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The Activation of Stress-induced Heat Shock Protein 27 and the Relationship of Physical Therapy (스트레스-유도 열충격단백질 27(Heat Shock Protein 27)의 활성과 물리치료의 상관성)

  • Kim, Mi-Sun;Lee, Sung-Ho;Kim, Il-Hyun;Hwang, Byong-Yong;Kim, Jung-Hwan
    • The Journal of Korean Physical Therapy
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    • v.20 no.1
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    • pp.57-65
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    • 2008
  • Purpose: Heat shock proteins (HSPs) are a group of proteins that are activated when cells are exposed to a variety of environmental stresses, such as infection, inflammation, exposure to toxins, starvation, hypoxia, brain injury, or water deprivation. The activation of HSPs by environmental stress plays a key role in signal transduction, including cytoprotection, molecular chaperone, anti-apoptotic effect, and anti-aging effects. However, the precise mechanism for the action of small HSPs, such as HSP27 and mitogen-activated protein kinases (MAPKs: extracellular-regulated protein kinase 1/2 (ERK1/2), p38MAPK, stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), is not completely understood, particularly in application of cell stimulators including platelet-derived growth factor (PDGF), angiotensin II (AngII), tumor necrosis factor $\alpha$ (TNF$\alpha$), and $H_2O_2$. This study examined the relationship between stimulators-induced enzymatic activity of HSP27 and MAPKs from rat smooth and skeletal muscles. Methods: 2-dimensional electrophoresis (2DE) and matrix assisted laser desorption ionizationtime-of-flight/time-of-flight (MALDI-TOF/TOF) analysis were used to identify HSP27 from the intact vascular smooth and skeletal muscles. Three isoforms of HSP27 were detected on silver-stained gels of the whole protein extracts from the rat aortic smooth and skeletal muscle strips. Results: The expression of PDGF, AngII, TNF$\alpha$, and $H_2O_2$-induced activation of HSP27, p38MAPK, ERK1/2, and SAPK/JNK was higher in the smooth muscle cells than the control. SB203580 (30${\mu}$M), a p38MAPK inhibitor, increased the level of HSP27 phosphorylation induced by stimulators in smooth muscle cells. Furthermore, the age-related and starvation-induced activation of HSP27 was higher in skeletal muscle cells (L6 myoblast cell lines) and muscle strips than the control. Conclusion: These results suggest, in part, that the activity of HSP27 and MAPKs affect stressors, such as PDGF, AngII, TNF$\alpha$, $H_2O_2$, and starvation in rat smooth and skeletal muscles. However, more systemic research will be needed into physical therapy, including thermotherapy, electrotherapy, radiotherapy and others.

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The Design of a X-Band Frequency Synthesizer using the Subharmonic Injection Locking Method (Subharmonic Injection Locking 방법을 이용한 X-Band 주파수 합성기 설계)

  • 김지혜;윤상원
    • The Journal of Korean Institute of Electromagnetic Engineering and Science
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    • v.15 no.2
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    • pp.152-158
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    • 2004
  • A low phase noise frequency synthesizer at X-Band which employs the subharmonic injection locking was designed and tested. The designed frequency synthesizer consists of a 1.75 GHz master oscillator - which also operates as a harmonic generator - and a 10.5 GHz slave oscillator. A 1.75 GHz master oscillator based on PLL technique used two transistors - one constitutes the active part of VCO and the other operates as a buffer amplifier as well as harmonic generator. The first stage operates a fixed locked oscillator and using the BJT transistor whose cutoff frequency is 45 GHz, the second stage is designed, operating as a harmonic generator. The 6th harmonic which is produced from the harmonic generator is injected into the following slave oscillator which also behaves as an amplifier having about 45 dB gain. The realized frequency synthesizer has a 7.4 V/49 mA, -0.5 V/4 mA of the low DC power consumption, 4.53 dBm of output power, and a phase noise of -95.09 dBc/Hz and -108.90 dBc/Hz at the 10 kHz and 100 kHz offset frequency, respectively.

Design and Verification of PCI 2.2 Target Controller to support Prefetch Request (프리페치 요구를 지원하는 PCI 2.2 타겟 컨트롤러 설계 및 검증)

  • Hyun Eugin;Seong Kwang-Su
    • The KIPS Transactions:PartA
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    • v.12A no.6 s.96
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    • pp.523-530
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    • 2005
  • When a PCI 2.2 bus master requests data using Memory Read command, a target device may hold PCI bus without data to be transferred for long time because a target device needs time to prepare data infernally. Because the usage efficiency of the PCI bus and the data transfer efficiency are decreased due to this situation, the PCI specification recommends to use the Delayed Transaction mechanism to improve the system performance. But the mechanism cann't fully improve performance because a target device doesn't know the exact size of prefetched data. In the previous work, we propose a new method called Prefetch Request when a bus master intends to read data from the target device. In this paper, we design PCI 2.2 controller and local device that support the proposed method. The designed PCI 2.2 controller has simple local interface and it is used to convert the PCI protocol into the local protocol. So the typical users, who don't know the PCI protocol, can easily design the PCI target device using the proposed PCI controller. We propose the basic behavioral verification, hardware design verification, and random test verification to verify the designed hardware. We also build the test bench and define assembler instructions. And we propose random testing environment, which consist of reference model, random generator ,and compare engine, to efficiently verify corner case. This verification environment is excellent to find error which is not detected by general test vector. Also, the simulation under the proposed test environment shows that the proposed method has the higher data transfer efficiency than the Delayed Transaction about $9\%$.

A Study on the Documentary Characteristics of "Chimgyeongjinam(鍼經指南)", "Chimguokryonggyeong(鍼灸玉龍經)" on Acupuncture and Moxibustion ("침경지남(鍼經指南)"과 "침구옥룡경(鍼灸玉龍經)"의 문헌적 특징에 관한 연구)

  • Kim, Sung-Chul;Kim, Ki-Wook;Park, Hyun-Guk
    • Journal of Korean Medical classics
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    • v.22 no.1
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    • pp.93-102
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    • 2009
  • During the Geum and Won dynasties, the documentary characteristics of "Chimgyeongjinam","Chimguokryonggyeong" can be summarized into the following. 1. "Chimgyeongjinam" 1) "Chimgyeongjinam" is an acupuncture and moxibustion anthology by the acupuncture expert of the Geum and Won dynasties, Duhangyeong(竇漢卿) which was edited and revised by Dugyebang and is a kind of "Chimgusaseo(鍼灸四書)" that was printed in the Huanggyeong Imja year of the Won dynasty(1312). 2. This book was printed as a kind of "Chimgusaseo" and the origins of the editions are as such. The entire text of "Chimgusaseo" originates from the Won edition[元刊本] of "Chimgyeongjinam". 3. This book has all the 12 acupuncture and moxibustion dissertations by Du. 4. Most of the contents of Du's works in this book are collections from older medical books like "Jaoyujuchimgyeong(子午流注鍼經)","Donginsuhyeolchimgudogyeong(銅人腧穴鍼灸圖經)","Yujupalhyeol(流注八穴)","Naegyeong(內經)". 5. Duhangyeong's works on acupuncture and moxibustion were mostly collected by later generations and reflected in books on Du's acupuncture methods. dynasty. 2. "Chimguokryonggyeong" 1) The full title of "Chimguokryonggyeong" is "Pyeonjaksineungchimguokryonggyeong(扁鵲神應鍼灸玉龍經)" and it was edited by Wanggukseo(王國瑞) in the Won dynasty. 2) This book was written before 1290 and there is the '"Munyeongaksagojeonseo(文淵閣四庫全書)" edition' which was pretty much spread around much. 3) The main part of this book is the 'Okryongga(玉龍歌)' and it's annotations. 4) The main contents of this book is a record of the acupuncture techniques of the acupuncture master of the Won dynasty, Duhangyeong.

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An Efficient Scheduling Scheme for Bluetooth Scatternets Based on the Sniff Mode (스니프 모드 기반의 효율적인 블루투스 스캐터넷 스케줄링 기법)

  • Lee, Woo-Sin;Lee, Hyuk-Joon
    • The KIPS Transactions:PartC
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    • v.10C no.2
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    • pp.185-190
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    • 2003
  • Bluetooth communication is based on piconet, which is composed by one master and maximum seven slaves. Several piconets can be interconnected via an inter-piconet Bluetooth unit called a bridge unit to form a Bluetooth scatternet. This bridge node can make its presence in each piconet by switching. This switching must be carefully scheduled so that slot wastage and, hence, packet delays are minimized. In this paper, we introduce an efficient inter-piconet scheduling scheme based on sniff mode. This scheme tries to minimize the wastage of slots by having the bridge unit sniff with its peering masters with time limits and communicate with its slaves in remaining slots. The sniff time limits are determined adaptively based on the amount of traffic in each piconet. Simulation results show this scheme outperforms round-robin scheme based on sniff intervals of equal lengths.

A Study on the Proper Position of Guide Sign for Bikeway in Korea (자전거 도로의 안내표지 설치 위치에 관한 연구)

  • Jeong, Gyu-Su;Lee, Yeong-In
    • Journal of Korean Society of Transportation
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    • v.28 no.6
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    • pp.99-108
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    • 2010
  • Due to the recent emergence of global warming concerns, the UN has made the issue of climate change its top priority. Accordingly, Korea has announced a new national master plan titled, 'Participation in global efforts in climate change through -Low Carbon, Green Growth-'. As part of the plan, the constructions of bicycle path networks are being pushed forward. Although the building of bicycle paths and infrastructure is being implemented, little consideration has been given for bicycle path signage. This essay is the study of methodology in the installation of signs on bicycle paths. The research includes a theoretical study of the standard and installation position of signs with consideration of the geometry of bicycles as well issues such as the distance required for the bicyclist to recognize and understand the road sign and to take actions like stopping, In addition, experimental verification of the test results has been carried out. Also, the test on height of signs by changing the installation heights according to a bicyclist's forward vision angle has been conducted.

A Study on the Deconstructive Characteristics of Interior Spaces of Ron Arad (론 아라드의 실내공간에 나타난 해체주의적 특성에 관한 연구)

  • Lee, Jin-Young
    • Korean Institute of Interior Design Journal
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    • v.15 no.5 s.58
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    • pp.95-103
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    • 2006
  • Ron Arad, the master of contemporary design in the U.K., is one of representative leaders of this age who has left distinguished achievements in the history of contemporary design through innovative design. Analyzing and understanding the Deconstructive design concept and the deconstructive characteristics of interior space of Ron Arad will contribute to finding directions for today's design and laying the ground for explaining the development pattern of design in the 21st century. After analyzing the deconstructive characteristics of each selected space, One Off and Ron Arad Associates have shown a deconstructive design trend of a creative formula by using methods that shed conventional processes and material while a space composition and form of new concept was attempted in the resting space of the New Tel Aviv Opera House, offering not only the establishment of a new circulation system, but also diverse experiences of space to visitors. Likewise, a temporal experience and communication between the user and the space was attempted in Belgo Noord and Belgo Central by partially applying a narrative space composition that sheds existing design concepts. At the Millennium House, they have produced an interior space for future house developed by breaking off from existing typical design development work and material through computer operation, and made various forms of space and atmosphere possible by attempting variable elements and the use of ultramodern material. Y's fashion shop has granted variability to the form and volume of space according to time by presenting display elements that have shed existing form and function. Hotel Puerta America as well, with a curved structure that has broken off with existing forms and maximized space variability through structures that have utilized ultramodern materials and instruments. Through this study, it has been verified that Ron Arad has been unraveling connections between interior space and its user, its requirements, and the original unique principles of space by applying deconstructive design concepts, and that through the mediation of these spaces, he is attempting indirect communication with the user. Eventually, he is taking part in the harmony and development of all elements of space connected with human beings by applying deconstructive design concepts.

Large Scale Entertainment System based on Gesture Recognition for Learning Chinese Character Contents (제스처 인식 대형 놀이 시스템 기반 한자 학습 콘텐츠)

  • Song, Dae-Hyeon;Park, Jae-Wan;Lee, Chil-Woo
    • The Journal of the Korea Contents Association
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    • v.10 no.9
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    • pp.1-8
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    • 2010
  • In this paper, we propose a large scale entertainment system based on gesture recognition for learning Chinese character contents. The system is consisted of parts that forecast user's posture in two infrared images and part that recognize gestures from continuous poses. And we can divide and acquire in front side pose and side pose about one pose in each IR camera. This entertainment system is immersive in nature and convenient for its gestures based controlling system. Also, it can maximize information transmission because induce immersion and interest using two large size displays and various multimedia elements. The learning Chinese character contents can master Chinese character naturally because give interest to user and supply game and education at the same time. Therefore, it can expect synergy effect that can learn playing to user combining with large entertainment system based on gesture recognition.

Analyis of stormwater and runoff characteristics in Anseongcun basin using HEC-HMS (HEC-HMS을 이용한 안성천 유역의 강우 유출 특성 분석)

  • Hwang, Byung-Gi;Yang, Seung-Bin
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.19 no.4
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    • pp.17-24
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    • 2018
  • The HEC-HMS model was applied to identify the rainfall-runoff processes for the Anseongchun basin, where the lower part of the stream has been damaged severely by tropical storms in the past. Modeling processes include incorporating with the SCS-CN model for loss, Clark's UH model for transformation, exponential recession model for baseflow, and Muskingum model for channel routing. The parameters were calibrated through an optimization technique using a trial and error method. Sensitivity analysis after calibration was performed to understand the effects of parameters, such as the time of concentration, storage coefficient, and base flow related constants. Two storm water events were simulated by the model and compared with the corresponding observations. Good accuracy in predicting the runoff volume, peak flow, and the time to peak flow was achieved using the selected methods. The results of this study can be used as a useful tool for decision makers to determine a master plan for regional flood control management.

Development of a Communication Protocol for a Digital Traffic Signal Controller (디지털 교통신호제어기 통신체계 개발)

  • Kim, Min-Sung;Ko, Kwang-Yong;Lee, Choul-Ki;Jeong, Jun-Ha;Heo, Nak-Won
    • The Journal of The Korea Institute of Intelligent Transport Systems
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    • v.12 no.3
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    • pp.1-10
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    • 2013
  • Most of the current traffic signal controller use load switches to transmit high voltage power to the signal lamps. The direct transmission of high voltage power may cause a lot of problems like leakages of electric power, obstructions of pedestrian, environmental disfigurements. To overcome these problems, the development of digital type signal controller has been trying in the various methods. Digital communication between a master controller and signal lamps is the most important part to improve control performance in the digital type controller. A communication system for the digital signal controller was developed in this study. The system bases on CAN specification, includes ID structure for most peripheral devices like loops, signal lamps, push buttons, police switches. The operability of this system verified with a software based CAN simulation tool.