• Clinical and Experimental Pediatrics
• /
• 제45권9호
• /
• pp.1097-1105
• /
• 2002

목 적 : 평소 건강한 학동전 아동에서 심전도 집단 검진을 이용한 WPW 증후군의 유병률을 조사하였고 심전도 이상 소견에 따른 WPW 증후군 유형을 분류하고 각 유형에 따른 심실 및 심중격 운동 이상 소견을 심초음파 검사로 관찰하였다. 방 법: 1999년 4월부터 2001년 8월까지 전북지역 4-7세 사이의 유치원생 77,824명을 대상으로 실시한 심전도 집단 검사에서 WPW 증후군으로 진단된 아동을 대상으로 심전도상 이상 소견에 따른 세부 분류와 심초음파 검사상 심벽 운동의 이상 여부를 조사하였다. 결 과: 총 77,824명 중 WPW 증후군으로 진단된 환아는 23명으로 유병률은 2.9/10,000명이었다. 대상 환아의 평균 연령은 5.4세이었고, 남아는 13명 여아는 10명으로 남녀비의 의의있는 차이는 보이지 않았다. 빈맥의 기왕력을 가진 환아는 2명이었으며, 2명의 환아는 남매간으로 가족력 소견을 보였다. Rosenbaum 등에 의한 부전도로 추정 위치에 따른 분류로 A형은 5명(21.8%), B형은 18명(78.2%)이었다. Boineau 등의 분류에 의한 I군 18명(78.2%), IV군은 3명(13.0%), III, V군은 각각 1명(4.3%)이었고, II군은 관찰되지 않았다. Gallagher 등의 분류에 의한 유형 중 1형 4명(17.3%), 2형 12명(52.1%), 3형, 5형, 6형, 10형은 각각 1명(4.3%), 9형은 3명(13.0%), 4형, 7형, 8형은 관찰되지 않았다. 19명의 환아에게 실시한 심초음파 검사에서 5명의 A형 환아 중 4명의 환아에서 좌심실 후벽의 초기 수축기 전방운동 소견을 보였으며, B형 환아 14명 중 12명의 환아에서 심중격의 초기 수축기 후방운동 소견이 관찰되었다. 결 론 : 학동전기 아동에서 WPW 증후군의 유병율은 10,000당 2.9명이었다. 심전도상 부전도로의 위치는 우심실이 우세하여 이전의 보고와 다른 소견을 보였고, 심초음파 검사 소견상 대부분의 무증상 WPW 증후군 환아에서 이상 심실운동 소견이 관찰되었다. WPW 증후군에서 부전도로의 위치를 추정할 수 있는 비침습적 검사 방법으로 심전도 소견 및 심초음파 검사가 이용될 수 있다.

• 대한의용생체공학회:의공학회지
• /
• 제24권5호
• /
• pp.459-464
• /
• 2003

심자도 신호로부터 전류원의 분포를 복원하는 알고리듬을 구성하고 이를 WPW 증후군 환자에 대해 적용하여 임상적 유용성을 검토하였다. 40 채널 superconducting quantum interference device (SQUID) 미분계를 이용하여 심자도를 측정하고 minimum norm estimation (MNE) 알고리듬과 truncated singular value decomposition (SVD)을 적용하여 2 차원 평면에서의 전류원 분포를 구하였으며. 전류원의 분포가 실제 전류원의 정보를 잘 반영하고 있음을 시뮬레이션으로 확인하였다. 또한 좌심방과 좌심실 사이에 부전도로를 가진 WPW 증후군 환자의 심자도를 측정하여 수술 전후의 전류원 분포를 비교한 결과 수술 전에는 부전도로를 통한 비정상전류의 흐름을 볼 수 있었으나 부전도로를 절제한 후에는 더 이상 볼 수 없었다. 이 결과는 심자도 선호로부터 구한 전류원 분포가 심장의 전기 활동을 잘 반영하고 있으며 임상적으로 유용하게 활용 될 수 있음을 보여준다.

• 대한의용생체공학회:학술대회논문집
• /
• 대한의용생체공학회 1991년도 춘계학술대회
• /
• pp.94-97
• /
• 1991

It is well known that multipoint and computerized intraoperative mapping systems improve the results of surgery for Wolff-Parkinson-White syndrome and show tremendous potential for opening an entirely new era of surgical intervention for the more common and lethal types of supraventricular tachyarrhythmias such as atrial flutter and atrial fibrillation. In addition, the ability to map and ablate the sometimes fleeting automatic atrial tachycardia is greatly enhanced by computerized mapping systems. In this study, we have developed 16 channel computerized data analysis system using microcomputer for basic research of electrophysiology and electrical propagation. This system is expected to enable us to study pathophysiology of cardiac arrhythmia and to improve the results of diagnosis and surgical treatment for cardiac arrhythmia.

• Molecules and Cells
• /
• 제25권2호
• /
• pp.149-157
• /
• 2008

Dopamine is a major neurotransmitter in the mammalian central nervous system (CNS) that regulates neuroendocrine functions, locomotor activity, cognition and emotion. The dopamine system has been extensively studied because dysfunction of this system is linked to various pathological conditions including Parkinson's disease, schizophrenia, Tourette's syndrome, and drug addiction. Accordingly, intense efforts to delineate the full complement of signaling pathways mediated by individual receptor subtypes have been pursued. Dopamine D1-like receptors are of particular interest because they are the most abundant dopamine receptors in CNS. Recent work suggests that dopamine signaling could be regulated via dopamine receptor interacting proteins (DRIPs). Unraveling these DRIPs involved in the dopamine system may provide a better understanding of the mechanisms underlying CNS disorders related to dopamine system dysfunction and may help identify novel therapeutic targets.

• 한국독성학회:학술대회논문집
• /
• 한국독성학회 2001년도 International Symposium on Dietary and Medicinal Antimutgens and Anticarcinogens
• /
• pp.164-164
• /
• 2001

Manganese (Mn) intoxication causes a parkinsonian syndrome. It may be difficult to distinguish Mn-induced parkinsonism from idiopathic Parkinson disease (IPD). Neuropathological descriptions on the brains with Mn intoxication showed the preferential damage in the globus pallidus and substantia nigra pars reticularis.(omitted)

• 대한약학회:학술대회논문집
• /
• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
• /
• pp.269.1-269.1
• /
• 2002

MPP$\^$＋/ is known to be a neurotoxic substance that induces the degeneration of dopaminergic neurons and Parkinson-like syndrome. Incubation with MPP$\^$＋/ induced the expression of heme oxygenase-l (HO-1) in PC-12 cells and HO-1 revealed a protective effect against MPP$\^$＋/ -induced cytotoxicity. In this study. we tested the effect of pre-conditioning on the MPP$\^$＋/-induced cytotoxicity. The PC-12 cells were incubated with MPP$\^$＋/ for 3 hrs. and then after 12 hrs the cells were exposed to several concentration of MPP$\^$＋/. (omitted)

• 수면정신생리
• /
• 제30권1호
• /
• pp.3-8
• /
• 2023

Periodic limb movement disorder (PLMD) is a sleep-related movement disorder characterized by involuntary, rhythmic limb movements during sleep. While PLMD itself is not considered life-threatening, its association with certain underlying health conditions raises concerns about mortality risks. PLMD has been found to be associated with cardiovascular diseases such as hypertension and cardiovascular disease. The fragmented sleep caused by the repetitive limb movements and associated arousals may contribute to sympathetic activation, chronic sleep disruption, sleep deprivation, and subsequent cardiovascular problems, which can increase mortality risks. The comorbidities and health factors commonly associated with PLMD, such as obesity, diabetes, and chronic kidney disease, may also contribute to increased mortality risks. PLMD is often observed alongside other neurological disorders, including restless legs syndrome (RLS) and Parkinson's disease. The presence of PLMD in these conditions may exacerbate the underlying health issues and potentially contribute to higher mortality rates. Further research is needed to elucidate the specific mechanisms linking PLMD to mortality risks and to develop targeted interventions that address these risks.

• 대한관절경학회지
• /
• 제4권1호
• /
• pp.49-53
• /
• 2000

목적 :. 만성 견관절 충돌증후군에 대한 수술적 치료로서 사용한 관절경적 전방 견봉 성형술의 치료 결과를 분석하고 임상적 효용성을 평가하고자 하였다. 대상 및 방법 : 1995년 7월부터 1997년 12월까지 만성 견관절 충돌증후군 환자 중 6개월 이상 보존적 치료에도 불구하고 증상이 호전되지 않아 관절경을 이용하여 전방 견봉 성형술을 시행한 26명의 환자, 27례의 견관절들을 대상으로 하였다. 심한 퇴행성 관절염 회전근 개 전층 파열 및 견관절 비출구 충돌증후군 (nonoutlet impingement) 등은 모두 연구 대상에서 제외하였다. 평균 추시 기간은 2년 3개월(범위, 1년 7개월-3년 11개월)이었다. 임상적인 결과 판정은 UCLA 견관절 평가지수를 이용하였다. 결과 : 27례 중 23례$(85.2\%)$에서 매우 우수 또는 우수한 결과를 보였으며, 4례$(14.8\%)$에서 양호의 결과를 나타내었다. 환자의 만족도는 27례 중 26례$(96.3\%)$에서 주관적인 만족을 나타내었고, 1례 $(3.7\%)$에서 불만족을 나타내었으며 이 경우 Parkinson 증후군과 경추 후종인대 골화증 및 제 5-6번 경추의 척추 협착증이 동반된 환자였다. 결론 : 관절경적 전방 견봉 성형술은 특히 술전 동통의 정도가 술후 현저히 개선되는 등 증상 완화에 우수한 결과를 예상할 수 있는 만성 견관절 충돌증후군의 효율적 치료법이지만, 견관절 및 그 주위의 병변이나 전신 질환 등이 동반될 경우 치료 결과에 영향을 미칠 수 있다.

• Journal of Acupuncture Research
• /
• 제27권6호
• /
• pp.11-21
• /
• 2010

Objective : This study was aimed at investigating the therapeutic effects of acupuncture on gastrointestinal side effect of Levodopa on idiopathic Pakinson's disease patients. Methods : The subjects of this study were 42 patients with idiopathic Parkinson's disease. We divided them into two groups; acupuncture treatment group, no treatment group. We treated the former group with acupuncture therapy focusing on gastrointestinal side effect of Levodopa while administering Levodopa as well. And the latter group was also dosed up with Levodopa without acupuncture therapy. To see the effect of acupuncture treatment clearly, we used gastrointestinal syndrome rating scale (GSRS) and visual analog scale (VAS) and compared the GSRS grade and VAS score of two groups statistically, after 1, 2, 3, 4 weeks since they have been under the treatment. Results : This study suggests that the group who has been treated with acupuncture on gastrointestinal side effect of Levodopa on idiopathic pakinson's disease patients showed higher GSRS grade and VAS score than the one that has not. But, We could't find statistical significance between the two groups on improvement of GSRS grade and VAS score. Conclusions : These results proved that acupucture theraphy might be available for re lieving symptoms related with gastrointestinal side effect of Levodopa than the one that has not. But further studies are necessary.

• Journal of Acupuncture Research
• /
• 제27권6호
• /
• pp.115-122
• /
• 2010

Objectives : The purpose of this study was to propose the utilization plan of Ryodoraku in the U-health care systems. Methods : Computerized literature searches were performed for Ryodoraku related articles using the following databases: KISS, RISS, DBPIA, NDSL from 1990 to Oct 2010. Search terms were '양도락' or 'Ryodoraku' or 'U-health'. Due to Ryodoraku coming from Japan, additional literature review(articles published by 2008) on Japanese journal of Ryodoraku medicine was done for compensation. Results : 1. Introduction of U-health : As rapid progress of population aging and strong interest in health, the demand for the traditional Korean medical service is increasing. Until now healthcare service has provided post treatment by face-to-face manner. But according to related researches, proactive treatment is resulted to be more effective for preventing diseases. Particularly, the existing healthcare services have limitations in preventing and managing chronic geriatric degenrative diseases such as metabolic syndrome, CVA, coronary heart diseases, parkinson's diseases, degenerative joint disease, spondylosis, etc., because the cause of the above is complex and even related to life habit. As the advent of ubiquitous technology, patients with the chronic geriatric degenrative diseases can improve life habit such as poor eating habits and physical inactivity without the constraints of time and space through u-healthcare service. Therefor, lots of researches for u-healthcare service focus on providing the personalized healthcare service for preventing and managing that. To cope with this situations, The concept of u-healthcare service should be adopted in the traditional korean medicine and diagnostic devices suitable for it should be also devised and developed based on traditonal korean medine. 2. Review of existing Ryodoraku related articles for applying to U-health : articles investigating feasibility applying Ryodoraku to meridian diagnosis and raising problems of it, articles providing recent research trends of Ryodoraku, Ryodoraku related articles considering usefulness for U-health, and articles confirming the repeatability and reproducity of Ryodoraku were included. Based on the review of the above Ryodoraku related articles, several application of Ryodoraku in the U-health care system. Conclusions : To make preparations for the increasing need of traditional Korean medicine due to rising morbidity rate of chronic geriatric degenerative diseases, it is necessary to appropriately apply Ryodoraku to the U-health care system. The application of Ryodoraku is as follows. 1. To use Ryodoraku additionally to the established diagnostic device of metabolic syndrome, CVA, coronary heart diseases, parkinson's diseases, degenerative joint disease, spondylosis. 2. To apply Ryodoraku to the symptoms or diseases having a tendency to be diagnosed by correlation between the affected meridian and the lesion such as headache, nuchal pain, shoulder pain, low back pain, sciatica, HNP, etc. 3. To secure the repeatability and reproducity of Ryodoraku. 4. To devise and develop Ryodoraku appliance in order to overcome the known drawbacks and to improve error of measurement.