• 약학회지
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• 제46권2호
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• pp.102-107
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• 2002

The particle size of medicinal materials is an important physical property which affects the pharmaceutical behaviors such as dissolution, chemical stability, compressibility and bioavailability of solid dosage forms. The size reduction of raw pharmaceutical powder is needed to formulize insoluble drugs or slightly soluble drugs and to improve the pharmaceutical properties such as the solubility, the pharmaceutical mixing and the dispersion. The objective of the present study is to evaluate the grinding characteristics of ursodeoxycholic acid(UDCA) as a model of insoluble drugs. The effects of the grinding time and the amount of additive on particle size distribution of ground UDCA were investigated. Grinding of insoluble drug, UDCA and a series of dry co-grinding experiments of UDCA with sodium lauryl sulfate(SLS) as an additive were carried out using a planetary ball mill. It was measured that the median diameter and the particle size distribution of ground products with grinding UDCA and additive SLS by Mastersizer. As a result of co-grinding of UDCA and SLS, the particle size of co-grinding products was decreased more than single grinding one. However, it was observed that co-grinding products were reaggregated to larger particles after 120 min.

• 환경영향평가
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• 제2권1호
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• pp.57-63
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• 1993

An analysis for particle settling effects via of plume centerline tilted exponentially under the influence of panicle settling velocity is carried out for particle of $30{\mu}m$ diameter with $1g/cm^3$ density and 0.02m/s settling velocity corresponding to its particle characteristic according to various wind speeds, atmospheric stabilities. Characteristic analysis of surface concentration distribution simulated by Lagrangian model also are carried out under the influence of plume centerline tilted exponentially at 10m stack height emitted 200 particles per second. This study reveals that plume centerline at the nearby source is sharply tilted exponentially under the condition of stable, weakly wind speed, therefore the lower concentration at the nearby source, the higher concentration at the downwind distance far away from source than actual one is brought out, if not apply the effect of plume centerline tilted exponentially to diffusion Model.

• 한국입자에어로졸학회지
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• 제12권3호
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• pp.65-72
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• 2016

Nanoporous $SiO_2$ particles containing different pore volume and size were prepared from silicic acid by a spray pyrolysis. The pore size, pore volume and particle size could be controlled with varying the precursor concentration, reaction temperature, and amount of organic templates such as Urea and poly ethylene glycol (PEG). The pore size distribution, pore volume and specific surface area of as-prepared particles were analyzed by BET and BJH methods, and the average particle sizes were measured by a laser diffraction method. The nanoporous $SiO_2$ particles ranged $0.6-0.9{\mu}m$ in diameter were successfully synthesized and the average particle size increased as the silicic acid concentration increased. The morphology of nanoporous $SiO_2$ particles was spherical and pores ranged 1 - 40 nm in diameter were measured in the particles. In case of Urea added into silicic acid, it showed no much difference in the morphology, pore size and pore volume at different Urea concentration. On the other hand, when PEG was added, it was clearly observed that pore diameter and pore volume of the particles surface increased with respect to PEG concentration.

• 한국대기환경학회지
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• 제31권3호
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• pp.255-268
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• 2015

Single particle soot photometer (SP2) is an advanced instrument capable of real-time measurement of concentration, coating thickness, and size distribution of individual BC particle using laser-induced incandescence. So far, there have been insufficient studies examining the real-time characteristics of BC in Korea. In this study, we examined temporal variations in BC concentration and mass size distribution of BC in volume equivalence diameter at a background site of Aewol, Jeju in May. Average concentration and mass median diameter (MMD) of BC particles measured during the study period (06~ 16 May 2013) were $0.69{\pm}0.48{\mu}g/m^3$ and $196{\pm}17nm$, respectively. The BC concentration measured in Aewol was very similar to that observed in the spring of 2012 in Baengnyeong island, and showed diurnal profiles similar to those in other background areas. MMD of BC ranged from 172 to 222 nm. It was found that the mass size distribution of BC varied depending on the location (ground-based), season, types of air masses, and altitude (aircraft-based).

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2003년도 The Fifth Asian Computational Fluid Dynamics Conference
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• pp.9-11
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• 2003

A homogeneous flow field including more than 2000 spherical particles was directly simulated. Particles are settling by gravity with the Reynolds number ranging from 50 to 300, based on diameter and slip velocity. Particular attention was focused on the distribution of particles. The Reynolds-number dependence, influences of particle rotation and loading ratio, and the dynamics of particle clusters are discussed. In the higher Reynolds number case, the wake attraction causes particle clusters and the average drag coefficient decreases significantly. Non-rotating particles maintain cluster structure and rotating ones moves randomly in the horizontal direction. It is because of the difference in the direction of the lift force.

• 동력기계공학회지
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• 제10권2호
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• pp.16-21
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• 2006

On this study, numerical analysis was performed for the 3 dimensional flow field of gas and particle phase for axial inlet cyclone, a part of dust collector. We applied FVM to visualize the gas phase. The flow was solved using ${\kappa}-{\varepsilon}$ turbulence model. The major parameters considered in this study were helical guide vane, inner diameter, length. Particle trajectory calculations were performed for the particle sizes of $5{\mu}m{\sim}75{\mu}m$. The distribution curve of particle sizes was made of Rosin-Rammler function. The simulation results show various gas flows, particle trajectories on numerical models.

• 반도체디스플레이기술학회지
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• 제5권1호
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• pp.45-49
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• 2006

In this paper, a new method that monitors the quantity of particles using ion-counter in vacuum environment is introduced. In-situ particle monitoring (ISPM) system is composed by Gerdien type ion-counter (house-made), DC power supply and electrometer. The ion-counter applied by positive voltage detects only positive charged particles. Therefore the particles to be detected should be in known charge state for further data analysis. ion-counter is installed at the exhaust line of process equipment where the pressure loss is structurally low. ISPM system performance has been verified with SMPS (Scanning Mobility Particle Sizer) system. The correlation coefficient is above 0.98 at the particle size range of $20{\sim}300nm$ in diameter with identified charge distribution under $0.1{\sim}10.0$ Torr.

• 한국재료학회지
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• 제17권10호
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• pp.532-537
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• 2007

A series of wet grinding experiments have been carried out using a stirred ball mill to systematically investigate consideration of grinding characteristics. The particle size distribution and median diameter of the grinding consumption power for a given grinding time were considered. Also, the effect of grinding aids on particle size and grinding consumption energy defined as the summation of grinding power was investigated. The grinding aids had influence on the smaller products size and decrease grinding consumption energy because the function of grinding aids were to be attribute to the prevention of agglomeration and ball and grinding chamber wall coating of sample powder. The grinding process seemed to be controlled by the force of agglomeration of the ground products. It was demonstrated that the particle size and grinding consumption energy could be more decreased by the addition of grinding aids.

• 한국입자에어로졸학회지
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• 제10권1호
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• pp.1-8
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• 2014

In this study, we have developed a real-time monitoring device for measuring $PM_{10/2.5/1}$ of ambient aerosol particles. The real-time PM (Particulate Matter) monitor was based on the light scattering method and had 16 channels in particle size. The laboratory and field tests were carried out to evaluate the performance of the PM monitor developed. Arizona Road Dust particles ranging from diameter of 0.1 to $20{\mu}m$ were generated as test particles in the laboratory test. The field test was carried out at the Seoul Meteorological Observatory. We can obtain the particle size and number concentration (particle size distribution) only from the real-time PM monitor developed. Therefore, the average density of aerosol particles was used to obtain the PM data from the particle size distribution. The $PM_{10/2.5/1}$ results of the PM monitor were compared with the data of the Grimm Dust Monitor (Model 1.108) and a beta ray gauge (Thermo Fisher Scientific). As a result, it was shown that the $PM_{10/2.5/1}$ results obtained by the real-time PM monitor agreed well with the data of the reference devices, and overall, the real-time PM monitor could be used as a PM monitoring device for real-time monitoring of the ambient particles.

• 환경위생공학
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• 제11권1호
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• pp.39-44
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• 1996

The pressure fluctuations in a gas-solid fluidized bed has been analysed using s statistical method interpreting fluidized 냥d behavior. The performing statistical a analysis of the pressure fluctuations in a fluidized bed of 6.7cm-ID. using uniform p particle size of 115 to $1015{\mu}m$ in diameter. The fluidized gas used air(velocity 0.1~1.2m/sec) at settled bed height to diameter ratios which is LlD=l.O. Then, the pressure fluctuations measured by DPT(differantial pressure transducer). The measuring characteristic values of pressure fluctuation were the mean value and standard value, and also, it has been found that the standard deviation of the pressure fluctuations can be effectively used to predict minimum fluidizing velocity and to explain the fluidized phenomena.