Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
- /
- Pages.251.1-251.1
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- 2002
Pharmacology of novel vanilloid receptor antagonists
- Park, Jin-Kyu (Drug Discovery, AmorePacific Corporation R＆D Center) ;
- Yi, Jung-Bum (Drug Discovery, AmorePacific Corporation R＆D Center) ;
- Koh, Hyun-Ju (Drug Discovery, AmorePacific Corporation R＆D Center) ;
-
Jeong, Yeon-Su
(Drug Discovery, AmorePacific Corporation R＆D Center)
;
- Lim, Kyung-Min (Drug Discovery, AmorePacific Corporation R＆D Center) ;
- Moh, Joo-Hyun (Drug Discovery, AmorePacific Corporation R＆D Center) ;
-
Suh, Young-Ger
(College of Pharmacy, Seoul National University)
;
- Oh, Uh-Taek (College of Pharmacy, Seoul National University) ;
- Kim, Hee-Doo (College of Pharmacy, Sookmyung Women′s University) ;
- Park, Hyeung-Geun (College of Pharmacy, Seoul National University) ;
- Park, Young-Ho (Drug Discovery, AmorePacific Corporation R&D Center)
- Published : 2002.10.01
Abstract
Capsaicin and analogues are valuable analgesic agents when administered to mammals. including humans. However. their pungency. hypothermia and the effects on the cardiovascular and respiratory systems through their general activation of primary afferents severely limit their use. So competitive antagonists have been pursued as a novel pharmacological agent for analgesics. rather than agonists. We have identified a new class of potent and selective vanilloid receptor (VR) antagonists. (omitted)
Keywords