• Proceedings of the KSME Conference
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• 2005.11a
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• pp.52.1-52.1
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• 2005

• Transactions of the Korean Society of Mechanical Engineers B
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• v.29 no.2 s.233
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• pp.232-238
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• 2005

The 'Mixing Index($D_I$)' is used as a conventional guidance measuring the degree of mixing for multiphase flows. For the case when insoluble solutions flow in a passive micromixer, a new method to calculate $D_I$ is proposed. The 'Vortex Index(${\Omega}_I$)' is suggested and formulated. We infer that ${\Omega}_I$ relates to the degree of chaotic advection. Various arbitrary shaped microchannels were tested to calculate the $D_I\;and\;{\Omega}_I$, and then a simple algebraic equation, $D_I=Aexp(B{\Omega}_I)$, is obtained. This equation may be used instead of the conventional partial differential equation, concentration equation, to estimate the degree of mixing.

• Journal of the Korea Convergence Society
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• v.9 no.10
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• pp.237-242
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• 2018

A micromixer is a component of a lab-on-a-chip or microfluidic device that mixes two or more chemicals together(convergence). The purpose of this study is to assess the performance of passive micromixer of various shapes. Six shapes of micromixers were compared and three dimensional modeling was carried out to have the same hydraulic diameter. The commercial code, ANSYS Fluent, was used to simulate the internal mixing flow. A numerical analysis method is described in detail in this paper. The performance of the micromixer was compared with the mixing index and pressure drop. Consequently, the CDM-8T shape showed reasonable mixing performance and relatively low pressure drop.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.32 no.8
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• pp.624-632
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• 2008

In this research, we developed new PDMS-glass based microbiochip consisted of the micromixer and microreactor for DNA ligation. The micromixer was composed of a straight channel integrated with nozzles and pillars, and the microreactor was composed of a serpentine channel. We coated the PDMS chip surface with the 0.25wt.% PVP solution to prevent the bubble generation which was caused by the hydrophobicity of the PDMS. The new micomixer was passive type and the mixing was enhanced by a convective diffusion using the nozzle and pillar. The 10.33mm long micromixer showed the good mixing efficiency of 87.7% at 500 l/min flow rate. We could perform the DNA ligation successfully in the microbiochip, and the ligation time was shortened from 4 hours in conventional laboratory method to 5 min in the microbiochip.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.34 no.9
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• pp.851-857
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• 2010

In this study, an experiment was performed to obtain the optimum design of a passive micromixer for effective mixing by using a microsized device and rectangular obstacles; a low Reynolds number was maintained in the microchannel. The experiment was carried out by varying the number, size, and location of the rectangular obstacles. Further, the Y-channel's shape was optimized for maximizing the mixture ratio, which has limit qualification that an allowed value of pressure drop. The increase in the efficiency of mixing was observed to be greater than that in the case of circular obstacles by approximately 2.5%.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.28 no.1
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• pp.63-69
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• 2004

It is of great interest to enhance mixing performance in a microchannel in which the flow is usually characterized as a low Reynolds number (Re) so that good mixing is quite difficult to be achieved in this laminar flow regime. In this regard, we present a new chaotic passive micromixer, named Barrier Embedded Micromixer (BEM), of which the mixing mechanism is based on chaotic flows. In BEM, chaotic flow is induced by periodic perturbation of the velocity field due to periodically inserted barriers along the channel wall while a helical type of flow is obtained by slanted grooves on the bottom surface of the channel in the pressure driven flow. To experimentally compare the mixing performance, a T-microchannel and a microchannel with only slanted grooves were also fabricated. All microchannels were made of PDMS (Polydimethylsiloxane) from SU-8 masters that were fabricated by conventional photolithography. Mixing performance was experimentally characterized with respect to an average mixing intensity by means of color change of phenolphthalein as pH indicator. It was found that mixing efficiency decreases as Re increases for all three micromixers. Experimental results obviously indicate that BEM has better mixing performance than the other two. Chaotic mixing mechanism, suggested in this study, can be easily applied to integrated microfluidic systems , such as Micro-Total-Analysis-System, Lab-on-a-chip and so on.

• Journal of the Korean Society for Precision Engineering
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• v.25 no.6
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• pp.143-149
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• 2008

This paper presents the results of the study on the novel micro mixer. Existing micro mixer is classified as active mixing and passive mixing by the mixing principles. Both mixing principles have problems. For solving these problems, this research has developed the novel micro mixers based on a totally different principle compared with former mixers. They not only have a simpler structure than former ones but also are able to achieve high mixing efficiency in spite of low power consumption due to using Lorentz Force. In addition, they are designed to increase the efficiency of mixing by changing the rotating direction of fluid with a polar switching circuit. Driving forces of the mixer are Lorentz force and a moving force of fluid due to electrophoresis. Because the efficiency of mixer is affected by electrode shape, several models have been made. The computer simulation has been made to estimate the efficiency of each mixer.

• Proceedings of the Korean Vacuum Society Conference
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• 2013.08a
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• pp.276-276
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• 2013

Here we report an integrated microdevice consisting of an efficient passive mixer, a magnetic separation chamber, and a capillary electrophoretic microchannel in which DNA barcode assay, target pathogen separation, and barcode DNA capillary electrophoretic analysis were performed sequentially within 30 min for multiplex pathogen detection at the single-cell level. The intestine-shaped serpentine 3D micromixer provides a high mixing rate to generate magnetic particle-pathogenic bacteria-DNA barcode labelled AuNP complexes quantitatively. After magnetic separation and purification of those complexes, the barcode DNA strands were released and analyzed by the microfluidic capillary electrophoresis within 5 min. The size of the barcode DNA strand was controlled depending on the target bacteria (Staphylococcus aureus, Escherichia coli O157:H7, and Salmonella typhimurium), and the different elution time of the barcode DNA peak in the electropherogram allows us to recognize the target pathogen with ease in the monoplex as well as in the multiplex analysis. In addition, the quantity of the DNA barcode strand (~104) per AuNP is enough to be observed in the laser-induced confocal fluorescence detector, thereby making single-cell analysis possible. This novel integrated microdevice enables us to perform rapid, sensitive, and multiplex pathogen detection with sample-in-answer-out capability to be applied for biosafety testing, environmental screening, and clinical trials.