• 한국치위생학회지
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• 제10권4호
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• pp.705-715
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• 2010

Objectives : This study is aimed to seek how to promote oral health care by leading the clients with dental fears to change their behaviors in oral hygiene care based on the analysis of the relationships between the dental fears and oral health care behaviors of the clients who visit the Dental Hygiene Education Room. Methods : This study analyzed the 361 dental hygiene records of the subjects with finished treatment and accurate records among a total of 370 clients who had received dental hygiene care at the Dental Hygiene clinic in Y University from March 2007 till June 2009. According to their general features, the study analyzed whether they had any dental fears and why such fears occurred and conducted Chi-square test to compare their oral hygiene care experiences and behaviors with dental fears. Data analysis was made using the SPSS 12.0K for Window, with level of significance set at 0.05. Results : 1. In terms of dental fear or non-fear, the comparison by gender showed that women had a higher level than men, with 76 women(47.2%) answering yes; the comparison by age showed that the age group of 30 years old or older had a higher level than other groups. 2. In terms of dental fear reasons, "the past pain experiences" recorded 34.2%, showing the highest rate. 3. In addition, dental fears had influences on regular dental examination, scaling and dental hygiene education and the subjects without dental fear showed higher levels in terms of tooth-brushing frequency and time. Conclusions : To control "the past pain experiences", future dental treatment should place priority on preventive treatment and get clients to cope with pains through the preliminary education with pains. Besides, to make an effective oral health care of the clients with dental fears, dental hygienists should control the fears of the clients and perform an appropriate oral health care for them using the communication techniques to make friendly and trustworthy impressions.

• 한국융합학회논문지
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• 제8권4호
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• pp.139-148
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• 2017

본 연구는 한국 청소년의 스트레스가 구강건강 및 건강행태에 미치는 융합적인 영향을 알아보고자 하였다. 제 11차(2015년) 청소년 건강행태 온라인 조사를 활용하여 72,060명을 대상으로 연구하였다. 일반적인 특성은 성별(Sex)에서는 여학생에서, 학년(Grade)에서는 고등학생이, 성적(Academic performance)에서는 하위그룹(Low)이, 주관적건강수준(Subjective health status)에서는 즉 나쁘다고 느끼는 학생이, 아침식사(Breakfast)를 하지 않는 학생이, 격렬한 신체운동(Exercise)에서도 하지 않는 학생에서 스트레스 지수가 또한 높게 나타났으며 통계적으로 유의하였다(p<0.001). 자가구강증상(Self-assessed Oral health status))에서는 저작시 통증(Tooth pain when eating)이 있으며, 잇몸에 출혈(Bleeding gum)이 있고, 구취(Bad breath)가 있는 학생에게서 스트레스가 높았으며, 통계적으로 유의하였다(p<0.001). 이 연구의 함축적인 결과 청소년들 사이에서 심리적인 스트레스가 구강건강 및 건강행태에 밀접한 영향을 주는 결과를 보였으며, 이러한 결과 더욱이 청소년 시기에 알맞은 구강건강프로그램의 지속적인 발전이 더욱 필요할 것으로 보인다.

• 한국치위생학회지
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• 제17권5호
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• pp.757-767
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• 2017

Objectives: The purpose of this study is to identify the associated factors with subjective oral symptoms experience of obesity adolescents. Methods: The study subjects were targeting 8,139 obesity adolescents and 55,601 non-Obesity adolescents who completed 2016 Korean Youth Risk Behavior Web-based survey. Dependent variables were subjective oral symptoms experiences of fracture teeth, pain, throbbing pain, periodontal pain & bleeding, mucosal disease and bad breath. Independent variables were demographic characteristics of the subjects, oral health behaviors, health behaviors and eating habits. Results: Obesity adolescents were 12.8% with 61.9% subjective oral symptoms experience. Regarding the related factors of subjective oral symptoms experience of obesity adolescents, the factors were identified to be significantly higher in high school (OR=1.72) compared to middle school, learning achievement was higher in middle (OR=1.09) and lower (OR=1.31) compared to high, economic status was higher in lower (OR=1.09) compared to high, sealant experience (OR=1.10) and scaling experiences (OR=1.12) responded no were higher compared to responded yes, smoking experiences responded yes(OR=1.08) were higher compared to responded no, sweet drink (OR=1.14) and fastfood (OR=1.13) consumption were higher in consumption compared to non-consumption and females (OR=0.46) were higher than males. Oral symptoms experience were lower that father and mother's level of education were under high school graduation (OR=0.86) compared to unknown, economic status was in case of middle (OR=0.93) compared to high, tooth brushing was lower in under 1 time (OR=0.76), 2 times (OR=0.61) compared to more than 3 times, vigorous physical activities responded no (OR=0.75) were lower, compared to yes, vegetable consumption was lower in non-consumption (OR=0.68) compared to consumption. Conclusions: Subjective oral symptoms experiences were identified higher in obesity adolescents than non-obesity adolescents. It would be useful to use the results of this study to reduce oral symptoms and necessary to develop a program system considering characteristics of obesity adolescents.

• The Korean Journal of Pain
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• 제30권2호
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• pp.98-103
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• 2017

Background: The root of Peucedanum japonicum Thunb., a perennial herb found in Japan, the Philippines, China, and Korea, is used as an analgesic. In a previous study, sec-O-glucosylhamaudol (SOG) showed an analgesic effect. This study was performed to examine the antinociceptive effect of intrathecal SOG in the formalin test. Methods: Male Sprague-Dawley rats were implanted with an intrathecal catheter. Rats were randomly treated with a vehicle and SOG ($10{\mu}g$, $30{\mu}g$, $60{\mu}g$, and $100{\mu}g$) before formalin injection. Five percent formalin was injected into the hind-paw, and a biphasic reaction followed, consisting of flinching and licking behaviors (phase 1, 0-10 min; phase 2, 10-60 min). Naloxone was injected 10 min before administration of SOG $100{\mu}g$ to evaluate the involvement of SOG with an opioid receptor. Dose-responsiveness and ED50 values were calculated. Results: Intrathecal SOG showed a significant reduction of the flinching responses at both phases in a dose-dependent manner. Significant effects were showed from the dose of $30{\mu}g$ and maximum effects were achieved at a dose of $100{\mu}g$ in both phases. The ED50 value (95% confidence intervals) of intrathecal SOG was 30.3 $(25.8-35.5){\mu}g$ during phase 1, and 48.0 (41.4-55.7) during phase 2. The antinociceptive effects of SOG ($100{\mu}g$) were significantly reverted at both phases of the formalin test by naloxone. Conclusions: These results demonstrate that intrathecal SOG has a very strong antinociceptive effect in the formalin test and it seems the effect is related to an opioid receptor.

• Korean Journal of Acupuncture
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• 제21권2호
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• pp.47-67
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• 2004

Objectives : In the present study, the effect of Scolopendrid Water-Alcohol Extract (SWAE) applied to acupuncture point BL23 (Shinsu) on the neuropathic pain was examined. A common source of persistent pain in humans is the neuropathic pain. Anti-convulsant drugs are used to treat the neuropathic pain. In the oriental medicine, Scolopendrid was used for long time to treat convulsant syndrome and back pain, etc. Methods : On the bases of the Scolopendrid clinical application, the effect of SWAE applied to the acupuncture point was tested in the rat model of neuropathic pain. Neuropathic pain was induced by tight ligation of L5 spinal nerve. When rats developed pain behaviors, One hundred microliter of SWAE was applied into the ipsilateral BL23 point at a dose of 10 mg/ml under enflurane anesthesia. The foot withdraw latency of the hind limb was measured for an indicator of pain level after each manipulation. Results : SWAE injection increased the mechanical threshold of the foot in the rat model of neuropathic pain significantly for the duration of 4h, suggesting a partial alleviation of pain. SWAE applied to BL23 point produced a significant improvement of mechanical sensitivity of the foot lasting for at least 4h. However, neither contralateral BL23 point, ST25 (Chonchu) point, nor LR3 (Taechung) point produce as much increase of mechanical sensitivity as ipsilateral BL23 point. And, this increase of mechanical sensitivity was dose-dependent. The improvement of mechanical threshold was interpreted as an analgesic effect. In addition, the analgesic effect of Scolopendrid 4 mg/kg injection is equivalent to that of gabapentin 50 mg/kg injection. The relations between SWAE-induced analgesia and endogenous nitric oxide(NO), inducible NO synthase (iNOS)/neuronal NO synthase (nNOS) were also examined. Results were turned out that both NO production and nNOS/iNOS protein expression which are increased by nerve injury were suppressed by SWAE injection applied to BL23 point. Conclusions : The data suggest 1) that SWAE produces a potent analgesic effect on the neuropathic pain model in the rat and 2) that SWAE-induced analgesia modulate endogenous NO through the suppression of nNOS/iNOS protein expression.

• Biomolecules & Therapeutics
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• 제27권2호
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• pp.168-177
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• 2019

Dysregulation of excitatory neurotransmission has been implicated in the pathogenesis of neuropsychiatric disorders. Pharmacological inhibition of N-methyl-D-aspartate (NMDA) receptors is widely used to model neurobehavioral pathologies and underlying mechanisms. There is ample evidence that overstimulation of NMDA-dependent neurotransmission may induce neurobehavioral abnormalities, such as repetitive behaviors and hypersensitization to nociception and cognitive disruption, pharmacological modeling using NMDA has been limited due to the induction of neurotoxicity and blood brain barrier breakdown, especially in young animals. In this study, we examined the effects of intraperitoneal NMDA-administration on nociceptive and repetitive behaviors in ICR mice. Intraperitoneal injection of NMDA induced repetitive grooming and tail biting/licking behaviors in a dose- and age-dependent manner. Nociceptive and repetitive behaviors were more prominent in juvenile mice than adult mice. We did not observe extensive blood brain barrier breakdown or neuronal cell death after peritoneal injection of NMDA, indicating limited neurotoxic effects despite a significant increase in NMDA concentration in the cerebrospinal fluid. These findings suggest that the observed behavioral changes were not mediated by general NMDA toxicity. In the hot plate test, we found that the latency of paw licking and jumping decreased in the NMDA-exposed mice especially in the 75 mg/kg group, suggesting increased nociceptive sensitivity in NMDA-treated animals. Repetitive behaviors and increased pain sensitivity are often comorbid in psychiatric disorders (e.g., autism spectrum disorder). Therefore, the behavioral characteristics of intraperitoneal NMDA-administered mice described herein may be valuable for studying the mechanisms underlying relevant disorders and screening candidate therapeutic molecules.

• The Korean Journal of Physiology and Pharmacology
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• 제20권1호
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• pp.129-136
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• 2016

This study was performed to investigate whether an intra-articular injection of transient receptor potential vanilloid 1 (TRPV1) receptor agonist, resiniferatoxin (RTX) would alleviate behavioral signs of arthritic pain in a rat model of osteoarthritis (OA). We also sought to determine the effect of RTX treatment on calcitonin gene-related peptide (CGRP) expression in the spinal cord. Knee joint inflammation was induced by intra-articular injection of monosodium iodoacetate (MIA, $8mg/50{\mu}l$) and weight bearing percentage on right and left hindpaws during walking, paw withdrawal threshold to mechanical stimulation, and paw withdrawal latency to heat were measured to evaluate pain behavior. Intra-articular administration of RTX (0.03, 0.003 and 0.0003%) at 2 weeks after the induction of knee joint inflammation significantly improved reduction of weight bearing on the ipsilateral hindlimb and increased paw withdrawal sensitivity to mechanical and heat stimuli. The reduction of pain behavior persisted for 3~10 days according to each behavioral test. The MIA-induced increase in CGRP immunoreactivity in the spinal cord was decreased by RTX treatment in a dose-dependent manner. The present study demonstrated that a single intra-articular administration of RTX reduced pain behaviors for a relatively long time in an experimental model of OA and could normalize OA-associated changes in peptide expression in the spinal cord.

• 한국임상수의학회지
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• 제22권1호
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• pp.6-15
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• 2005

본 연구는 개에서 장문합술 후 비침습적인 행동관찰을 통해 통증을 평가하기 위하여 수행되었으며, 또한 이를 토대로 butorphanol의 진통효과에 대해 연구하였다. 본 실험에서 대조군은 마취를 실시하였으나 장문합술은 시행되지 않았다. 진통제 투여군의 5마리 개들에게는 장문합술을 실시하였고 butorphanol을 투여하였다. 진통제 비투여군의 5마리 개들에게는 진통제 투여 없이 장문합술을 실시하였다. 진통제 투여군의 개들은 수술 전 그리고 수술직후 butorphanol(0.4mg/kg, IM)이 투여되었고, 반면에 대조군과 진통제를 투여하지 않은 군에서는 동일한 양의 멸균 생리식염수가 투여되었다. 개의 행동은 마취 후 400분 동안 비디오테이프로 기록되었고, 그 시간에 실험자는 매 80분마다 개와 상호작용을 하였다. 각각의 상호작용에서, 실험자는 관찰된 행동을 바탕으로 멜버른 대학의 통증 측정방법을 이용하여 통증 점수를 기록하였다. 한 사람의 관찰자에 의해 정량화 된 상호작용과 비 상호작용의 행동을 측정하기 위하여 한 개체에 집중하는 연속적 표본 추출 방법이 적용되었다. 발성은 마취 후 400분 동안 녹음하였고 소리 길이, 소리 강도, 소리 pitch와 1-4 포먼트를 분석하였다. 외과수술은 통증측정 점수를 증가시켰다. 실험자와의 상호작용 중에서 수술 후 인사하는 행동이 감소되었다. 진통제를 투여한 수술군과 위약을 투여한 군사이의 차이점은 정량화된 행동측정과 발성을 통하여 구별할 수 있었다. Butorphanol을 투여한 수술군과 위약을 투여한 군 사이에는 유의적인 차이를 관찰할 수 있었다 (p< 0.05).

• Journal of Acupuncture Research
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• 제21권5호
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• pp.123-136
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• 2004

Objective : Because the cause and etiology of chronic headache is not yet fully explained, the treatment of this symptom is not simple. This study compares the effects of aroma acupuncture and normal acupuncture applied on chronic headache patients, in order to establish a primary data for further studies of new treatments and developments of new practical acupunctures. Methods : 38 clinical experiment participants were gathered and through a questionnaire patients who experienced headache for more than 4 hours a day and more than 15 days per month were qualified as Chronic Headache patients. The qualified patients were classified in to two groups, aroma acupuncture group(Aroma AT group, n=23) and normal acupuncture group(AT group, n=15). Treatment was applied 2 times a weeks for 8 weeks. The acupoints, GV20, HN23, ST8, HN46, TE17, GB20, LI20, LI11, LI14, ST36, and LR3 were stimulated for 20 minutes in both the groups. The effects of both groups were analyzed using VAS scores and BPI (Brief Pain Inventory). Results : The VAS pain scores improved significantly in both groups. The decrease rate was larger in the Aroma AT group(p<0.05). The BPI scores for the both groups also decreased. The improvement in the Aroma AT group was larger(p<0.05). Conclusion : Aroma acupuncture applied on chronic headache patients showed effects of relieving pain, improving general activities, changing the mood, and improving sleeping behaviors. These effects were analyzed using VAS scores and BPI. The Aroma AT group showed significant changes of VAS and BPI compared to the AT group, suggesting that this new practical acupuncture is very effective when treating chronic headaches. Further researches are needed to evaluate the distinct functional mechanism of aroma acupuncture, but this study is meaningful in the sense that it will act as a fundamental study to build on.

• 치위생과학회지
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• 제14권3호
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• pp.411-416
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• 2014

본 연구는 임플란트 수술 시 의식하진정법이 환자의 통증과 불안에 미치는 영향을 평가하고자 2013년 6월 1일부터 8월 30일까지 천안시 일개 치과병원에 내원한 임플란트 수술환자 95명을 대상으로 조사하였다. 임플란트 수술 전과 후의 불안 및 통증의 정도를 파악하고 치과불안과 통증에 영향을 미치는 요인을 규명하기 위하여 수술 전, 후 통증(VAS)과 수술 중 불안(PQ)을 측정하고 수술 후 통증(SF-MPQ)을 측정하였다. 연구결과를 요약하면 다음과 같다. 임플란트 수술 형태의 특성에 따라 분석한 결과 수면군과 비수면군간의 통계적으로 유의한 차이를 보인 특성은 수술부위, 수술치아개수, 수술시간, 부가적인 수술형태 등이었다(p<0.001). 수술 전, 후 통증의 차이를 살펴본 결과 수술 전 예상되는 통증과 수술 후 경험했던 통증의 차이는 수면군(2.30)이 비수면군(0.98)이 비해 통계적으로 유의한 차이가 있었다(p<0.05). 임플란트 수술환자의 통증 및 불안에 영향을 미치는 요인은 성별과 연령, 임플란트 수술경험및 수술시간, PCS였으며 공통적으로 관련된 요인은 PCS였다(p<0.05). 따라서, 치과 임상에서는 임플란트 수술 전, 후 심리적인 안정을 제공할 수 있도록 여성이거나 나이가 적을수록 수술치아개수와 수술시간이 길어질 것으로 예상될 때 의식 하진정법의 추천과 정확한 정보를 제공함으로써 편안한 환경에서 치료할 수 있도록 해야 한다. 또한, 의식 하 진정법시 PCS를 통해 보다 체계적이고 객관적인 행동 전략이 필요하며, 환자관리를 위한 끊임없는 연구 및 교육프로그램 개발이 진행되어야 할 것이다.