• Korean Chemical Engineering Research
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• v.46 no.4
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• pp.792-798
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• 2008

Supply chain management (SCM) has been drawn increasing attention in industries and academia. The attention is mainly due to a need to integrate the multiple activities in a process network from the overall perspective under the constantly varying economic environment. While many researchers have been addressing various issues of SCM, there is not much research explicitly handling the overall dynamics of supply chain entities from PSE literature. In this two-part series paper, it is investigated how the overall supply chain processing times vary in response to the variation of individual entities using Monte Carlo simulation. Instead of figuring out the operation levels of individual entities, the overall operation time called TAT(Turn-Around-Time) is proposed as a performance indicator. An example of 7 entity-supply chain is presented to illustrate the proposed methodology.

• Annual Conference of KIPS
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• 2004.05a
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• pp.883-886
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• 2004

그리드 환경을 이용한 분산된 자원의 활용은 현재 많은 분야에서 활용되고 있으며 그 연구가 활발히 진행되고 있다. 그러나 자신의 분야에 관련된 PSE나 그리드용 어플리케이션이 개발되지 않으면 유저의 입장에서는 그리드 환경을 접하는 것이 어려워진다. 본 논문에서는 다양한 분야의 사용자들이 워크플로우를 직접 디자인하여 그리드의 분산된 환경을 통한 병렬처리가 가능하도록 그래픽 인터페이스를 제공하는 워크플로우 에디터의 구현에 관한 전반적인 내용을 기술하였다. 에디터의 구체적인 기능들을 살펴보며 유저에게 제공되어야 하는 기능들이 무엇인지 고찰해 본다.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.13 no.4
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• pp.99-107
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• 2003

In this paper we propose an international cross certification model using cross certificate. We propose a new model by analyzing and solving current problems of the National PKI. We recommend a certificate profile, design a directory schema, and propose a method to access PSE(personal security environment) using PKCS＃11, which gives the expansibility and convenience. Finally, we propose a certificate path verification method using RFC 3280 and show how to get the certificate chain by using the trust anchor. This model is recommended to the detailed level of specification for the interoperability of each country's PKI.

• International Journal of Computer Science & Network Security
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• v.24 no.9
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• pp.150-156
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• 2024

With the advent of personalized search engines, a myriad of approaches came into practice. With social media emergence the personalization was extended to different level. The main reason for this preference of personalized engine over traditional search was need of accurate and precise results. Due to paucity of time and patience users didn't want to surf several pages to find the result that suits them most. Personalized search engines could solve this problem effectively by understanding user through profiles and histories and thus diminishing uncertainty and ambiguity. But since several layers of personalization were added to basic search, the response time and resource requirement (for profile storage) increased manifold. So it's time to focus on optimizing the layered architectures of personalization. The paper presents a layout of the multi agent based personalized search engine that works on histories and profiles. Further to store the huge amount of data, distributed database is used at its core, so high availability, scaling, and geographic distribution are built in and easy to use. Initially results are retrieved using traditional search engine, after applying layer of personalization the results are provided to user. MongoDB is used to store profiles in flexible form thus improving the performance of the engine. Further Weighted Sum model is used to rank the pages in personalization layer.

• Asian-Australasian Journal of Animal Sciences
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• v.30 no.6
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• pp.857-864
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• 2017

Objective: The purpose of this study was to investigate the influence of AMP-activated protein kinase (AMPK) activation on protein acetylation and glycolysis in postmortem muscle to better understand the mechanism by which AMPK regulates postmortem glycolysis and meat quality. Methods: A total of 32 mice were randomly assigned to four groups and intraperitoneally injected with 5-Aminoimidazole-4-carboxamide1-${\beta}$-D-ribofuranoside (AICAR, a specific activator of AMPK), AICAR and histone acetyltransferase inhibitor II, or AICAR, Trichostatin A (TSA, an inhibitor of histone deacetylase I and II) and Nicotinamide (NAM, an inhibitor of the Sirt family deacetylases). After mice were euthanized, the Longissimus dorsi muscle was collected at 0 h, 45 min, and 24 h postmortem. AMPK activity, protein acetylation and glycolysis in postmortem muscle were measured. Results: Activation of AMPK by AICAR significantly increased glycolysis in postmortem muscle. At the same time, it increased the total acetylated proteins in muscle 45 min postmortem. Inhibition of protein acetylation by histone acetyltransferase inhibitors reduced AMPK activation induced increase in the total acetylated proteins and glycolytic rate in muscle early postmortem, while histone deacetylase inhibitors further promoted protein acetylation and glycolysis. Several bands of proteins were detected to be differentially acetylated in muscle with different glycolytic rates. Conclusion: Protein acetylation plays an important regulatory role in postmortem glycolysis. As AMPK mediates the effects of pre-slaughter stress on postmortem glycolysis, protein acetylation is likely a mechanism by which antemortem stress influenced postmortem metabolism and meat quality though the exact mechanism is to be elucidated.

• Journal of Life Science
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• v.14 no.3
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• pp.467-471
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• 2004

Bacillus sp. SD-10 was investigated to develope biological pesticides for control of mushroom diseases. Bacillus sp. SD-10 showed high antifungal activity when cultured at 35∼4$0^{\circ}C$ for 30∼4$0^{\circ}C$. The culture filtrate of the bacterium inhibited the growth of mycelium of T. virens which is a kind of mushroom pathogene. On the test of inhibition of spore germination of T. virens, more than 5% of the culture filtrate in the media inhibited completely the germination of the spores. An antimicrobial substance, UPX-1 was purified from the culture filtrate of the Bacillus. From the $^1H$-NMR and $^{13}C$-NMR spectrum analysis, the substance was indentifed as disaccharide composed to six carbon sugars. UPX-1 has not only strong antifungal activity against T. virens but also antibacterial activity against Pseudomonas tolaassi.

• Journal of Microbiology and Biotechnology
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• v.20 no.6
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• pp.1042-1052
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• 2010

Forty-seven Salmonella Typhimurium (33 zoonotic, 14 clinical) strains were tested for antimicrobial resistance using the standard disk diffusion method. The presence of relevant resistance genes and class 1 integrons were investigated by using PCR. Pulsed-field gel electrophoresis (PFGE) and plasmid profiling were carried out to determine the genomic diversity of Salmonella Typhimurium. Approximately 57.4% of the S. Typhimurium strains were multidrug resistant (MDR) and showed high resistance rates to tetracycline (70.2%), sulfonamides (57.4%), streptomycin (53.1%), ampicillin (29.7%), nalidixic acid (27.6%), kanamycin (23.4%), chloramphenicol (21.2%), and trimethoprim (19.1%). Resistance towards cephalosporins was noted for cephalothin (27.6%), cephradine (21.2%), amoxicillin clavulanic acid (17.0%), and cephalexin (17.0%). Resistance genes, $bla_{TEM}$, strA, aadA, sul1, sul2, tetA, tetB, and tetC, were detected among the drug-resistant strains. Thirtythree strains (70.2%) carried class 1 integrons, which were grouped in 9 different profiles. DNA sequencing identified sat, aadA, pse-1, and dfrA genes in variable regions on class 1 integrons. Thirty-five strains (74.4%) were subtyped to 22 different plasmid profiles, each with 1-6 plasmids (2.0 to 95 kb). PFGE subtyped the 47 strains into 39 profiles. In conclusion, high rates of multidrug resistance were found among the Malaysian Salmonella Typhimurium strains. The emergence of multidrug-resistant Salmonella Typhimurium to cephalosporin antibiotics was also observed. The strains were very diverse and no persistent clone was observed. The emergence of MDR Salmonella Typhimurium is a worldwide problem, and this report provides information for the better understanding of the prevalence and epidemiology of MDR S. Typhimurium in Malaysia.

• Journal of Microbiology and Biotechnology
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• v.28 no.9
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• pp.1563-1572
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• 2018

Gold nanoparticles (AuNP) and their conjugates have been gaining a great deal of recognition in the medical field. Meanwhile, extended-spectrum ${\beta}$-lactamases (ESBL)-producing bacteria are also demonstrating a challenging problem for health care. The aim of this study was the biosynthesis of AuNP using Rosa damascenes petal extract and conjugation of ceftriaxone antibiotic (Cef-AuNP) in inhibiting ESBL-producing bacteria and study of in vitro anticancer activity. Characterization of the synthesized AuNP and Cef-AuNP was studied. ESBL-producing strains, Acinetobacter baumannii ACI1 and Pseudomonas aeruginosa PSE4 were used for testing the efficacy of Cef-AuNP. The cells of MCF-7 breast cancer were treated with previous AuNP and Cef-AuNP at different time intervals. Cytotoxicity effects of apoptosis and its molecular mechanism were evaluated. Ultraviolet-visible spectroscopy and Fourier transform infrared spectroscopy established the formation of AuNP and Cef-AuNP. Transmission electron microscope demonstrated that the formed nanoparticles were of different shapes with sizes of 15~35 nm and conjugation was established by a slight increase in size. Minimum inhibitory concentration (MIC) values of Cef-AuNP against tested strains were obtained as 3.6 and $4{\mu}g/ml$, respectively. Cef-AuNP demonstrated a decrease in the MIC of ceftriaxone down to more than 27 folds on the studied strains. The biosynthesized AuNP displayed apoptotic and time-dependent cytotoxic effects in the cells of MCF-7 at a concentration of $0.1{\mu}g/ml$ medium. The Cef-AuNP have low significant effects on MCF-7 cells. These results enhance the conjugating utility in old unresponsive ceftriaxone with AuNP to restore its efficiency against otherwise resistant bacterial pathogens. Additionally, AuNP may be used as an alternative chemotherapeutic treatment of MCF-7 cancer cells.

• Journal of the Korean Society of Systems Engineering
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• v.11 no.1
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• pp.81-93
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• 2015

Steam Reforming H2 Generation (SRH2G) System is a chemical process to produce hydrogen through steam reforming of hydrocarbon. Largely speaking, there are two types of materials for the SRH2G: 1) Oil and coal, and 2)Natural Gas such as shale gas. From the perspective of cost, quality (purity), and environmental burden (pollution), the latter is much more desirable than the former. For this reason, research on SRH2G using natural gas is actively carried out, and implemented and operated in the various industry. In this paper, we develop a natural gas based SRH2G system via systems engineering approach. Specifically, we first derived stakeholder requirements, followed by systems requirements and finally system architecture via a tailored SE process for plant (called Plant Systems Engineering (PSE) process) based on ISO/IEC 15288. The developed method was applied to iron and steel plant as a case study. Through the case study, by the SE approach, we were convinced that a successful system satisfying stakeholders' requirements within the given constraints can be developed, verified and validated.

• Korean Journal of Poultry Science
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• v.35 no.2
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• pp.191-196
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• 2008

This study was carried out to investigate the changes in carcass characteristics during slaughter process and to evaluate the physical properties of ostrich muscles. After blooding, pH of carcass was declined rapidly and showed 5.89 of final pH, whilst temperature was slightly decreased during slaughter process. Carcass of ostrich yielded 49.3%. For the comparison between muscles, m. gastrocneminus and m. iliofemoralis externus showed a significantly high pH (P<0.05). The muscle of which pH tended to be high in water holding capacity (WHC), however, m. gastrocneminus showed a significantly low WHC (P<0.05) due to low moisture content. M. obturatorius medialis showed the significantly lower shear force, whilst m. gastrocneminus was higher than other muscles (P<0.05). Therefore the results indicated that the production of high quality carcass was to reduce the time during slaughter process, and that high WHC and tenderness of ostrich meat had a potential application as a substitutional species to other animals.