• Title/Summary/Keyword: Parameters Sensitivity

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Aerobic and Graduated Treadmill Exercise Decreases Blood Glucose Levels, Lipid Levels and Oxidative Stress in an Animal Model of Type 1 Diabetes Mellitus

  • Kim, Eun-Jung;Kim, Gye-Yeop
    • The Journal of Korean Physical Therapy
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    • v.22 no.6
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    • pp.65-70
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    • 2010
  • Purpose: Exercise has been shown to be a simple and economical therapeutic modality that may be considered as an effective aid for diabetic mellitus. For example, exercise training increases insulin sensitivity in type 2 diabetes. But we found no reported of how exercise affect type 1 diabetes. This study investigated the impact of aerobic and graduated treadmill exercise regimens on body weight, glucose and insulin concentrations, lipid profiles, and oxidative stress indicators in rats with streptozotocin (STZ) induced diabetes. Glycosylated hemoglobin ($HbA_{1c}$) was determined as an indicator of glucose control during exercise. Methods: In our study, a total of 40 rats were used. Three groups of 10 rats each were given STZ to induce diabetes. The remaining 10 rats became the normal group. After 28 days we determined biochemical parameters such as glucose, glycosylated hemoglobin ($HbA_{1c}$), insulin concentration, serum total cholesterol (TC), triglycerides (TG), and high-density lipoprotein (HDL). Superoxide dismutase (SOD) and catalase activities were also measured. Results: Concentrations of blood glucose and $HbA_{1c}$ in the moderated exercise groups were significantly decreased after 28 days compared with the control group (p<0.05). There was a significant reduction in serum TC and TG in the experimental groups. The activity of SOD increased significantly by 17.70% and 48.25% respectively. Conclusion: These results indicate that physical training and exercise training affects body weight, fasting blood glucose, $HbA_{1c}$, insulin, lipid profiles, and antioxidant status in rats with streptozotocin-induced diabetes. We suggest that graduated treadmill exercise may have therapeutic, preventative, and protective effects against diabetes mellitusby improving glycemic control, oxidant defenses, and lipid metabolism.

Recent Issues in the Design and Construction of High-Performance Shotcrete Lining (고성능 숏크리트 라이닝의 설계 및 시공기술 분석)

  • 배규진;이석원;박해균;이명섭;김재권;장수호
    • Tunnel and Underground Space
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    • v.14 no.1
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    • pp.1-15
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    • 2004
  • The development of high-performance shotcrete lining is essential in improving the long-term durability of tunnels and in introducing single-shell tunnelling methods, where shotcrete as well as rockbolts are used as permanent support members. In this paper, new and advanced admixtures to improve shotcrete performance are introduced. In addition, requirements for mechanical properties as well as test items for quality control of shotcrete are summarized. A case study on the application of the pneumatic pin penetration test which can estimate compressive strength of shotcrete more easily and quickly is also illustrated. Previous studies to analyze the behaviors of shotcrete lining by considering its transient hardening and to carry out the sensitivity analysis of the design parameters of shotcrete lining are discussed to give fundamental concepts on rock-support interactions. Representative single-shell tunnelling methods where high-performance shotcrete lining is applied as a permanent support are also introduced.

Applicability Study of Geotextile Mesh Soil Nail on Slope Reinforcement Using Numerical Analysis (수치해석을 이용한 토목섬유망 네일의 사면보강에 대한 적용성 연구)

  • You, Kwang Ho;Jung, Yeun Hak;Ha, Ji Young
    • Tunnel and Underground Space
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    • v.25 no.3
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    • pp.264-274
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    • 2015
  • In this study, the applicability of geotextile mesh soil nails on slopes was evaluated by numerical analysis to reduce environmental problems which a general soil nailing might produce and to improve its economical efficiency and construction convenience. To this end, in situ pull-out tests were conducted for both general soil nail and geotextile mesh soil nail and their pull-out characteristics were analyzed. Also, finite difference method was used to verify the suitability of numerical simulation. Parameters for nail and ground conditions were selected and sensitivity analysis was performed for the evaluation of slope stability. In addition, analysis was performed by limit equilibrium method which is widely used for slope stability analysis in practice. As a result, if the nail diameter was same, there is no big difference between geotextile mesh soil nails and general soil nails in terms of slope stability. Therefore it can be expected that geotextile mesh soil nails could be effective for slope reinforcement since they could keep a slope as stable as general soil nails and give better economical efficiency and construction convenience than general soil nails.

Stability Analysis for Ground Uplift in Underground Storage Caverns for High Pressurized Gas using Hoek-Brown Strength Criterion and Geological Strength Index (GSI) (Hoek-Brown 강도기준식 및 암질강도지수를 이용한 고압 유체 지하저장 공동의 융기에 대한 안정성 평가)

  • Kim, Hyung-Mok
    • Tunnel and Underground Space
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    • v.24 no.4
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    • pp.289-296
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    • 2014
  • A simple analytical approach for stability assessment of underground storage caverns against ground uplift of overburden rock above the rock caverns for high pressurized fluid such as compressed air energy storage (CAES) and compressed natural gas (CNG) was developed. In the developed approach, we assumed that failure plane of the overburden is straight upward to ground surface, and factor of safety can be calculated from a limit equilibrium analysis in terms of this cylindrical shape failure model. The frictional resisting force on the failure plane was estimated by Hoek-Brown strength criterion which replaces with Mohr-Coulomb criterion such that both intact rock strength and rock mass conditions can be considered in the current approach. We carried out a parametric sensitivity analysis of strength parameters under various rock mass conditions and demonstrated that the factor of safety againt ground uplift was more sensitive to Mohr-Coulomb strength criterion rather than Hoek-Brown criterion.

Development of Biological Criteria for Water Quality Assessment using Benthic Diatoms (부착돌말류를 이용한 생물학적 수질평가지표 개발)

  • Noh, Seongyou;Byeon, Myeongseop;Kim, Miah;Lee, Jaekwan
    • Journal of Korean Society on Water Environment
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    • v.25 no.6
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    • pp.879-885
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    • 2009
  • The present study was carried out to develop biological criteria for water quality assessment using benthic diatoms. Selecting of the indicator diatoms, three parameters were considered: broad distribution (180 taxa occurred over 3% at upper level), species abundance (158 taxa occurred over $1.5{\times}10^5cells/cm^2$), and sensitivity (184 taxa occurred more than once as 1st and 2nd dominant species). Overall, total 208 taxa were selected, including 38 varieties, 170 species, 34 genera, 9 families, 3 orders, and 1 phylum. The most dominant taxonomic group (family) was Naviculaceae (52%), followed by Diatomaceae (15%), Nitzschiaceae (12%) and Achnantaceae (11%). COD and TP were proposed as new water quality standards (draft) to improve the existing BOD standard and to manage and control efficiently non-biodegradable organic pollutants. With this regard, we used TP standard (draft) in developing biological water quality criteria for diatoms. TP standards (draft) proposed as Ia = 0.02 mg/L or less, Ib = 0.05 mg/L or less, II = 0.1 mg/L or less, III = 0.2 mg/L or less, IV = 0.4 mg/L or less, V = 0.6 mg/L or less and VI = above 0.6 mg/L. Biological assessment system (4 class system) was developed and proposed for diatom using modified Tropic Diatom Index (TDI). Biological assessment of TDI appear B grade (Good).

Robust Optimization Using Supremum of the Objective Function for Nonlinear Programming Problems (비선형계획법에서 목적함수의 상한함수를 이용한 강건최적설계)

  • Lee, Se Jung;Park, Gyung Jin
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.38 no.5
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    • pp.535-543
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    • 2014
  • In the robust optimization field, the robustness of the objective function emphasizes an insensitive design. In general, the robustness of the objective function can be achieved by reducing the change of the objective function with respect to the variation of the design variables and parameters. However, in conventional methods, when an insensitive design is emphasized, the performance of the objective function can be deteriorated. Besides, if the numbers of the design variables are increased, the numerical cost is quite high in robust optimization for nonlinear programming problems. In this research, the robustness index for the objective function and a process of robust optimization are proposed. Moreover, a method using the supremum of linearized functions is also proposed to reduce the computational cost. Mathematical examples are solved for the verification of the proposed method and the results are compared with those from the conventional methods. The proposed approach improves the performance of the objective function and its efficiency.

Vibration control of a single-link flexible manipulator using fuzzy- sliding modes (퍼지-슬라이딩 모드를 이용한 단일링크 유연 매니퓰레이터의 진동제어)

  • Choi, Seung-Bok
    • Journal of KSNVE
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    • v.6 no.1
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    • pp.35-44
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    • 1996
  • This paper presents a new type of fuzzy-sliding mode controller for robust tip position control of a single-link flexible manipulator subjected to parameter variations. A sliding mode controller is formulated with an assumption that imposed parameter variations are bounded so that certain deterministic performance can be guaranted. In the design of the sliding mode controller, so called moving sliding surface is adopted to minimize the reaching phase and thus mitigate system sensitivity to the variations. The sliding mode controller is then incorporated with a fuzzy technique to reduce inherently ever-existing chattering which is impediment in position control of flexible manipulators. A set of fuzzy parameters and control rules are obtained from a relation between predetermined sliding surface and representative points in the state space. Computer simulations are undertaken in order to demonstrate superior control performance of the proposed methodology.

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Design of a Neuro-Euzzy Controller for Hydraulic Servo Systems (유압서보 시스템을 위한 뉴로-퍼지 제어기 설계)

  • 김천호;조형석
    • Transactions of the Korean Society of Mechanical Engineers
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    • v.17 no.1
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    • pp.101-111
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    • 1993
  • Many processes such as machining, injection-moulding and metal-forming are usually operated by hydraulic servo-systems. The dynamic characteristics of these systems are complex and highly non-linear and are often subjected to the uncertain external disturbances associated with the processes. Consequently, the conventional approach to the controller design for these systems may not guarantee accurate tracking control performance. An effective neuro-fuzzy controller is proposed to realize an accurate hydraulic servo-system regardless of the uncertainties and the external disturbances. For this purpose, first, we develop a simplified fuzzy logic controller which have multidimensional and unsymmetric membership functions. Secondly, we develop a neural network which consists of the parameters of the fuzzy logic controller. It is show that the neural network has both learning capability and linguistic representation capability. The proposed controller was implemented on a hydraulic servo-system. Feedback error learning architecture is adopted which uses the feedback error directly without passing through the dynamics or inverse transfer function of the hydraulic servo-system to train the neuro-fuzzy controller. A series of simulations was performed for the position-tracking control of the system subjected to external disturbances. The results of simulations show that regardless of inherent non-linearities and disturbances, an accuracy tracking-control performance is obtained using the proposed neuro-fuzzy controller.

Safety Assessment on the Human Intrusion Scenarios of Near Surface Disposal Facility for Low and Very Low Level Radioactive Waste (저준위 및 극저준위 방사성폐기물 표층처분시설의 인간침입 시나리오 안전평가에 대한 고찰)

  • Hong, Sung-Wook;Park, Sangho;Park, Jin Beak
    • Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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    • v.14 no.1
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    • pp.79-90
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    • 2016
  • The second-stage near surface disposal facility for low and very low level radioactive waste's permanent disposal is to be built. During the institutional control period, the inadvertent intrusion of the general public is limited. But after the institutional control period, the access to the general public is not restricted. Therefore human who has purpose of residence and resource exploration can intrude the disposal facility. In this case, radioactive effects to the intruder should be limited within regulatory dose limits. This study conducted the safety assessment of human intrusion on the second-stage surface disposal facility through drilling and post drilling scenario. Results of drilling and post drilling scenario were satisfied with regulatory dose limits. The result showed that post-drilling scenario was more significant than drilling scenario. According to the human intrusion time and behavior after the closure of the facility, dominant radionuclide contributing to the intruder was different. Sensitivity analyses on the parameters about the human behavior were also satisfied with regulatory dose limits. Especially, manual redistribution factor was the most sensitive parameter on exposure dose. A loading plan of spent filter waste and dry active waste was more effective than a loading plan of spent filter waste and other wastes for the radiological point of view. These results can be expected to provide both robustness and defense in depth for the development of safety case further.

Predicting the Greenhouse Air Humidity Using Artificial Neural Network Model Based on Principal Components Analysis (PCA에 기반을 둔 인공신경회로망을 이용한 온실의 습도 예측)

  • Owolabi, Abdulhameed B.;Lee, Jong W;Jayasekara, Shanika N.;Lee, Hyun W.
    • Journal of The Korean Society of Agricultural Engineers
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    • v.59 no.5
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    • pp.93-99
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    • 2017
  • A model was developed using Artificial Neural Networks (ANNs) based on Principal Component Analysis (PCA), to accurately predict the air humidity inside an experimental greenhouse located in Daegu (latitude $35.53^{\circ}N$, longitude $128.36^{\circ}E$, and altitude 48 m), South Korea. The weather parameters, air temperature, relative humidity, solar radiation, and carbon dioxide inside and outside the greenhouse were monitored and measured by mounted sensors. Through the PCA of the data samples, three main components were used as the input data, and the measured inside humidity was used as the output data for the ALYUDA forecaster software of the ANN model. The Nash-Sutcliff Model Efficiency Coefficient (NSE) was used to analyze the difference between the experimental and the simulated results, in order to determine the predictive power of the ANN software. The results obtained revealed the variables that affect the inside air humidity through a sensitivity analysis graph. The measured humidity agreed well with the predicted humidity, which signifies that the model has a very high accuracy and can be used for predictions based on the computed $R^2$ and NSE values for the training and validation samples.