• Proceedings of the Korea Water Resources Association Conference
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• 2021.06a
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• pp.47-47
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• 2021

글로벌 물산업의 규모는 2019년 기준 약 1,000조원 수준으로 2024년까지 연평균 3.5%의 성장률을 달성할 것으로 예측하고 있다. 특히 코로나 19의 영향으로 디지털 물산업에 대한 투자가 증가하고 있으며 4차산업혁명 등으로 지속 성장이 예상되고 있다. 이러한 디지털 물산업 시장의 성장은 물산업분야의 기술경쟁력의 중요도가 더욱 높아질 것을 예상하게 한다. 우리나라의 물산업에 있어서 기술경쟁력 분석을 위해 많은 연구가 진행되어왔으나 대부분 설문조사에 근거한 정석적 분석에 의존하여 왔다. 정성적인 분석에 의존한 연구의 경우, 대상 응답자들이 특정 분야에 치중되어 분석되거나 긍정적으로 판단하는 경향이 있어 우리나라의 물산업 기술의 현재 상황을 과대평가할 가능성이 있다. 또한 연구시점, 설문분야에 따라 결과가 상이할 수 있어 결과의 신뢰성 및 시계열적 추이분석이 어려워 물산업정책 수립을 위해 활용되는데 한계가 존재하였다. 본연구에서는 기존의 정성적 분석에서 벗어나 정량적인 자료에 근거하여 우리나라의 물산업 기술수준과 시장지배를 동시에 고려하여 분석하였다. 물산업의 기술영향력지수(Cites per Patent)와 시장지배력지수(Patent Family Size)를 기준으로 선도국가와 국내 물산업 기술수준 및 시장영향력을 비교하고 평가하였다. 연구결과의 정책적 활용을 위해 물기술과 물시장의 상이한 분류체계를 물시장 중심으로 재분류하여 물산업 기술경쟁력을 분석하여 제시하였다. 연구결과 우리나라의 국내 기술영향력 중 가장 낮은 분야는 하수도 디지털 분야로 선도국가 대비 30% 수준이었으며 시장지배력분야 또한 하수분야로 7% 수준으로 파악되었다.

• Journal of Korean Society of Disaster and Security
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• v.15 no.3
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• pp.57-66
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• 2022

According to the official letter of the Ministry of Employment and Labor (recent guidance on the status of deaths in the construction industry and thorough safety management, April 4, 2022), 17 deaths occurred in construction works worth more than 5 billion won until March 31, 2022. In terms of the size of the construction, 7 cases of 5 billion won to 12 billion won, 5 cases of 12 billion won to 80 billion won, and 5 cases of more than 80 billion won occurred. The causes of death accidents were found to be nine cases (50%), five cases (28%), two cases of collapse (11%), one case of entrapment (5%), and one case of drowning (5%). Safety facilities need to be strengthened to reduce deaths caused by falling, which accounts for most of the deaths, and if fall prevention nets, openings, and safety rails are completely installed, most falling accidents can be prevented. Therefore, this paper intends to present cases of development and use of patent technology through improvement of safety facilities in order to prevent accidents corresponding to the fall of new urban living housing sites, which are small apartment houses.

• Clinical and Experimental Pediatrics
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• v.45 no.7
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• pp.917-922
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• 2002

An unbalanced translocation is frequently the result of inheritance of an unbalanced haploid set from a parent with a balanced translocation. Families in which one parent is a balanced translocation carrier fall into the following classes : Those in which none of the possible abnormal offsprings is viable; Those in which one type of offspring, usually the one with the smaller deletion, is born alive; Those in which two types of abnormal offspring are viable. We report a neonate whose karyotype was 46,XX,der(2)t(2;7)(q21;p21.2),der(20)t(2;20)(q21;p13). She was small for her gestational age and had multiple anomalies such as exophthalmos, corneal opacity, short neck, tongue tie, clinodactyly, atrial septal defect, patent ductus arteriosus and ventriculomegaly. Moreover, her mother's karyotype was 46,XX,der(2)t(2;7)(q21;p21.2),del(16)(q22.1),der(20)t(2;20)(q21;p13) but her father had normal karyotype. The same derivative chrosomes were found between mother and her infant, except for del(16)(q22.1) in her mother and these same unbalanced translocations in a two-generation family are extremely rare.

• The Journal of Korean Medical History
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• v.33 no.1
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• pp.99-112
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• 2020

In this study, we examine the changes to Korean medicine that occurred when 'proprietary medicines' (賣藥) swept through the pharmaceutical market during the Japanese occupation (1910-1945 C.E.). Proprietary medicine during the Japanese colonial period took various forms including ready-made, over-the-counter, patent, and nostrum type pharmaceuticals. This paper examines how Korean medicine, which was the dominant form of medicine during the Joseon Dynasty, was forced to adapt to the rise of proprietary medicines. We found that the prescription of Korean medicine herbal decoctions became more like proprietary medicine in the way that they were formulated. In addition, prescriptions in Korean medicine books were reformulated with prescriptions and medicines from outside the tradition. Proprietary medicines, many of which were made with secret recipes handed down in a family, also attracted attention. Such prescriptions were made famous through advertisements and further influenced future Korean medicine doctors. New prescriptions took advantage of the trust and authority existing in traditional Korean medicine by introducing ginseng and traditional medicinal herbs such as deer antler velvet (鹿茸, Cervi Parvum Cornu). This paper argues that proprietary medicine of the Japanese colonial period distorted the concept of traditional herbal medicine.

• Journal of Hospice and Palliative Care
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• v.5 no.2
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• pp.94-100
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• 2002

Purpose : The system to refer terminally ill patients to palliative or hospice care which ultimately give them emotional, psychological, and social support hasn't been fully developed and organized yet in Korea. The controversies concerning the current referral system are being analyzed to present the improvements. Methods : The questionnaires were asked to be filled out by family members of the 76 patients by phone interview, who were referred from the Seoul National University Hospital between April, 2001 to March, 2002. They were referred to the 35 palliative and hospice care-giving institutes and hospitals which were given questionnaires by mail. Results : Of the 76 patient's family members, 47 family members accepted to answer the questionnaire. The first thing that influence to family to determine the referral of patient was solicitation of doctors or nurses (44%). And they were influenced by allowance for the other things such as convenience of patients (32%), convenience of caring family members (24%). In the course of determining of referred institutes, responders had considered at first their dwelling area, and then fame of institutes, the place which patent had wanted to spend last hours or which is suitable for patient's funeral service, and their financial condition. Thirty-eight the 47 responders answered that they had experienced difficulties in referral procedure. The worst among difficulties was unwanted discharge, and followings were lack of information about the referred institutes, concern about patient's suffering, resistance of patient and opposition of other family members, etc. Although they expressed dissatisfaction in referral procedure, most of them answered they had been satisfied with hospice care at referred institute after referral. Merits of referral which responders counted were patient's peace, caring family's comfort and reduced cost in order. Of the 35 referred institutes, 24 institutes' staffs responded mail questionnaires and sent to us in return. Except one responder, the rest approved the referral system and thought that referred patients had been satisfied with their hospice care. And they claimed that systemic support of the government is definitely necessary. The most difficult thing which responders experienced in care of referred patients was lack of information about patients. Besides, there were patient's financial problems, lack of understanding about their institutes of patients or family, and inconvenience of terminal cancer patient's pain control. Conclusion : The development and support of the organized referral system is needed to alleviate the troubles which patients, family members, and palliative or hospice institutes and hospitals have to face through the procedure of the referral.

• IMMUNE NETWORK
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• v.3 no.1
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• pp.16-22
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• 2003

Background: The S100A2 gene, also known as S100L or CaN19, encodes a protein comprised of 99-amino acids, is a member of the calcium-binding proteins of EF-hand family. According to a recent study, this gene was over-expressed in several early and malignant carcinomas compared to normal tissues. To elucidate the role of S100A2 protein in the process during carcinogenesis, production of monoclonal antibody specific to the protein is essential. Methods: First, cDNA sequence coding for ORF region of human S100A2 gene was amplified and cloned into an expression vector to produce GST fusion protein. Recombinant S100A2 protein and subsequently, monoclonal antibody to the protein were produced. The specificity of anti-S100A2 monoclonal antibody was confirmed by immunoblot analysis of cross reactivity to other recombinant proteins of S100A family (GST-S100A1, GST-S100A4 and GST-S100A6). To confirm the relation of S100A2 to cervical carcinogenesis, S100A2 protein in early cervical carcinoma tissue was immunostained using the monoclonal antibody. Results: GST-S100A2 recombinant protein was purified by affinity chromatography and then fusion protein was cleaved and S100A2 protein was isolated. The monoclonal antibody (KK0723; Korean patent pending #2001-30294) to the protein was produced and the antibody did not react with other members of EF-hand family proteins such as S100A1, S100A4 and S100A6. Conclusion: These data suggest that anti-S100A2 monoclonal antibody produced in this study can be very useful for the early detection of cervical carcinoma and elucidation of mechanism during the early cervical carcinogenesis.

• Journal of Korea Technology Innovation Society
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• v.15 no.2
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• pp.299-322
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• 2012

Biotechnology is considered a new propeller to national economic growth. Although BT-based converging technology is one of keywords in nowadays, few studies analyze the characteristics of Korean BT convergence market. This study has conducted the analysis of BT-based converging technology market by using patent database in KIPO (Korean Intellectual Property Office) from 2000 to 2010. We, especially, have classified BT convergence into homogeneous and heterogeneous ones, and compare the nature of BT convergence market with that of non-convergence one. To achieve the object of this study, the following methods are used: concentration across IPC technological classes; concentration of patenting activity across firms; PFS (Patent Family Size) index. Furthermore, according to FOS technology-industry table, we have intended to find new converging industry of BT heterogeneous converging technologies. As very few studies have focused on Korean converging technology market so far, this analysis is considered to be meaningful. It is found that the market of BT converging technology is rather robust than that of BT non-converging one, which refers that BT convergence shows the tendency of concentration towards few technologies by few conglomerate firms in Korea. Meanwhile, we have derived a BINET keyword map to research the convergence of sub-technologies in detail and the related industries. We expect the implications of this study to be utilized in establishing the BT-based converging technology policy.

• Journal of Society of Preventive Korean Medicine
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• v.26 no.3
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• pp.59-71
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• 2022

Objective : This study examines the historical changes of Ssangwha-'tang', traditional restorative medicine, to a type of tea in tea rooms(Da-bang) named Ssangwha-'cha' in the modern era in South Korea. The goal is to understand how traditional Korean medical culture has been related to the food culture of everyday life. Method : We analyzed traditional medical texts, newspaper articles and advertisements, literary works, and folk song lyrics in which Ssangwha-tang and Ssangwha-cha are mentioned. Results : Ssangwha-tang used to be mentioned as a medicine to tonify 'Yang' energy(Bo-yang) in traditional medical texts from the late Goryeo dynasty to the mid-Joseon dynasty. Since the late Joseon dynasty, it has also been prescribed for cold, as the tonifying method(Bo-beop) gradually prevailed from the royal family to the public. Since then, Ssangwha-tang has been more popular with the public, with the emergence of the patent medicine(Mae-yak) market since the Opening port period and the Colonial period. As the number of Da-bang sharply increased nationwide amid the period of the country's liberation, Ssangwha-tang has been included in the Da-bang menu served as Ssangwha-cha, corresponding to the increasing demands of the public and government policy that tends to favor traditional beverages over coffee. Conclusion : The historical process in which Sssangwha-tang, a type of herbal medicine, became also considered as tea, Ssangwha-cha, provides an example of how Korean traditional medical culture emphasizing the tonification of the body is interconnected with the daily lives of the public and food culture.

• IMMUNE NETWORK
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• v.2 no.3
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• pp.175-181
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• 2002

Background: S100A6 is a calcium-binding protein overexpressed in several tumor cell lines including melanoma with high metastatic activity and involved in various cellular processes such as cell division and differentiation. To detect S100A6 protein in patient' samples (ex, blood or tissue), it is essential to produce a monoclonal antibody specific to the protein. Methods: First, cDNA coding for ORF region of human S100A6 gene was amplified and cloned into the expression vector for GST fusion protein. We have produced recombinant S100A6 protein and subsequently, monoclonal antibodies to the protein. The specificity of anti-S100A6 monoclonal antibody was confirmed using recombinant S100A recombinant proteins of other S100A family (GST-S100A1, GST-S100A2 and GST-S100A4) and the cell lysates of several human cell lines. Also, to identify the specific recognition site of the monoclonal antibody, we have performed the immunoblot analysis with serially deleted S100A6 recombinant proteins. Results: GST-S100A6 recombinant protein was induced and purified. And then S100A6 protein excluding GST protein was obtained and monoclonal antibody to the protein was produced. Monoclonal antibody (K02C12-1; patent number, 330311) has no cross-reaction to several other S100 family proteins. It appears that anti-S100A6 monoclonal antibody reacts with the region containing the amino acid sequence from 46 to 61 of S100A6 protein. Conclusion: These data suggest that anti-S100A6 monoclonal antibody produced can be very useful in development of diagnostic system for S100A6 protein.

• The Journal of Korean Academy of Sensory Integration
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• v.18 no.1
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• pp.1-12
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• 2020

Objective : In this study, we are going to check the impact of the daily performance of a child with developmental disabilities on the parent's burden and quality of life. Methods : 120 parents of children with developmental disabilities were targeted in Chungcheong and Jeolla provinces. To measure the daily performance ability of children with developmental disabilities, we used evaluative Pediatric Evaluation of Disability Inventory and The burden of parents was measured by Family Burden Questionnaire and the quality of life by Beach Center Family Quality of Life Scale. Based on the data collected, independent t-test, one-way anova, Pearson correlation analysis and regression analysis were conducted to check the impact of a child's daily performance ability of developmental disability on the parent's burden and quality of life. Results : The daily performance ability of a children with developmental disabilities showed a negative correlation with the burden of the parents and a positive correlation with the quality of life. The hygiene and bowel & bladder control of children with developmental disabilities had an important influence on parent's burden, while hygiene, toileting, and bowel & bladder control of children with developmental disabilities had a significant effect on their parent's quality of life. Conclusion : It has been shown that the daily performance ability of a children with developmental disabilities has a major influence on parent's burden and quality of life. In order to reduce the burden and improve quality of life, therapeutic intervention, education and interview programs for daily life of children with developmental disabilities need to be carried out systematically by occupational therapists.