• Molecules and Cells
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• v.46 no.6
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• pp.337-344
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• 2023

N-glycosylation, a common post-translational modification, is widely acknowledged to have a significant effect on protein stability and folding. N-glycosylation is a complex process that occurs in the endoplasmic reticulum (ER) and requires the participation of multiple enzymes. GlcNAc-1-P-transferase (GPT) is essential for initiating N-glycosylation in the ER. Tunicamycin is a natural product that inhibits N-glycosylation and produces ER stress, and thus it is utilized in research. The molecular mechanism by which GPT triggers N-glycosylation is discussed in this review based on the GPT structure. Based on the structure of the GPT-tunicamycin complex, we also discuss how tunicamycin reduces GPT activity, which prevents N-glycosylation. This review will be highly useful for understanding the role of GPT in the N-glycosylation of proteins, as well as presents a potential for considering tunicamycin as an antibiotic treatment.

• Proceedings of the Korea Contents Association Conference
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• 2004.11a
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• pp.11-16
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• 2004

e-Learning has been expected as a new educational method and paradigm in knowledge information society. However e-Learning industry has not been in tremendous development on the contrary to people's expectations. Up to present time, collaborative learning is one of the learning approaches that promote active participation and engagement in learning. Learners can set up common goal, accomplish collaborative activity to solve the problem, and achieve individual and group goals while group work. In this paper, we present collaborative e-Learning environment to improve interactions among learners and identify the roles of collaborative learning agent to promote learner's learning activity.

• International Journal of Human Ecology
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• v.9 no.2
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• pp.93-105
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• 2008

This study investigates the different characteristics (mainly of community life) in representative intentional communities, between the ecovillage and cohousing, since the different purpose of the establishment of the community might result different characteristics. The study method is data analysis: the analysis material is Community Directory, A Comprehensive Guide to Intentional Communities and Cooperative Living (Rutledge, 2005). Of 750 listed communities, 397 (211 ecovillages and 186 cohousings) communities were analyzed. The findings of the study reveal that there are clear differences of community life between ecovillages and cohousings even though two communities are regarded as similar intentional communities. The similarities between the two communities are as follows: 1) Those mostly distributed in the USA, and established before 2000. 2) Dominant size of intentional communities is less than 20 residents and 20 houses. 3) They make decisions in consensus. 4) They eat together very frequently; at least once a week or more. 5) Shared work is required. The differences between the two communities are as follows: 1) They have different aims of establishment. For instance, ecovillage focus more on eco-living, while cohousing focuses more on the cohousing idea. 2) There are more female residents in cohousings than in ecovillages. 3) There are more cohousings in urban areas with a smaller area of land, contrary to that there are more ecovillages in rural areas with larger areas of land. 4) There are less identified leaders or leadership core groups in cohousing than in ecovillages. 5) Income sharing is more common in ecovillages than in cohousings. According to there findings, it is evident that a different purpose of establishment result in different characteristics of community life even though those belong to the similar category of the intentional community. Thus, it is recommended to adapt the correct characteristics that fit the aim of the community in the establishment an intentional community Topics and discussions about establishing intentional Topics and discussions abut establishing intentional communities could contribute to gather the intentional communities could contribute to gather the interests communities could contribute to gather the interests of residents as well as those of relevant civil-workers and administrators in Korea.

• Journal of Digital Convergence
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• v.8 no.2
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• pp.69-87
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• 2010

This research is to investigate phatic communication by puting the purpose in maintaining and strengthening social relationship among people in groups in Korean residential community space. Phatic communication is the activity for friendship, expressing and sharing the tastes, expectations, and common features of residents by inducing the participation of residents in all sorts of events, meetings, and activities in residential space. Through this pathic activity, the range of communication age, the time of communication, the selection of location, and the topic of communication discourse are examined. The investigation methods of this research were taken two ways: First, it carried out the observation of participation and in-depth interview by the participation of researcher in a way of life as a member. In order to prove more objectively, it enhances the reliability of data by adding the questionnaire survey through the convenience sampling of 150 residents of three communities. Moreover, $x^2$; chi-square test was conducted in order to verify the difference in heterogeneous groups. Accordingly, this research will bring about the great development in cultural studies by exploring a way of Korean life, based on the communication of Korea community in residential life space, which can unify the community through sharing the meaning, interacting and delivering the message.

• The Journal of Korean Physical Therapy
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• v.28 no.2
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• pp.77-87
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• 2016

Purpose: The purpose of the study was to review functioning components of studies for measuring functional information using International Classification of Functioning, disability and health (ICF) in Korea. Methods: A literature review was conducted and eligible studies were identified via search of RISS, KISS, DBpia, KoreaMed, PubMed, and ISI databases published from 2001 to 2015. For inclusion in this review, a study should be published in a peer-review journal, must have participation of Korean researchers and/or developed in Korea, and should provide functioning data related ICF. Descriptive studies containing only ICF concepts and review studies were also excluded. Collected functioning data in each study were analyzed using frequency based on ICF domain. Data assessment was performed by two independent reviewers. Results: Eighty publications were included in the analysis. The majority of studies collected data from clinical patients (n=38) and from the disabled (n=28). Fourteen studies assessed functioning data from the elderly and students under special education. The studies reported functioning data using various tools, including ICF itself, ICF checklist, coresets, and conventional measurement tools. Body function domain was most commonly used and the least used domain was the body structure across areas. Interestingly, increasing data related to environmental factors was observed in all studied populations. Conclusion: Functioning data was collected from four domains of ICF across professional areas. The most common collected data was body function and activity and participation for which conventional measurement tools are already available. To understand clients, components of environmental factors that might influence a person's functioning should be considered.

• Journal of Korean Orthopaedic Sports Medicine
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• v.2 no.1
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• pp.37-43
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• 2003

Purpose: This study is to analyse the injury patterns of knee ligament and the factors influencing ligament injuries of knee, and to evaluate the changes of knee function and activity after ski injury. Materials and Methods: Thirty cases of ligament injuries of knee were studied with a questionaire, stress radiographs, magnetic resolution imaging, and physical examination. Mean age was 28.6 years old and mean follow up was 29.6 months. Clinical evaluation of Lysholm knee scoring scale was used for knee function and Tegner activity score was used for activity change after ski injury. Results: The anterior cruciate ligament (ACL) injury accompanied with medial collateral ligament(MCL) injury was most in 11 cases and isolated MCL injury was the next in 9 cases. The common types of injury mechanism were Phantom foot phenomenon (13 cases, 43$\%$) and valgus external rotation injury (12 cases, 40$\%$), which constitute 83$\%$ of all case. At the last follow up, the mean Lysholm score was 93.4 and mean Tegner activity score was 4.2. The reduced Tegner activity score after injury was 1.9. Among several injury groups, the evaluation of knee function and activity was best in the isolated MCL injury group and worst in the ACL injury accompanied with MCL injury group. The factors to influence ski injury were participation to ski class, release of binding, and skiing long time more than 2 hours. Conclusions: Lysholm score at last follow up revealed good grading, but sports activity after ski injury was reduced when compared with pre-injury state. It seems to need a active, systemic sports rehabilitation program after sports injury.

• 재활복지
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• v.21 no.1
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• pp.253-277
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• 2017

The purpose of this study was to develop the Constraints in Physical Activity Scale for people with physical Disabilities(CPASD) which measures the constraints in physical activity of people with physical disabilities. For this study, the 5 step analytic framework of unified validity developed by Messick (1995), the framework for conducting a strong program of construct validation by Benson (1998) method were applied. Furthermore, the validity of CPASD was systematically presented by applying common factor model and measurement model to 264 persons with physical disabilities. The conclusion based on the results and discussions of this study is as follows. First, CPASD presented evidence of job validity. Four factors (17 items) were developed, consisting of leader constraints, economic constraints, prejudice, and exercise environment constraints through the analysis of the factor structure and the fit of factor coefficients. Second, the factor structure of the developed CPASD (leader constraint, economic constraint, prejudice, exercise environment constraint) was statistically distinguished and stably reflected the existing exercise participation constraints theory. Third, the developed CPASD presented evidence of the validity of the criteria. Leader constraints and prejudice were negatively correlated with positive motor emotions, leader constraints, prejudice, and exercise environment constraints were positively correlated with negative motor emotions. Therefore, in future research, it is necessary to reevaluate the current system and actual condition related to leader constraints, economic constraints, prejudices, and exercise environment constraints derived as factors of CPASD. To do this, it is necessary to judge the degree of reality based on the causal relationship verification and IRT theory using CPASD.

• Korean Institute of Interior Design Journal
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• v.26 no.4
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• pp.75-83
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• 2017

The cultural tendency based on sharing and cooperation, which has recently been a hot issue, accelerates throughout the world. This study began with a perception that a sharing culture is inherent in urban public spaces. This study aims to conduct a theoretical study of the sharing culture and to analyze the characteristics of the design composition of public spaces. This study selected squares in 16 European cities as cases for analysis. The results are summarized as follows:1)To analyze the design characteristics of public spaces in which a sharing culture is inherent, this study drew the shape and type of planes and sharing elements such as accessibility, symbolism and activity with the squares in the cases. 2)The shape of planes in the squares in the cases has been formed in close relations with the historic meaning and events of the area and the process of the construction of buildings surrounding the square. The squares in the cases were classified into seven plane types, and these squares have developmentally contributed to the formation of a sharing culture as a place for free participation and communication concerning social issues. 3)In the squares in the cases, the weight of road-centered access appears high, and in terms of the construction of human-friendly / environment-friendly infrastructure in the city or judging from the trend of the recent increase of pedestrian-centered plans for public space, it is judged that approaches with a high utilization rate of sidewalk or public transportation would be desirable. 4)Symbolic elements of the square become a device by which citizens can share the historic symbolism, along with artistic inspiration. In addition, by serving as an observatory from which people can take a view of the landscape of the city, it allows visual sharing of the entire city as well as the square. 5)A square is common pool resources in the community, and it is necessary to vitalize that in a direction of increasing the possibility of sharing, through the characteristics and methods of the composition of public design.

• Journal of Korean Elementary Science Education
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• v.36 no.4
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• pp.379-393
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• 2017

This study analyzed the relationship between self-directedness of science-gifted elementary students and their expression of scientific creativity in science-gifted class. A science-gifted program on the topic of Hydraulic Machine was implemented to 34 fifth-graders in the Science-Gifted Education Center of an education office in Seoul, Korea for four weeks. The self-directedness of the gifted students was divided into three types of 'General, Scientific, and Topic-Related Self-Directedness'. The products of the students' activities were assessed by using a scientific creativity assessment formula. Qualitative research, such as analysis of observations and interviews, was also conducted in order to identify characteristics that were not apparently revealed by quantitative data. The main results of this study are as follows: First, science-gifted elementary students' general self-directedness and their scientific creativity were significantly correlated (r=.373). Second, the students' scientific self-directedness and scientific creativity did not have a significant correlation (r=.294). Third, there was a positive correlation between the students' topic-related self-directedness and their expression of scientific creativity. Their self-rated scores (r=.420) for the topic-related self-directedness and the number of activity types associated with the topic had a positive correlation (r=.350). Fourth, the students were categorized into four groups according to the levels of their self-directedness and scientific creativity, and the result showed that Type HH (high self-directedness and high scientific creativity) was the most common type (15 students, 38.5%), followed by Type LL (low self-directedness and low scientific creativity) (11 students, 28.2%). Eight (20.5%) and five students (12.8 %) belonged to Type LH (low self-directedness and high scientific creativity) and Type HL (high self-directedness and low scientific creativity) respectively. Fifth, the classroom observation of the students in groups revealed that groups with more number of Type HH demonstrated better cooperation and performance. Sixth, the analysis results of the observation were almost matched to the results of the self-directedness and scientific creativity tests. The students with higher self-directedness demonstrated active class participation and good cooperative skills. The students with higher scientific creativity had a tendency to generate creative ideas more frequently in given situations. Seventh, dynamic activities were perceived as enjoyable and exciting by 76.9% of the students, but static activities that require creativity were regarded as interesting only by 23.1% of the students. Among the students who were satisfied with both the creative and static activities, Type HH accounted for the largest proportion (55.6%). In conclusion, factors such as students' interests, initiatives, and attitudes displayed through voluntary participations originated from their own daily life can predict the degree of scientific creativity associated with the topic. Also, when students were categorized into four types according to the level of self-directedness and scientific creativity, there was a tendency of active behavior in class, cooperative skill, and activity satisfaction. This suggested that we should consider self-directedness and scientific creativity in selecting the gifted, grouping them in class, and designing and executing programs for science-gifted elementary students.

• Journal of Digital Convergence
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• v.14 no.12
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• pp.515-524
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• 2016

The purpose of this study was to investigate the effects of a culture and art education program on adolescents with disabilities. Craft education oriented toward activities convergence education. The investigator conducted an in-depth interview with seven adolescents with developmental disabilities in a special high school class for a month after the educational sessions were over. The findings were as follows: first, the adolescents with developmental disabilities experienced the joy, pleasure, and interest of study, which they used to have a difficult time experiencing in a common class. Second, they became relaxed with their participation in lessons, felt comfortable through educational activities, and had a positive attitude. Third, they had a feeling of being together and coexistence through collaborative activities. Finally, they were able to share each other's ideas, listen carefully to their friends, talk about works they created, and experience close relationships with classmates.