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Consecutive automated production of carbon-11 labeled radiopharmaceuticals by sharing 11C-methylation reagent from one 11C-synthetic module

  • Park, Hyun Sik;Lee, Hong Jin;An, Hyun Ho;Moon, Byung Seok;Lee, Byung Chul;Kim, Sang Eun
    • Journal of Radiopharmaceuticals and Molecular Probes
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    • v.2 no.2
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    • pp.123-131
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    • 2016
  • Increasing clinical demand for carbon-11 labeled radiopharmaceuticals has triggered technological advances in fields of radiochemistry and automated modules. Even though carbon-11 has a short half-life ($t_{1/2}=20.4min$), the consecutive second production of carbon-11 labeled radiopharmaceutical in one $^{11}C$-synthetic module should be delayed at least over 4 h to avoid the high radiation exposure. We herein aimed to produce two different carbon-11 labeled radiopharmaceuticals ([$^{11}C$]PIB and [$^{11}C$]methionine) by sharing of [$^{11}C$]methylation source in one $^{11}C$-synthetic module. The synthesis of $^{11}C$-labeling reagents ($[^{11}C]CH_3I$ or $[^{11}C]CH_3OTf$) is fully automated using the commercial TRACERlab $FX_{C-pro}$ module and is readily adaptable to $^{11}C$-labeling reactor for [$^{11}C$]PIB as well as another $^{11}C$-labeling apparatus for [$^{11}C$]methionine via the three-way valve. After completing the [$^{11}C$]PIB production, the re-synthesized $[^{11}C]CH_3I$ was passed through the three-way valve connected the polyetheretherketone (PEEK) line and loaded into the C18 Sep-Pak cartridge including the methionine precursor. The labeled product [^${11}C$]methionine was purified by a simple cartridge separation and reformulated into saline. The radiochemical yield of [$^{11}C$]PIB and [$^{11}C$]methionine were $5.3{\pm}0.6%$ and $18.7{\pm}0.8%$ (n.d.c.), respectively, with over 97% of radiochemical purity. The specific activity of [$^{11}C$]PIB was over $110GBq/{\mu}mol$. Total production time of two radiopharmaceuticals needs about 2 h from $1^{st}$ beam irradiation including quality control tests. Final [$^{11}C$]PIB and [$^{11}C$]methionine were satisfied all quality control test standards.

Decision-Tree Model of Long-term Abstention from Smoking: Focused on Coping Styles (장기적 금연 지속기간 예측 모형: 스트레스 대처를 중심으로)

  • Suh, Kyung-Hyun;You, Jae-Min
    • Korean Journal of Health Education and Promotion
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    • v.22 no.4
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    • pp.73-90
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    • 2005
  • Objectives: Smokers who had failed to quit smoking were frequently reported that life stress mostly interrupted their abstention. Stress vulnerability model for smoking cessation has been considered, and most of contemporary smoking cessation programs help smokers develop coping strategies for stressful situations. This study aims to investigate the appropriate coping styles for stress of abstention from smoking. The result of investigating the relationship between abstention following smoking cessation program and coping styles would suggest useful information for those who want to stop smoking and health practitioners who help them. Methods: Participants were 69 smokers (62 males, 7 females) participated in a hospitalized smoking cessation program, whose mean age was 44.89 (SD=9.61). Participants took medical test and completed questionnaires and psychological tests including: Fagerstrom Test for Nicotine Dependence and Multidimensional Coping Scale. To identify participants' abstention, researchers followed them for 2 years. To identify whether abstained or not and encourage them to abstain, researchers called them on the telephone once a week for 3 months. After 3 months, they were contacted every other week till 6 months passed since they left smoking cessation program. And they were contacted once a month for other 18months. Researchers also contacted their family to identify their abstention. Data Mining Decision Tree was performed with 37 variables (13 variables for the coping styles and 24 smoking-related variables) by Answer Tree 3.0v Results: Forty four (63.8%) out of sixty nine for 2 weeks, 34 (49.3%) for 6 months, 25 (36.2%) abstained for 1 year, and 22 (31.9%) abstained for 2 years. Participants of this study abstained average of 286.77 days from smoking. Included variables of a Decision Tree model for this study were positive interpretation, emotional expression, self-criticism, restraint and emotional social support seeking. Decision Tree model showed that those (n=9) who did not interpret positively (<=7.5) and criticized themselves (>6.5) abstained 23 days only, while those (n=9) who interpreted positively (>7.5), expressed their emotion freely (>6.5), and sought social support actively (>11.5) abstained 730 days, till last day of the investigation. Conclusion: The results of this study showed that certain coping styles such as positive interpretation, emotional expression, self-criticism, restraint and emotional social support seeking were important factors for long-term abstention from smoking. These findings reiterate the role of stress for abstention from smoking and suggest a model of coping styles for successful abstention from smoking. Despite of limitation of this study, it might help smokers who want to stop smoking and health practitioners who help them.

Preparation and Properties of Flame Retardant Epoxy Resins Containing Phosphorous/Silicone Components (인/실리콘 함유 난연성 에폭시 수지의 제조 및 물성)

  • Kim, Chang-Heon;Ha, Do-Young;Lee, Young Hee;Lee, Dong-Jin;Kim, Han-Do
    • Clean Technology
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    • v.23 no.4
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    • pp.378-387
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    • 2017
  • To obtain epoxy resin with permanently attached flame-retardant groups, phosphorus compound containing di-hydroxyl group [10-(2,5-dihydroxyphenyl)-9,10-dihydro-9-oxa-10-phospha phenanthrene-10-oxide, DOPO-HQ] and silicone compound containing di-hydroxyl group (polydimethylsiloxane, hydroxyl terminated, PDMS) were reacted with uncured epoxy prepolymer (diglycidyl ether of bisphenol A, DGEBA) and then cured using 4,4-diaminodiphenylmethane (DDM) as a crosslinking agent. The properties of the resulting epoxy materials were characterized using Fourier transform infrared (FTIR) spectrometer, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), limiting oxygen index (LOI) test/vertical burning test (UL 94-V test), tensile properties test and impact test. This study examined the effect of phosphorus/silicone compound contents on the thermal/mechanical properties and flame retardancy of cured epoxy resins containing phosphorus and silicone compounds. It was found that the thermal/mechanical properties of epoxy resins containing phosphorus and silicone components were higher than those of simple epoxy resin. The flame-retardancy (LOI: 29.9 ~ 31.8% and UL 94-V: V-0) of all samples containing phosphorus compound and phosphrous compound/silicone compound was found to be passed the flame-retardant requirements (LOI: > 30%, UL 94-V: V-0) of LOI and vertical burning tests. However, the flame-retardancy (LOI: 21.4% and UL 94-V: no rating) of simple epoxy resin was found to be failed the flame-retardant requirements.

Analysis of Changes in Skin Dose During Weight Loss when Tomotherapyof Nasopharynx Cancer (비인두암 토모테라피 시 체중 감소에 따른 피부선량 변화 분석)

  • Jang, Joon-Young;Kim, Dae Hyun;Choi, Cheon Woong;Kim, Bo-Hui;Park, Cheol-Soo
    • Journal of the Korean Magnetics Society
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    • v.26 no.3
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    • pp.99-104
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    • 2016
  • For patients receiving chemotherapy and radiation therapy treatment progresses as vomiting, nausea, weight of the patient because of a loss of appetite it is reduced. The patient's weight and the distance from the skin and the treatment site is expected to be closer, thereby reducing the change in the skin because of this dose. This study tests using a loose see the difference between the volume change appears as the weight of the patient using the same phantom and the phantom body of the patient. To using the same as the position EBT film is attached to the skin of the treatment site and was adjusted to the thickness of the Bolus. And using a computerized treatment planning only tomotherapy equipment was passed under the conditions according to the thickness of the radiation dose. To baseline for accurate reproduction position using the MVCT was applied to treated with verification. By passing a total of three dose reduced the error, it was a measure of the film by using a dedicated scanner, EBT VIDAR scanner. Got an increase in the skin dose is displayed each time the thickness of the bolus reduced, in a bolus was completely removed with the highest value. If the changes appeared dose was greater weight loss patients to chemotherapy and therefore bolus thickness variation considering the weight loss of the patient when applying the tomotherapy of nasopharynx cancer was found that the increase in skin dose be increased. This large patient before treatment due to weight loss over the image verification is considered to be established should consider how to re-create your mask and treatment plan for fixing it.

Agricultural Radial Collector Wells in South Korea and Sustainability (한국의 농업용 방사상 집수정 현황 및 지속가능성)

  • Hong, Soun-Ouk;Song, Sung-Ho;An, Jung-Gi;Kim, Jin-Sung
    • The Journal of Engineering Geology
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    • v.26 no.3
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    • pp.331-337
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    • 2016
  • Radial collector wells (RCWs) have been managed by Korea Rural Community Corporation (KRC) since 1983, installing 98 wells for agriculture in rural area over the country. Among them, 20 wells were installed upstream of 5 subsurface dams and the remaining were installed regardless of the subsurface dam. Most of RCWs have been developed in 1980s and 1990s, and 83 wells have been passed more than 20 years after construction. The number of horizontal arms for RCWs varies from 9 to 28, with length and diameter being 10~30 m and 65 mm, respectively. The central caisson with an inner diameter of 3.5 m was commonly constructed to a depth of 10 m. The maximum pumping rates in RCWs, which are located at distances of 10 to 1,200 m from the river, are 2,000~10,000 m3/day. RCW has a fundamental problem that reduced pumping capacity and degraded well efficiency, due to the physical and chemical clogging. From the feasibility test for improving RCW performance, specific capacity increased to 67% after rehabilitation. TV logging for RCW horizontal arm shows that near the caisson is more severe clogging. From the results of this study, KRC has established the guidebook for monitoring and improving well efficiency through physical/chemical treatment, well logging, and hydraulic tests and managed RCWs periodically with its rehabilitation methods.

Effects of the Salting of Chinese cabbage on Taste and Fermentation of Kimchi (배추 절임 방법이 김치의 맛과 숙성에 미치는 영향)

  • 송주은;김명선;한재숙
    • Korean journal of food and cookery science
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    • v.11 no.3
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    • pp.226-232
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    • 1995
  • This study is a result of the experiments to determine the optimum conditions of salting of Chinese cabbages for making tasty Kimchi. For the experiments, various methods of salting of Baechu were set up and the best method of salting had prepared Kimchi to investigated the best salt kind. In the two best results by method of salting salt kind, were investigated for salting time of Kimchi. There were certain amounts of Kimchi had prepared for each case of the combinations of the three conditions. Every case of Kimchi was refrigerated and was evaluated by sensory tests. In the salt concentration, pH and acidity of the Kimchi were measured. The results are as follows; In three cases of Kimchi, for salt concentration, level of 2.4-3.0$^{\circ}$ was maintained in Kimchi solid from the beginning to the end, while it was high in the beginning and gradually lowered in Kimchi liquid. The level of pH in both solid and liquid of Kimchi quickly dropped at the beginning of fermentation period and turned slow as time passed. And the level of acidity was increased little bit in the beginning, but it suddenly multipied until the third day of preservation. Since then, it had increased gradually thereafter as it was before. This experiments show that Kimchi can be the best taste in the case of Chinese cabbage soak in brine- free natural salt are kept for five hours.

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Study on Acidification and Neutralization Characteristics of Precipitation in JejuCity between 1997 and 2005 (1997~2005년 제주시 지역 강수의 산성화 및 중화 특성 연구)

  • Kang Chang-Hee;Hong Sang-Bum;Kim Won-Hyung;Ko Hee-Jung;Lee Sun-Bong;Song Jung-Min
    • Journal of Korean Society for Atmospheric Environment
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    • v.22 no.4
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    • pp.487-498
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    • 2006
  • Total 438 precipitation samples were collected in Jeju City between 1997 and 2005, and their major ionic components were analyzed. The comparison tests using ion balance, electric conductivity and acid fraction were performed. It was found their correlation coefficients were in the range of 0.977$\sim$0.994, indicating the good quality of collected dam. The volume-weighted mean pH and electric conductivity were 4.8 and 23.0 $\mu$S/cm, respectively. with the ionic strength of 0.23$\pm$0.20 mM. The marine ($Na^+$, $Mg^{2+}$, and $CI^-$), anthropogenic (nss$SO_4{2-}$, $NO_3^-$, and $NH_4^+$) and soil (nss-$Ca^{2+}$) species have contributed to the ionic components of precipitation samples with 43$\sim$74%, 16$\sim$37% and $\sim$5%, respectively. The seasonal variations of $NO_3^-$ and nss-$SO_4^{2-}$ showed a distinct seasonality with higher concentrations in winter than summer, indicating an increase of fossil fuel consumption and a possibility of long-range transport of those pollutants from continental area along the dominant winter westerly. The levels of nss-$Ca^{2+}$ also were appeared the highest in winter and increased comparatively in spring season. possibly due to the soil influences including the Asian Dust. The acidification contribution of nss-$SO_4^{2-}$ and $NO_3^-$ showed 88$\sim$96%, and the free acidity was in the range of 6.0$\sim$40.1%. Interestingly, the backward trajectories for the case of upper 10% nss-$SO_4^{2-}$ and $NO_3^-$ levels have passed through the China continent before their arrival to Jeju. The precipitation of pH below 4.5 has been occurred frequently when the trajectory's path lied over the China continents. On the other hand, the air masses from the North Pacific area were characterized by lower 10% of nss-$SO_4^{2-}$- and $NO_3^-$ concentration, which demonstrated that air mass from the North Pacific was the cleanest among air masses moved to Jeju.

The Effects of High Temperature on Infection by Potato virus Y, Potato virus A, and Potato leafroll virus

  • Chung, Bong Nam;Canto, Tomas;Tenllado, Francisco;Choi, Kyung San;Joa, Jae Ho;Ahn, Jeong Joon;Kim, Chun Hwan;Do, Ki Seck
    • The Plant Pathology Journal
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    • v.32 no.4
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    • pp.321-328
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    • 2016
  • We examined the effects of temperature on acquisition of Potato virus Y-O (PVY-O), Potato virus A (PVA), and Potato leafroll virus (PLRV) by Myzus persicae by performing transmission tests with aphids that acquired each virus at different temperatures. Infection by PVY-O/PVA and PLRV increased with increasing plant temperature in Nicotiana benthamiana and Physalis floridana, respectively, after being transmitted by aphids that acquired them within a temperature range of $10-20^{\circ}C$. However, infection rates subsequently decreased. Direct qRT-PCR of RNA extracted from a single aphid showed that PLRV infection increased in the $10-20^{\circ}C$ range, but this trend also declined shortly thereafter. We examined the effect of temperature on establishment of virus infection. The greatest number of plants became infected when N. benthamiana was held at $20^{\circ}C$ after inoculation with PVY-O or PVA. The largest number of P. floridana plants became infected with PLRV when the plants were maintained at $25^{\circ}C$. PLRV levels were highest in P. floridana kept at $20-25^{\circ}C$. These results indicate that the optimum temperatures for proliferation of PVY-O/PVA and PLRV differed. Western blot analysis showed that accumulations of PVY-O and PVA coat proteins (CPs) were lower at $10^{\circ}C$ or $15^{\circ}C$ than at $20^{\circ}C$ during early infection. However, accumulation increased over time. At $25^{\circ}C$ or $30^{\circ}C$, the CPs of both viruses accumulated during early infection but disappeared as time passed. Our results suggest that symptom attenuation and reduction of PVY-O and PVA CP accumulation at higher temperatures appear to be attributable to increased RNA silencing.

An Analysis of Undergraduate School Admission Policy of France (프랑스 대학입학제도의 주요 특징 및 시사점 분석)

  • Park, Sang-wan
    • Korean Journal of Comparative Education
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    • v.26 no.4
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    • pp.1-30
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    • 2016
  • The purposes of this study are to analyze the higher education admission policy of France and to draw policy implications for Korea. For this study, literature reviews and interviews (face-to-face, email, telephone) were adopted for main research methods. The major findings were as follows: First, baccalaur?at diploma is necessary for higher education admission in France but each higher education has different admission policy according to their legal status. University has open enrollment policy and has no student selection process. Other higher institutions such as grands ?coles select students based on students' academic achievements. Second, baccalaur?at is national diploma which shows successful conclusion of the upper secondary education and gives right of access to higher education. This diploma is awarded to candidates who have passed a series of standardized written and oral tests drawn up at national level (10/20points). Third, students' academic achievements in high schools are major criteria for admission for higher institutions which has student selection process. Fourth, entrance exams implemented at college level are various according to higher institution. Last, 'Admission Post-bac-APB' site is used to support and facilitate the whole admission process. Based on these findings, several policy implications were suggested.

Analysis of the Reinforcement Effect of Aging Reservoir Reinforced by Environmental Soil Stabilizer as Chemical Grouting Material (친환경 지반안정재를 약액주입재로 사용하여 보강한 노후 저수지의 보강효과 분석)

  • Kim, Se-Min;Seo, Se-Gwan;Cho, Dae-sung
    • Journal of the Korean Geosynthetics Society
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    • v.20 no.2
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    • pp.1-11
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    • 2021
  • In this study, a study related to laboratory and pilot test were performed to use an environmental soil stabilizer developed to induce a hardening reaction similar to that of Ordinary Portland Cement (OPC) by using industrial by-products of blast furnace slag and the combustion ash of a circulating fluidized bed boiler as the main material. For this, specimens were prepared using liquid A of sodium silicate and silica sol, and liquid B of an environmental soil stabilizer (or OPC), and laboratory tests were performed to analyze the strength and environmental characteristics. And pilot test was performed on the aging reservoir, field permeability test and electrical resistivity survey were performed in the field to analyze the applicability. As a result of the laboratory test, the homo-gel compressive strength of the chemical injection material using the environmental soil stabilizer as liquid B was about 2.88 to 3.23 times greater than that of OPC. In addition, the elution amount of most heavy metals was lower than that of OPC, and the survival rate in the fish, acute toxicity test was 100%. Therefore, when judged based on the results of the laboratory test, it was analyzed to be superior to OPC in terms of strength and environment. In the results of the pilot test in the aging reservoir, when the environmental soil stabilizer was reinforced with liquid B of the chemical injection material, the coefficient of permeability in the aging reservoir decreased to 1/50 level. In addition, as a result of the electrical resistivity survey, it was analyzed that the electrical resistivity inside the aging reservoir increased as time passed, the saturation zone disappeared, and the overall reinforcement.