• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.27 no.2
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• pp.129-134
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• 2001

Since NNK is one of the most abundant tobacco-specific alkaloids and a strong carcinogenic nitrosamine, it has been used for evaluating a potential of carcinogenicity in the animal models. The present study has attempted to examine the potential of carcinogenicity of NNK in human epithelial cells, from which the cell type the most of cancers including oral cancer and nasal cavity cancer are originated. The cellular model used for the study is a human keratinocyte cell system immortalized by Ad12-SV40 hybrid virus. The cellular system has successfully been used for the carcinogenicity studies because of its limitless life span, epithelial morphology and nontumorigenicity. When cells were treated with a variety of NNK concentrations, levels of saturation density and soft agar colony formation were increased in a dose-dependent fashion. Colonies of large cell aggregates were above 5 at the higher doses. The results indicate that exposure of human cells with NNK induced loss of contact inhibition and increases of anchorage independence and cellular adhesion, which are typical characteristics of the neoplatically transformed cells. When cells were exposed with 100uM NNK for 2hr, mRNA levels of IL-1 and PAI-2 were increased in a dose-dependent manner, but expression of TGF- 1 was not affected. While expression of growth regulatory factors were altered with a short-term exposure, there was no alteration of these factors in the NNK-transformed cells. However, mRNA levels of fibronectin were increased both in the short-term treatment and in the transformation. The results suggest that altered expression of extracellular matrix such as fibronectin following short-term exposure might be fixed in the genome and these altered properties be continuously transfered throughout the cell division. Western blot analysis showed a translocation of PKC- from cytosolic fraction to the particulate fraction, indicating a possible role of NNK in the signal transduction pathway. The present study provided an evidence that NNK in the smoking may be associated with epithelial origin cancer such as oral and nasal cavity cancers. In addition, this study suggested that altered expression of extracellular matrix and PKC may play an important role in the carcinogenic mechanism of NNK.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.3
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• pp.668-676
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• 2016

This study reviewed the planning characteristics of contemporary Japanese middle school architecture on which related studies are insufficient, aiming to obtain new ideas for planning Korean middle school facilities. Fourteen case schools built after 1990s were selected and analyzed. They were divided into learning-living space and other major spaces. The planning characteristics of the case schools are summarized as follows 1) The case schools were classified into two categories, departmentalized classroom type (D type) and usual with variation type (UV type) by school system. These categories can also be the classification standard for basic architectural characteristics in learning and living space of case schools. 2) D type case schools have departmentalized classrooms, home base, media space and teacher's space for learning-living space. D type case schools are divided into 'attached-to-classroom type' and 'separate type' depending on the adjacency of the home base and departmentalized classroom. 3) UV type case schools have multipurpose space around the classroom for learning-living space and can be divided into two types, i.e., 'directly adjacent' and 'separate', depending on the connectivity to classroom of multipurpose room. 4) Specialized classrooms are designed to have the openness to the public and the own characteristics of school subjects strengthened and show the spatial differentiation with connected ancillary spaces. 5) Libraries are designed as complex zones grouped with computer labs, audio visual rooms and multipurpose halls not as a single room and as open plan not with a closed wall. 6) The gymnasium is the basic sports facility with a martial arts room and outdoor pool, which are for after-school activities as well as physical education class. 7) The terrace, balcony and outdoor stairs are frequently used architectural vocabularies as diverse outdoor spaces with a variety of functions.

• Journal of Preventive Medicine and Public Health
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• v.28 no.3 s.51
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• pp.678-689
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• 1995

Chromium is one of the representative toxic substance by occupational exposure which damage the mucosa of respiratory tract including nasal septal perforation. The aim of this study is to evaluate the effect of chromium exposure on olfactory function and to obtain the fundamental information about chromium exposure. The authors performed olfactory function test, laboratory tests and questionnaire interview on the subject of three groups, that is, two exposed groups and one nonexposed group from May 1 to June 30, 1994. Exposed group 1 was 15 male workers without nasal septal perforation, exposed group 2 was 15 male workers with nasal septal perforation among 103 workers in 22 chromium plating factories, and nonexposed group was 15 male medical students. The gathered informations were histories of chromium exposure, habits of smoking and alcohol drinking, the concentrations of chromium in serum and urine, and asparate aminotransferase(AST), alanine aminotransferase(ALT), gamma-glutamyl transferase, etc. Olfactory function was checked by T and T olfectometer using phenyl ethyl alcohol(material A), methyl cyclopentenolone(material B), iso-valeric acid(material C), $\gamma$-undecalactone(material D), skatole(material E) and the results were expressed by detection threshold(DT) and recognition threshold(RT). There was a significant difference between exposed groups and nonexposed group in A, B, C, D, E substances by DT and in A, B, C, D substances by RT(P<0.01). The degree of olfactory dysfunction was highest in the exposed group 2 and lowest in the nonexposed group in all five substances by DT and it was same in A B, D substances RT and the difference of RT and DT. As summary, olfactory dysfunction by chromium exposure was recognized and the degree of olfactory dysfunction was higher in the exposed group with nasal septal perforation. Therefore, it would be helpful to apply olfactory function test for the early detection of olfactory dysfunction, and this test would be considered as the basic tool within workers' compensation system.

• Journal of architectural history
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• v.12 no.1 s.33
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• pp.25-41
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• 2003

This paper is a study of Le Corbusier's trace regulateur of the 1920s, particularly its role in the design of the Villas La Roche-Jeanneret and Stein-de Monzie. It proceeds on the basis of the following three themes: first, the relation between the regulating line and the dom-ino frame; second, its status as a proportional device based not on a module system but one that defines relations; third, its function as an essential practical device in the design process. In the Villa La Roche-Jeanneret, the embedded horizontal planes of the dom-ino frame were constant, but the vortical lines of the columns were altered according to the changes in plan. Initially, a left-hand bay window formed a symmetry with the right-hand bay window, the only constant in the design process. With subsequent changes, mullion sections of the horizontal window and roof elements came to provide the reference points for the regulating line. Eventually, a regulating line different from the one that controlled the bay window and the elongated volume came to control the entrance hall of Villa La Roche, resulting in three different kinds of regulating lines in the final version. In contrast to the Villa La Roche-Jeanneret, a singular and consistent regulation line was anticipated in the earliest design stages of the Villa Stein-de Monzie. The repetition of its A:B grid and the standard $2.5m{\times}1.0m$ sliding window determined the proportions of both its plan and elevation, and thus the regulating line became 'automatic,' losing its viability as a practical tool. Though the regulating titles of the La Roche-Jeanneret look as if they were an afterthought, drawn after the design was complete, they were most active, requiring tenacity and discipline in their application. On the other hand, the seemingly 'redundant' regulating line of the Villa Stein-de Monzie gains its raison d'etre from the dom-ino frame. Its cantilevers and uninterrupted horizontal window could be used in decisive fashion because of the guarantee that the correct proportion would always be maintained. Thus we discover that Le Corbusier's discipline of the 1920s had a certain spectrum of flexibility. His 'parti' ranged from the extremely loose and malleable grid of the Villa La Roche-Jeanneret to the fixed grid of the Villa Stein-de Monzie. In different ways, these projects retain the tension between the dom-ino frame and the regulating line. For Le Corbusier, as much as the grid was an object with fixed attributes, it was also an active medium manipulated by the will of the architect.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.4
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• pp.596-601
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• 2020

Silicon carbide is considered a potentially useful material for high-temperature electronic devices because of its large band gap energy and p-type or n-type conduction that can be controlled by impurity doping. Accordingly, the thermoelectric properties of -SiC powder prepared by refined diatomite were investigated for high value-added applications of natural diatomite. -SiC powder was synthesized by a carbothermal reduction of the SiO₂ in refined diatomite using carbon black. An acid-treatment process was then performed to eliminate the remaining impurities (Fe, Ca, etc.). n-Type semiconductors were fabricated by sintering the pressed powder at 2000℃ for 1~5h in an N2 atmosphere. The electrical conductivity increased with increasing sintering time, which might be due to an increase in carrier concentration and improvement in grain-to-grain connectivity. The carrier compensation effect caused by the remaining acceptor impurities (Al, etc.) in the obtained -SiC had a deleterious influence on the electrical conductivity. The absolute value of the Seebeck coefficient increased with increasing sintering time, which might be due to a decrease in the stacking fault density accompanied by grain or crystallite growth. On the other hand, the power factor, which reflects the thermoelectric conversion efficiency of the present work, was slightly lower than that of the porous SiC semiconductors fabricated by conventional high-purity -SiC powder, it can be stated that the thermoelectric properties could be improved further by precise control of an acid-treatment process.

• The Korean Journal of Nuclear Medicine
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• v.32 no.3
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• pp.250-258
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• 1998

Purpose: ATP (adenosine triphosphate) is a potent coronary vasodilator with a rapid onset of action and a very short half-life. Myocardial perfusion scintigraphy with intravenous ATP has not yet been sufficiently proven in the diagnosis, follow-up, and risk stratification of coronary artery disease. The purpose of this study was to evaluate the safety, feasibility and diagnostic accuracy of pharmacologic stress thallium-201 myocardial SPECT using an intra-venous ATP infusion in patients with suspected coronary artery disease. Materials and Methods: Thallium-201 myocardial SPECT in 319 patients with suspected coronary artery disease were performed after the infusion of ATP (0.08 mg/kg/min for 6 min). The adverse effects were carefully monitored. Coronary angiography was also performed within 3 weeks. Results: Although 76.5% of the patients had some adverse effects, they were transient, mild, and well tolerated. In all patients, the ATP infusion protocol was completed and only 2 patients required aminophylline. The adverse effects were dyspnea in 63%, headache in 31%, flushing in 21%, chest pain in 14% and abdominal discomfort in 5% of the patients. The sensitivity and specificity were 80% and 90% respectively. Conclusion: Thallium-201 myocardial SPECT after 6 min-infusion of ATP at a rate of 0.08 mg/kg/min is safe and has a diagnostic value in detecting coronary artery disease.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.8
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• pp.5355-5362
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• 2014

This study reviewed the planning characteristics of dormitories for secondary schools in the Japanese Colonial Era by analyzing the architectural drawings collected by the National Archives of Korea. The dormitory was one of the essential facilities in secondary schools but there have been few studies in this area. The analysis items were the site plan and the planning characteristics of student bedrooms, dining hall, and supervisor's area, which were the main elements of the dormitory. The results of this study were summarized as follows. 1) Generally, the dormitory area was placed in the rear of buildings for teaching with a close connection. 2) The student bedroom wings were laid out in parallel to the south as a rule making the typical site plan pattern for a dormitory, whereas the other parts of dormitory, such as the dining hall and supervisor's area were placed in the site conditions. 3) Generally, the unit plans of bedrooms for Korean schools were the ondol type and were small in size, whereas those for Japanese were the tatami type and large in size with separate study and sleeping areas. 4) The dining hall annex was made up of a dining hall and kitchen-bathroom area in general. For Japanese schools, the school store area was added to these areas. The typical shapes of dining hall plans were narrow and long with an adjacent corridor, so the overall plan of the dining hall annex was like that of a single-corridor type block plan. 5) The supervisor's area was a smaller part of the dormitory but it was considered to be a symbolic part of the whole dormitory in site planning and design.

• The International Journal of Costume Culture
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• v.2 no.2
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• pp.97-118
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• 1999

Ever since China adopted a free market economy, it has been basking in unprecedented economic growth. It has now emerged as one of the most promising markets in the world for the near future. The purpose of this study was to investigate of Chinese and Korea college female students's cognitive body type and to suggest basic informations for high quality clothing merchandising for china export. The subjects in this study were 430 college female students, aged from 18 to 24 living in Beijing(215) and Seoul(215). The survey were taken from June to July, 1999. SAS(Statistical Analysis System) is used for frequency, percentage, average, standard deviation, χ²-test. The results of this study are as follows. The 90% of Chinese collge female students has under 4000 yuan for monthly income, and they consume less than 1000 yuan for clothing purchasing for one year. About 42% chinese students are interested in controlling of physical body shape. The Korean college female students has from 1,000,000 won to 10,000,000 won for monthly income, and the 84% of them consume less than 1,000,000 for clothing purchasing for one year. It represents of economical difference between China and Korea. Examination on the Korean and Chinese self-perception on obesity of the body as a whole showed that both groups perceived themselves as normal or slightly overweight. More Korean respondents regarded their weight as normal than the Chinese did. The Chinese female college students perceived themselves rather overweight, and held a lower satisfaction level about their physical construction. While the Korean female college students showed low satisfaction level about specific bodily parts, they held a normal level of satisfaction about their physical construction as a whole. It is noteworthy that more Chinese respondents generally held lower satisfaction impressions about their physical construction than their Korean counterparts. It is needed to different merchandising project for export clothing in China.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.13 no.5
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• pp.425-431
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• 2020

Recent advancements in industries and technologies have resulted in an increase in the volume of transportation, management, and distribution of logistics. Radio-frequency identification (RFID) technologies have been developed to efficiently manage such a large amount of logistics information. The use of RFID for management is being applied not only to the logistics industry, but also to the power transmission and energy management field. However, due to the limitation of program development capacity, the RFID device is limited in development, and this limitation is vulnerable to security because the existing strong encryption method cannot be used. For this reason, we designed a chaotic system for security with simple operations that are easy to apply to such a restricted environment of RFID. The designed system is a two-dimensional tent map chaotic system. In order to solve the problem of a biased distribution of signals according to the parameters of the chaotic dynamical system, the system has a cryptographic parameter(𝜇₁), a distribution parameter(𝜇₂), and a parameter(𝜃), which is the constant point, ID value, that can be used as a key value. The designed RFID authentication system is similar to random numbers, and it has the characteristics of chaotic signals that can be reproduced with initial values. It can also solve the problem of a biased distribution of parameters, so it is deemed to be more effective than the existing encryption method using the chaotic system.

• The Journal of Engineering Research
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• v.1 no.1
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• pp.5-14
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• 1997

The purpose of thesis is to analyze the radiation characteristics of an offset gregorian antenna in order to design the satellite-loaded antenna. In order to compute the radiation pattern of the sub-reflector, the reflected wave is obtained by GO(Geometric Optics) at an arbitrary shaped sub-reflector. Then the total radiation EM wave is obtained by summing the diffracted fields obtained by UTD(Uniform Geometrical Theory of Diffraction) and the GO fields. In order to calculate the far field radiation pattern of the main reflector, the radiation integral equation is derived from the induced current density on reflector surface using PO(Physical Optics). The kernel is expanded in terms of Jacobi-Bessel series for increasing the computational efficiency, then the modified radiation integral is represented as the double integral equation independent of observation points. When the incident fields are assumed to be x-or y-polarized field, the characteristics of radiation patterns in the gregorian antenna is analyzed in case of the main reflector having the focal length of 62.4$\lambda$, diameter of 100$\lambda$, and offset height of 75$\lambda$, and the sub-reflector having the eccentricity of 0.501, the inter focal length og 32.8$\lambda$, the horn axis angle of $9^{\circ}$ and the half aperture angle of $15.89^{\circ}$. The cross-polarized level and side lobe level in the offset geogorian reflector are reduced by 30dB and 10dB, respectively, in comparison with those of the offset parabolic antenna.