• 한방안이비인후피부과학회지
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• 제15권1호
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• pp.96-126
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• 2002

In the course of screening natural extracts for hair growth, we found that the extract of dried root of Sophora flavescens has the prominent hair growth promoting effect. After topical application of Sophora flavescens extract to the back of C57BL/6 mice, the earlier conversion of telogen-to-anagen phase was induced. In addition, the Sophora flavescens extract revealed to possess potent inhibitory effect on $5{\alpha}$-reductase Ⅰ and Ⅱ activity. The growth of dermal papilla cells and mouse vibrissae hair follicle cultured in vitro, however, was not affected by Sophora flavescens extract treatment. RT-PCR analysis showed that Sophora flavescens extract induced mRNA levels of growth factors such as insulin-like growth factor-Ⅰ and keratinocyte growth factor in dermal papilla cells, suggesting hair growth promoting effect of Sophora flavescens extract is mediated through inhibition of $5{\alpha}$-reductase type Ⅱ activity and the regulation of growth factors in dermal papilla cells. Furthermore, Sophora flavescens extract also showed anti-bacterial effect on Propionibacterium acnes. These results suggest that Sophora flavescens can be used as a potent treatment agent for helping hair growth stimulation and acne inhibition.

• 공업화학
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• 제32권6호
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• pp.647-652
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• 2021

본 연구에서는 에탄올과 노말헥산을 이용하여 당목향 뿌리 추출물을 제조하고, 인체 모유두세포의 세포증식 및 모발성장 관련 신호전달에 미치는 영향을 평가하였다. 당목향 뿌리 추출물의 세포증식 효과는 MTT assay를 실시하였으며, ERK, Akt, Wnt/𝛽-catenin 신호 경로, 5𝛼-reductase의 발현을 western blot 분석을 통해 측정하였다. 당목향 뿌리 추출물은 인체 모유두세포의 증식을 유의하게 증가시켰고, 세포증식에 관여하는 ERK와 Akt의 인산화를 촉진하였으며, 당목향 뿌리 추출물에 의해 증가된 ERK, Akt 인산화 촉진과 세포증식은 MEK/ERK 억제제 PD98059와 PI3K/Akt 억제제 LY294002에 의해 유의하게 감소되었다. 또한 당목향 뿌리 추출물은 GSK-3𝛽 (Ser9)의 인산화를 통한 𝛽-catenin(Ser552, 675)의 인산화를 촉진함으로써 핵 내의 𝛽-catenin 축적을 유도하였고, 5𝛼-reductase type I, II의 활성을 억제하였다. 종합적으로 당목향 뿌리 추출물은 모유두세포의 ERK, Akt 경로의 활성화를 통해 세포의 증식을 유도하며, 𝛽-catenin 신호 경로 활성화 및 5𝛼-reductase 활성 억제를 통해 탈모 예방 및 모발 성장 효과를 나타냄으로써 헤어케어제품의 소재로 응용가능성이 있음을 시사한다.

• 대한치주과학회:학술대회논문집
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• 대한치주과학회 1999년도 제39회 종합학술대회 연제초록
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• pp.106-106
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• 1999

• 대한치과보철학회:학술대회논문집
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• 대한치과보철학회 2002년도 춘계학술대회
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• pp.89-89
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• 2002

• 대한의용생체공학회:의공학회지
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• 제16권2호
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• pp.121-128
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• 1995

Information about retinal blood vessels can be used in grading disease severity or as part of the process of automated diagnosis of diseases with ocular menifestations. In this paper, we address the problem of detecting retinal blood vessels and optic disk (papilla) in eye-fundus images. We introduce an algorithm for feature extraction based on Fuzzy Clustering algorithm (fuzzy c-means). A method of finding the optic disk (papilla) is proposed in the eye-fundus images. Additionally, the inrormations such as position and area of the optic disk are extracted. The results are compared to those obtained from other methods. The automatic detection of retinal blood vessels and optic disk in the eye-rundus images could help physicians in diagnosing ocular diseases.

• Archives of Reconstructive Microsurgery
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• 제22권2호
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• pp.69-73
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• 2013

Facial esthetics and smiling are key components in nonverbal communication and have an important role in determination of the first impression of a person. The various components of the smile in dental esthetics include Gingival scaffold, lip framework, and Teeth. The periodontist creates a smile by performing various periodontal plastic microsurgery procedures for management of mucogingival problems. A 25-year-old patient reported to the Department of Periodontology at Teerthanker Mahaveer Dental College and Research Center, Moradabad, Northern India, with the chief complaint of long looking teeth in the upper jaw, making him conscious while smiling. Miller class I gingival recession with Maxillary left canine (23) was diagnosed. Periodontal plastic microsurgery employing double papilla grafting with connective tissue graft harvested from the palate in order to cover denuded root was performed using microsurgical instruments and microsuturing with 6-0 suturing material under magnification. Healing was uneventful, with achievement of 100% root coverage of denuded root after three months. The patient was highly impressed and satisfied with his enhanced smile.

• Ocean Science Journal
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• 제42권2호
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• pp.61-67
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• 2007

Three barracudina fishes (Paralepididae) were newly recorded from the southern sea of Korea. Lestidium prolixum is characterized by a single band of luminous ducts on the midventral line and absence of a papilla anterior to the eye. Lestrolepis intermedia and L. japonica are similar in having a black papilla immediately in front of the eye and two bands of luminous ducts on the midventral line. However, the dorsal fin of L. intermedia is located more posterior along the body than that of L. japonica, and L. intermedia have larger number of anal fin rays 42 (vs. 36-40) and vertebrae 95 (vs. 86-87) than L. japonica.

• 대한치과기공학회지
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• 제12권1호
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• pp.95-102
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• 1990

The distances from the center line between maxillary right and left central incisors(the dental midline) to the various anatomical landmarks were measured. Fifty five students(thirth four males and twenty one females) who have at least natural teeth including maxillary and mandibular incisors and bicuspids were examined. 1. There was statistically significant difference between the dental midline and the center line of maxillary labial frenum(p<0.05). 2. There was no statistically significant difference between the dental midline and the point of incisive papilla, philtrum line, the center line between two mandibular central incisors, and the median palatine suture line(p>0.05). 3. There was no statistically significant sexual difference among data. 4. The philtrum line showed the highest value of correspondence to the center line between two maxillary central incisors followed by the center point of incisive papilla, the center line of two mandibular central incisors, median plaltine suture line and the center line of maxillary labial frenum at the decreasing rate.

• 대한치과의사협회지
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• 제23권9호통권196호
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• pp.803-811
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• 1985

• 대한치과의사협회지
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• 제13권7호
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• pp.661-666
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• 1975