• Molecular & Cellular Toxicology
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• v.4 no.2
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• pp.144-149
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• 2008

Despite versatile activity (cancericidal, antimicrobial, hypoxia inducible factor (HIF) inhibition, immune deactivation of DNA bis-intercalation agent, echinomycin, its specific mechanism has been elusive. Of these novel mechanisms, we reported that using human colon cancer cells (HT-29), apoptotic machinery induced by echinomycin might be dependent of caspase-3 pathway. Despite a partial enlightenment of prototypic signal path triggered by echinomycin, the role of Bcl-2 in this signaling pathway is unclear. To address this issue, we explored whether or not echinomycin would overcome the anti-apoptotic impact of Bcl-2 in HT-29 cells by the controlled Bcl-2 overexpression. Prior to this proof, we confirmed that echinomycin induces mitochondrial depolarization, then triggering the mitochondrial pathway of apoptosis with an involvement of upstream cas-pases-3. Transiently transfection with inactive Bax-DNA failed to prevent echinomycin-induced apoptosis in HT-29 cells. To dissect the role of Bcl-2 in echinomycin-induced apoptosis, HT-29 cells were transiently transfected with Bcl-2 DNA for overexpression and then treated with echinomycin for 24h. Combined analyses of DNA fragmentation and flow cytometric analysis clearly verified that echinomycin-induced apoptosis was drastically attenuated by Bcl-2 overexpression, whereas a control vector rarely affected echinomycin-induced apoptosis. Collectively, these data verify that Bcl-2 regulates echinomycin-induced apoptosis in HT-29 cells. To my knowledge, this is the first evidence that of diverse, structured minor groove binders (MGB), the prototypic echinomycin might control the apoptotic signaling via Bcl-2-mitochondrial pathway.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.23
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• pp.10057-10059
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• 2015

Positron emission tomography (PET) as the functional component of current hybrid imaging (like PET/CT or PET/MRI) seems to dominate the horizon of medical imaging in coming decades. $^{18}$Flourodeoxyglucose ($^{18}FDG$) is the most commonly used probe in oncology and also in cardiology and neurology around the globe. However, the major capital cost and exorbitant running expenditure of low to medium energy cyclotrons (about 20 MeV) and radiochemistry units are the seminal reasons of low number of cyclotrons but mushroom growth pattern of PET scanners. This fact and longer half-life of $^{18}F$ (110 minutes) have paved the path of a centralized model in which $^{18}FDG$ is produced by commercial PET radiopharmacies and the finished product (multi-dose vial with tungsten shielding) is dispensed to customers having only PET scanners. This indeed reduced the cost but has limitations of dependence upon timely arrival of daily shipments as delay caused by any reason results in cancellation or rescheduling of the PET procedures. In recent years, industry and academia have taken a step forward by producing low energy, table top cyclotrons with compact and automated radiochemistry units (Lab-on-Chip). This decentralized strategy enables the users to produce on-demand doses of PET probe themselves at reasonably low cost using an automated and user-friendly technology. This technological development would indeed provide a real impetus to the availability of complete set up of PET based molecular imaging at an affordable cost to the developing countries.

• Journal of the Earthquake Engineering Society of Korea
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• v.3 no.1
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• pp.67-74
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• 1999

In this study, coda Q has been determined by the single scattering model in the Kyeongsang Basin region using the decay of the amplitudes of coda waves on bandpass-filtered seismograms of local microearthquakes in the frequency range 1.5~18 Hz. Reported frequency dependence of Q is of the form $Q_C=Q_O^n$$(83.9{ll}Q_0{ll}155.9,;0.76{ll}n{ll}1.05$. Considering a model incorporating both scattering and intrinsic attenuation, and assuming that the attenuation is entirely due to the scattering loss, the minimum mean free paths are about 51~56 km and the coefficients of inelastic attenuation(${\gamma}$) are between 0.0093 and 0.0098 were found. Earthquake-station paths pass through the fault zone show high attenuation and strong frequency dependency compared to other ones.

• Journal of the Korea Convergence Society
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• v.9 no.7
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• pp.33-40
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• 2018

The convergence of intelligent information technology and energy technology affects many stakeholders because it involves not only technology itself but also social, institutional and organizational changes. Therefore, it is necessary to develop a back-casting approach to create a new industry that deviates from the path dependence on the traditional energy industry. This study examines the changes in the future energy industry that intelligence information technology will bring, and then we derived the future energy service model that can satisfy the energy policy goals from the national perspective and the interests of each stakeholder at the same time. After that, we analyzed the technical prerequisites for the realization of future energy services and presented the specific configuration technology and the areas that require R&D investment at present.

• Human Ecology Research
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• v.52 no.6
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• pp.561-571
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• 2014

This study investigated the relationships between the husband's support, depression, parenting self-efficacy, and parenting behavior of Korean American mothers and their children's self-esteem. The participants were 113 Korean American child-mother dyads (grades 3-8) from Southern California, USA. The data, including the mothers' parenting behavior as assessed by their children, were collected from self-report questionnaires. A path analysis indicated that the effects of the above mentioned variables on the children's self-esteem depended on the subscale model of the parenting behavior. In every subscale model of parenting behavior, the husband's support was positively related to the parenting self-efficacy and the mother's depression was negatively related to the parenting self-efficacy. Further, in the warmth-acceptance model, the husband's support was positively related to the parenting behavior, the mother's depression was negatively related to the parenting behavior, parenting self-efficacy was positively related to both the parenting behavior and the children's self-esteem, and the parenting behavior was positively related to the children's self-esteem. In the rejection-restriction model, the husband's support was negatively related to the parenting behavior, the mother's depression was positively related to the parenting behavior, the parenting self-efficacy was negatively related to the parenting behavior and was positively related to the children's self-esteem, and the parenting behavior was negatively related to the children's self-esteem. In the permissiveness-nonintervention model, the parenting behavior was negatively related to the children's self-esteem. These results, particularly the dependence on the subscale model of parenting behavior, will be helpful in understanding the effects of parenting on Korean American children's self-esteem.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.4 no.2
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• pp.55-64
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• 1984

Presented is a nonlinear constitutive model for progressive tensile fracturing of concrete. The model is incremental, path-dependent, and tensorialy invariant. The total strain tensor is assumed to be a sum of a purely elastic component and an inelastic component. The material is considered to contain weak planes of all directions which characterize the planes of the microcracks. A one-to-one functional dependence is assumed between the normal stress and the normal strain across each of the weak planes. The tangential stiffness of concrete is then derived form the principle of virtual work. The present theory can be applied to loading histories which are nonproportional or during which the principal directions rotate. Good agreement with the available direct tensile test data which cover strain-softening is demonstrated.

• The Bulletin of The Korean Astronomical Society
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• v.42 no.1
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• pp.49.2-49.2
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• 2017

Star forming dwarf galaxies in various environments are attractive objects for investigating the environmental effects on chemical evolution of dwarf galaxies. Using SDSS DR7 spectroscopic data and GALEX ultraviolet (UV) imaging data, we study the chemical properties of star forming dwarf galaxies in various environments of the Virgo cluster, Ursa Major group, and field. We derived gas-phase abundance, galaxy mass, and UV specific star formation rate (sSFR) of subsample, early-type (ETD) and late-type star forming dwarf (LTD) galaxies, which are divided by visually classified galaxy morphology. We found no O/H enhancement of LTDs in cluster and group environments compared to the field, implying no environmental dependence of the mass-metallicity relation for LTDs. LTDs in the Virgo cluster and Ursa Major group have similar sSFR at a given galaxy mass, but they exhibit systematically lower sSFR than those in isolated field environment. We suggest that LTDs in the Virgo cluster are an infalling population that was recently accreted from the outside of the cluster. We found that ETDs in the Virgo cluster and Ursa Major group exhibit enhanced O/H compared to those in the field. However, no distinct difference of N/O of galaxies between different environments. The chemically evolved ETDs in the Virgo cluster and Ursa Major group also show similar mass-sSFR relation, but systematically lower sSFR at a fixed galaxy mass compared to the field counterparts. We suggest that ETDs in the Virgo cluster and Ursa Major group have evolved under the similar local environments. We also discuss the evolutionary path of ETDs and LTDs with respect to the environmental effects of ram pressure stripping and galaxy interaction/merging.

• Korean Journal of Materials Research
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• v.22 no.8
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• pp.409-415
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• 2012

$TiO_2$ thin films for high energy density capacitors were prepared by r.f. magnetron sputtering at room temperature. Flexible PET (Polyethylene terephtalate) substrate was used to maintain the structure of the commercial film capacitors. The effects of deposition pressure on the crystallization and electrical properties of $TiO_2$ films were investigated. The crystal structure of $TiO_2$ films deposited on PET substrate at room temperature was unrelated to deposition pressure and showed an amorphous structure unlike that of films on Si substrate. The grain size and surface roughness of films decreased with increasing deposition pressure due to the difference of mean free path. X-ray photoelectron spectroscopy (XPS) analysis revealed the formation of chemically stable $TiO_2$ films. The dielectric constant of $TiO_2$ films was significantly changed with deposition pressure. $TiO_2$ films deposited at low pressure showed high dissipation factor due to the surface microstructure. The dielectric constant and dissipation factor of films deposited at 70 mTorr were found to be 100~120 and 0.83 at 1 kHz, respectively. The temperature dependence of the capacitance of $TiO_2$ films showed the properties of class I ceramic capacitors. $TiO_2$ films deposited at 10~30 mTorr showed dielectric breakdown at applied voltage of 7 V. However, the films of 500~300 nm thickness deposited at 50 and 70 mTorr showed a leakage current of ${\sim}10^{-8}{\sim}10^{-9}$ A at 100 V.

• Structural Engineering and Mechanics
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• v.17 no.1
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• pp.51-68
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• 2004

Since the linear elastic fracture analysis has been proved to be insufficient in predicting the failure of strain hardening materials, a number of fracture concepts have been studied which remain applicable in the presence of plasticity near a crack tip. This work thereby presents a new finite element model to predict the elastic-plastic crack-tip field and fatigue life of center-cracked panels(CCP) with ductile fracture under large-scale yielding conditions. Also, this study has been carried out to investigate the path-dependence of J-integral within the plastic zone for elastic-perfectly plastic, bilinear elastic-plastic, and nonlinear elastic-plastic materials. Based on the incremental theory of plasticity, the p-version finite element is employed to account for the accurate values of J-integral, the most dominant fracture parameter, and the shape of plastic zone near a crack tip by using the J-integral method. To predict the fatigue life, the conventional Paris law has been modified by substituting the range of J-value denoted by ${\Delta}J$ for ${\Delta}K$. The experimental fatigue test is conducted with five CCP specimens to validate the accuracy of the proposed model. It is noted that the relationship between the crack length a and ${\Delta}K$ in LEFM analysis shows a strong linearity, on the other hand, the nonlinear relationship between a and ${\Delta}J$ is detected in EPFM analysis. Therefore, this trend will be depended especially in the case of large scale yielding. The numerical results by the proposed model are compared with the theoretical solutions in literatures, experimental results, and the numerical solutions by the conventional h-version of the finite element method.

• Journal of Satellite, Information and Communications
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• v.9 no.4
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• pp.111-116
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• 2014

Thanks to diffusions of mobile devices and advances of network technologies, demands for mobile app have been increased dramatically. It has resulted in mobile app industries as well as mobile app authoring tools are facing a crisis over subordinate to specific OS and platform such as iOS, Android and Apple App Store. Because these particular OS and platforms are obstacles to overcome for supporting interoperability and compatibility. In this study, we have conducted expert interviews and surveys to analyze status of mobile app markets and needs for mobile app user and developer. As a result, mobile app based on HTML5 leads to interconnect various mobile devises without additional efforts. Thereby, mobile app user and developer take a positive view of HTML5. However, mobile app developers tend to have the technical path dependence, they especially in venture and small enterprises need to government support for professional manpower training.