• Physical Therapy Korea
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• v.13 no.1
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• pp.9-15
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• 2006

Work-related musculoskeletal disorder has been associated with long hours of computer work and prolonged periods of static posture. In clinical settings, postural correction is a common treatment approach for individuals with neck, shoulder, and back pain. This study was designed to identify the effect of Forward Head Posture Correctional Device during computer work. Twelve healthy adults (mean age, 27.4 yrs; mean height, 165.0cm mean weight, 65.8 kg) participated in the study. They had no medical history of neurological or surgical problems with their upper extremity. The subjects were asked to perform Head Forward Posture under the guidance of physical therapists and the measured angles were analyzed using a 3-D motion analysis system. Markers were placed on the C7 spinous process, tragus of the ear and forward head angle was between the line from the tragus to the C7 line and the Y-axis at the C7. The statistical significance of difference between, "without" and "with" correctional device was tested by paired t-test. A level of significance was set at ${\alpha}$=.05. In comparison of the computer work between "without" and "with" correctional device, Forward Head Angle was showed significant difference (p<.05). In conclusion, the range of Forward Head Angle was significantly decreased during computer work with the correctional device. Further research is needed to understand the nature of motor control problems in deep muscles in patients with neck, shoulder, and back pain.

• The Korean Journal of Physiology and Pharmacology
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• v.10 no.5
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• pp.235-242
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• 2006

Cortical malformation-associated epileptic seizures are resistant to conventional anticonvulsant drugs. Relatively little research has been conducted on the effects of antiepileptic drugs (AEDs) on seizure activity in a rat model of dysplasia. We have used rats exposed to methylazoxymethanol acetate (MAM) in utero, an animal model featuring nodular heterotopia, to investigate the effects of ethosuximide (ETX) in the dysplastic brain. Pilocarpine was used to induce acute seizure in MAM-exposed and age-matched vehicle-injected control animals. Field potential recordings were used to monitor the amplitude and number of population spikes, and paired pulse inhibition in response to stimulation of the commissural pathway. Pharmaco-resistance was tested by measuring seizure latencies after pilocarpine administration (320 mg/kg, Lp.) with and without pre-treatment with ETX. Pre-treatment with 300 mg of ETX significantly prolonged the latency to the status epilepticus (SE) in both control and MAM-treated groups. Pre-treatment with ETX 100mg and ETX 200 mg had little effect in MAMexposed rats. However, ETX 200 mg prolonged the latency to the SE in control groups. Spontaneous field potential and secondary after-discharges were higher for MAM-treated rat in comparison with control rats injects with ETX. The main findings of this study are that acute seizures initiated in MAM-exposed rats are relatively resistant to standard ETX assessed in vivo. These data suggest that ETX do not prolong seizure latencies in MAM-rats exposed to pilocarpine.

• Korean Journal of Applied Biomechanics
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• v.15 no.3
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• pp.1-7
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• 2005

Excessive pronation and impact force during running are related to various running injuries. To prevent these injuries, three type of running shoes are used, such as cushioning, stability, and motion control. Although there were may studies about the effect of midsole hardness on impact force, no study to investigate biomechanical effect of motion control running shoes. The purpose of this study was to determine biomechanical difference between cushioning and motion control shoes during treadmill running. Specifically, plantar and rearfoot motion, impact force and loading rate, and insole pressure distribution were quantified and compared. Twenty male healthy runners experienced at treadmill running participated in this study. When they ran on treadmill at 3.83 m/s. Kinematic data were collected using a Motion Analysis eight video camera system at 240 Hz. Impact force and pressure distribution data under the heel of right foot were collected with a Pedar pressure insole system with 26 sensors at 360 Hz. Mean value of ten consecutive steps was calculated for kinematics and kinetics. A dependent paired t-test was used to compare the running shoes effect (p=0.05). For most kinematics, motion control running shoes reduced the range of rearfoot motion compared to cushioning shoes. Runners wearing motion control shoe showed less eversion angle during standing less inversion angle at heel strike, and slower eversion velocity. For kinetics, cushioning shoes has the effect to reduce impact on foot obviously. Runners wearing cushioning shoes showed less impact force and loading rate, and less peak insole pressure. For both shoes, there was greater load on the medial part of heel compared to lateral part. For pressure distribution, runners with cushioning shoes showed lower, especially on the medial heel.

• Korean Journal of Applied Biomechanics
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• v.28 no.1
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• pp.29-35
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• 2018

Objective: The purpose of this study was to determine the asymmetry of vertical ground reaction force (GRF) components between dominant and non-dominant legs in rested and fatigued states in prolonged running. Method: Twenty healthy men, heel strikers, were included (age: $24.00{\pm}5.0years$; height: $176.1{\pm}6.0cm$; body mass: $69.0{\pm}6.0kg$) in this study. Subjects ran on an instrumented treadmill for 130 minutes. During treadmill running, GRF data (1,000 Hz) were collected for 20 strides at five minutes (rested) and 125 minutes (fatigued) running while they were unaware of collecting data. Asymmetry indexes (ASI) were calculated to quantify the asymmetry magnitude in rested and fatigued states. Paired t-test was used to verify the differences between dominant and non-dominant legs in rested and fatigued states. In addition, one-way repeated measure analysis of variance was applied for comparison of ASI of both states. The level of significance was set at p < .05. Results: Passive force peak magnitude, loading rate, and impulse affecting the development of running injury were found significantly greater in dominant leg than in non-dominant leg at rested state (p < .05). However, passive force peak time and active force peak magnitude were found significantly different between legs in fatigued state (p < .05). To determine changes in percentage of asymmetry between legs in both states, ASI was used. ASI for all variables increased in fatigued state; however, no significant differences were found between both states. Conclusion: This study found that fatigue did not affect differences in vertical GRF between dominant and non-dominant legs and asymmetry changes.

• Korean Journal of Applied Biomechanics
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• v.17 no.3
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• pp.173-180
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• 2007

The purpose of study was to compare plantar pressure during walking wearing the curved rear balance and normal shoes. Twelve university students(height: $177.2{\pm}4.6cm$, weight: $68.4{\pm}5.8kg$, age: $26.2{\pm}1.6yrs.$) who have no known musculoskeletal disorders were recruited as the subjects. Plantar foot pressures were evaluated using the Tekscan's pressure measurement systems while subjects walked upright position wearing the curved rear balance and normal shoes in random order at a speed of 1.3 m/s. The contacting dimension, the mean plantar pressure, and the peak plantar pressure were determined for each trial. For each dependent variable, paired t-test was performed to test if significant difference existed between shoe conditions (p<.05). As a result, the curved rear balanced shoes showed as large as 38 up to 50 % of area at the rear side of feet than the normal shoes when measuring the contact area with upright position. In the distribution of average pressure, the curved rear balanced shoes displayed fairly low pressure compared to other normal shoes in general except for one area, which is M2, and especially, the measured pressures at the both rear (M1) and middle (M5) side of feet were low and statically significant. The contact area of the curved rear balanced shoes when walking was significantly larger at the rear (M1) and fore (M6, M7) side of feet. When considering pressure distribution at walking, low pressure was detected at the rear side of feet with the curved rear balanced shoes and at the fore side of feet for other normal shoes. The results showed that the contacting dimension of the curved rear balance shoes that acts between shoes and feet was higher than the corresponding value for the normal shoes in general; therefore it would reduce the pressure to the feet by allowing the each sole of the foot on the ground evenly.

• The Journal of Korean Physical Therapy
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• v.28 no.6
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• pp.381-384
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• 2016

Purpose: Previous studies reported changes in the first metatarsophalangeal (MTP) joint angle in relation with and without weight bearing, but it is unclear whether sesamoid bone of the great toe changes in weight bearing conditions particularly in subjects with hallux valgus (HV). To investigate how weight bearing conditions can affect the position of the medial sesamoid bone (MSB), first MTP joint angle, and second intermetatarsal angle (IMA) in the recruited subjects. Methods: Subjects were recruited 24 with HV and 21 without HV in study. X-rays were taken in the weight bearing and non-weight bearing conditions. The distance of the MSB, first MTP joint angle, and second IMA were measured from the radiographs. Data were analyzed by paired and Independent t-test. The statistical significance level was p<0.05. Results: In both groups, the first MTP joint angles and the distance of the MSB were significantly smaller, while the second IMA was significantly greater in the weight bearing condition. The difference in the distance of the MSB between the two postures was significantly greater in the group with HV. Conclusion: Weight bearing can affect the first MTP joint angle, second IMA, and position of the MSB; the change in the position of the MSB in weight bearing was greater in the group with hallux valgus. The difference in these variables between weight bearing and non-weight bearing conditions may be considered when measuring HV.

• Radiation Oncology Journal
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• v.34 no.2
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• pp.145-155
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• 2016

Purpose: Radiation therapy targeting axilla and groin lymph nodes improves regional disease control in locally advanced and high-risk skin cancers. However, trials generally used conventional two-dimensional radiotherapy (2D-RT), contributing towards relatively high rates of side effects from treatment. The goal of this study is to determine if three-dimensional conformal radiation therapy (3D-CRT), intensity-modulated radiation therapy (IMRT), or volumetric-modulated arc therapy (VMAT) may improve radiation delivery to the target while avoiding organs at risk in the clinical context of skin cancer regional nodal irradiation. Materials and Methods: Twenty patients with locally advanced/high-risk skin cancers underwent computed tomography simulation. The relevant axilla or groin planning target volumes and organs at risk were delineated using standard definitions. Paired t-tests were used to compare the mean values of several dose-volumetric parameters for each of the 4 techniques. Results: In the axilla, the largest improvement for 3D-CRT compared to 2D-RT was for homogeneity index (13.9 vs. 54.3), at the expense of higher lung $V_{20}$ (28.0% vs. 12.6%). In the groin, the largest improvements for 3D-CRT compared to 2D-RT were for anorectum $D_{max}$ (13.6 vs. 38.9 Gy), bowel $D_{200cc}$ (7.3 vs. 23.1 Gy), femur $D_{50}$ (34.6 vs. 57.2 Gy), and genitalia $D_{max}$ (37.6 vs. 51.1 Gy). IMRT had further improvements compared to 3D-CRT for humerus $D_{mean}$ (16.9 vs. 22.4 Gy), brachial plexus $D_5$ (57.4 vs. 61.3 Gy), bladder $D_5$ (26.8 vs. 36.5 Gy), and femur $D_{50}$ (18.7 vs. 34.6 Gy). Fewer differences were observed between IMRT and VMAT. Conclusion: Compared to 2D-RT and 3D-CRT, IMRT and VMAT had dosimetric advantages in the treatment of nodal regions of skin cancer patients.

• Journal of Korean Society on Water Environment
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• v.20 no.3
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• pp.281-289
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• 2004

Optimal analytical conditions have been established for mixing and reaction coil length, concentrations of ECR, CTAB, and acetate, reaction temperature and pH in the determination of aluminum by using flow injection analysis(FIA). Detection limit and repeatability for this system were $3{\mu}g/L$ and better than 1% of relative standard deviation, respectively. The interference from iron(III) was suppressed up to 6mg/L of iron(III) by $0.1{\mu}M$ ascorbic acid, and the interference from fluoride could be tolerated in absorption of Al/ECR/CTAB derivative by 10mM boric acid at pH 3.5 adjusted with nitric acid. This FIA system was applied to the determination of aluminum leached from cooking utensils by distilled and tap water containing fluoride ranged from 0.5 to 2mg/L by measurement of absorbance for Al/ECR/CTAB at 585nm. The leached aluminum content was increased with increasing concentration of fluoride. The aluminum contents leached from aluminum utensils by tap water were about 9 fold higher than those leached by distilled water, whereas aluminum contents leached by distilled water containing fluoride were about 2 fold higher compared to those leached by distilled water. That represented that other dissolved substances as well as fluoride in tap water contributed to liberation of aluminum from aluminum utensils. A comparison between FIA data and ICP-AES data by correlation and paired t test showed that the FIA system could be accepted as a good alternative method for the determination of aluminum in tap water.

• Journal of the Korean Society of Physical Medicine
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• v.7 no.3
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• pp.339-348
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• 2012

Purpose : The purpose of this study is to compare muscle activations of neck, trunk and leg in cerebral palsy of spastic diplegia with genu recurvatum and knee flexion contracture, when using anterior and posterior walkers. Methods : We selected 21 cerebral palsy and received the written consent to participate in this study. The inclusion criteria for participation required patients to have spastic diplegic CP; to be between 3~6 years of age, to have a GMFCS III grade, to have no botulinum toxin injection and orthopedics surgery within before six months starting the study. Measurements of muscle activities (sternocleidomastoid, splenius capitis, rectus abdominis, erector spinea, gluteus maximus, rectus femoris, medial hamstring and calf muscles) were evaluated anterior and posterior walker ambulations. Statistical evaluation of these data were accomplished by utilizing the paired t-test and independent t-test by SPSS 20.0 program. Significance level was set at p<.05. Results : The following results were obtained. There was significant difference on muscle activation of neck, trunk and legs(soleus except) in anterior and posterior walkers. There was no significant difference in muscle activation of neck but significant difference in muscle activation of trunk, legs between genu recurvatum and knee flexion contracture(rectus abdominis, medial hamstring when using anterior walker, rectus abdominis, erector spinea, gluteus maximus, medial hamstring when using posterior walker). Conclusion : The conclusion of this study is the different knee joint forms would have different effect on muscle activation of trunk and legs while cerebral palsy of spastic diplegic ambulated with anterior walker and posterior walker.

• Korean Journal of Food Science and Technology
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• v.32 no.2
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• pp.424-430
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• 2000

The purpose of the study was to investigate effect of addition of mutant strains of both Leuconostoc mesenteroides and Leu. paramesenteroides on extending shelf-life of Kimchi. The mutant strains have an increased adipic acid resistance in comparison with that of their paired wild types. Addition of both strains was more effective than that of one strain alone to extend shelf-life of Kimchi. The optimal amount of inoculation was determined as 0.005% of the two mixed mutant strains with a ratio of 1 : 10, Leu. mesenteroides : Leu. paramesenteroides based on the results of acidification and organoleptic tests.