• 정보저장시스템학회논문집
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• 제6권2호
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• pp.68-73
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• 2010

The interest in acquiring high efficiency solar cells has been steadily increasing due to various advantages such as low-cost installation, pollution free and everlasting energy generation. In order to raise the cell efficiency, there has been a lot of effort to develop effective anti-reflection coatings. In this work, the main objective was to investigate the effects of particle size and annealing temperature of silica anti-reflection coatings to maximize the cell efficiency as well as reliability. It was shown that the light transmittance could be increased by a few percent over a certain range of wavelength using the silica coating. Also, the tribological properties of the coating could be improved through the annealing process, which led to better reliability of the coating.

• E2M - 전기 전자와 첨단 소재
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• 제8권5호
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• pp.633-639
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• 1995

Dropouts in magnetic media are a primary quality deficiency which is detrimental to magnetic signal quality and thus the major impediment to error-free recording, especially in high density digital recorders. The specific form of defects and causes found to be responsible for signal dropouts occurring in magnetic tape were studied. Dropout occurred when the RF signal falls to low level due to the various types of surface defects. However, the fall in the level of the RF signal in gravure roll coated tapes was most often caused by foreign particles adhering to the magnetic tape. It was also shown from the present study that scattered particles trapped under the tape surface or put on the top can lift it as it crosses the head, creating a spherical tent shaped defect and causing a temporary signal drop. Dropout producing substances were identified through optical and microchemical analyses. The results were correlated with measured electrical signal losses combined with analytical microscopy to clarify source identification of defects.

• 한국표면공학회지
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• 제33권4호
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• pp.233-240
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• 2000

A novel electrostatic spraying method to solidify molten zinc coating layer was studied by SEM and measurement of sample's temperature. The sprayed droplets also served as nucleation sites in the solidification reaction of molten zinc but might leave the pitting mark by impinging on its surface especially at high spray pressure. Our experimental results showed that electric field could change the sprayed particle trajectories and assist the fine droplets to attach on the surface. Thus, by reducing the spray pressure and by applying the electric voltage higher than -20 KV to charge the droplets electrostatically, we could produce the spangle free galvanized coating layer without pitting.

• Membrane and Water Treatment
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• 제9권2호
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• pp.129-136
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• 2018

In this contribution, the control of multivariable reverse osmosis (RO) desalination plant using proportional-integral-derivative (PID) controllers is presented. First, feed-forward compensators are designed using simplified decoupling method and then the PID controllers are tuned for flux (flow-rate) and conductivity (salinity). The tuning of PID controllers is accomplished by minimization of the integral of squared error (ISE). The ISEs are minimized using a recently proposed algorithm named as teacher-learner-based-optimization (TLBO). TLBO algorithm is used due to being simple and being free from algorithm-specific parameters. A comparative analysis is carried out to prove the supremacy of TLBO algorithm over other state-of-art algorithms like particle swarm optimization (PSO), artificial bee colony (ABC) and differential evolution (DE). The simulation results and comparisons show that the purposed method performs better in terms of performance and can successfully be applied for tuning of PID controllers for RO desalination plants.

• Journal of Cancer Prevention
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• 제23권4호
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• pp.153-161
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• 2018

Imbalance of protein homeostasis (proteostasis) is known to cause cellular malfunction, cell death, and diseases. Elaborate regulation of protein synthesis and degradation is one of the important processes in maintaining normal cellular functions. Protein degradation pathways in eukaryotes are largely divided into proteasome-mediated degradation and lysosome-mediated degradation. Proteasome is a multisubunit complex that selectively degrades 80% to 90% of cellular proteins. Proteasome-mediated degradation can be divided into 26S proteasome (20S proteasome + 19S regulatory particle) and free 20S proteasome degradation. In 1980, it was discovered that during ubiquitination process, wherein ubiquitin binds to a substrate protein in an ATP-dependent manner, ubiquitin acts as a degrading signal to degrade the substrate protein via proteasome. Conversely, 20S proteasome degrades the substrate protein without using ATP or ubiquitin because it recognizes the oxidized and structurally modified hydrophobic patch of the substrate protein. To date, most studies have focused on protein degradation via 26S proteasome. This review describes the 26S/20S proteasomal pathway of protein degradation and discusses the potential of proteasome as therapeutic targets for cancer treatment as well as against diseases caused by abnormalities in the proteolytic system.

• Journal of information and communication convergence engineering
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• 제21권3호
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• pp.233-238
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• 2023

This study presents a method for identifying partial discharge defects in an eco-friendly gas insulated system using a backpropagation algorithm. Four partial discharge (PD) electrode systems, namely, a free-moving particle, protrusion on the conductor, protrusion on the enclosure, and voids, were designed to simulate PD defects that can occur during the operation of eco-friendly gas-insulated switchgear. The PD signals were measured using an ultrahigh-frequency sensor as a nonconventional method based on IEC 62478. To identify the types of PD defects, the PD parameters of single PD pulses in the time and frequency domains and the phase-resolved partial discharge patterns were extracted, and a back-propagation algorithm in the artificial neural network was designed using a virtual instrument based on LabVIEW. The backpropagation algorithm proposed in this paper has an accuracy rate of over 90% for identifying the types of PD defects, and the result is expected to be used as a reference database for asset management and maintenance work for eco-friendly gas-insulated power equipment.

• Journal of Pharmaceutical Investigation
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• 제38권4호
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• pp.241-247
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• 2008

Paclitaxel is a taxane diterpene amide, which was first extracted from the stem bark of the western yew, Taxus brevifolia. This natural product has proven to be useful in the treatment of a variety of human neoplastic disorders, including ovarian cancer, breast and lung cancer. Paclitaxel is a highly hydrophobic drug that is poorly soluble in water. It is mainly given by intravenous administration. Therefore, The pharmaceutical formulation of paclitaxel ($Taxol^{(R)}$; Bristol-Myers Squibb) contains 50% $Cremophor^{(R)}$ EL and 50% dehydrated ethanol. However the ethanol/Cremophor EL vehicle required to solubilize paclitaxel in $Taxol^{(R)}$ has a pharmacological and pharmaceutical problems. To overcome these problems, new formulations for paclitaxel that do not require solubilization by $Cremophor^{(R)}$ EL are currently being developed. Therefore this study utilized a supercritical fluid antisolvent (SAS) process for cremophor-free formulation. To select hydrophilic polymers that require solubilization for paclitaxel, we evaluated polymers and the ratio of paclitaxel/polymers. HP-${\beta}$-CD was used as a hydrophilic polymer in the preparation of the paclitaxel solid dispersion. Although solubility of paclitaxel by polymers was increased, physical stability of solution after paclitaxel/polymer powder soluble in saline was unstable. To overcome this problem, we investigated the use of surfactants. At 1/20/40 of paclitaxel/hydrophilic polymer/ surfactant weight ratio, about 10 mg/mL of paclitaxel can be solubilized in this system. Compared with the solubility of paclitaxel in water ($1\;{\mu}g/mL$), the paclitaxel solid dispersion prepared by SAS process increased the solubility of paclitaxel by near 10,000 folds. The physicochemical properties was also evaluated. The particle size distribution, melting point and amophorization and shape of the powder particles were fully characterized by particle size distribution analyzer, DSC, SEM and XRD. In summary, through the SAS process, uniform nano-scale paclitaxel solid dispersion powders were obtained with excellent results compared with $Taxol^{(R)}$ for the physicochemical properties, solubility and pharmacokinetic behavior.

• 대한기계학회논문집B
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• 제26권6호
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• pp.893-901
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• 2002

Effect of boundary layer thickness on the flow characteristics around a rectangular prism has been investigated by using a PIV(Particle Image Velocimetry) technique. Three different boundary layers(thick, medium and thin)were generated in the Atmospheric Boundary Layer Wind Tunnel at Pusan National University. The thick boundary layer having 670 mm thickness was generated by using spires and roughness elements. The medium thickness of boundary layer($\delta$=270 mm) was the natural turbulent boundary layer at the test section floor with fairly long developing length(18 m). The thin boundary layer($\delta$=36.5 mm) was generated on the smooth panel elevated 70cm from the wind tunnel floor. The Reynolds number based on the free stream velocity(3 ㎧) and the height of the model(40 mm) was 7.9$\times$10$^3$. The mean velocity vector fields and turbulent kinetic energy distributions were measured and compared. The effect of boundary layer thickness was clearly observed not only in the length of separation bubble but also in the location of reattachment point. The thinner the boundary layer thickness, the higher the turbulent kinetic energy Peak around the model roofbecame. It is strongly recommended that the height ratio between the model and the approaching boundary layer thickness should be encountered as a major parameter.

• 폴리머
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• 제34권6호
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• pp.534-539
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• 2010

라텍스 블렌딩 기법을 이용하여 폴리스티렌(PS)/다중벽 탄소나노튜브(MWCNT) 나노복합재료를 제조하여 나노튜브 길이에 따른 나노복합재료의 유변학적 특성을 고찰하였다. 나노복합재료 제조에 사용된 단분산 PS 입자는 무유화제 유화중합으로 제조하였고, MWCNT는 불순물 제거와 분산성 향상을 위해 표면개질 과정을 거친 후 사용하였다. 최종적인 나노복합재료는 단분산 PS 입자와 개질한 MWCNT를 초음파 교반조에서 분산시킨 후 동결건조 과정을 거쳐 제조하였다. 나노복합재료의 MWCNT 함량과 나노튜브 길이에 따른 유변학적 특성은 소진폭 진동 전단유동을 부과시켜 평가하였다. 본 연구에서 고찰한 PS/MWCNT 나노복합재료는 MWCNT의 함량이 증가할수록, 나노튜브 길이가 길수록 유변물성 향상 효과가 뚜렷하였다. 이는 MWCNT 함량이 증가할수록 나노복합재료의 유변학적 특성이 액체적 특성에서 점차 고체적 특성으로 변화하기 때문이며, 나노튜브 길이가 길수록 네트워크 구조를 달성하는 임계 농도가 작아지기 때문인 것으로 판단된다.

• 한국진공학회지
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• 제16권6호
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• pp.489-495
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• 2007

KSTAR 토카막은 현재 주장치 조립을 완료하고 "최초 플라즈마" 발생과 시운전을 준비하고 있다. 이를 위해 설치되어 있는 연료주입계는 배기 덕트 반대 쪽 한 곳만 주입구로 사용하기 때문에 균일하고 신속한 입자공급이 어렵다. 시운전이 끝나고 기본운전 단계가 되면 단순한 플라즈마 생성이 아니라 일정한 고밀도 토카막플라즈마 상태를 일정시간 고르게 유지해야 하므로 공간적으로 균일한 입자공급과 플라즈마 밀도 변화에 따른 신속한 제어가 가능한 연료공급계로 개선되어야 한다. 이런 개선점을 찾는 작업의 일환으로 우선 D-형 진공용기 및 플라즈마 컬럼을 사각단면 토러스로 묘사하는 모델을 만들고 연료공급 위치와 플라즈마의 전리율 및 배기확률에 따라 공간적인 입자분포가 어떻게 바뀌는지 몬테카를로 계산을 통해 분석했다.