• Journal of Periodontal and Implant Science
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• v.24 no.1
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• pp.98-108
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• 1994

Gingival hyperplasia is frequently associated with the long-term use of phenytoin for control of convulsive disorder. The purpose of this study was to investigate on the effects of lipopolysaccharides (LPS), ursolic acid and oleanolic acid to phenytoin-induced cell activity in human gingival fibroblast. Human gingival fibroblasts were cultured form the healthy gingiva of orthodontic patients. Gingival fibroblasts were trypsinized and transferred to the weels of microtest plates. Fibroblast were cultured in growth medium added $5{\mu}g/ml$ of phenytoin, $5{\mu}g/ml$ of LPS, $10^{-7}M$ of ursolic acid and oleanolic acid. The passage number of cultured fibroblasts were fifth and eight. Cell morphology was examined by inverted microscope and the cell activity was measured by proliferation assay. Ursolic acid significantly modulated cell morphology into globular shape at the concentrantion of $10^{-7}M$ in the presence of phenytoin and LPS, and the cell activity was significantl decreased by ursolic acid or oleanolic acid regardless of the presence of phenytoin and LPS. These results suggested that the increased phenytoin-induced cell activity might be modulated by ursolic acid regardless of the presence of phenytoin and LPS. These results suggested that the increased phenytoin-induced cell activity might be modulated by ursolic acid or oleanolic acid. Further study is needed to clarify their toxicological effects on cellular modulation and mRNA expression change.

• The Bulletin of The Korean Astronomical Society
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• v.36 no.2
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• pp.99-99
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• 2011

A statistical study of coronal hole merging and splitting has been performed through Solar Cycle 23. The NOAA/SESC solar synoptic maps are examined to identify inarguably clear events of coronal hole merging and splitting. The numbers of merging events and splitting events are more or less comparable regardless of the phase in the solar cycle. The number of both events, however, definitely shows the phase dependence in the solar cycle. It apparently has a minimum at the solar minimum whereas its maximum is located in the declining phase of the sunspot activity, about a year after the second peak in Solar Cycle 23. There are more events of merging and splitting in the descending phase than in the ascending phase. Interestingly, no event is found at the local minimum between the two peaks of the sunspot activity. This trend can be compared with the variation of the average magnetic field strength and the radial field component in the solar wind through the solar cycle. In Ulysses observations, both of these quantities have a minimum at the solar minimum while their maximum is located in the descending phase, a while after the second peak of the sunspot activity. At the local minimum between the two peaks in the solar cycle, the field strength and the radial component both have a shallow local minimum or an inflection point. At the moment, the physical reason for these resembling tendencies is difficult to understand with existing theories. Seeing that merging and splitting of coronal holes are possible by passage of opposite polarity magnetic structures, we may suggest that the energizing activities in the solar surface such as motions of flux tubes are not exactly in phase with sunspot generation, but are more active some time after the sunspot maximum.

• Structural Engineering and Mechanics
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• v.43 no.5
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• pp.637-655
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• 2012

In this study, stochastic responses of a cable-stayed bridge subjected to the spatially varying earthquake ground motion are investigated by the finite element method taking into account soil-structure interaction (SSI) effects. The considered bridge in the analysis is Quincy Bay-view Bridge built on the Mississippi River in between 1983-1987 in Illinois, USA. The bridge is composed of two H-shaped concrete towers, double plane fan type cables and a composite concrete-steel girder deck. In order to determine the stochastic response of the bridge, a two-dimensional lumped masses model is considered. Incoherence, wave-passage and site response effects are taken into account for the spatially varying earthquake ground motion. Depending on variation in the earthquake motion, the response values of the cable-stayed bridge supported on firm, medium and soft foundation soil are obtained, separately. The effects of SSI on the stochastic response of the cable-stayed bridge are also investigated including foundation as a rigidly capped vertical pile groups. In this approach, piles closely grouped together beneath the towers are viewed as a single equivalent upright beam. The soil-pile interaction is linearly idealized as an upright beam on Winkler foundation model which is commonly used to study the response of single piles. A sufficient number of springs on the beam should be used along the length of the piles. The springs near the surface are usually the most important to characterize the response of the piles surrounded by the soil; thus a closer spacing may be used in that region. However, in generally springs are evenly spaced at about half the diameter of the pile. The results of the stochastic analysis with and without the SSI are compared each other while the bridge is under the sway of the spatially varying earthquake ground motion. Specifically, in case of rigid towers and soft soil condition, it is pointed out that the SSI should be significantly taken into account for the design of such bridges.

• Journal of Digital Convergence
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• v.13 no.7
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• pp.169-175
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• 2015

An effective way to understand the dynamic and time series that follows the passage of time, as valuation is to establish a model to analyze the phenomena of the system. Model of the decision process is efficient clustering information of the total mass of the time series data of the relevant population been collected in a particular number of sub-groups than to look at all a time to an understand of the overall data through each community-specific model determination. In this study, a sub-grouping of the group and the first of the two process model of each cluster by determining, in the following in sub-population characterized by a fusion with heuristic Bayesian clustering techniques proposed a process which can reduce calculation time and cost was confirmed by experiments using actual effectiveness valuation.

• Fire Science and Engineering
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• v.30 no.5
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• pp.36-45
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• 2016

Integral fire shutters are installed indiscriminately, regardless of evacuation. There is always the risk of an accident because integral shutters are applied mainly to corridors, passages, and stairs of schools This study evaluated the problem of integral shutter's entrance, evacuation, construction management, and maintenance control through a fire shutter accident case, including present condition of fire shutter installed at school of Okgil, Bucheon and Dongtan, Hwaseong. The results suggest that emergency lighting or signs for passage be set up to check location of entrance easily and install obstruction sensors at fire shutter to reduce life damage. In addition, the number of efficiency tests of fire shutters should be increased by running a trial test monthly or weekly to maintain the performance of fire shutter. Schools need to install a fire shutter- applied sprinkler at the entire floor.

• Journal of Periodontal and Implant Science
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• v.23 no.3
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• pp.622-634
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• 1993

Gingiva is remarkly sensitive to certain drugs. Especially, long term use of phentoin, dihydropyrydine (including nifedipine), cyclosporin and other drugs can be lead to pathologic changes in gingival tissue, especially in terms of proliferation of epithelium and connective tissue. Recent study in terms of proliferation of epithelium and connective tissue. Recent study is focused on the inhibition of drug-induced gingival hyperplasia by using medicaments. The purpose of this study was to investigate on the pharmacological effects of nifedipine, retinoic acid and glycyrrhetini acid to the activity in human gingival fibroblast. Human gingival fibroblasts were cultured from the healthy gingiva of orthodontic patients. Gingival fibroblasts were trypsinized and cultured in growth medium added $5{\mu}g/ml$ of nifedipine, $10^{+7}M$ of retinoic acid and glycyrrhetinic acid. The passage number of cultured fibroblasts were between fifth and eighth. The cell morphology was examined by inverted microscope and the cell acitivity was measured by the MTT assay. Nifedipine at the concentration of $5{\mu}g/ml$ was revealed significantly effective to increase the cell activity and lipopolysaccharide was cofactor to increase cell activity in the presence of nifedipine. However, retinoic acid was significantly effective on the globular change of cell morphology and loss of cell process regardless of the presence of nifedipine and LPS. Cell activity was significantly decreased by the glycyrrhetinic acid at the concentration of $10^-M$ regardless of the presence of nifedipine and LPS. These results suggested that the increased cell activity by nifedipine might be modulated by retinoic acid and glycyrrhetinic acid. Further study is needed to clarify on their toxicological effects during cellular modulation and mRNA expression change.

• Journal of the Korean Institute of Gas
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• v.15 no.2
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• pp.33-39
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• 2011

This study presented quantitative risk analysis in case of transporting explosive materials by railway. Accident types were classified into accidents of in station and in transit. And the study presented an initial value of accident frequency through derailment accident and crushing one according to each type, and drew the results of accident frequency through event tree analysis. Damage impact evaluation used TNT equivalent method and probit analysis method. As the result of risk evaluation, railway transportation of explosive materials passing through areas which are high in population density is appeared to be able to cause a large number of personnel injury when occurring accidents. Specially, the accident of explosive transportation combined with petroleum was forecasted as easily resulting in large explosive accident. Consequently, there is a necessity to reduce consequences by decreasing passage through areas where are high in population density, and take measures for lessening the risks in case of transporting dangerous explosive materials.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.35 no.9B
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• pp.1259-1265
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• 2010

Recently, on-line social network has been increasing according to development of internet. The most representative service is blog. A Blog is a type of personal web site, usually maintained by an individual with regular entries of commentary. These blogs are related to each other, and it is called Blog Network in this paper. In a blog network, posts in a blog can be diffused to other blogs. Analyzing information diffusion in a blog world is a very useful research issue, which can be used for predicting information diffusion, abnormally detection, marketing, and revitalizing the blog world. Existing studies on network analysis have no consideration for the passage of time and these approaches can only measure network activity for a node by the number of direct connections that a given node has. As one solution, this paper suggests the new method of measuring the blog network activity using logistic curve model and Cosine-similarity in key words by the Map/Reduce programming model.

• Biomedical Science Letters
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• v.24 no.3
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• pp.239-244
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• 2018

Recently, many researches regarding the natural products which alternate with chemical products have been done. Among them, boswellia is well known for effect on anti-oxidative effect and inflammation. The aim was the effect boswellia of formalin- induced orofacial and temporomandibular joint (TMJ) pain on experimental animals was investigated. Experiments were carried out using subcutaneous (SC) pain model and TMJ pain model that were induced by the injection of 5% formalin into the right vibrissa pad (SC, $50{\mu}L$) or TMJ ($30{\mu}L$) of rats, respectively. In both models, formalin (5%), formalin after distilled water (vehicle), formalin after boswellia extract (p.o., concentrations of 15, 30 mg/kg) (n=6). The number of scratching on the injected region was scored during the 9 successive periods of 5 min intervals following injection of formalin. Oral administration of boswellia (15, 30 mg / kg) reduced formalin-induced SC orofacial pain behavioral responses. SC orofacial pain behavioral responses was significantly reduced at 20~35 min. In the experimental group injected into temporomandibular joints, the pain response was significantly reduced by $276.2{\pm}8.20$ and $78.3{\pm}4.7$ after oral administration of boswellia (15, 30 mg / kg) at $398.3{\pm}24.8$ times. As a result of the passage of time, the oral administration of boswellia showed a significant effect of reducing the temporomandibular joint pain 30 minutes after the injection of formalin. This study confirmed that oral administration of boswellia modulated the pain behavior in both models. In conclusion, boswellia extract may be a potential therapeutic treatment for orofacial pain.

• Journal of Advanced Marine Engineering and Technology
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• v.37 no.2
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• pp.213-219
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• 2013

Recently, with the rapid advancement in information and communication technology, indoor location-based services(LBSs) that require precise position tracking have been actively studied with outdoor-LBS using GPS. However, in case of a ship which consists of steel structure, it is difficult to measure a precise localization due to significant ranging error by the diffraction and refraction of radio waves. In order to reduce location measurement errors that occur in these indoor environments, this paper presents distance compensation algorithms that are suitable for a narrow passage such as ship corridors without any additional sensors by using UWB(Ultra-wide-band), which is robust to multi-path and has an error in the range of a few centimeters in free space. These improvement methods are that Pythagorean theory and adjacent node technique are used to solve the distance error due to the node deployment and distance variation analysis technique is applied to reduce the ranging errors which are significantly fluctuated in the corner section. The experimental results show that the number of nodes and the distance error are reduced to 66% and 57.41%, respectively, compared with conventional CSS(Chirp spread spectrum) method.