• Electronics and Telecommunications Trends
• /
• v.31 no.3
• /
• pp.1-8
• /
• 2016

최근 개인화된 미디어의 출현과 더불어 방송통신 미디어 분야에서 개인별 맞춤형 방송 서비스에 대한 관심과 지원이 빠르게 확산되는 추세다. 특히, 다중 카메라를 이용한 관심 인물에 대한 다각도 영상과 같은 차별화된 영상을 제공하려는 수요가 꾸준히 증가하고 있다. 객체 중심의 영상을 생성하기 위한 관련 기술의 발전 및 수요 변화에 발맞춰 본고에서는 관련 기술의 개요 및 연구동향을 살펴보고, ETRI에서 개발 중인 객체 추적 기반의 다중 Pan-Tilt-Zoom(PTZ) 카메라 제어를 통한 객체 중심 다각도 영상 획득 기술을 소개하고자 한다.

• Proceedings of the IEEK Conference
• /
• 2006.06a
• /
• pp.883-884
• /
• 2006

In this paper, we propose the real-time system that detects and recognizes the human face by PTZ camara. Generally, Face detection algorithms are disturbed by variable illuminations in a image. To avoid those, we use the robust adaboost algorithm for face detection. For recognition, we use PCA algorithm. we focus on the real-time system. It will be necessary in many applications.

• Archives of Pharmacal Research
• /
• v.19 no.3
• /
• pp.248-250
• /
• 1996

In conclusion, a series of N-Cbz-.alpha.-amono-glutarimides (1a-f), combining common structures such as N-CO-C-N and cyclic imide in a single molecule, were prepared from the (R)- or (S)-N-Cbz-glutamic acid and evaluated for their anticonvulsant activities in MES and PTZ tests in order to develope new and broad spectrum anticonvulsant. In this study, N-Cbz-.alpha.-aminoglutarimides (1) except ac and af, showed significant anticonvulsant activity in both MES and PTZ tests enough to be recommended as promising new anticonvulsant drug candidates. Now we are continuing to investigate further anticonvulsant test (quantification)for these compounds and synthesize their analogues in order to develop more active anticonvulsant and define the structure activity relationship more precisely.

• BMB Reports
• /
• v.53 no.9
• /
• pp.484-489
• /
• 2020

Epilepsy is a neurological disorder characterized by unpredictable seizures, which are bursts of electrical activity that temporarily affect the brain. Cereblon (CRBN), a DCAFs (DDB1 and CUL4-associated factors), is a well-established protein associated with human mental retardation. Being a substrate receptor of the cullin-RING E3 ubiquitin ligase (CRL) 4 complex, CRBN mediates ubiquitination of several substrates and conducts multiple biological processes. In the central nervous system, the large-conductance Ca²⁺-activated K⁺ (BK_Ca) channel, which is the substrate of CRBN, is an important regulator of epilepsy. Despite the functional role and importance of CRBN in the brain, direct injection of pentylenetetrazole (PTZ) to induce seizures in CRBN knock-out mice has not been challenged. In this study, we investigated the effect of PTZ in CRBN knock-out mice. Here, we demonstrate that, compared with WT mice, CRBN knock-out mice do not show the intensification of seizures by PTZ induction. Moreover, electroencephalography recordings were also performed in the brains of both WT and CRBN knockout mice to identify the absence of significant differences in the pattern of seizure activities. Consistently, immunoblot analysis for validating the protein level of the CRL4 complex containing CRBN (CRL4^Crbn) in the mouse brain was carried out. Taken together, we found that the deficiency of CRBN does not affect PTZ-induced seizure.

• Archives of Pharmacal Research
• /
• v.20 no.1
• /
• pp.53-57
• /
• 1997

For the purpose of defining the effects of the N-substituted alkyl groups on the anticonvulsant activities of N-Cbz-.alpha.-aminosuccinimides, various (R)- and (S)-N-alkyl substituted N-Cbz-.alpha.-aminosuccinimides (1 and 2) were prepared from the corresponding (R)- and (S)-N-Cbz-aspartic acid by using known reaction and were evaluated the anticonvulsant activies in the MES and PTZ tests, including their neurotoxicities. The most active compound in the MES test was (R)N-Cbz-.alpha.-amino-N-methylsuccinimide (1b) $(ED_{50}=52.5 mg/kg, Pl=3.2)$. And in case of the PTZ test, (R)-N-Cbz-.alpha.-amino-N-ethylsuccinimide (1c) was the most active compound $(ED_{50}/=32.5mg/kg, Pl=3.1)$. The order of anticonvulsant activities of these compounds against the MES test, as judged from the ED_50values for the R series (1), was N-methyl > N-isobutyl > non-substituted > N-ethyl, N-allyl > N-benzyl compound; for the S series (2) N-methyl > N-altyl > non-substituted > N-isobutyl > N-ethyl > N-benzyl compound. The anticonvulsant activities in the PTZ tests of these compounds exhibited somewhat different pattern ; for the R series (1) Nethyl > N-methyl > N-isobutyl> non-substituted > N-allyl > N-benzyl compound in order of decreasing activity; for S series (2) N-ethyl > N-allyl, non-substituted > N-isobutyl > N-methyl > N-benzyl compound in order of decreasing activity.

• Archives of Pharmacal Research
• /
• v.29 no.12
• /
• pp.1080-1085
• /
• 2006

A series of 8-alkoxy-4,5-dihydro-[1,2,4]triazole[4,3-a]quinoline-1-one derivatives were synthesized using 7-hydroxy-3,4-dihydro-2(1H)-quinolone as the starting material. Their anticonvulsant activities were evaluated by the maximal electroshock test (MES) and the subcutaneous pentylenetetrazole test (sc-PTZ), and their neurotoxicities were measured by the rotarod neurotoxicity test (Tox). The tests demonstrated that 8-hexyloxy-4,5-dihydro-[1.2.4]triazole[4.3-a]quinoline-1-one (4e) and 8-heptyloxy-4,5-dihydro-[1,2,4]triazole[4, 3-a]quinoline-1-one (4f) were the most potent anticonvulsants, with 4e having $ED_{50}$ values of 17.17 mg/kg and 24.55 mg/kg and protective index ($PI=TD_{50}/ED_{50}$) values of 41.9 and 29.3 in the MES and sc-PTZ tests, respectively, and 4f having $ED_{50}$ values of 19.7 mg/kg and 21.2 mg/kg and PI values of 36.5 and 33.9 in the MES and sc-PTZ tests, respectively. The PI values of 4e and 4f were many fold better than that of the marketed drugs phenytoin, carbamazepine, phenobarbital and valproate, which have PI values in the range of 1.6-8.1 in the MES test and <0.22-5.2 in the sc-PTZ test. Structure-activity relationships were also discussed.

• Archives of Pharmacal Research
• /
• v.22 no.5
• /
• pp.491-495
• /
• 1999

In order to examine the effects of N-substituted alkyl group on the anticonvulsant activities of N-Cbz-$\alpha$-aminoglutarimides as novel anticonvulsants with broad spectrum, a series of (R) or (S) N-Cbz-$\alpha$-amino-N-alkylglutarimides (1 and 2) were prepared from the corresponding (R) or (S) N-Cbz-glutamic acid and evaluated for the anticonvulsant activities in the maximal electroshock seizure (MES) test and pentylenetetrazol induced seizure(PTZ) test, including the neurotoxicity. The most potent compound in the MES test was (S) N-Cbz-$\alpha$-amino-N-methylglutarimide($ED_{50}$=36.3 mg/kg, PI=1.7). This compound was also most potent in the PTZ test ($ED_{50}$=12.5 mg/kg, PI=5.0). The order of anticonvulsant activities against the MES test as evaluated form $ED_{50}$ values for (R) series was N-methyl > N-H > N-ethyl > N-allyl ; for the (S) series N-methyl > N-H > N-ethyl > N-alkyl > N-isobutyl compound. Against the PTZ tests, the order of anticonvulsant activities showed similar pattern ; for the (R) series, N-methyl > N-H > N-ethyl > N-allyl ; for the (S) series N-methyl > N-H > N-ethyl > N-allyl > N-isobutyl compound. From the above results, N-substituted alkyl groups were though to play an important role for the anticonvulsant activities of N-Cbz-$\alpha$-amino-N-alkylgutarimides.

• Journal of Digital Convergence
• /
• v.14 no.11
• /
• pp.143-148
• /
• 2016

There is increasing concern about security as a need for increased safety in the information industry society. However, it does not meet the needs for safety including CCTV. Therefore, in this paper, we link the processing technology using the image information to the IPS system consisting of GPS and Beacon. It designed a conventional RFID tag attached discomfort and image tracking system is limited to complement the disadvantages identifiable area. To this end, we designed a smart device and the Internet of Things convergence system and a research to ensure the accuracy and reliability of the IPS of the access control system. Finally, by leveraging intelligent video information using a PTZ camera, and set the entrant management policies it was carried out to control the situation and control. Also, by designing the integrated video tracking system, an authentication server, visualization systems were designed to establish an efficient technique for analyzing the IPS entrant behavior patterns.

• Journal of Digital Convergence
• /
• v.11 no.10
• /
• pp.359-366
• /
• 2013

Due to the development and market expansion of image analysis and recognition technology, video security such as CCTV cameras and digital storage devices, are required for real-time monitoring systems and intelligent video security systems. This includes the development of more advanced technologies. A rotatable PTZ camera, in a CCTV camera system, has a zoom function so you can acquire a precise picture. However it can cause blind spots, and can not monitor two or more moving objects at the same time. This study concerns, the intelligent tracking of multiple moving objects, CCTV systems, and methods of video surveillance. An intelligent video surveillance system is proposed. It can accurately shoot broad areas and track multiple objects at the same time, much more effectively than using one fixed camera for an entire area or two or more PTZ cameras.

• Journal of Pharmacopuncture
• /
• v.26 no.4
• /
• pp.327-337
• /
• 2023

Objectives: Epilepsy is a neurological condition characterized by repeated seizures attributable to synchronous neuronal activity in the brain. The study evaluated the effect of acetone extract of Adansonia digitata stem bark (ASBE) on seizure score, cognition, depression, and neurodegeneration as well as the level of Gamma-Aminobutyrate acid (GABA) and glutamate in Pentylenetetrazol-kindled rats. Methods: Thirty-five rats were assigned into five groups (n = 7). Groups 1-2 received normal saline and 35 mg/kg PTZ every other day. Groups 3-4 received 125 mg/kg and 250 mg/kg ASBE orally while group 5 received 5 mg/kg diazepam daily for twenty-six days. Group 3-5 received PTZ every other day, 30 mins after ASBE and diazepam. Results: The results showed that Pentylenetetrazol (PTZ) induces seizure, reduces mobility time in force swim test and decreases the normal cell number in the brain. It also significantly decreases (p < 0.05) catalase, superoxide dismutase and reduced glutathione activities compared to the ASBE pre-treated rats. Pre-treatment with ASBE reportedly decreases seizure activities significantly (p < 0.05) and increases mobility time in the force swim test. ASBE also significantly elevate (p < 0.05) the normal cell number in the hippocampus, temporal lobe, and dentate gyrus. Conclusion: ASBE reduced seizure activity and prevented depression in PTZ-treated rats. It also prevented neurodegeneration by regulating glutamate and GABA levels in the brain as well as preventing lipid peroxidation.