• Childhood Kidney Diseases
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• v.6 no.2
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• pp.155-168
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• 2002

Purpose; Systemic lupus erythematosus(SLE) is an autoimmune disease with multi-system involvement and renal damage is a major cause of morbidity and mortality in children. Renal involvement is more common and severe in children than in adults. Therefore, renal biopsy plays a crucial role in planning effective therapy. In this study, we investigated the clinical and pathological findings of lupus nephritis in children to aid clinical care of the disease. Methods: The clinical and pathological data of 40 patients who were diagnosed as SLE with renal involvement in Shinchon Severance Hospital from Jan. 1990 to Sep. 2002 were analyzed retrospectively. Results: The ratio of male to female patients was 1:3 and the median age at diagnosis was 12.1(2-18) years old. FANA(95.0%), anti-ds DNA antibody(87.5%), malar rash(80.0%) were the most common findings among the classification criteria by ARA. Microscopic hematuria with proteinuria(75.0%), nephrotic syndrome(55.0%), and microscopic hematuria alone(15.0%) were the most common renal presentations in the respective order at diagnosis. There were 27 cases with WHO class IV lupus nephritis confirmed by renal biopsy and 3 cases with pathological changes of WHO class type. Different treatment modalities were carried out : prednisolone only in 5 cases, prednisol-one+azat-hioprine in 9 cases, prednisolone+azathioprine+intravenous cyclophosphamide in 14 cases, prednisolone+cyclosporine A+intravenous cyclophosphamide in 12 cases, plasma exchange in 9 cases and intravenous gamma-globulin in 2 cases. The average follow-up period was $51.8{\pm}40.5$ months. During $51.8{\pm}40.5$ months. During follow-up, 4 patients expired. The risk factors associated with mortality were male, WHO class IV and acute renal failure at diagnosis. Conclusion: Renal involvement was noted in 63.5% of childhood SLE, and 67.5% of renal lesion was WHO class IV lupus nephritis which is known to be associated with a poor prognosis. Therefore aggressive treatment employing immunosuppressant during the early stages of disease could be helpful in improving long-term prognosis. But careful attention should be given to optimize the treatment due to unique problems associated with growth, psychosocial development and gonadal toxicity, especially in children.

• Childhood Kidney Diseases
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• v.3 no.1
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• pp.80-87
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• 1999

Purposes : Renal involvement is a potentially serious complication of systemic lupus erythematosus (SLE). There have been only few studies of lupus nephritis in pediatric age. In this study, the clinical manifestations, pathologic findings, response to treatment, and clinical course of lupus nephritis in children were analyzed. And the results will provide basic data for future nation-wide prospective multi-center study. Methods . The medical records of 46 children clinically and pathologically diagnosed to have lupus nephritis at Seoul National University Children's Hospital during 1986 to 1997 were analyzed retrospectively. Results : 1) The median age of diagnosis of lupus nephritis was 12.8 years ($2\;years\~\;15year$ 8months), and the sex ratio was 1:2.5. 2) FANA($85.7\%$), anti-ds-DNA antibody ($78.0\%$), and malar rash ($60.8\%$) were the most common findings among the classification criteria by ARA Decreased C3 was detected in $88.9\%$ of patients. 3) Hematuria ($87.0\%$) was the most common renal symptom, and WHO class IV lupus nephritis was identified in 41 cases by renal biopsy. 4) In most of patients, the disease activity was controlled relatively well with a single or combined therapy of prednisolone, azathioprine, or cyclophosphamide. The response revealed no difference according to the mode of treatment. 5) Infection, especially of Varicella-Zoster virus and candida, was the most common complication during the disease course. Conclusion : The renal involvement was noted in $87.0\%$ of childhood SLE, and $89.1\%$ of renal lesions was WHO class IV lupus nephritis known to associated with poor long-term prognosis. So, aggressive treatment using immunosuppressants in the early disease course may be helpful to increase long-term prognosis of lupus nephritis. A prospective multi-center study is necessary to analyze the therapeutic efficacy of various treatment modalities.

• Neonatal Medicine
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• v.18 no.1
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• pp.96-103
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• 2011

Purpose: Although infants with bronchopulmonary dysplasia (BPD) are at risk of developing secondary pulmonary hypertension (PH), which is associated with significant morbidity and mortality, little has been reported about the incidence, clinical course and prognosis of PH secondary to BPD in premature infants. This study was done to investigate the incidence, risk factors, clinical course, and the ultimate prognosis of PH developed secondary to BPD in very low birth weight infants (<1,500 g). Methods: Medical records of very low birth weight infant (VLBWI) admitted to Samsung Medical Center NICU from January 2000 to July 2007 were reviewed retrospectively. BPD was defined by Jobe's classification. The diagnosis of pulmonary hypertension was established as velocity of tricuspid valve regurgitation (TR) ${\geq}$3 m/s and a flattening of the intraventricular septum by conducting Doppler echocardiography. Results: The incidence of pulmonary hypertension was 6% in VLBWI with BPD and it developed in moderate to severe BPD. The diagnosis of pulmonary hypertension was made on postnatal 133 days (range 40-224 days) and the risk factors related to developing pulmonary hypertension were severe BPD, small for gestational age and outborn infants. The mortality rate was 57% and especially higher in severe BPD (70%). The time to recovery spent 3 months (range 1-10 months) in survived patients. Conclusion: Based on the results of this research, pulmonary hypertension secondary to BPD in VLBWI related to severity of BPD and had a poor prognosis. We expect that regular long-term echocardiography may be helpful in treating reversible in VLBWI with moderate to severe BPD.

• Nuclear Medicine and Molecular Imaging
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• v.40 no.6
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• pp.309-315
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• 2006

Purpose: Accurate evaluation of cervical lymph node (LN) metastasis of head and neck squamous cell canter (SCC) is important to treatment planning. We evaluated the diagnostic accuracy of F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for the detection of cervical LN metastasis of head and neck SCC and performed a retrospective comparison with CT/MRI findings. Materials & Methods: Seventeen patients with pathologically proven head and neck SCC underwent F-18 FDG PET/CT and CT/MRI within 4 week before surgery. We recorded lymph node metastases according to the neck level system of imaging-based nodal classification. F-18 FDG PET/CT images were analyzed visually for assessment of regional tracer uptake in LN. We analyzed the differences in sensitivity and specificity between F-18 FDG PET/CT and CT/MRI using the Chi-square test. Results: Among the 17 patients, a total of 123 LN levels were dissected, 29 of which showed metastatic involvement. The sensitivity and specificity of F-18 FDG PET/CT for detecting cervical LN metastasis on a level-by-level basis were 69% (20/29) and 99% (93/94). The sensitivity and specificity of CT/MRI were 62% (18/29) and 96% (90/94). There was no significant difference in diagnostic accuracy between F-18 FDG PET/CT and CT/MRI. Interestingly, F-18 FDG PET/CT detected double primary tumor (hepatocellular carcinoma) and rib metastasis, respectively. Conclusion: There was not statistically significant difference of diagnostic accuracy between F-18 FDG PET/CT and CT/MRI for the detection of cervical LN metastasis of head and neck SCC. The low sensitivity of F-18 FDG PET/CT was due to limited resolution for small metastatic deposits.

• Journal of Oral Medicine and Pain
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• v.35 no.2
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• pp.123-133
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• 2010

The purpose of this study is to investigate Tension-type headache associated with pericranial tenderness and Headache attributed to temporomandibular joint disorder among Characteristic pain index, Disability points, Chronic pain grade, Depression index, Nonspecific physical symptoms (pain items included), Nonspecific physical symptoms (pain items excluded), Jaw disability score using RDC/TMD Axis II. Eighty five patients who visited the Kyung Hee University Dental Hospital were diagnosed as Tension-type headache associated with pericranial tenderness(n=48) and Headache attributed to temporomandibular joint disorder(n=37) by the International Classification of Headache Disorders, 2nd Edition, and were administered the Korean versions of the RDC/TMD Axis II- Characteristic pain index, Disability points, Chronic pain grade, Depression index, Nonspecific physical symptoms (pain items included), Nonspecific physical symptoms (pain items excluded), Jaw disability score. Then it was analyzed statistically by SPSS(ver. 10.0). T-test, The Wilcoxon-signed rank test and Mann-Whitney U test (p<0.05) were used. There were no significant differences in Characteristic pain index, Disability points, Chronic pain grade, Depression index, Nonspecific physical symptoms (pain items included), Nonspecific physical symptoms (pain items excluded), Jaw disability score between two groups. Tension type headache associated with pericranial tenderness and Headache attributed to temporomandibular joint disorder showed similar Axis II feature. Tension-type headache associated with pericranial tenderness may be related to Headache attributed to temporomandibular joint disorder.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.10 no.6
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• pp.15-26
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• 2015

The purpose of this study was to examine the area, theme and method of domestic articles on the successful establishment of venture companies, which were presented between 1998 and 2014, according to related basic classification criteria in an effort to shed light on the characteristics of these studies. It's basically meant to make a contribution to the development of research on the success of venture business and to be of practical use for the success of venture companies in our country. After related earlier studies were analyzed, 164 articles were collected, and 64 articles were selected from among them. The articles that were overlapped, not presented or not registered were excluded. The related studies had been conducted by different learned societies that were interested in the same research themes, and the studies were primarily led by the Korean Society of Business Venturing as of 2014, especially by Asia-Pacific Journal of Business Venturing and Entrepreneurship that was a journal published by this society. This society seemed to have taken the initiative in this field. There was a tendency that the related studies increased in number due to the shifts of modern industrial society and the changing policies of the government, as the number of the studies has been on the steady rise since 2012. In terms of method, quantitative research methods, especially descriptive studies, were prevailing. To step up the development of research into this field, a wide variety of research methods should be utilized in the future. As for the sphere of research, the characteristics of founders, strategic characteristics and environmental characteristics were mainly covered as the success factors of venture business. More diverse variables should be explored as well to make more advanced, extended research in the years to come. The findings of the study are expected to provide both theoretical and practical information on the establishment and success of venture business to make a contribution to the development of research.

• Environmental and Resource Economics Review
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• v.14 no.1
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• pp.167-199
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• 2005

The following policy implications can be drawn from this study: 1) The Air Pollution Emission Amount Report published by the Ministry of Environment since 1991 classifies industries into 4 sectors, i. e., heating, manufacturing, transportation and power generation. Currently, the usability of report is very low and extra efforts should be given to refine the current statistics and to improve the industrial classification. 2) Big pollution industries are as follows - s7, s17 and s20. The current air pollution control policy for these sectors compared to other sectors are found to be inefficient. This finding should be noted in the implementation of future air pollution policy. 3) s10 and s17 are found to be a big polluting industrial sector and its pollution reduction effect is also significant. 4) The effect of emission coefficient (${\Delta}f$) has the biggest impact on the reduction of emission amount change and the effect of economic growth coefficient (${\Delta}y$) has the biggest impact on the increase of emission volume. The effect of production technology factor (${\Delta}D$) and the effect of the change of the final demand structure (${\Delta}u$) are insignificant in terms of the change of emission volume. 5) Further studies on emission estimation techniques on each industry sector and the economic analysis are required to promote effective enforcement of the total volume control system of air pollutants, the differential management of pollution causing industrial sectors and the integration of environment and economy. 6) Korea's economic growth in 1990 is not pollution-driven in terms of the Barry Commoner's hypothesis, even though the overall industrial structure and the demand structure are not environmentally friendly. It indicates that environmental policies for the improvement of air quality depend mainly on the government initiatives and systematic national level consideration of industrial structures and the development of green technologies are not fully incorporated.

• The Korean Journal of Pesticide Science
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• v.16 no.4
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• pp.328-335
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• 2012

In order to use in the classification of minor crop for the mutual application of safe use guideline, it was investigated the residue property of fungicide dimethomorph and pyraclostrobin in green onion, a stem-crop. After pesticides were applied 2 times with 1 week interval in that day of harvest, 3 days, 7 days, 10 days and 14 days before harvest, a green onion was harvested. The residue of dimethomorph in a green onion was 26.31 and 39.08 mg/kg in that day of harvest, however, in according to elapse time, it was reduced to 6.86 and 9.34 mg/kg in 14 days before harvest. In case of pyraclostrobin, it was also reduced from 13.46 and 39.08 mg/kg to 3.57 and 5.21 mg/kg. Based on the residue in that day of harvest, the deposit of spray solution in a green onion was calculated. The deposit of spray solution of dimethomorph was 274.35~345.84 mL/kg, in case of pyraclostrobin, it was calculated 213.65~343.33 mL/kg. When the amount of the deposit of both pesticides was compared in a green onion, it was so similar. On the other hand, it was estimated the predicted dissipation curve of pesticides in the green onion during cultivation. The half-life of dimethomorph was 6.95~7.45 days, in case of pyraclostrobin, 7.15~7.45 days. When both pesticides were compared with the residue property, the deposit of spray solution and half-life of dissipation were so similar.

• The Korean Journal of Pesticide Science
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• v.16 no.2
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• pp.98-108
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• 2012

In order to use in the classification of minor crop for the mutual application of safe use guideline, it was investigated the residue property of fungicide boscalid and fludioxonil at the same time harvest leafy-vegetables, such as spinach, ulgaribaechu, vitaminchae and cheongkyungchae. After pesticides were applied 2 times with 1 week interval in that day of harvest, 2 days, 5 days and 7 days before harvest, vegetables were harvested, and the residue of pesticides was investigated. Base on the residue in that day of harvest, the deposit of spray solution in vegetables was calculated. The deposit of spray solution of boscalid was 253.9 mL/kg in spinach, 83.0 mL/kg in ulgaribaechu, 97.8 mL/kg in vitaminchae, and 88.3 mL/kg in cheongkyungchae, respectively. In case of fludioxonil, it was calculated 157.6 mL/kg in spinach, 67.6 mL/kg in ulgaribaechu, 64.8 mL/kg in vitaminchae, and 66.6 mL/kg in cheongkyungchae, respectively. When the amount of the deposit of both pesticides was compared in leafy-vegetables, it was the highest in the spinach. On the other hand, it was estimated the predicted dissipation curve of pesticides in leafy-vegetables during cultivation. The half-life of boscalid was 5.9 days in spinach, 7.4 days in ulgaribaechu, 4.6 days in vitaminchae, and 4.3 days in cheongkyungchae, respectively. Also, it was estimated half-life in fludioxonil, it was 3.0 days in spinach, 4.0 days in ulgaribaechu, 3.2 days in vitaminchae, and 3.5 days in cheongkyungchae, respectively. The half-life was the longest in the ulgaribaechu. When both pesticides were compared with the residue property, the deposit of spray solution and half-life of dissipation of boscalid were more than those of fludioxonil.

• The Korean Journal of Pesticide Science
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• v.16 no.4
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• pp.294-301
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• 2012

In order to use in the classification of minor crop for the mutual application of safe use guideline, it was compared a green onion with a scallion on the residue property of insecticide bifenthrin and chlorfenapyr. After pesticides were applied 2 times with 1 week interval in that day of harvest, 3 days, 7 days, 10 days and 14 days before harvest, vegetables were harvested, and the residue of pesticides was investigated. Base on the residue in that day of harvest, the deposit of spray solution in vegetables was calculated. The deposit of spray solution of bifenthrin was 123.0 mL/kg in a green onion, and 74 mL/kg in a scallion. In case of chlorfenapyr, it was calculated 126.5 mL/kg in a green onion, and 70.0 mL/kg in a scallion. When the amount of the deposit of both pesticides was compared a green onion with a scallion, it was higher in a green onion. On the other hand, it was estimated the predicted dissipation curve of pesticides in a green onion and a scallion during cultivation. The dissipation curve of bifenthrin was y = 1.0334 $e^{-0.0602x}$ ($R^2$= 0.8606) in a green onion, and y = 0.7693 $e^{-0.1823x}$ ($R^2$= 0.9756) in a scallion. In case of chlorfenapyr, it was y = 2.2603 $e^{-0.0519x}$ ($R^2$= 0.9043) in a green onion, and y = 1.2940 $e^{-0.1051x}$ ($R^2$ = 0.9782) in a scallion. The half-life of bifenthrin was 11.51 days in a green onion, and 3.80 days in a scallion, respectively. Also, it was estimated half-life in chlorfenapyr, it was 13.35 days in a green onion, and 6.59 days in a scallion, respectively. The half-life of both pesticides in a green onion was longer than in a scallion. When both vegetables were compared with the residue property, the deposit of spray solution and half-life of dissipation in a green onion were more than those in a scallion.