• Progress in Medical Physics
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• v.15 no.1
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• pp.45-53
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• 2004

SPM has been widely applied for comparison studios of the functional image data among groups of patients or individuals under different conditions and these images are from people ranging from children to adults. However, the analysis of children's brain images by using SPM can make children's brain images normalized to an adult's template image and this can result in some errors. So this study created the children's mean MR images based on the Magnetic Resonance Images of 36 normal children (age: 2～6, average age: 4.36, SD age: 1.41, M/F: 17/19), and the children's mean SPECT images by using SPECT images of 13 normal children (age: 2～6, average age: 4.80, SD age: 1.17, M/F: 10/3). We created the Korean children's brain template image, based on those mean images, and then we compared between the positions of the clusters, based on the blood flow, by normalizing ADHD children's SPECT image to Korean children's template image and SPM adult's template image. As a result of the analysis, the variation of the cluster positions was found to be a maximum of 25 ㎜. Therefore, we should be aware that we need to consider the template image and the p-value when we analyze the chlidren's brain image by using SPM.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.12
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• pp.6391-6395
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• 2012

Background: Ovarian cancer is ranked as the fifth most common cause of cancer death in women. In Malaysia, it is the fourth most common cancer in females. CA125 has been the tumor marker of choice in ovarian cancer but its diagnostic specificity in early stages is only 50%. Hence, there is a critical need to identify an alternative tumor marker that is capable of detecting detect ovarian cancer at an early stage. HE4 is a new tumor marker proposed for the early diagnosis of ovarian cancer and disease recurrence. Currently, none of the normal ranges of HE4 quoted in the literature are based on data for a multiethnic Asian population. Therefore, the aim of this study was to determine reference intervals for HE4 in an Asian population presenting in University Malaya Medical Centre, a tertiary reference hospital. Materials and Methods: 300 healthy women were recruited comprising 150 premenopausal and 150 postmenopausal women, aged from 20-76 years. All women were subjected to a pelvic ultrasonograph and were confirmed to be free from ovarian pathology on recruitment. Serum HE4 levels were determined by chemiluminescent microparticle immunoassay (CMIA, Abbott Architect). The reference intervals were determined following CLSI guidelines (C28-A2) using a non-parametric method. Results: The upper limits of the $95^{th}$ percentile reference interval (90%CI) for all the women collectively were 64.6 pmol/L, and 58.4 pmol/L for premenopausal) and 69.0 pmol/L for postmenopausal. The concentration of HE4 was noted to increase with age especially in women who were more than 50 years old. We also noted that our proposed reference limit was lower compared to the level given by manufacturer Abbott Architect HE4 kit insert (58.4 vs 70 pmol/L for premenopausal group and 69.0 vs 140 pmol/L in the postmenopausal group). The study also showed a significant difference in HE4 concentrations between ethnic groups (Malays and Indians). The levels of HE4 in Indians appeared higher than in Malays (p<0.05), while no significant differences were noted between the Malays and Chinese ethnic groups. Conclusions: More data are needed to establish a reference interval that will better represent the multiethnic Malaysian population. Probably a larger sampling size of equal representation of the Malay, Chinese, Indians as well as the other native ethnic communities will give us a greater confidence on whether genetics plays a role in reference interval determination.

• Korean Journal of Social Welfare
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• v.37
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• pp.1-31
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• 1999

In Korea, little is known about unemployment duration and exit rate from unemployment. This paper empirically examines the duration of unemployment using data for the years 1996 and 1997 on unemployed individuals who are eligible for unemployment insurance benefits in Korea. A parametric survival model (log-normal model) is adopted to identify factors predicting transitions to reemployment. Factors that affect unemployment duration are sex, age, employment duration (year), prior salary, region, prior employment industry, cause of unemployment, officially determined unemployment benefit duration, degree of benefit exhaustion, and amount of benefits for early reemployment. However, education is not statistically significant In degree of benefit exhaustion, the exit rate from unemployment decreases as benefit exhaustion is approached. In amount of benefits for early reemployment, the exit rate from unemployment increases as amount of benefits increases. Hazards for reemployment gradually increase until 80 days after unemployment and gradually decrease in the following period. Thus, we find that distribution of hazards for reemployment has log-normal shapes between inverted U and inverted L This paper takes advantage of a unique analysis about unemployment duration and exit rate from unemployment in the Korean Unemployment Insurance system which functions as the most valuable social safely-net mechanism in the recent national economic crisis. Indeed, this paper provides a basic knowledge about realities of unemployed individuals in the Unemployment Insurance system and identifies research areas that require further study.

• Journal of the Korea Concrete Institute
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• v.29 no.2
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• pp.189-200
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• 2017

Nonplanar structural walls with C-shaped and H-shaped sections have been used as an efficient lateral force-resisting system for building structures. Since the nonplanar walls are subjected to axial load and bending moments about two orthogonal axes, complicated section analysis is required for flexure-compression design. In the present study, a straightforward design method for biaxially loaded C- and H-shaped walls was proposed by modifying the existing load contour method for columns with symmetric solid sections. For this, a strain compatibility section analysis program that can calculate biaxial moment strengths of arbitrary wall section was developed and its validity was verified by comparing with existing test results. Then, through parametric study, the interaction of biaxial moments at constant axial loads in prototype C- and H-shaped walls was investigated. The results showed that, due to unsymmetrical geometry of the wall sections, the biaxial interaction was significantly affected by the moment directions and axial loads. From those investigations, non-dimensional contour equations of the biaxial moments at constant axial loads for C- and H-shaped walls were suggested. Further, design examples using the proposed contour equations were given for engineering practice.

• Journal of the Korean GEO-environmental Society
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• v.17 no.7
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• pp.15-25
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• 2016

In the present work, a number of advanced three-dimensional (3D) parametric finite element numerical analyses have been conducted to study the behaviour of single piles and pile groups in consolidating ground from coupled consolidation analyses. Single piles, $4{\times}4$ and $6{\times}6$ piles inside groups with a spacing of 2.5D were considered, where D is the pile diameter. It has been found that dragload and downdrag on the piles developed rather quickly at the early stage of consolidation. However, when the degree of consolidation was more than 50~75%, only little increases of dragload and downdrag were induced on the pile. Negative Skin Friction (NSF) on the pile in the fill layer was mobilised quickly and remained constant throughout further consolidation. The development of NSF is influenced both by the relative shear displacements at the pile-soil interface and the vertical effective soil stresses during consolidation. The former governed the early stage of consolidation and the latter affected the later stage of consolidation. The vertical effective soil stresses adjacent to the piles were reduced due to the shear stress transfer at the pile-soil interface, in particular for piles inside the pile groups. The range of NSF influence zone concerning the reductions of the effective vertical soil stresses was about 20D measured from the piles in the horizontal direction. On the contrary, the effective horizontal soil stresses acting on the piles were similar to those at the far field.

• Journal of the Korean Geographical Society
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• v.39 no.5 s.104
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• pp.786-803
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• 2004

These days, interests on land cover classification using not only multi-sensor data but also thematic GIS information, are increasing. Often, although we have useful GIS information for the classification, the traditional classification method like maximum likelihood estimation technique (MLE) does not allow us to use the information due to the fact that the MLE and the existing computer programs cannot handle GIS data properly. We proposed a new method for updating the image classification using multi-spectral and multi-temporal images. In this study, we have simultaneously extended the MLE to accommodate both multi-spectral images data and land cover data for land cover classification. In addition to the extended MLE method, we also have extended the empirical likelihood ratio estimation technique (LRE), which is one of non-parametric techniques, to handle simultaneously both multi-spectral images data and land cover data. The proposed procedures were evaluated using land cover map based on Landsat ETM+ images in the Anmyeon-do area in South Korea. As a result, the proposed methods showed considerable improvements in classification accuracy when compared with other single-spectral data. Improved classification images showed that the overall accuracy indicated an improvement in classification accuracy of $6.2\%$ when using MLE, and $9.2\%$ for the LRE, respectively. The case study also showed that the proposed methods enable the extraction of the area with land cover change. In conclusion, land cover classification produced through the combination of various GIS spatial data and multi-spectral images will be useful to involve complementary data to make more accurate decisions.

• Journal of the Korean School Mathematics Society
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• v.17 no.3
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• pp.359-384
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• 2014

The purpose of this study is inquire the reaction and adaptability of the mathematically gifted student, in the case of introduce learning materials based on GeoGebra in real class. The study program using GeoGebra consist of 'construction of fundamental figures', 'making animation with using slider tools' (graph of a function, trace of a figure, definite integral, fixed point, and draw a parametric curve), make up the group report after class. In detail, 1st to 15th classes are mainly problem-solving, and topic-exploring classes. To analyze the application effects of developed learning materials, divide students in four groups and lead them to make out their own creative products. In detail, guide students to make out their own report about mathematical themes that based on given learning materials. Concretely, build up the program to make up group report about their own topics in six weeks, after learning on various topics. Expert panel concluded that developed learning materials are successfully stimulate student's creativity in various way, after analyze of the student's activities. Moreover, those learning programs also contributed to the develop of the mathematical ability to thinking that necessary to writing a report. As well, four creative products are assessed as connote mathematically gifted student's creative thinking and meaningful elements in mathematical aspects.

• Journal of the Korea institute for structural maintenance and inspection
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• v.16 no.6
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• pp.63-72
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• 2012

The high-flowing concrete requires additionally or excessively more expensive admixture than conventional concrete. So, the concrete has not to be widely used in practical field due to the increase of production price, need of additional facilities, and excessive development of concrete strength in associate with addition of too much cementitious material even though it has more significant advantages than conventional concrete. Thus, this study aims at developing high-flowing concrete with general strength unlike high strength which has been carried out in conventional study. To observe the role of aggregate in the concrete quantitatively and to increase the performance of high-flowing concrete effectively, parametric studies were carried out such as W/C, s/a, fineness modulus of aggregate, contribution degree of particle sizes, and the effect of 13mm aggregate and fine stone powder as a partial replacement of aggregates. And the effect of these factors on performance of the concrete was evaluated by measuring slump-flow and gap of penetration height in U-typed instrument. As a result, it was found that flowability of high-flowing concrete depends upon grading of fine aggregate more significantly than that of coarse aggregate and is enhanced greatly as fineness modulus of fine aggregate decreases and the value of s/a increases. In addition, the application of 13mm aggregate and fine stone powder are expected as a partial replacement of aggregate in order to increase the performance of high-flowing concrete more effectively.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.31 no.6C
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• pp.203-212
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• 2011

This paper investigates the caharactheristics of the earth pressure magnigue and distribution in jointed rockmass for a safe and economic design and construction of earth retaining structures installed in rock stratum. For this purpose, this study will first investigate the limitations and problems of the existing earth pressure studies and then to overcome them th study will conduct the discontinuum numerical parametric studies based on the Discrete Element Method (DEM), which can consider the joint characteristics in rock stratum. The controlled parameters include rock type and joint conditions (joint shear strength and joint angle), and the magnitude and distribution characteristics of earth pressure have been investigated considering the interactions between the ground and the retaining structures. In addition, the comparison between the earth pressures induced in rock stratum and Peck's earth pressure for soil ground has been carried out. From the comparison, it is found that the earth pressure magnitude and distribution in jointed rockmass has been highly affected by rock type and joint condition and has shown different characteristics compared with the Peck's empirical earth pressure. This result would hereafter be utilized as an important information and a useful data for the assessment of earth pressure for designing a retaining structures installed in jointed rockmass.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.31 no.3
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• pp.23-30
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• 2003

In this study, the various load cases by specified by the IEC61400-1 international specification and GL Regulations for the wind energy conversion system were considered, and a specific composite structure configuration which can effectively endure various loads was proposed. In order to evaluate the structure, the structural analysis for the composite wind turbine blade was performed using the finite element method(FEM). In the structural design, the acceptable configuration of blade structure was determined through the parametric studies, and the most dominant design parameters were confirmed. In the stress analysis using the FEM, it was confirmed that the blade structure was safe and stable for all the considerd load cases. Moreover the safety of the blade root joint with insert bolts, newly devised in this study, was checked against the design loads and also the fatigue loads. The fatigue life for operating more than 20 years was estimated by using the well-known S-N linear damage rule, the load spectrum and Spera's empirical equations. The full-scale static test was performed under the simulated aerodynamic loads. from the experimental results, it was found that the designed blade had the structural integrity. Furthermore the measured results were agreed with the analytical results such as deflections, strains, the mass and the radial center of gravity. The studied blade was successfully certified by an international institute, GL, of Germany.