• Title/Summary/Keyword: Parametric Study

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Safety of Bojungikgi-tang Soft Extract after Single Oral Administration in Healthy Male Volunteers, Single Center Study (보중익기탕연조엑스의 1회 경구투여 후 안전성 평가에 관한 단일기관 연구)

  • An, Sung-Hu;Jeong, Yeong-jin;Kim, Jong-gyu;Shin, Hyeryung;Kwon, Young-Dal
    • Journal of Korean Medicine Rehabilitation
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    • v.31 no.4
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    • pp.157-166
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    • 2021
  • Objectives This study is designed to evaluate the safety of Bojungikgi-tang soft extract in healthy male volunteers. Methods 12 healthy male volunteers were recruited and this study was carried out by a single center. Laboratory test results, vital signs of the volunteers were collected to evaluate safety. According to registration order, the 12 subjects were allocated by serial number. To evaluate safety, blood samples were taken and vital signs were checked 4 times - screening, pre administration, post administration and follow up-during the whole trial. The difference between pre (before medication [0 hr]) and post-administration (after medication [48 hr]) variables was summarized as mean±standard deviation. The normality test was performed using the Kolmogorov-Smirnov test and Shapiro-Wilk test. When the normality is satisfied, the paired t-test is applied. Otherwise, the non-parametric method, Wilcoxon signed rank test is applied. The significance level was p<0.05. The incidence of all adverse effects are shown in percentage. Results In the case of red blood cell, hemoglobin, hematocrit, lymphocytes, neutrophils, protein, γ-glutamyl transpeptidase values, the normality test result of the variable for the difference value before and after the dosing has a significance level <0.05. But most of values did not deviate from the normal range, and the deviation from the normal range could not be regarded as the significance associated with this clinical trial. And adverse event wasn't observed associated with the clinical trial drug. Conclusions Bojungikgi-tang soft extract were considered to be safe for healthy male volunteers.

Effectiveness and patient satisfaction of dental emergencies in Pitié Salpêtrière Hospital, Paris, during the COVID 19 pandemic

  • Rodriguez, Isabelle;Zaluski, Daniel;Jodelet, Pierre Alain;Lescaille, Geraldine;Toledo, Rafael;Boucher, Yves
    • Journal of Dental Anesthesia and Pain Medicine
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    • v.22 no.4
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    • pp.255-266
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    • 2022
  • Background: A previous study reported the effectiveness and patient satisfaction in the dental emergency unit (DEU) of the Pitie Salpetrière Hospital in Paris before coronavirus disease 2019 (COVID-19). The same methodology was used during the COVID-19 pandemic to compare pain, anxiety, and patient satisfaction during the two periods. Methods: This prospective study was conducted in 2020 (NCT04354272) on adult patients. Data were collected on day zero (D0) on site and then by phone during the daytime on day one (D1), day three (D3), and day seven (D7). The primary objective was to assess the pain intensity at D1. Secondary objectives were to assess pain intensity at D3 and D7, anxiety intensity at D1, D3, and D7, and patient satisfaction. Patients were evaluated on a 0-10 numeric scale on D1, D3, and D7; mean scores were compared with non-parametric statistics (ANOVA, Dunn's). Results: A total of 445 patients were given the opportunity to participate in the study, and 370 patients consented. Seventy-one were lost during follow-up. Ultimately, 299 patients completed all the questionnaires and were included in the analysis. In the final sample (60% men, 40% women, aged 39 ± 14 years), 94% had health insurance. The mean pain scores were: D0, 6.1 ± 0.14; D1, 3.29 ± 0.16; D3, 2.08 ± 0.16; and D7, 1.07 ± 0.35. This indicates a significant decrease of 46%, 67%, and 82% at D1, D3, and D7, respectively, when compared to D0 (P < 0.0001). The mean anxiety scores were D0, 4.7 ± 0.19; D1, 2.6 ± 0.16; D3, 1.9 ± 0.61; and D7, 1.4 ± 0.15. This decrease was significant between D0 and D7 (ANOVA, P < 0.001). Perception of general health improved between D1 and D7. The overall satisfaction was 9.3 ± 0.06. Conclusion: DEU enabled a significant reduction in pain and anxiety with high overall satisfaction during COVID-19, which was very similar to levels observed pre-COVID-19 pandemic.

An Empirical Study on Factors Affecting the Survival of Social Enterprises Using Non-Financial Information (비재무정보를 이용한 사회적기업의 생존에 영향을 미치는 요인에 관한 실증연구)

  • Hyeok Kim;Dong Myung Lee;Gi Jung Nam
    • Journal of Industrial Convergence
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    • v.21 no.1
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    • pp.111-122
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    • 2023
  • The purpose of this study is to verify the factors affecting survival time by estimating survival rate and survival time using non-financial information of social enterprises using credit guarantee in credit guarantee institutions, and provide information to stakeholders to improve survival rate and employ to contribute to maintaining and expanding the As a research method, survival analysis was performed using a non-parametric analysis method, Kaplan-Meier Analysis. As a sample, 621 companies (577 normal companies, 44 insolvent companies) established between 2009 and 2018 were selected as the target companies. As a result of examining the factors affecting survival time by classifying social enterprise representative information and corporate information, representative credit rating, representative home ownership, credit transaction period, and corporate credit rating were derived as significant variables affecting survival time. In the future, financial institutions will be able to induce corporate soundness by reflecting factors that affect survival when examining loans for social enterprises, contributing to job retention and reduction of social costs. Supporting organizations such as the government and private organizations will be able to use it in various ways, such as policy establishment and education and training for the growth and sustainability of social enterprises. With this study as an opportunity, I hope that research will continue with more interest in the factors influencing social enterprise performance as well as corporate insolvency.

Damage Evaluation of Adjacent Structures for Detonation of Hydrogen Storage Facilities (수소저장시설의 폭발에 대한 인접 구조물의 손상도 평가)

  • Jinwon Shin
    • Journal of Korean Society of Disaster and Security
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    • v.16 no.1
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    • pp.61-70
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    • 2023
  • This study presents an analytical study of investigating the effect of shock waves generated by the hydrogen detonation and damage to structures for the safety evaluation of hydrogen storage facilities against detonation. Blast scenarios were established considering the volume of the hydrogen storage facility of 10 L to 50,000 L, states of charge (SOC) of 50% and 100%, and initial pressures of 50 MPa and 100 MPa. The equivalent TNT weight for hydrgen detonation was determined considering the mechanical and chemical energies of hydrogen. A hydrogen detonation model for the converted equivalent TNT weight was made using design equations that improved the Kingery-Bulmash design chart of UFC 3-340-02. The hydrogen detonation model was validated for overpressure and impulse in comparison to the past experimental results associated with the detonation of hydrogen tank. A parametric study based on the blast scenarios was performed using the validated hydrogen detonation model, and design charts for overpressure and impulse according to the standoff distance from the center of charge was provided. Further, design charts of the three-stage structural damage and standoff distance of adjacent structures according to the level of overpressure and impact were proposed using the overpressure and impulse charts and pressure-impulse diagrams.

Development of Detailed Design Automation Technology for AI-based Exterior Wall Panels and its Backframes

  • Kim, HaYoung;Yi, June-Seong
    • International conference on construction engineering and project management
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    • 2022.06a
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    • pp.1249-1249
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    • 2022
  • The facade, an exterior material of a building, is one of the crucial factors that determine its morphological identity and its functional levels, such as energy performance, earthquake and fire resistance. However, regardless of the type of exterior materials, huge property and human casualties are continuing due to frequent exterior materials dropout accidents. The quality of the building envelope depends on the detailed design and is closely related to the back frames that support the exterior material. Detailed design means the creation of a shop drawing, which is the stage of developing the basic design to a level where construction is possible by specifying the exact necessary details. However, due to chronic problems in the construction industry, such as reducing working hours and the lack of design personnel, detailed design is not being appropriately implemented. Considering these characteristics, it is necessary to develop the detailed design process of exterior materials and works based on the domain-expert knowledge of the construction industry using artificial intelligence (AI). Therefore, this study aims to establish a detailed design automation algorithm for AI-based condition-responsive exterior wall panels and their back frames. The scope of the study is limited to "detailed design" performed based on the working drawings during the exterior work process and "stone panels" among exterior materials. First, working-level data on stone works is collected to analyze the existing detailed design process. After that, design parameters are derived by analyzing factors that affect the design of the building's exterior wall and back frames, such as structure, floor height, wind load, lift limit, and transportation elements. The relational expression between the derived parameters is derived, and it is algorithmized to implement a rule-based AI design. These algorithms can be applied to detailed designs based on 3D BIM to automatically calculate quantity and unit price. The next goal is to derive the iterative elements that occur in the process and implement a robotic process automation (RPA)-based system to link the entire "Detailed design-Quality calculation-Order process." This study is significant because it expands the design automation research, which has been rather limited to basic and implemented design, to the detailed design area at the beginning of the construction execution and increases the productivity by using AI. In addition, it can help fundamentally improve the working environment of the construction industry through the development of direct and applicable technologies to practice.

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A Study on the Lateral Behavior of Pile-Bent Structures with $P-{\Delta}$ Effect ($P-{\Delta}$ 효과를 고려한 Pile-Bent 구조물의 수평거동 연구)

  • Jeong, Sang-Seom;Kwak, Dong-Ok;Ahn, Sang-Yong;Lee, Joon-Kyu
    • Journal of the Korean Geotechnical Society
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    • v.22 no.8
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    • pp.77-88
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    • 2006
  • In this study, the lateral behavior of Pile-Bent structures subjected to lateral loading was evaluated by a load-transfer approach. An analytical method based on the Beam-Column model and nonlinear load transfer curve method was proposed to consider material non-linearity (elastic and yielding) and $P-{\Delta}$ effect. Special attention was given to the lateral deflection of Pile-Bent structures depending on different soil properties, lateral load, slenderness ratio based on pier length and reinforcing effect of casing. From the results of the parametric study, it is shown that the increase of lateral displacement in a pile is much less favorable for an inelastic analysis than for an elastic analysis. It is found that for inelastic analysis, the maximum bending moment is located within a depth approximately 3.5D(D: pile diameter) below ground surface, but within 1.5D when $P-{\Delta}$ effect is considered. It is also found that the magnitude and distribution of the lateral deflections and bending moments on a pile are highly influenced by the inelastic analysis and $P-{\Delta}$ effect, let alone soil properties around an embedded pile.

Effects of Personal Protective Equipment Practice Education on the Effectiveness of Repeated Learning and Satisfaction (개인보호구 실습교육의 반복학습 효과와 만족도에 미치는 영향)

  • Dae Jin Jo;Won Souk Eoh
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.33 no.2
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    • pp.156-170
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    • 2023
  • Objectives: This study conducted practical training to improve the proper usage of personal protective equipment(PPE), which greatly impacts workplace safety and health management. Personal protective equipment education was conducted through active participation, without theoretical modules, and aimed to identify the effects of repeated practical education and determine ways to increase participant satisfaction. Methods: Study data were analyzed using the IBM SPSS Statistics ver.29 software. First, participants' general characteristics were analyzed with frequency analysis. Second, the normality and equality of variances (Leven's test) were tested for the dependent variables prior to statistical analyses to determine the use of parametric tests. In general, normality is assumed when the sample size is 30 or more per the central limit theorem (Park et al., 2014). As our sample size of health management workers was 43, normality can be assumed. However, to ensure rigor of the study, we examined skewness and kurtosis. The results confirmed that the data were normally distributed. Third, the effects of repeated PPE training were analyzed using paired t-tests. Fourth, differences in satisfaction with PPE training according to the safety and health job position and safety and health certification were analyzed with t-test and Welch's t-test. For parameters that did not meet the assumption of equal variances, the Welch's t-test was performed. Results: Repeated PPE training improved the educational outcomes, and the improvements were significant in the 1st and 2nd respiratory PPE and safety and hygiene PPE training evaluations (p<.001). In terms of safety and health job position, repeated training led to improvements in educational outcomes, with significant improvements observed among supervisors and specialized health management institution workers in the 1st and 2nd training evaluations (p<.005). In terms of safety certification, repeated training led to improvements in educational outcomes, with significant improvements observed among both certified and non-certified individuals (p<.005). Regarding satisfaction with PPE training according to safety and health job positions, specialized health management institution workers showed greater satisfaction than supervisors, with significant differences in the satisfaction for expertise of lecture, work relevance, and lecturer's attitude (p<.001). Regarding satisfaction with PPE training according to safety and health certification, satisfaction was higher among certified individuals, with significant differences in satisfaction for work relevance and lecture attitude (p<.05) Conclusions: PPE education should be recommended to be provided as practical training. Repeated training can enhance educational outcomes for individuals with inadequate knowledge and understanding of PPE prior to education. For individuals with high levels of pre-existing knowledge and understanding of PPE, the results show that various training experiences should be provided to enhance their satisfaction. Therefore, it suggests that the workplace should actively seek educational media and methods to acquire expertise and skills in wearing personal protective equipment and improve the ability to use

Fundamental Frequency Extraction of Stay Cable based on Energy Equation (에너지방정식에 기초한 사장 케이블 기본진동수 추출)

  • Kim, Hyeon Kyeom;Hwang, Jae Woong;Lee, Myeong Jae
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.28 no.1A
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    • pp.125-133
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    • 2008
  • According to longer and longer span, dynamic instability of stay cable should be prevented. Dynamic instability occurs mainly symmetric 1st mode and antisymmetric 1st mode in stay cable. Especially symmetric 1st mode has a lot of influence on sag. Therefore fundamental frequency of stay cable is different from that of taut sting. Irvine, Triantafyllou, Ahn etc. analyzed dynamic behavior of taut cable with sag through analytical technical and their researches give important results for large bounds of Irvine parameter. But each research shows mutually different values out of characteristic (cross-over or mode-coupled) point and each solution of frequency equations of all researchers can be very difficultly found because of their very high non-linearity. Presented study focuses on fundamental frequency of stay cable. Generalized mechanical energy with symmetric 1st mode vibration shape satisfied boundary conditions is evolved by Rayleigh-Ritz method. It is possible to give linear analytic solution within characteristic point. Error by this approach shows only below 3% at characteristic point against existing researches. And taut cable don't exceed characteristic point. I.e. high accuracy, easy solving techniques, and a little bit limitations. Therefore presented study can be announced that it is good study ergonomically.

Longitudinal Dynamic Relationships of Delinquent Peers and Delinquency Trajectories (비행또래집단과 청소년비행 간의 종단적인 역동적 관계)

  • Chung, Ick-Joong;Lee, Eun-Ju
    • Korean Journal of Social Welfare Studies
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    • v.41 no.1
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    • pp.119-144
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    • 2010
  • This study advances the knowledge of developmental patterns in affiliation with delinquent peers and delinquency during adolescence; data were obtained from waves 1-5 (2003-2007) of the Korea Youth Panel Survey. Semi-parametric group-based modeling (SGM) identified 3 affiliative trajectories of delinquent peers from age 13 to 16: rarely or never, persistently affiliative, and declining groups; and five developmental trajectories of delinquency: non-offending, late onset, low-level continuous, desisting, and chronic groups. A joint trajectory analysis predicted the membership of delinquency trajectories conditional on delinquent peer trajectories. Persistently affiliative group was more likely than others to follow chronic trajectory of delinquency; the rarely or never affiliative group was more likely to be non-offending. This study may help reconcile different theoretical models such as influence, selection, and enhancement models with respect to the role of delinquent peers in delinquency. The distinct theoretical models are equally valid, albeit each model pertains to a specific aspect of longitudinal patterns of affiliation with delinquent peers. Implications of this study for youth welfare were discussed to reduce increased risks for both affiliation with delinquent peers and delinquency.

AI-Based Object Recognition Research for Augmented Reality Character Implementation (증강현실 캐릭터 구현을 위한 AI기반 객체인식 연구)

  • Seok-Hwan Lee;Jung-Keum Lee;Hyun Sim
    • The Journal of the Korea institute of electronic communication sciences
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    • v.18 no.6
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    • pp.1321-1330
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    • 2023
  • This study attempts to address the problem of 3D pose estimation for multiple human objects through a single image generated during the character development process that can be used in augmented reality. In the existing top-down method, all objects in the image are first detected, and then each is reconstructed independently. The problem is that inconsistent results may occur due to overlap or depth order mismatch between the reconstructed objects. The goal of this study is to solve these problems and develop a single network that provides consistent 3D reconstruction of all humans in a scene. Integrating a human body model based on the SMPL parametric system into a top-down framework became an important choice. Through this, two types of collision loss based on distance field and loss that considers depth order were introduced. The first loss prevents overlap between reconstructed people, and the second loss adjusts the depth ordering of people to render occlusion inference and annotated instance segmentation consistently. This method allows depth information to be provided to the network without explicit 3D annotation of the image. Experimental results show that this study's methodology performs better than existing methods on standard 3D pose benchmarks, and the proposed losses enable more consistent reconstruction from natural images.