(少陽人 表熱病) was divided into Yukuang Disease(鬱狂證) and Mangyang Disease(亡陽證) according to sweating or not. The conception of these diseases was mostly achived in Shanhanlun(優寒論). The treatment of Shanhanlun(優寒論) was alike to that of Dongyi-Soose-Bowon(東醫壽世保元) in a part. 3. Je ma, Lee thinked that the cause of the Soumin's Pyoyul-Byung(少陽人 表熱病) is the breakdown of the balanced equilibrium in ascending and descending Yin Yang(陰陽升降) for a Large Sin and a Small Bi(腎大脾小), and it is treated by warming and ascending Yang(溫補升陽). 4. The medicinal substances composing prescriptions for the Soumin's Pyoyul-Byung(少陰人 表熱病) is characterized with the efficacy of Ascending Yang and supplying Qi(升陽益氣) and regulating the digestive organs with the efficacy of warming it. 5. The medicinal substances composing the precriptions for the Soumin's Pyoyul-Byung(少陰人 表熱病) is divided into four parts with the state of Yang Qi(陽氣) in the disease it used. 6. The purpose of prescriptions for the Soumin's Pyoyul-Byung(少陰人 表熱病) is to strengthen the Soumin(少陰人)'s Yangnan Qi(陽暖之氣). Je ma, Lee kept the principle not to mix with another constitution's medicinal substances in the creation of the priscription.

• Annals of Clinical Neurophysiology
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• v.19 no.2
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• pp.101-112
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• 2017

Detection of underling proteinopathies is becoming increasingly important across neurodegenerative conditions due to upcoming disease intervention trials. In this review, we explored how temporal lobe changes in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) can potentially predict underlying TDP-43 pathology subtypes in FTD. To date, emphasis has been given to frontal lobe changes in the study of the cognitive and behavioural impairments in both syndromes but an increasing number of pathological, imaging and neuropsychological studies suggest how temporal lobe changes could critically affect the cognition and behaviour of these conditions. In this current article, we reviewed pathological, imaging as well as clinical/neuropsychological findings of temporal involvement in the ALS-FTD continuum, how they relate to temporal lobe changes and the underlying TDP-43 pathology in FTD. Findings across studies show that TDP-43 pathology occurs and coincides in many structures in ALS and FTD, but especially in the temporal lobes. In particular, anterior and medial temporal lobes atrophy is consistently found in ALS and FTD. In addition, memory and language impairment as well as emotional and Theory of Mind processing deficits that are characteristics of the two diseases are highly correlated to temporal lobe dysfunction. We conclude by showing that temporal lobe changes due to TDP-43 type B might be particular predictive of TDP-43 type B pathology in behavioural variant FTD, which clearly needs to be investigated further in the future.

• Journal of Sasang Constitutional Medicine
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• v.22 no.2
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• pp.135-142
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• 2010

1. Objectives: The purpose of this case is to report that a Tae-eumin patient diagnosed as drug-induced liver injury (DILI) caused by Galgeunhaegi-tang (Gegenjieji-tang) treated with Taeumjowe-tang reduced ephedra to 2g (Taiyintiaowei-tang) and then liver function test Results: improved. 2. Methods: We diagnosed him as Tae-eumin Exterior cold disease induced from the esophagus affected by cold. We made him stop taking Galgeunhaegi-tang (Gegenjieji-tang) and take Taeumjowe-tang reduced ephedra to 2g. (Taiyintiaowei-tang) 3. Results: After our treatment, the symptom and the liver function test Results: improved. 4. Conclusions: The wrong diagnosis of constitution and pathological syndromes can be caused drug-induced liver injury. Taeumjowe-tang reduced ephedra to 2g (Taiyintiaowei-tang) may have an effect on treatment of drug-induced liver injury of Tae- eumin.

• Journal of Sasang Constitutional Medicine
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• v.22 no.1
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• pp.9-16
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• 2010

1. Background: GalgeunNabokja-Tang(葛根蘿葍子湯) is suggested as treatment and prescription of Exterior Heat syndrome Diarrhea(表熱證泄瀉) in Donguisusebowon Tae-eumin Interior febrile disease induced form the liver affected by heat("東醫壽世保元" "太陰人肝受熱裏熱病論"), but is not recorded the treatment contents in Sinjungbang("新定太陰人病應用要藥二十四方"). 2. Methods: Accordingly, the writer surveyed, compared, and arranged the relevant contents by collecting books of doctors of Four-Constitutional Medicine(四象醫) since Lee Je-ma including Lee Je-ma's books. 3. Results: and Conclusions: 1) The treatment contents in GalgeunNabokja-Tang are thought to be valid to have the criterion as the contents of appearing in SanggyohyuntoDonguisusebowon Boyubang("詳校懸吐東醫壽世保元" "補遺方"). 2) The origin in GalgeunNabokja-Tang is GalgeunNabokja-Tang in Bimang-lok("備忘錄"). And the period of having made treatment for the first time may be estimated to be the one between Donguisuse- bowonSasangchobonguan("東醫壽世保元四象草本卷") and HamsansachonDonguisusebowonGabogubon ("咸山沙村東醫壽世保元甲午舊本"). 3) GalgeunNabokja-Tang is thought to be probably what Han Du-jeong recorded in Boyubang by searching for what Lee Je-ma modified some of GalgeunNabokja-Tang in Bimang-lok while writing Pathological Syndromes("病證論") in Donguisusebowon("東醫壽世保元").

• Journal of Ginseng Research
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• v.47 no.1
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• pp.23-32
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• 2023

Coronavirus disease 2019 (COVID-19) is a highly infectious respiratory disease caused by a severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). SARS-CoV-2 infection may cause clinical manifestations of multiple organ damage, including various neurological syndromes. There are currently two oral antiviral drugs-Paxlovid and molnupiravir-that are recognized to treat COVID-19, but there are still no drugs that can specifically fight the challenges of SARS-CoV-2 variants. Nucleotide-binding oligomerization domain-like receptor pyrin domain-containing-3 (NLRP3) inflammasome is a multimolecular complex that can sense heterogeneous pathogen-associated molecular patterns associated with neurological disorders. The NLRP3 activation stimulates the production of caspase-1-mediated interleukin (IL)-1β, IL-18, and other cytokines in immune cells. Panax (P.) ginseng is a medicinal plant that has traditionally been widely used to boost immunity and treat various pathological conditions in the nervous system due to its safety and anti-inflammatory/oxidant/viral activities. Several recent reports have indicated that P. ginseng and its active ingredients may regulate NLRP3 inflammasome activation in the nervous system. Therefore, this review article discusses the current knowledge regarding the pathogenesis of neurological disorders related to COVID-19 and NLRP3 inflammasome activation and the possibility of using P. ginseng in a strategy targeting this pathway to treat neurological disorders.

• Journal of Sasang Constitutional Medicine
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• v.35 no.4
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• pp.1-9
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• 2023

Objectives This study is designed to examine the relationship between healthy state (完實無病) of Sasang constitution and pulse wave (脈波). Methods The subjects were 100 patients who were diagnosed with Sasang constitution and underwent pulse analyzer test. The status of urination, defecation, perspiration, and digestion was classified as good, intermediate, and poor. The power, depth, speed, and roughness of pulse waves (脈波) were analyzed. Results Patients with poor digestion had relatively powerless pulse wave (無力脈). Soeumin patients had a higher rate of poor digestion compared to other constitutions. Soyangin patients had a higher rate of poor perspiration compared to other constitutions. Soyangin with poor defecation had relatively choppy pulse wave (澁脈), and poor perspiraton had relatively slippery (滑脈). Soeumin patients with poor digestion had relatively powerless pulse wave (無力脈). Conclusions The pulse wave of poor healthy state (完實無病) is an expression of a pathological syndromes (病證) caused by lack of or damage to healthy energy (保命之主). It was concluded that the pulse analyzer can be used to evaluate healthy state (完實無病).