• Journal of Biomedical Engineering Research
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• v.26 no.1
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• pp.37-42
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• 2005

We construct and test the polarization-sensitive optical coherence tomography (PS-OCT) system for imaging porcine and human articular cartilages. PS-OCT is a new imaging technology that provides information regarding not only the tissue structures but tissue components that show birefringence such as collagen. In this study, we measure the cartilage thickness of the porcine joint and the phase retardation due to collagen birefringence. Also, we demonstrate that changes of the collagen fiber orientation could be detected by the PS-OCT system. Finally, differences between normal and damaged human articular cartilage are observed using the PS-OCT system, which is then compared with the regular histology pictures. As a result, the PS-OCT system is proven to be effective for diagnosis of the pathology related to the cartilage. In the future, this technology may be used for discrimination of the collagen types. When combined with endoscope technologies, the PS-OCT images may become a useful tool for in vivo tissue testing.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.9 no.4
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• pp.861-864
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• 2005

In this paper, we system the system design and numerical analysis of the ultrafast optical delay line using by optical phase modulator. The numerical analysis carried out with 1310nm, lops laser and electro-optic phase modulator. As the results of numerical analysis, we show a scanning rate of 0.5 GHz and a delay range of 19.0ps. Compare with mechanical delay line, the optical delay line has a high scanning speed and a high repetition rate.

• Proceedings of the Optical Society of Korea Conference
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• 2006.02a
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• pp.189-190
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• 2006

• Proceedings of the Optical Society of Korea Conference
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• 2003.07a
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• pp.256-257
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• 2003

Composite materials are widely used in industry because of its high ration of strength vs. weight, and consequently many nondestructive methods have been developing to find stress or subsurface defects like crack, and delamination inside composite material. Among them, optical inspection methods have been widely neglected because of translucent or opaque nature of composite. (omitted)

• Proceedings of the Optical Society of Korea Conference
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• 2003.02a
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• pp.286-287
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• 2003

Polarization-sensitive optical coherence tomography (PS-OCT) was developed to image highly scattering tissues with accounting for polarization effects in the sample. These polarization-sensitive images can provide additional information on the structure of the tissue because of a polarization state of the light is changed at its interaction with biological tissues. The scattering and birefringence are two phenomena, which change the polarization state of light passing through medium. (omitted)

• Korean Journal of Optics and Photonics
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• v.18 no.5
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• pp.367-372
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• 2007

Cervical dysplasia induces morphologic changes in the cervical epithelium which involve changes in the nuclear/cytoplasmic (N/C) ratio. Since the nucleus is one of the significant scattering sources, the N/C ratio change reflects the degree of circular polarization (DOCP) with the depth of signals. Therefore, we used the polarization-sensitive OCT (PS-OCT) technique to measure the polarization changes caused by scattering. Cervical tissues were obtained from a high-grade squamous intraepithelial lesion (H-SIL) of one woman and from low normal women. We obtained the mean of the DOCP as a function of depth in the cervix and quantified the change ratio of the DOCP using slopes that were determined by linear fits in the epithelium layer. We found that DOCP of H-SIL decayed faster than that of normal tissue because of the higher scattering in H-SIL as expected. This result indicates that the PS-OCT system might be useful in measurements of change ratio of DOCP with depth for screening of cervical dysplasia.

• Korean Journal of Optics and Photonics
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• v.31 no.1
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• pp.1-6
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• 2020

The chest wall, an organ directly affected by environmental particles through respiration, consists of ribs, a pleural layer and intercostal muscles. To diagnose early and treat disease in this body part, it is important to visualize the details of the chest wall, but the structure of the pleural layer cannot be seen by chest computed tomography or ultrasound. On the other hand, optical coherence tomography (OCT), with a high spatial resolution, is suited to observe pleural-layer response to talc, one of the fine materials. However, intensity-based OCT is weak in providing information to distinguish the detailed structure of the chest wall, and cannot distinguish the reaction of the pleural layer from the change in the muscle by the talc. Polarization-sensitive OCT (PS-OCT) takes advantage of the fact that specific tissues like muscle, which have optical birefringence, change the backscattered light's polarization state. Moreover, the birefringence of muscle associated with the arrangement of myofilaments indicates the muscle's condition, by measuring retardation change. The PS-OCT image is interpreted from three major perspectives for talc-exposure chest-wall imaging: a thickened pleural layer, a separation between pleural layer and muscle, and a phase-retardation measurement around lesions. In this paper, a rabbit chest wall after talc pleurodesis is investigated by PS-OCT. The PS-OCT images visualize the pleural layer and muscle, respectively, and this system shows different birefringence of normal and damaged lesions. Also, an analyisis based on phase-retardation slope supports results from the PS-OCT image and histology.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• v.9 no.1
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• pp.438-440
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• 2005

광위상변조기를 이용하여 OCT용 초고속 광지연단을 설계하고 수치해석을 수행하였다. 수치해석은 electro-optic 위상 변조기에 1310nm, 10ps의 펄스폭을 갖는 레이저 광원을 적용하여 수행하였다. 수치해석결과로 500MHz의 변조 주파수일때 19ps의 시간 지연을 얻었으며, 이는 기존의 기계적 검출방식(수십kHz)의 OCT장치에 비해 1000배이상 빠른 검출이 가능할 것으로 예상된다.

• Proceedings of the Optical Society of Korea Conference
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• 2003.02a
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• pp.128-129
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• 2003

최근 수년간 polarimetry, Raman spectroscopy, near infrared (NIR) absorption spectroscopy, NIR scattering, optoacoustics 등의 방법을 통하여 비침습적으로 Glucose의 농도를 측정하려는 연구가 많이 시도되었다. 일반적으로 이들 방법은 sensitivity 와 signal-to-noise ratio가 매우 낮고 복잡한 알고리즘이 요구되어져 glucose 농도 측정에 한계가 있음이 드러났다. 본 연구에서는 polarization sensitive optical coherence tomography (PS-OCT)에 사용되는 polarization sensitive low coherence inter-ferometer (PS-LCI) 기법을 이용하여 비침습적으로 glucose의 농도 측정을 가능하게 하는 시스템 개발에 중점을 두었다. (중략)

• Proceedings of the Optical Society of Korea Conference
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• 2009.02a
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• pp.171-172
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• 2009