• Title/Summary/Keyword: PTC

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MicroRNAs and Lymph Node Metastasis in Papillary Thyroid Cancers

  • Mutalib, Nurul-Syakima Ab;Yusof, Azliana Mohamad;Mokhtar, Norfilza Mohd;Harun, Roslan;Muhammad, Rohaizak;Jamal, Rahman
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.1
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    • pp.25-35
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    • 2016
  • Lymph node metastasis (LNM) in papillary thyroid cancer (PTC) has been shown to be associated with increased risk of locoregional recurrence, poor prognosis and decreased survival, especially in older patients. Hence, there is a need for a reliable biomarker for the prediction of LNM in this cancer. MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene translation or degradation and play key roles in numerous cellular functions including cell-cycle regulation, differentiation, apoptosis, invasion and migration. Various studies have demonstrated deregulation of miRNA levels in many diseases including cancers. While a large number of miRNAs have been identified from PTCs using various means, association of miRNAs with LNM in such cases is still controversial. Furthermore, studies linking most of the identified miRNAs to the mechanism of LNM have not been well documented. The aim of this review is to update readers on the current knowledge of miRNAs in relation to LNM in PTC.

Effect of Reduction-Reoxidation Firing on PTCR Properties of Sm-doped Barium Titanate Ceramics (Sm이 첨가된 티탄산바륨의 PTCR 특성에 대한 환원-재산화의 영향)

  • Chun, Myoung-Pyo;Myoung, Seong-Jae;Han, Ik-Hyun
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2005.11a
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    • pp.35-38
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    • 2005
  • The effect of reduction and re-oxidation firing on the PTCR properties of Sm-doped Barium Titanate ceramics was investigated for the application of multilayered PTC thermistor. The lattice parameter a, c decreases monotonically with increasing oxygen concentration in the reoxidation atmosphere, which seems to be related with the electrostatic Coulomb interaction between oxygen vancancy and nearest other atoms. With increasing oxygen concentration, the resistivity at room temperature and the magnitude of resistivity jump as a function of temperature increased in the region of oxygen concentration of 0 $\sim$ 10%. However, the resistivity at room temperature and the magnitude of resistivity jump is nearly constant and saturated in the region of oxygen concentration of 10 $\sim$ 20%. These phenomena is considered to be related with the variation of oxygen and barium-vancany concentration near the grain boundary.

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Metastatic Papillary Thyroid Carcinoma Masquerading as Type II Branchial Cleft Cyst : A Case Report (제2형 새열 낭종으로 오인된 전이성 갑상선 유두상 암종 1예)

  • Kim, Seung-Woo;Kim, Jung-Min;Kim, Choon-Dong
    • Korean Journal of Head & Neck Oncology
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    • v.28 no.1
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    • pp.34-36
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    • 2012
  • In case of lateral cervical cystic lesions, the differential diagnoses include branchial cleft cyst(BCC), teratoma, dermoid, hemangioma and lymphangioma etc. But sometimes metastatic cystic lymph nodes may exist in lateral neck. In such circumstance, the primary lesions are known to stem from oropharynx, nasopharynx, salivary and thyroid gland etc. A-66-year-old-male came to our clinic, due to the lateral cervical mass for 5 years. We performed the neck CT, sonography and sono-guided FNAC. He was initially diagnosed with the benign cyst such as BCC. We performed the excisional biopsy on left level II, but the pathologic report was revealed as metastatic papillary thyroid carcinoma(PTC). And then he received the total thyroidectomy with neck dissection. The final diagnosis was cystic metastasis from PTC. We learn a valuable lesson form this case in the following. Even if the simple cervical cyst is presumed with radiology and clinical pattern, more careful considerations on the basis of history and radiologic findings are mandatory.

A study on the piece creation of hull-structure with PC-CADRA (PC-CADRA에서 선체 내부재 피스(piece)생성에 관한 연구)

  • 박제웅;이현상
    • Journal of Ocean Engineering and Technology
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    • v.11 no.3
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    • pp.191-199
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    • 1997
  • This paper develops the piece creation of Hull-structure using PC(Personal Computer) which is from CADRA of graphic program. Large-sized shipbuilding yard was carried out on the development of CNC(Computer Numerical Control) auto cutting system used in super S/W such as AUTODEF, TRIBON. But this system needs lots of expenses and high technician, and only used in large-sized shipbuilding yard, not medium-sized and small-sized shipbuilding yard. To bring up the small and medium-sized ship building yard lacking a little competitive power. Small and medium-sized shipbuilding yard need the piece creation of Hull Structure S/W which is joined with the CADRA. Therefore the piece creation of Hull-Structure S/W is developed to joined with the CADRA of graphic S/W to create the piece to be needed on as auto cutting process using PC.

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Conjugate Heat Transfer for Circular Absorber in Parabolic Trough Concentrator (PTC형 집열기의 원관형 흡수기에서의 복합열전달)

  • Chung, J.M.;Seo, T.B.;Kang, Y.H.
    • Solar Energy
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    • v.20 no.1
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    • pp.81-89
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    • 2000
  • In the present study, the characteristics of conductive and convective heat transfer occurred in a circular absorber of PTC (parabolic trough concentrator) for medium temperature solar energy utility were numerically investigated. A circular tube was considered as an absorber and the shape of PTC modeled in this study was based on the system that was installed in Korea Institute of Energy Research. Not only convection inside the tube but also conduction through the wall of the tube were analyzed, simultaneously. Circumferentially non-uniform heat flux that was simulated from the non-uniform solar disc model proposed by Jose was applied as thermal boundary condition on the tube surface. And, hydrodynamically fully developed laminar velocity profile was used as the inlet boundary condition and it was assumed that the working fluid was water. And, local heat fluxes at the interface of the tube and the working fluid were calculated for different wall thickness and thermal conductivity of the tube at various Reynolds number. Based on the results, the effects of thermal conduction of the tube on the local heat transfer were investigated.

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Simulation and Model Validation of a Parabolic Trough Solar Collector for Water Heating

  • Euh, Seung-Hee;Kim, Dae Hyun
    • Journal of the Korean Solar Energy Society
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    • v.33 no.3
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    • pp.17-26
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    • 2013
  • The aim of this study is to analyze the performance of a parabolic trough solar collector (PTC) for water heating and to validate the model performance. The simulated model was compared, calibrated and verified with the experimental results. RMSE (Root mean square error) was used to calibrate the convective heat transfer coefficient between the absorber pipe and the ambient air which was the main factor affecting the heat transfer associated with the PTC. The calibrated model was better fitted with the experimental model. The maximum, minimum and mean deviation between the measured and predicted water temperatures differed only $0.81^{\circ}C$, $0.09^{\circ}C$ and $0.31^{\circ}C$ respectively in the calibrated model. RMSE values were decreased from 0.5389 to 0.4910, 0.0134 to 0.0125 and R-squared was increased from 0.9955 to 0.9956 after calibration. The temperature of water was increased from $33.7^{\circ}C$ to $48^{\circ}C$ in 12hour test. The thermal efficiency of the collector was calculated to be 55%. The calibrated model showed good agreement with the experimental data for model validation.

A Case of Columnar Cell Variant of Papillary Thyroid Carcinoma (갑상선 유두암 원주세포변형 1예)

  • Choe, Si Hong;Lee, Donghoo;Jung, Soo Jin;Kim, Do Hun
    • Journal of Clinical Otolaryngology Head and Neck Surgery
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    • v.29 no.2
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    • pp.281-285
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    • 2018
  • Columnar cell variant of papillary thyroid carcinoma (CCV-PTC) is a rare variant representing 0.15-0.2% of all PTCs. The CCV is aggressive, due to its rapid growth, high local recurrence rate, and frequent lung, brain and bone metastasis. Aggressive surgical and medical management are recommended for these neoplasias. The authors experienced a case of CCV-PTC in a 45-year-old man. We performed total thyroidectomy with neck dissection. The patient received radiation and radioactive iodine therapy. There were no recurrences or complications in the following 24 months after the operation. The patient will closely undergo continuous follow up. We present the clinical characteristics, pathology, treatment, and prognosis of the tumor with a review of the literature.

Wireless Power Transfer via Magnetic Resonance Coupling (MRC) with Reduced Standby Power Consumption

  • Lee, Byoung-Hee
    • Journal of Power Electronics
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    • v.19 no.3
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    • pp.637-644
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    • 2019
  • Wireless power transfer (WPT) technology with various transfer mechanisms such as inductive coupling, magnetic resonance and capacitive coupling is being widely researched. Until now, power transfer efficiency (PTE) and power transfer capability (PTC) have been the primary concerns for designing and developing WPT systems. Therefore, a lot of studies have been documented to improve PTE and PTC. However, power consumption in the standby mode, also defined as the no-load mode, has been rarely studied. Recently, since the number of WPT products has been gradually increasing, it is necessary to develop techniques for reducing the standby power consumption of WPT systems. This paper investigates the standby power consumption of commercial WPT products. Moreover, a standby power reduction technique for WPT systems via magnetic resonance coupling (MRC) with a parallel resonance type resonator is proposed. To achieve a further standby power reduction, the voltage control of an AC/DC travel adapter is also adopted. The operational principles and characteristics are described and verified with simulation and experimental results. The proposed method greatly reduces the standby power consumption of a WPT system via MRC from 2.03 W to 0.19 W.

Genetic Studies on the Isolated Population in Korean (韓國人 隔離集團의 遺傳學的 硏究)

  • Lee, Chung Choo
    • The Korean Journal of Zoology
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    • v.21 no.1
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    • pp.19-27
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    • 1978
  • This study has been carried out with the object of researching into the situation of the genetic isolation of a Korean population located near Seoul. The results obtained are summarized as follows: In general, the distribution of P.T.C. threshold values in the population is close to that of the Seoul population. But the nonataster frequency of male in the population is higher than that of female, and this is in agreement with the status of ankyloglossia frequency in male. However the relationship between the two traits has not been clarified. The gene frequencies of rolling and folding of tongue are slightly lower than that of the Seoul population. The gene frequency conditioning the ability to twist the tongue is lower in the male than in the female. The color-blindness is 6.21 percent, and it is slightly higher than that of other Korean population. All considered, the studied population might be regarded to have been kept in genetic isolation.

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Ultrasound Imaging in Active Surveillance of Small, Low-Risk Papillary Thyroid Cancer

  • Sangeet Ghai;David P Goldstein;Anna M Sawka
    • Korean Journal of Radiology
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    • v.25 no.8
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    • pp.749-755
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    • 2024
  • The recent surge in the incidence of small papillary thyroid cancers (PTCs) has been linked to the widespread use of ultrasonography, thereby prompting concerns regarding overdiagnosis. Active surveillance (AS) has emerged as a less invasive alternative management strategy for low-risk PTCs, especially for PTCs measuring ≤1 cm in maximal diameter. Recent studies report low disease progression rates of low-risk PTCs ≤1 cm under AS. Ongoing research is currently exploring the feasibility of AS for larger PTCs (<20 mm). AS protocols include meticulous ultrasound assessment, emphasis on standardized techniques, and a multidisciplinary approach; they involve monitoring the nodules for size, growth, potential extrathyroidal extension, proximity to the trachea and recurrent laryngeal nerve, and potential cervical nodal metastases. The criteria for progression, often defined as an increase in the maximum diameter of the PTC, warrant a review of precision and ongoing examinations. Challenges exist regarding the reliability of volume measurements for defining PTC disease progression. Although ultrasonography plays a pivotal role, challenges in assessing progression and minor extrathyroidal extension underscore the importance of a multidisciplinary approach in disease management. This comprehensive overview highlights the evolving landscape of AS for PTCs, emphasizing the need for standardized protocols, meticulous assessments, and ongoing research to inform decision-making.