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http://dx.doi.org/10.3807/KJOP.2020.31.1.001

Polarization-sensitive Optical Coherence Tomography Imaging of Pleural Reaction Caused by Talc in an ex vivo Rabbit Model  

Park, Jung-Eun (Department of Biomedical Engineering and Center for Marine-Integrated Biomedical Technology, Pukyong National University)
Xin, Zhou (Department of Electrical and Computer Engineering, University of British Columbia)
Oak, Chulho (Department of Internal Medicine, Kosin University College of Medicine)
Kim, Sungwon (Department of Otolaryngology-Head and Neck Surgery, Kosin University College of Medicine)
Lee, Haeyoung (Department of Thoracic and Cardiovascular Surgery, Kosin University College of Medicine)
Park, Eun-Kee (Department of Medical Humanities and Social Medicine, Kosin University College of Medicine)
Jung, Minjung (Department of Pathology, Kosin University College of Medicine)
Kwon, Daa Young (Department of Biomedical Engineering and Center for Marine-Integrated Biomedical Technology, Pukyong National University)
Tang, Shuo (Department of Electrical and Computer Engineering, University of British Columbia)
Ahn, Yeh-Chan (Department of Biomedical Engineering and Center for Marine-Integrated Biomedical Technology, Pukyong National University)
Publication Information
Korean Journal of Optics and Photonics / v.31, no.1, 2020 , pp. 1-6 More about this Journal
Abstract
The chest wall, an organ directly affected by environmental particles through respiration, consists of ribs, a pleural layer and intercostal muscles. To diagnose early and treat disease in this body part, it is important to visualize the details of the chest wall, but the structure of the pleural layer cannot be seen by chest computed tomography or ultrasound. On the other hand, optical coherence tomography (OCT), with a high spatial resolution, is suited to observe pleural-layer response to talc, one of the fine materials. However, intensity-based OCT is weak in providing information to distinguish the detailed structure of the chest wall, and cannot distinguish the reaction of the pleural layer from the change in the muscle by the talc. Polarization-sensitive OCT (PS-OCT) takes advantage of the fact that specific tissues like muscle, which have optical birefringence, change the backscattered light's polarization state. Moreover, the birefringence of muscle associated with the arrangement of myofilaments indicates the muscle's condition, by measuring retardation change. The PS-OCT image is interpreted from three major perspectives for talc-exposure chest-wall imaging: a thickened pleural layer, a separation between pleural layer and muscle, and a phase-retardation measurement around lesions. In this paper, a rabbit chest wall after talc pleurodesis is investigated by PS-OCT. The PS-OCT images visualize the pleural layer and muscle, respectively, and this system shows different birefringence of normal and damaged lesions. Also, an analyisis based on phase-retardation slope supports results from the PS-OCT image and histology.
Keywords
Polarization imaging; Optical coherence tomography; Phase retardation; Chest wall; Talc;
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