• 제목/요약/키워드: Park Jin-young

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Design. Synthesis and Biological Activities of Novel Vanilloid Receptor (VR) Agonists and Antagonists

  • Suh, Young-Ger;Lee, Bo-Young;Kim, Jin-Kwan;Min, Kyung-Hoon;Park, Ok-Hui;Lee, Young-Sil;Oh, Uh-Taek;Park, Young-Ho;Joo, Yung-Hyup;Choi, Jin-Kyu;Jeong, Yeon-Su;Koh, Hyun-Ju
    • 대한약학회:학술대회논문집
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    • 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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    • pp.355.1-355.1
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    • 2002
  • Recently. we have reported that several lipoxygenases products directly activate the capsaicin-activated channel as intracellular messengers in neuron. In particular, 12-(S)-hydroperoxyeicosatetraenoic acid turned out to be the most potent endogenous VR activator. This finding prompted us to search for a novel non-vaniloid VR agonists and antagonists. We have designed and synthesized a series of non-vanilloid VR binding ligands based on the structural simllarity between 12-HPETE and capsaicin, the natural VR agonist. Our recent studies on the development of selective vanilloid receptor agonists and antagonists will be presented.

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