Journal of Periodontal and Implant Science
- Volume 23 Issue 3
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- Pages.622-634
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- 1993
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- 2093-2278(pISSN)
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- 2093-2286(eISSN)
THE EFFECTS OF NIFEDIPINE ON THE ACTIVITY OF HUMAN GINGIVAL FIBROBLAST
Nifedipine이 인체 치은섬유모세포의 세포활성에 미치는 효과
- Choi, Jong-Gil (Dept. of Periodontology, College of Dentistry, Wonkwang University) ;
- Kim, Jai-Hun (Dept. of Periodontology, College of Dentistry, Wonkwang University) ;
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Shin, Hyung-Shik
(Dept. of Periodontology, College of Dentistry, Wonkwang University)
- Published : 1993.11.30
Abstract
Gingiva is remarkly sensitive to certain drugs. Especially, long term use of phentoin, dihydropyrydine (including nifedipine), cyclosporin and other drugs can be lead to pathologic changes in gingival tissue, especially in terms of proliferation of epithelium and connective tissue. Recent study in terms of proliferation of epithelium and connective tissue. Recent study is focused on the inhibition of drug-induced gingival hyperplasia by using medicaments. The purpose of this study was to investigate on the pharmacological effects of nifedipine, retinoic acid and glycyrrhetini acid to the activity in human gingival fibroblast. Human gingival fibroblasts were cultured from the healthy gingiva of orthodontic patients. Gingival fibroblasts were trypsinized and cultured in growth medium added
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