• Bulletin of the Korean Chemical Society
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• v.27 no.6
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• pp.909-917
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• 2006

2,2-Dimethyl-3,4-dialkoxy-substituted 6-aminobenzopyran analogues (eg., 7 and 8) were identified as prolyl 4-hydroxylase inhibitors via a screening process using HSC-T6 and LI 90 cells that express an immortalized rat hepatic stellate cell line and as part of a test of the type I collagen contents employing the ELISA method. A subsequent lead optimization effort based on solid-phase parallel synthesis led to the identification of 2,2-dimethyl-3,4-dialkoxy-substituted 6-aminobenzopyrans as potent inhibitors of prolyl 4-hydroxylase.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.37 no.1A
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• pp.57-63
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• 2012

In this paper, we propose a real-time view interpolation method using virtual viewpoint disparity estimation and convergence check. For the real-time process, we estimate a disparity map at the virtual viewpoint from stereo images using the belief propagation method. This method needs only one disparity map, compared to the conventional methods that need two disparity maps. In the view synthesis part, we warp pixels from the reference images to the virtual viewpoint image using the disparity map at the virtual viewpoint. For real-time acceleration, we utilize a high speed GPU parallel programming, called CUDA. As a result, we can interpolate virtual viewpoint images in real-time.

• Journal of Microbiology and Biotechnology
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• v.30 no.5
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• pp.762-769
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• 2020

Vitamin K2 (menaquinone) is an essential vitamin existing in the daily diet, and menaquinone-7 (MK-7) is an important form of it. In a recent work, we engineered the synthesis modules of MK-7 in Bacillus subtilis, and the strain BS20 could produce 360 mg/l MK-7 in shake flasks, while the methylerythritol phosphate (MEP) pathway, which provides the precursor isopentenyl diphosphate for MK-7 synthesis, was not engineered. In this study, we overexpressed five genes of the MEP pathway in BS20 and finally obtained a strain (BS20DFHG) with MK-7 titer of 415 mg/l in shake flasks. Next, we optimized the fermentation process parameters (initial pH, temperature and aeration) in an 8-unit parallel bioreactor system consisting of 300-ml glass vessels. Based on this, we scaled up the MK-7 production by the strain BS20DFHG in a 50-l bioreactor, and the highest MK-7 titer reached 242 mg/l. Here, we show that the engineered strain BS20DFHG may be used for the industrial production of MK-7 in the future.

• Biomolecules & Therapeutics
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• v.22 no.2
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• pp.83-92
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• 2014

Fatty acids (FAs) are highly diverse in terms of carbon (C) chain-length and number of double bonds. FAs with C>20 are called very long-chain fatty acids (VLCFAs). VLCFAs are found not only as constituents of cellular lipids such as sphingolipids and glycerophospholipids but also as precursors of lipid mediators. Our understanding on the function of VLCFAs is growing in parallel with the identification of enzymes involved in VLCFA synthesis or degradation. A variety of inherited diseases, such as ichthyosis, macular degeneration, myopathy, mental retardation, and demyelination, are caused by mutations in the genes encoding VLCFA metabolizing enzymes. In this review, we describe mammalian VLCFAs by highlighting their tissue distribution and metabolic pathways, and we discuss responsible genes and enzymes with reference to their roles in pathophysiology.

• Journal of Powder Materials
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• v.22 no.3
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• pp.216-220
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• 2015

Vertically oriented nickel nanowire arrays with a different diameter and length are synthesized in porous anodic aluminium oxide templates by an electrodeposition method. The pore diameters of the templates are adjusted by controlling the anodization conditions and then they are utilized as templates to grow nickel nanowire arrays. The nickel nanowires have the average diameters of approximately 25 and 260 nm and the crystal structure, morphology and microstructure of the nanowires are systematically investigated using XRD, FE-SEM and TEM analysis. The nickel nanowire arrays show a magnetic anisotropy with the easy axis parallel to the nanowires and the coercivity and remanence enhance with decreasing a wire diameter and increasing a wire length.

• 제어로봇시스템학회:학술대회논문집
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• 1994.10a
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• pp.334-339
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• 1994

In this work, we propose a planar three degree-of-freedom parallel mechanism as another type of assembly device which utilized joint compliances. These joint compliances can be adjusted either by properly replacing the joint compliances or by actively controlling stiffness at joints, in order to generate the desired operational compliance characteristics at RCC point, The operational compliance matrix for this mechanism is explicitly obtained by symbolic manipulation and its operational compliance characteristics are examined, it is found that the RCC point exists at the center of the workspace when the mechanism maintains symmetric configurations. Compliance characteristic and its sensitivity of this mechanism is analyzed with respect to the magnitude of the diagonal compliance components and two different matrix norms measuring compliance sensitivity. It is expected that the analysis results provide the designer with a helpful information to determine a set of optimal parameters of this RCC mechanism.

• JSTS:Journal of Semiconductor Technology and Science
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• v.17 no.1
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• pp.101-109
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• 2017

This paper presents a high-throughput low-complexity 512-point eight-parallel mixed-radix multipath delay feedback (MDF) fast Fourier transform (FFT) processor architecture for orthogonal frequency division multiplexing (OFDM) applications. To decrease the number of twiddle factor (TF) multiplications, a mixed-radix $2^4/2^3$ FFT algorithm is adopted. Moreover, a dual-path shared canonical signed digit (CSD) complex constant multiplier using a multi-layer scheme is proposed for reducing the hardware complexity of the TF multiplication. The proposed FFT processor is implemented using TSMC 90-nm CMOS technology. The synthesis results demonstrate that the proposed FFT processor can lead to a 16% reduction in hardware complexity and higher throughput compared to conventional architectures.

• Journal of Life Science
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• v.2 no.4
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• pp.232-239
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• 1992

UDP_GlcNAc is metabolized to form vegetative cell wall, cortical peptidoglycans, and outermost layer consisting of galactosamine-6-phosphate ploysaccharide in life cycle of Bacillus megaterium. To obtain a better understanding of the UDP-GlcNAc regulation, we examined the activity of the common first enzyme for the synthesis of nucleotide precursors of peptidoglycans, enoylpyruvate transferase by newly developed method. Both the specific and the total activity decreased after the end of exponential growth followed by and increase from t5 but decreased again parallel to the appearance of the activity of UDP_GlcNAc-4-epimerase. Antibody specificity to anti-transferase IgG and the elution profile on DEAE-Sepharose revealed that B. megaterium has at least two enoylpyruvate transferase isozymes, and UDP_GlcNAc was metabolized to vegetative cell wall and cortical peptidoglycan by each isozme in exponential growth and in sporulation, respectively in life cycle.

• The Bulletin of The Korean Astronomical Society
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• v.35 no.2
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• pp.81.2-81.2
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• 2010

Based on Yonsei Evolutionary Population Synthesis (YEPS), we have investigated the effect of horizontal branch stars (HBs) on the age-dating of simple stellar populations (SSPs). A detailed comparison of YEPS SSP with H_beta of M31 globular clusters (GCs) reveals (1) that the age dating without HB prescription gives ~5 Gyr younger ages for metal-poor M31 GCs, and (2) the age dating with HB prescription does not need any age gap between metal-poor and metal-rich GCs. This result is parallel to the well-known discrepancy in ages derived from integrated Balmer strengths and isochrone fittings of Milky Way GCs (MWGCs). Without a synthetic blue HB model, we cannot explain strong Balmer indices of metal-poor and old MWGCs. Our results suggest that the SSP model with well calibrated HBs should be used for the age-dating of SSPs to avoid a serious underestimation of ages due to the strong Balmer indices.

• Proceedings of the IEEK Conference
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• 2003.07e
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• pp.2471-2474
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• 2003

The modified discrete cosine transform (MDCT) and its inverse transform (IMDCT) are employed in subband/transform coding schemes as the analysis/synthesis filter bank based on time domain aliasing cancellation (TDAC). And they are the most computational intensive operations in layer III of the MPEG audio coding standard. In this paper, we propose a new efficient algorithm for the MDCT/IMDCT computation. It is based on the MDCT/IMDCT computation algorithm using the discrete cosine transforms (DCTs), and it employs two discrete cosine transform of type II(DCT-II) to compute the MDCT/IMDCT. In addition to, it takes advantage of ability in calculating the MDCT/IMDCT computation, where the length of a data block is divisible by 4. The proposed algorithm in this paper requires less calculation complexity than the existing methods. Also, it can be implemented by the parallel structure,, and its structure is particularly suitable for VLSI realization.