• Anxiety and mood
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• v.5 no.1
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• pp.36-41
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• 2009

Objectives : The purpose of this pilot study was to investigate the potential clinical benefits a single group session of cognitive behavioral therapy in the treatment of patients with panic disorder. Methods : The study participants were 18 patients (14 males, 4 females; mean age=38.9 years), all of whom were assessed as meeting the DSM-IV-TR criteria for panic disorder. All participants attended one two-hour session of structured group cognitive behavioral therapy (CBT). Clinical symptoms was assessed before and eight weeks after the single therapy session using the Panic Disorder Severity Scale (PDSS). Results : Eight weeks after a single session of group CBT significant improvements were found in panic attack frequency, distress during panic attacks, severity of anticipatory anxiety, agoraphobic fear/avoidance, panic-related sensation fear/avoidance, impairment in work functioning, impairment in social functioning. Conclusions : One session of group CBT appears to be an effective treatment of panic disorder by reducing the severity of all symptoms assessed on the PDSS. An attempt should be made to replicate the findings of this pilot study in a larger and controlled, comparative clinical trial.

• Anxiety and mood
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• v.13 no.1
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• pp.10-16
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• 2017

Objective : This study aimed to investigate differences in demographic, clinical characteristics, and quality of life between panic-disorder patients with generalized anxiety disorder (PD+GAD) and without generalized anxiety disorder (PD-GAD). Methods : We examined data from 218 patients diagnosed with PD+GAD (150 patients) and PD-GAD (68patients). The following instruments were applied: Stress coping strategies, Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Panic Disorder Severity Scale (PDSS), Anxiety Sensitivity Index-Revised (ASI-R), Albany Panic and Phobia Questionnaire (APPQ), NEO-neuroticism(NEO-N), Short Form health survey-36 (SF-36). Results : Compared to the PD-GAD group, the PD+GAD group had higher scores in emotion-focused coping strategies and clinical severity, such as BDI, BAI, PDSS, ASI, APPQ, and neuroticism. The PD+ GAD group showed lower scores in most scales in SF-36 status than PD-GAD group. Conclusions : This study shows that PD+GAD patients are different from PD-GAD patients in coping strategies, clinical severity and quality of life. It emphasizes the need of personalized therapy in clinical approach among patients with PD+GAD.

• Journal of Oriental Neuropsychiatry
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• v.16 no.2
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• pp.1-11
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• 2005

Objective : This study was to evaluate the clinical improvement of Panic attack and Anticipatory anxiety on Panic Disorder patients after Oriental medical treatment. Methods : We compared post-treatment with pre-treatment on Panic attack and Anticipatory anxiety with Thirty eight Panic Disorder patientsafter Oriental medical treatment - acupunture, herbal medicine, oriental psychotherapy. Results and Conclusions : 1. Foremost herbal medicines were Siwuanshentang(四物安神揚)(39.47%), Qingxinwendantang(情心溫膽揚)(13.16%). Types of demonstration weredeficiency of the heart blood(心血不足)(39.47%), deficiency of qi and blood in the heart and spleen(心脾兩虛)(28.95%), timidity die to insufficiency of qi and deficiency of blood of the heart(心脫虛法)(15.79%), stagnation of phlegm(痰獨阻滯)(13.16%), deficiency of liver-yin and kidney-yin(肝腎陰虛)(2.63%) in order. 2. The physical constitutions in Thirty eight Panic Disorder patients weretwenty nine of Taiyinren(76.3%),six of Shaoyinren(15.8%), three of Shaoyangren(7.9%) in order. 3. This oriental medical treatment was effective in Panic attack from $7.68{\pm}0.87$ to $2.68{\pm}1.613$ and in Anticipatory anxiety from $7.47{\pm}1.006$ to $2.47{\pm}1.841$ in comparison post-treatment with pre-treatment. 4. A percentage of subjective improvement was 72.6%. There were 18.4% in the same, 15.8% in slight improvement, 18.4% in medium improvement, 47.4% in remarkable improvement.

• Sleep Medicine and Psychophysiology
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• v.12 no.1
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• pp.50-57
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• 2005

Objectives: This study was designed to evaluate the differences in clinical characteristics and severity of symptoms between panic patients with and without comorbid major depressive disorder, and to ascertain the differences in the function of the autonomic nerve system measured by heart rate variability (HRV). Methods: The subjects were 60 patients who have panic disorder without major depressive disorder and 19 patients who met DSMIV criteria for both panic disorder and major depressive disorder. First, they drew up symptom checklists and self-rating scales, and were measured by Anxiety Disorder Inventory Schedule-Panic Attack & Agoraphobia (ADIS-P&A), Clinical Global Impression (CGI), Hamilton Rating Scale for Depression (HAM-D), Panic Disorder Severity Scale (PDSS) and Heart Rate Variability (HRV). For statistical analysis, we performed t-test to compare the scores of self reported scales and clinician’s rating scales in panic patients with comorbid major depressive disorder and those without major depressive disorder. ANCOVA was used to compare the variables of HRV, considering age as a covariate. Results: The subjective severities of depression and anxiety that comorbid patients complained of were higher than those of patients with only panic disorder. Futhermore, comorbid patients were more sensitive to anxiety and physical sensations, and they tend to be more negative in their thinking. The scores of clinician-rating scales such as CGI and PDSS were also higher in the comorbid patients. However, there were no significant differences in HRV variables between both groups, despite a tendency to low heart rate variability in the comorbid group. Conclusion: This study suggests that patients with panic disorder and comorbid major depressive disorder tend to complain of more symptoms and to be more sensitive to various symptoms than those with panic disorder without comorbid depression. However, in this study comorbid major depressive disorder did not have a significant impact on the HRV variables of patients with panic disorder.

• Journal of the Korean Society for information Management
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• v.38 no.2
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• pp.153-172
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• 2021

This study is to create a deep learning based classification model to examine the characteristics of panic disorder and to classify the panic disorder tendency literature by the panic disorder corpus constructed for the present study. For this purpose, 5,884 documents of the panic disorder corpus collected from social media were directly annotated based on the mental disease diagnosis manual and were classified into panic disorder-prone and non-panic-disorder documents. Then, TF-IDF scores were calculated and word co-occurrence analysis was performed to analyze the lexical characteristics of the corpus. In addition, the co-occurrence between the symptom frequency measurement and the annotated symptom was calculated to analyze the characteristics of panic disorder symptoms and the relationship between symptoms. We also conducted the performance evaluation for a deep learning based classification model. Three pre-trained models, BERT multi-lingual, KoBERT, and KcBERT, were adopted for classification model, and KcBERT showed the best performance among them. This study demonstrated that it can help early diagnosis and treatment of people suffering from related symptoms by examining the characteristics of panic disorder and expand the field of mental illness research to social media.

• The Journal of Churna Manual Medicine for Spine and Nerves
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• v.3 no.2
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• pp.1-8
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• 2008

Objective : This study is designed to evaluate the effects of an oriental medical therapy, the Chuna Manual Relaxation Therapy on symptom of Panic disorder. Method : The clinical data was analyzed on a patient with Panic disorder whose main symptoms were palpitation, perpirtion, hydrodipsomania, chest pain, burning sensation. Result : After treatment, the patient's main symptoms were disappeared and secondary symptoms were improved. Conclusion : This study suggests that the Chuna Manual Relaxation Therapy is significantly effective in treatment of Panic disorders.

• Anxiety and mood
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• v.7 no.1
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• pp.3-8
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• 2011

Cognitive models of panic disorder have emphasized cognitive distortions' roles in the maintenance and treatment of panic disorder (PD). However, the patient's difficulty with identifying and managing emotional experiences might contribute to an enduring vulnerability to panic attacks. Numerous researchers, employing emotion processing paradigms and neuroimaging techniques, have investigated the empirical evidence for poor emotion processing in PD. For years, researchers considered that abnormal emotion processing in PD might reflect a dysfunction of the frontal-temporal-limbic circuits. Although neuropsychological studies have not provided consistent results regarding this model, a few studies have tried to find the biological basis of dysfunctional emotion processing in PD. In this article, we examine the possibility of dysregulation of emotion processing in PD. Specifically we discuss the neural basis of emotion processing and the manner in which such neurocognitive impairments may help clarify PD's core symptoms.

• Anxiety and mood
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• v.10 no.2
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• pp.108-114
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• 2014

Objective : The correlation between age of onset and symptoms/severity of panic disorder has not yet been determined. The aim of this research is to determine the different clinical features of panic disorder according to the age of onset. Methods : Patients diagnosed with panic disorder were placed into two groups according to onset of age. The subjects were checked for 13 different panic symptoms presented in the DSM-IV. The investigation was also executed by severity, the anxiety sensitivity index, the scale for depression and anxiety. Results : The early onset group had significantly higher frequencies than the late onset group in the areas of "choking feeling" and "derealization or paresthesia". It was found that only "choking feeling" was statically significant as a risk factor of early onset panic disorder. Among the objective anxiety scale, the subscale of psychological anxiety was higher in the early onset group compared to the late onset group. Conclusion : "Choking feeling" was the only panic symptom that showed a significant difference in accordance with onset age. Earlier onset patients tend to experience a more frequent "choking feeling," which is related to respiratory symptoms. This could mean that earlier onset patients are more likely to have higher psychological anxiety.

• Anxiety and mood
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• v.19 no.2
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• pp.69-76
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• 2023

Objective : This study aimed to find out whether the Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF) scales are useful in distinguishing social anxiety disorder, panic disorder, and major depressive disorder. Methods : The study sample included 118 patients: 33 with social anxiety disorder, 53 with major depressive disorder, and 32 with panic disorder. Participants were classified according to the diagnosis indicated on their medical records. MMPI-2-RF scores were derived from MMPI-2 protocols. Results : The results of multivariate analysis of variance showed that the elevated scales were consistent with the diagnostic and clinical characteristics of each diafnostic group. Logistic regression analyses identified several scales that were useful in differentiating the diagnostic groups. The higher Cognitive Complaints (COG) scale significantly differentiated major depressive disorder from the other groups. The higher Self-Doubt (SFD) scale and Somatic Complaints (RC1) scale were useful in differentiating social anxiety disorder and panic disorder respectively. The lower Cynicism (RC3) scale was also useful in differentiating social anxiety disorder. Other scales that were useful in distinguishing between pairs of groups were also identified. Conclusion : The results of this study suggest that the MMPI-2-RF scales can be useful for discriminating anxiety disorders.

• Korean Journal of Biological Psychiatry
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• v.11 no.2
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• pp.136-145
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• 2004

Objectives:Genetic variations of the tryptophan hydroxylase(TPH) gene and the serotonin transporter linked polymorphic region(5-HTTLPR) polymorphism have been associated with its functional capacity. The authors investigated whether the allelic constitution of the TPH gene and 5-HTTLPR are associated in Korean panic patients. Methods:244 Korean patients with panic disorder and 227 normal healthy controls were tested for a genetic polymorphism of TPH A218C and 5-HTTLPR polymorphism. To assess the severity of panic disorder during the last one month, anticipatory anxiety, panic difficulty, panic distress, agoraphobic difficulty and agoraphobic distress were measured with visual analogue scale(VAS) score, STAI-S & T, BDI, SCL-90-R, ASI-R, CGI, PDSS, and HAMD. Results:There was no significant difference in genotype and allele frequencies of TPH A218C and 5-HTTLPR polymorphism between panic patients and controls. Although we observed some differences in genotype and allele frequencies of TPH A218C polymorphism among male subjects, these differences disappeared after Bonferroni correction. And there were no significant differences in clinical variables. Conclusion:Our results suggested that there are no association between the genetic polymorphism of TPH gene and 5-HTTLPR with panic disorder.