• Proceedings of the PSK Conference
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• 2003.10b
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• pp.173.2-173.2
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• 2003

Vanilloid receptor I (VR1) is a nonselective cation ion channel placed in the plasma membrane of peripheral sensory neurons that is potential target for analgesia A series of N-4-substituted-benzyl-N'-tert-butylbenzyl thioureas were prepared for the study of their agonistic/antagonistic activities to the vanilloid receptor in rat DRG. Their structure-activity relationship in reveals that not only the two oxygens and amide hydrogen of sulfonamido group but also the optimal size of methyl in methanesulfonamido group play an integral role for the antagonistic activity on vanilloid receptor.

• 한국약용작물학회:학술대회논문집
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• 2007.05a
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• pp.280-281
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• 2007

• Journal of the Society of Cosmetic Scientists of Korea
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• v.22 no.2
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• pp.9-19
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• 1996

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.355.1-355.1
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• 2002

Recently. we have reported that several lipoxygenases products directly activate the capsaicin-activated channel as intracellular messengers in neuron. In particular, 12-(S)-hydroperoxyeicosatetraenoic acid turned out to be the most potent endogenous VR activator. This finding prompted us to search for a novel non-vaniloid VR agonists and antagonists. We have designed and synthesized a series of non-vanilloid VR binding ligands based on the structural simllarity between 12-HPETE and capsaicin, the natural VR agonist. Our recent studies on the development of selective vanilloid receptor agonists and antagonists will be presented.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.251.1-251.1
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• 2002

Capsaicin and analogues are valuable analgesic agents when administered to mammals. including humans. However. their pungency. hypothermia and the effects on the cardiovascular and respiratory systems through their general activation of primary afferents severely limit their use. So competitive antagonists have been pursued as a novel pharmacological agent for analgesics. rather than agonists. We have identified a new class of potent and selective vanilloid receptor (VR) antagonists. (omitted)

• Bulletin of the Korean Chemical Society
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• v.32 no.12
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• pp.4411-4414
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• 2011

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.350.1-350.1
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• 2002

A series of diaralkylthiourea derivatives was prepared and tested for its antagonistic activity against vanilloid receptor. In this study we explored the possibility of selected compound type (Ⅰ) with tetrahydronaphthyl group as rigid pendant moiety. Our premise for antagonistic activity of molecules was modeled on the capsazepine. the first antagonist for vanilloid receptor. These compounds (Ⅰ) showed less potent antagonistic activity than that of capsazepine. but they were devoid of agonistic activity. (omitted)

• Ocean and Polar Research
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• v.34 no.1
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• pp.29-35
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• 2012

We investigated the interannual relationship between chlorophyll concentrations in the western North Pacific and tropical cyclones (TCs) in the western North Pacific by analyzing data collected for >12 years. Despite the short-term scale (2~3 weeks) in the contribution of tropical cyclones to phytoplankton, the current study revealed that the long-term chlorophyll variability in the western North Pacific is profoundly related to long-term variability in the frequency of TCs. It was also found that the Pacific decadal oscillation (PDO) tends to control such relationships between the 2 bio-physical systems. This result suggests a significant climatic relationship between TC activity and marine phytoplankton, and also suggests the possibility of more accurate estimations of primary production in the western North Pacific.

• Proceedings of the PSK Conference
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• 2001.10a
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• pp.266.1-266.1
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• 2001

• Proceedings of the PSK Conference
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• 2005.04a
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• pp.67-68
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• 2005