• Korean Journal of Fisheries and Aquatic Sciences
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• v.29 no.6
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• pp.893-899
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• 1996

The studies on the detoxification of paralytic shellfish poison (PSP)-infested blue mussels, Mytilus edulis and oyster, Crassostrea gigas were performed for using of available processing resource. Toxic blue mussel and oysters from Nampo in Masan Bay, Hachong in Koje Bay and Woepori in Koje were used for experimental samples. The toxicity of low toxic blue mussel $(A,\;84{\mu}g/100g;\;B,\;166{\mu}g/100g;\;C,\;295{\mu}g/l00g;\;D,\;557{\mu}g/100g)$ and oyster $(740{\mu}g/100g)$ were reduced below the regulation limit of PSP $(80{\mu}g/100g)$ or undetected level by mouse bioassay after boiling at $98^{\circ}C$ for 10 min and retorting at $115^{\circ}C$ for 70 min, while the toxicity of high toxic blue mussel $(E,\;8,760{\mu}g/100g)$ remained beyond the regulation limit after boiling and retorting at same condition. These results suggested that the regulation limit of PSP could be level up from $(80{\mu}g/100g)$ to about $160{\mu}g/100g$.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.38 no.1
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• pp.69-78
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• 2001

This paper presents the design and FPGA implementation of a FLEX PSP(Protocol Signal Processor) for the portable high speed paging system. In this approach, two algorithms are newly proposed for implementing the PSP which provides capabilities of the maximum 6,400bps at speed, high-channel throughput, real time error correction and an effective frame search function. One is an accurate symbol synchronization algorithm which is applied for synchronizing the interleaved 4-level bit symbols which are received at input stage of A/D converter, and the other is a modified fast decoding algorithm which is provided for realizing double error correction of (31,21)BCH signal. The PSP is composed of six functional modules, and each module is modelled in VHDL(VHSIC Hardware Description Language). Both functional simulation and logic synthesis have performed for the proposed PSP through the use of Synopsys$^{TM}$ tools on a Axil-320 Workstation, and where Altera 10K libraries are used for logic synthesis. From logic synthesis, we can see that the number of gates is about 2,631. For FPGA implementation, timing simulation is performed by using Altera MAX+ PLUS II, and its results will be also given. The PSP which is implemented in 6 FPGA devices on a PCB has been verified by means of Logic Analyzer.r.

• Journal of KIISE:Software and Applications
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• v.33 no.11
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• pp.923-935
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• 2006

As the knowledge-based society has been constructed, the size of work process that has to be done grows bigger and the amount of the information that has to be analyzed increases. So each company is trying to construct more conformable process models in business model. In order to support the process construction of companies practically, in this paper tools of Six Sigma is applied to process definition and tools of PSP is applied schedule management. And to use the proposed tools efficiently, the procedure of process definition and schedule management are suggested. The goal of the proposed method is to achieve the process aim within the Time-To-Market by applying the process management of organizations and persons. And the goal of individuals is to improve personal process with the collected data.

• Journal of Chest Surgery
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• v.52 no.2
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• pp.85-90
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• 2019

Background: Variation exists in the initial treatment for the first episode of primary spontaneous pneumothorax (PSP), and no definitive consensus exists due to a lack of high-quality evidence. This study examined the outcomes of needle aspiration and closed thoracostomy in first episodes of PSP requiring intervention. Methods: This study was a randomized, prospective, single-center trial conducted between December 2015 and August 2016. Patients of all ages with a documented first episode of PSP who were unilaterally affected, hemodynamically stable, and had a pneumothorax measuring over 25% in size were included. Patients with underlying lung disease, severe comorbidities, bilateral pneumothorax, tension pneumothorax, recurrent pneumothorax, traumatic pneumothorax, and pregnancy were excluded. Patients were randomly assigned to the needle aspiration or closed thoracostomy group using a random number table. Results: Forty patients with a first episode of PSP were recruited, and 21 and 19 patients were included in the needle aspiration group and the closed thoracostomy group, respectively. The hospital stay of each group was $2.1{\pm}1.8days$ and $5.4{\pm}3.6days$, respectively (p<0.01). However, no significant differences were found in the success rate of initial treatment or the 1-month and 1-year recurrence rates. Conclusion: Needle aspiration is a favorable initial treatment in patients experiencing a first episode of PSP.

• Journal of Chest Surgery
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• v.54 no.1
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• pp.53-58
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• 2021

Background: We aimed to investigate the characteristics of primary spontaneous pneumothorax (PSP) in adolescents and to analyze the relationship between the occurrence of PSP and air pollutants. Methods: Data pertaining to age, sex, body mass index, smoking status, initial pneumothorax volume, presence of bullae, treatment methods, and city of residence were retrospectively obtained from January 2010 to December 2014. We investigated the association between short-term exposure to air pollutants (SO2, NO2, O3, CO, and PM10) and the occurrence of PSP using a case-crossover design with conditional logistic regression. Results: We collected information from 598 patients who were admitted for PSP, with a mean follow-up duration of 62.9 months. The majority (91.1%) of the patients were male. In the case-crossover design, conditional logistic regression showed that no air pollutant was associated with the occurrence of pneumothorax. The results were consistent across all city subgroups (Anyang, Gunpo, Uiwang, and Gwacheon). Conclusion: In our study, the incidence rate of pneumothorax was 153.8 per 100,000 person-years in male adolescents and 16.7 per 100,000 person-years in female adolescents. The case-crossover design showed that PSP in adolescents is unlikely to be related to air pollution.

• Fisheries and Aquatic Sciences
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• v.12 no.3
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• pp.227-235
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• 2009

The marine toxic dinoflagellate Alexandrium catenella has been implicated in numerous paralytic shellfish poisoning (PSP) events in many countries. Due to difficulties in rapidly identifying A. catenella, field-based study of this species has been problematic. The present study developed a TaqMan format A. catenella-specific probe for real-time PCR assay (specific to Korean genotype) based on LSU rDNA sequence information for studying geographic and temporal distribution of the species in surface sediments and water columns of Jinhae Bay, Korea. The field survey from 2007 to 2008 revealed that A. catenella occurred in most seasons at low densities, mostly below 1 cell $mL^{-1}$, and was more abundant in spring (maximum cell density of 2 cells $mL^{-1}$) when shellfish exceed the quarantine toxin level for PSP toxins in Jinhae Bay.

• Journal of Environmental Science International
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• v.18 no.12
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• pp.1331-1338
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• 2009

Marine dinoflagellate Alexandrium minutum producing paralytic shellfish toxins is responsible for paralytic shellfish poisoning (PSP). To investigate its temporal distributions in Chinhae Bay where PSP occurs annually, SYBR Green I based A. minutum-specific real-time PCR probe was developed on the LSU rDNA region. Assay specificity and sensitivity were tested against related species, and its specificity was further confirmed by sequencing of field-derived samples. Ten months field survey in 2008 (a total 100 surface water samples) by using the real-time PCR probe showed that A. minutum was detected at very low densities of 1-4 cells $L^{-1}$ in May and June being spring in Chinhae Bay, Korea.

• Proceedings of the Korean Society of Fisheries Technology Conference
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• 2000.05a
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• pp.198-199
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• 2000

유독 와편모조 Gymnodinium catenatum Graham은 인간과 해양동물에 마비성패독(PSP) 발생의 원인이 되는 신경독을 생산한다. 1976년에 스페인 북서쪽 해안에서 G. catenatum에 의한 PSP 발생이 처음으로 알려졌고(Estrada et al. 1984) 특히 호주와 스페인 등지에서 문제가 되고 있다. 한국에서도 1991년 10월 진해만에서 채집된 저질로부터 처음 휴면포자가 발견되었고, 휴면포자량은 전체 와편모조류 중 0.9~l.7%를 차지하였다(Kim et al., 1996). 1996년 9월에는 영양세포가 7,250 cells/$\ell$로 진해만의 수정리에서 출현하였고, 1997년 5월에는 550 cells/$\ell$로 출현하였다(김과 신, 1997). 이는 Alexandrium속이 주로 봄철에 대량발생을 하여 패류 독화가 문제되는 것에 반해 C. catenatum은 봄, 가을에 출현함으로써 봄철에 이어 가을철에도 패류독화가 문제될 수 있다는 것을 의미한다. 따라서 본 연구에서는 서해안 및 남해안에서 분리된 지역분리주의 PSP 생산성을 검증하고, 지역 개체군의 독조성을 비교하여 지역 독화의 가능성을 예측하고자 한다. (중략)

• Journal of Microbiology and Biotechnology
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• v.21 no.6
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• pp.637-645
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• 2011

Production of recombinant proteins by excretory expression has many advantages over intracellular expression in Escherichia coli. Hyperexpression of a secretory exoglucanase, Exg, of Cellulomonas fimi was previously shown to saturate the SecYEG pathway and result in dramatic cell death of E. coli. In this study, we demonstrated that overexpression of the PspA in the JM101(pM1VegGcexL-pspA) strain enhanced excretion of Exg to 1.65 U/ml using shake-flask cultivation, which was 80% higher than the highest yield previously obtained from the optimized JM101(pM1VegGcexL) strain. A much higher excreted Exg activity of 4.5 U/ml was further achieved with high cell density cultivation using rich media. Furthermore, we showed that the PspA overexpression strain enjoyed an elevated critical value (CV), which was defined as the largest quotient between the intracellular unprocessed precursor and its secreted mature counterpart that was still tolerable by the host cells prior to the onset of cell death, improving from the previously determined CV of 20/80 to the currently achieved CV of 45/55 for Exg. The results suggested that the PspA overexpression strain might tolerate a higher level of precursor Exg making use of the SecYEG pathway for secretion. The reduced lethal effect might be attributable to the overexpressed PspA, which was postulated to be able to reduce membrane depolarization and damage. Our findings introduce a novel strategy of the combined application of metabolic engineering and construct optimization to the attainment of the best possible E. coli producers for secretory/excretory production of recombinant proteins, using Exg as the model protein.

• Journal of Preventive Medicine and Public Health
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• v.21 no.1 s.23
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• pp.163-171
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• 1988

The paralytic shellfish poisoning was occurred among 25 laborers who worked at breaking-up of ships in Pusan for 5 days from March 29 to April 2 of 1956. For the purpose of accurately defining the paralytic shellfish poison(PSP) , the authors carried out mouse bioassay and chemical analysis. The results were summarized as follows: 1. The mean amount of Paralytic shellfish toxin was $1,207.8{\mu}g$ Per 100gm meat, and the mean death time of mouse was 5 minutes 16 second. 2. The properties of the PSP were mainly gonyautoxin group by chemical analysis(TLC, IR, $^{1}H-NMR$).