• Natural Product Sciences
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• v.19 no.1
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• pp.1-7
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• 2013

AMP-activated protein kinase (AMPK) is a major cellular energy sensor and master regulator of metabolic homeostasis. On activation, this cellular fuel sensing enzyme induces a series of metabolic changes to balance energy consumption via multiple downstream signaling pathways controlling nutrient uptake and energy metabolism. This pivotal role of AMPK has led to the development of numerous AMPK activators which might be used as novel drug candidates in the treatment of AMPK related disorders, diabetes, obesity, and other metabolic diseases. Consequently, a number of patents have been published on AMPK activators from natural products and other sources. This review covers the patented AMPK activators from natural products and their therapeutic potential in treatment or prevention of metabolic diseases including diabetes and obesity.

• Journal of Korean Institute of Industrial Engineers
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• v.39 no.3
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• pp.156-162
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• 2013

Social manufacturing architecture is based on information delivery through social media and SNS, PLM and social platform, crowd source and knowledge base on whole phase of product life cycle. Although advanced social manufacturing issues are rising globally, its technology emerging into domestic industry is likely to be slow. We focused to review technological changes and R&D trend, patent issues, and then suggest assignments and advices to be practiced for social manufacturing modeling.

• Journal of Mushroom
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• v.21 no.3
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• pp.88-92
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• 2023

In this review, we examine the latest technological developments in the utilization of truffles, a gourmet ingredient reputed to be one of the "world's three greatest delicacies," considering changing global consumption trends. Global demand for truffles is expected to increase steadily, with an average annual growth rate of 8.9% from 2023 to 2030. As truffles are expensive, the demand for truffles is expected to be concentrated in developed countries such as the United States, European countries, and Japan. In Korea, truffles are utilized in various industries, including food, functional foods, and cosmetics. Korean consumer demand for truffles has consistently remained high since 2019, and truffle products have been performing well in the market. Consequently, there exists substantial potential demand for newly developed truffle-related products and technologies. This review aims to provide objective research information through the systematic analysis of patent applications in Korea and internationally, focusing on technologies involving truffles, and can aid in setting directions for research and development.

• Journal of Arbitration Studies
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• v.21 no.2
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• pp.85-112
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• 2011

These days utilization of copyright in daily life and economic activities is becoming more important than ever, and IT technology is developing day by day. Along with those fact, copyright infringement and dispute is naturally increasing. This thesis dealt with the 3 different issues of ADR on copyright. The First part, introduce ADR system that was performed by Korea Copyright Committee according to Copyright law. This paper evaluate the committee's efforts to provide resolution of copyright disputes via conciliation was effective. So it needs to be look over several countries' ADR, beside conventional judicial remedy. And Korea's copyright conciliation system which is successfully operating also introduced. Second, In many countries, including South Korea are take advantage of conciliation as the way to settle down the dispute over copyright. Furthermore, looked over if we can use arbitration as tool to settle dispute or not. Currently in Korea, patent dispute is handled by Industrial Property Dispute Conciliation Committee(The Invention Promotion Act Ch.5) and Layout-design Review and Mediation Committee(The Act on the Layout-designs of Semiconductor Integrated Circuits Art.29-34), but using performance of those two committee is still too low. In comparison, the copyright committee, a affiliation organization of the ministry of culture, sports and tourism has much more result in conciliation compare with patent dispute. Copyright disputes has arbitrability of it's subject-matter and many regulating organs are interested in it. (especially, binding of arbitral award and final resolution). Take advantage of both conciliation and arbitration could be good way to resolve copyright disputes. Third, the writer look at the proposal on the creation of Northeast Regional Center for Intellectual Property ADR. Because of the nature of copyright and rapid development of internet technology, international use of work become more frequent and accordingly infringement cases are increasing. The role of commercial arbitration regimes and institutions which has progressed significantly worldwide level, but which has only just begun in the intellectual property ADR area, leads also to a clash of often very different legal cultures and protection in a market economy. International cooperation in regional area with conflict interests becomes an important alternative. But it will depend on the building of regional institutions and mechanisms. The feasibility of this proposal and preconditions were examined. Establishment of new international organization requires a lot of time, cost and efforts. And risk of failure is much too high. Therefore factual, statistical review should be preceded. In addition, technical measures, such as on-line arbitration is necessary to review also. Furthermore in order to establish new organization, the relative law, legal environment, public sentiment and international compliance must be carefully considered with factual review about the needs and economic benefits of each country Yet on complex regulatory matters such as IP and ADR, a great deal of the potential benefits from international standards arises not from the international legal framework nor even the formal content of national legislation, but from the informed and effective use made of the possibilities within the system, including by policymakers and regulators.

• Management & Information Systems Review
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• v.35 no.3
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• pp.195-212
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• 2016

Utilizing intra-day volume weighted average price (VWAP) based on 1 minute return data of stocks traded on the Korean Stock Exchange, this paper examines and analyzes abnormal returns in reaction to patent listing disclosures as well as the cumulative abnormal returns, traded volumes, the interaction of VWAP spreads, the reaction of volumes, the reaction of VWAP spreads and the realized returns obtained from trading using an event driven arbitrage strategy. The results of the aforementioned research topics are follows. First, our analysis suggests that on average, 0.92% positive cumulative returns arise 1 minute after the patent listing disclosure announcement with high statistical significance, thereby reconfirming that the Korean stock market is a semi-strong form of the efficient market. Employing 3 separate panel tests differentiated by the size factor, we find that the abnormal returns of small sized stocks were less than the returns of medium sized stocks, which goes to support recent research findings suggesting that the size premium is no longer existent in the Korean stock market. Secondly, we show that among the event driven type strategies, the most outstanding realized returns are from the market making strategies. Furthermore, placing market order trades only at the bid or ask price resulted in negative returns. This implies that strategies utilizing a combination of market orders and limit orders, order cancelations ratios and order flows can enhance realized returns.

• Korean small business review
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• v.42 no.1
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• pp.19-41
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• 2020

In Korea, punitive damages were introduced in the 2011 Fair Transactions in Subcontracting Act(FTSA), and in 2019 the Patent Act, Trade Secret Protection Act(TSPA), Industrial Technology Protection Act(ITPA), and Mutually Beneficial Cooperation Act(MBCA). In punitive damages, the judgment of 'intentional' is especially important, and it is necessary to refer to US precedents since there is no accumulated case. Major Company can avoid intentional counseling through the advice of lawyers, but SMEs may have to punish punitive damages due to a lack of awareness of the system. In the case of TSPA, ITPA, FTSA, and MBCA, except for Patent Act, the provisions related to proof of damage have not been well maintained yet. Therefore, the data submission order system of these laws needs to be revised to the level of patent Act need to be. TSPA needs to be amended in the future to estimate the amount of the royalties in estimating the amount of damages so that it can receive the 'reasonably' estimated amount rather than the usual amount. On the other hand, ITPA, FTSA, and MBCA do not have any provisions for the estimation of damages. Besides, it is difficult to evaluate the technology value in the case of leakage or deodorization of new technologies. Therefore, valuation needs to be carried out by a credible institution along with the development of a model for calculating damages.

• The Journal of Internal Korean Medicine
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• v.35 no.3
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• pp.332-342
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• 2014

Objectives: This study was investigated in order to analyse the characteristics of recent Chinese medicine treatment of gastric cancer, and provide literature basis for the development of effective therapy of gastric cancer by reviewing Chinese journals. Methods: The literature on Chinese medicine treatment of gastric cancer were collected, analyzed and summarized from the China National Knowledge Infrastructure (CNKI) from 2000 to 2013. Results: Physicians have not shown consistent opinion with the pattern identification of gastric cancer. Recently, traditional Chinese Medicine patent prescriptions have been much used in the treatment of gastric cancer, which is classified into the reinforcement of healthy qi and elimination of the pathogenic factors. Chinese medicine combined with western medicine can improve the immune system and quality of life, while reducing toxic side effects. Conclusions: Further studies on traditional Chinese Medicine are needed to increase the survival rate of gastric cancer and effectiveness of combination therapy with western medicine.

• Journal of Korean Society of Water and Wastewater
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• v.22 no.3
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• pp.343-350
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• 2008

Many reports have warned of insufficient water supply in most countries in future and prospected providing safe and clean water become more difficult by lack of access to sustainable drinking water resources. Several facts and figures explained the impact by natural climate change and human activity results in the water scarcity and deterioration. Among many scientific solutions, the seawater desalination using a reverse osmosis membrane, so called SWRO (Seawater Reverse Osmosis) process, has been recognized as one of the most promising alternatives because of its stability and efficiency in producing large amount of drinking water from seawater through desalination by membrane filtration. Recently, in Korea, numerous researches are conducted to develop more productive and cost effective SWRO process for its wide implementation. The objective of this paper is to review the patents concerning SWRO technologies involving the plant engineering, maintenance including pretreatment of seawater and fouling control, module design, and mechanical units development for energy saving. The patents in Korea, U.S., Japan, Europe, and PCT were intensively researched and analyzed to provide the state of the art as well as leading edge technology on SWRO. This information can hopefully suggest meaningful guidelines on future research and development.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.1
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• pp.9-14
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• 2010

The purpose of this study was to review the direction of Korean medicine treatment in hyperlipidemia, focusing on Korean herbal medicine and to suggest sources for drug development in treatment of hyperlipidemia. We searched 115 articles which had been published from 1997 to 2009 in journals in Korean Oriental Medical Society and its sub-societies. Those articles were selected from the search engine of web site of each journal with the key words 'hyperlipidemia'. Excluding 21 articles in no relation to herbs, we finally reviewed 94 articles. There are many studies of 'hyperlipidemia' in Korean Medicine. Analyzing the articles, we found that the medicinal effects of the herbs used in recent studies and patents coincides with treatment of hyperlipidemia in Korean medicine. Although many herbs in articles is granted patent, it doesn't proceeds to develop herbal drug. It requires to study in treatment of hyperlipidemia in Korean medicine and then to develop herbal drug.

• Natural Product Sciences
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• v.27 no.3
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• pp.141-150
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• 2021

This short review on the chemistry, pharmacological properties and patents of obovatol and obovatal from Magnolia obovata is the first publication. Pharmacological properties are focused on anti-cancer, anti-inflammatory, anti-platelet and neuroprotective activities. Obovatol and obovatal were first isolated from the leaves of M. obovata. Also reported in the bark and fruits of M. obovata, obovatol and obovatal are neolignans i.e., biphenolic compounds bearing a C-O coupling. Other classes of compounds isolated and identified from M. obovata include sesquiterpene-neolignans, dineolignans, trineolignan, lignans, dilignans, phenylpropanoids, phenylethanoid glycosides, flavonoids, phenolic acids, alkaloids, sesquiterpenes, ketone and sterols. The anti-cancer properties of obovatol and obovatal involve apoptosis, inhibition of the growth, migration and invasion of cancer cell lines. However, obovatol displays cytotoxicity against cancer cells but not obovatal. Similarly, anti-inflammatory, anti-platelet, neuroprotective, anxiolytic and other pharmacological activities were only observed in obovatol. The disparity in pharmacological properties of obovatol and obovatal may be attributed to the -CHO group present in obovatal but absent in obovatol. From 2007 to 2013, eight patents were published on obovatol with one mentioning obovatal. They were all published at the U.S. Patent and Trademark Office by scientists of the Korea Research Institute of Bioscience and Biotechnology (KRIBB) as inventors and assignee, respectively. Some future research and prospects are suggested.