• Title/Summary/Keyword: PROPYLENE GLYCOL

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Preparation and Skin Permeation of Poloxamer 407 Hydrogel with Extract of Centella $asiatica-{\beta}-Cyclodextrin$ Solid Dispersion System (병풀(Centella asiatica) 엑스-베타시클로덱스트린 고체 분산체를 함유한 폴록사머 407 히드로겔 제조 및 피부투과)

  • Kim, Kyoung-Kook;Kwak, Eun-Sun;Lee, Gye-Won;Park, Jin-Kyu;Park, Mork-Soon;Jee, Ung-Kil
    • Journal of Pharmaceutical Investigation
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    • v.28 no.1
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    • pp.15-23
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    • 1998
  • Extract of Centella asiatica(ECA), which is poorly water-soluble extract from the Centella asiatica is known to express excellent wound healing properties. $ECA-{\beta}-cyclodextrin$ $(asiaticoside-{\beta}-cyclodextrin\;and\;genin-{\beta}-cyc1odextrin)$ solid dispersion system, which was prepared by freezedrying method, was formulated as gels containing poloxamer 407 and propylene glycol, and evaluated with respect to their viscosity, stability, skin permeation and drug amount in the skin of hairless mouse. The average molar ratio $asiaticoside-{\beta}-CD$ and $genin-{\beta}-CD$ was 1:1.7 and 1:22, respectively. When the molar ratio of genin and ${\beta}-CD$ was 1:5, madecassic acid made 100% solid dispersion system and asiatic acid about 65%. In dissolution study, >99% of asiaticoside from $asiaticoside-{\beta}-CD$ was dissolved in 5 minutes, and >99% madecassic acid and >64% asiatic acid from $genin-{\beta}-CD$. The apparent viscosity of poloxamer 407 gels with $ECA-{\beta}-CD$ solid dispersion system increased in proportion to poloxamer 407 and propylene glycol concentration. In the accelerated stability test, all $ECA-{\beta}-CD$ poloxamer 407 gels showed that asiaticoside was most stable and madecassic acid stable and asiatic acid similar to stability of gel with free ECA. The permeation amount of asiaticoside in poloxamer gels through hairless mouse skin decreased as the concentration of poloxamer 407 increased. When propylene glycol was added at the level of 10%, the permeation amount of asiaticoside at poloxamer gels through hairless mouse skin increased but from 15% it decreased. The permeation of asiaticoside into the skin of hairless mouse was estimated to be about $0.10\;{\mu}g/cm^2$.

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A Study on Polyurethane Adhesive Based Polyester Polyol Polymerized from Sebacic Acid (세바식 산으로 중합된 폴리에스터 폴리올을 원료로 사용한 폴리우레탄 접착제에 관한 연구)

  • Jin, Kyung Ho;Kim, Min Su;Cho, Ur Ryong
    • Elastomers and Composites
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    • v.48 no.3
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    • pp.190-194
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    • 2013
  • In this study, sebacic acid made from castor oil was used as monomer with isophthalic acid and glycols for polyester polyol synthesis. Polyurethane adhesive was synthesized from the various polyester polyol. From the result of adhesion strength test, polyester polyol made from sebacic acid showed better adhesive force than that of adipic acid due to higher cohesive energy. Branched glycol containing methyl group represented better adhesion than linear glycol. In the chain extender, adhesion strength increased going from PG, EG, BD. From the measurement of TGA, BD showed the best heat stability, and followed by PG, EG. Glass transition temperature increased in the order PG, EG, BD by the result of DMA.

A Study on Mirror Surface Manufacturing Process for Solar Cell (태양전지용 경면 제조 공정에 대한 연구)

  • 이종권;박지환;송태환;류근걸;이윤배
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.4 no.1
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    • pp.47-49
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    • 2003
  • The cost of material and slicing of silicon wafer occupied more than 30% of solar cell manufacturing cost. The substitution of silicon wafer into STS 304 stainless steel could be the promising solution to decrease the material cost. Moreover the stainless steel solar cell could have the advantage of low weight and durability. However, the highly polished surface is required to meet the characteristic of solar cell. The electropolishing process in phosphoric acid based solution was used to get the surface quality. The obtained result was 28 nm obtained in current density of 2Amfi/$cm^2$ at $80^{\circ}C$. The leveller effect of glycerine, ethylene glycol and propylen glycol was studied. When the 0.4 g/l of ethylene glycol was added to the electrolyte, the surface roughness was best, 15 nm.

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Carrier Dyeing of Polyester Fabrics in Alkaline Dyebath (폴리에스테르직물의 알칼리욕에서의 Carrier염색)

  • 조은자;남성우;김인회
    • Textile Coloration and Finishing
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    • v.13 no.6
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    • pp.381-390
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    • 2001
  • The optimum carrier concentrations were obtained by the maxmium exhaustion ratios of polyester fabrics at 8$0^{\circ}C$ . The optimum concentrations of methylsalicylate, acetophenone, anisole, propiophenone, 2-ethyl hexyl alcohol, ethylene glycol and propylene glycol were $3g/\ell,\;12g/\ell,\;7g/\ell,\;5g/\ell,\;3g/\ell,\;35g/\ell,\;and\;40g/\ell$, respectively Azo, anthraquinone, and quinoline disperse dyes were quite stable up to PH 10.3, but nitro disperse dye were severely hydrolyzed in alkaline dyeing. The tensile strength decreased with increasing dyebath pH because the polyester fabrics were easily decomposed by alkali. The reduction cleaning could be canceled in alkaline dyeing because the carriers were solved by alkali during dyeing.

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Carrier Dyeing of Polyester Fabrics in Alkaline Dyebath (폴리에스테르직물의 알칼리욕에서의 Carrier염색)

  • Jo, Eun Ja;Nam, Seong U;Kim, In Hoe
    • Textile Coloration and Finishing
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    • v.13 no.6
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    • pp.23-23
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    • 2001
  • The optimum carrier concentrations were obtained by the maxmium exhaustion ratios of polyester fabrics at 80℃. The optimum concentrations of methylsalicylate, acetophenone, anisole, propiophenone, 2-ethyl hexyl alcohol, ethylene glycol and propylene glycol were 3g/ℓ, 12g/ℓ, 7g/ℓ, 5g/ℓ, 3g/ℓ, 35g/ℓ, and 40g/ℓ, respectively. Azo, anthraquinone, and quinoline disperse dyes were quite stable up to pH 10.3, but nitro disperse dye were severely hydrolyzed in alkaline dyeing. The tensile strength decreased with increasing dyebath pH because the polyester fabrics were easily decomposed by alkali. The reduction cleaning could be canceled in alkaline dyeing because the carriers were solved by alkali during dyeing.

Solubilization of Ibuprofen in Aqueous Solution (이부프로펜의 가용화)

  • Lee, Jang-Won;Park, Eun-Seok;Chi, Sang-Cheol
    • Journal of Pharmaceutical Investigation
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    • v.27 no.4
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    • pp.279-286
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    • 1997
  • In order to formulate 2% ibuprofen solution, the effects of various solublizing agents, such as cosolvents (propylene glycol, polyethylene glycol, glycerin), a complexing agent $(CELDEX{\circledR}\;CH20)$, surfactants $(Poloxamers\;and\;Cremophor{\circledR}\;RH40)$ on the solubility of ibuprofen in aqueous solution were evaluated. Among them, Poloxamer 407 and $Cremophor{\circledR}$ RH40 showed the excellent capacity on the solubilization of ibuprofen. After 2% ibuprofen solution of choice were administered orally to rats, in reference to a 2% ibuprofen syrup in the market, the pharmacokinetic parameters were determined. The absorption rate of ibuprofen from the solution was higher than that from the suspension.

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Toxicity of Cryoprotectants to Gametophytic Thalli of Red Algae Porphyra yezoensis

  • Choi, Youn-Hee;Nam, Taek-Jeong
    • Fisheries and Aquatic Sciences
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    • v.15 no.1
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    • pp.77-81
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    • 2012
  • We assessed the toxicity of cryoprotectant agents (CPAs) to gametophytic thalli of red alga Porphyra yezoensis at room temperature. The CPAs used were: dimethyl sulfoxide (DMSO), ethylene glycol (EG), glycerol (GC), 1,2-butanediol (1,2-BD), 1,3-butanediol (1,3-BD), 2,3-butanediol (2,3-BD), 1,3-propanediol (1,3-PD) and propylene glycol (PG). CPA concentrations of 10, 15, 20, 25, 30, 35, 40, 45, and 50% were employed with 30 or 60 s immersion. The toxicity of the eight CPAs to gametophytic thalli of P. yezoensis was in the order: 1,3-BD < DMSO ${\approx}$ 2,3-BD ${\approx}$ PG ${\approx}$ EG < GC < 1,3-PD ${\approx}$ 1,2-BD. All thalli were more sensitive to high CPA concentrations, and most (>75%) thalli survived exposure to 10-25% CPA for 60 s. These data will facilitate selection of the optimal cryoprotectant concentration for cryopreservation of P. yezoensis thalli.

Physical and chemical Cross-Linking Effects in Thermoplastic Polyurethane Elastomers with Different Macroglycol

  • Heo, Jae-Ho;Jeong, Du-Gam;Kim, Eun-Young;Kim, Han-Do
    • Proceedings of the Korean Fiber Society Conference
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    • 1997.10a
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    • pp.126-130
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    • 1997
  • A series of Thermoplastic polyurethane elastomers was prepared via a two-step polymerization process. The NCO/OH feed ratio of polyurethane synthesized in this study was varied from 1 to 1.3. Studies have been made on the effects of chemical and physical cross-linkina, and the properties of thermoplastic polyurethane elastomers based on isophorone diisocyanate (IPDI)/1,4-butanediol (BD)/poly(propylene glycol) (PPG, MW:2000), isophorone diisocyanate (IPDI)/BD /poly(oxytetramethylene) glycol (PTMG, MW:2000) was compared. These materials were characterized using FTIR spectrometer, dynamic mechanical thermal analyzer, and tensile retraction tester. PTMG based polyurethane elastomers showed higher elasomeric behavior than PPG based polyurethane elastomers at the same NCO/OH ratio. This feature has been connected with the specific nature of the polyols. The permanent set(%) was decreased with increasing maximum elongation from 50% to 300%.

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Optimum Conditions to Esterify Alginic Acid (알긴산의 적정 에스테르화 조건)

  • HA Jae-Ho;HAWER Woo-derck;SHIN Dong-Hwa
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.20 no.3
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    • pp.202-207
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    • 1987
  • Esterifying conditions to produce propylene glycol alginate (PGA) with alginic acid and propylene oxide were determined, and physico-chemical properties of the PGA were also determined. The rate of esterification increased with the content of propylene oxide up to 4 mole. Alginic acid containing $30\%$ of water shelved maximum esterification, however, it was dificult to remove the surplus moisture in the alginic acid when it cotained the moisture above $70\%$. Maximum esterification was taken place when alginic acid with $44.15\%$ water was reacted with 4mole of propylene oxide at $70^{\circ}C$. The rate of esterification of alginic acid with $50.05\%$ of water increased up to 1 hour at $70^{\circ}C$, followed by no significant increase with reaction time. No significant decrease in the viscosity of $2-3\%$ PGA solution occurred, up to pH 3.0. Pseudoplastic characteristics were kept in case of $1\%,\;2\%\;3\%$ and $5\%$ of PGA solution in the pH of 1.0-5.0.

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생면 품질에 미치는 각종 인산염의 효과

  • 김진성;문주수;이옥환;손종연
    • Proceedings of the Korean Society of Food and Cookery Science Conference
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    • 2003.10a
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    • pp.84-84
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    • 2003
  • 생면제조시 각종 인산염의 효과를 구명하기 위하여 PG(propylene glycol), 폴리인산나트륨, 메타인산나트륨, 피로인산나트륨 등을 단독 또는 복합으로 첨가하여 제면특성 및 저장 중 생기는 이화학적 특성을 비교, 조사하였다. 인산염의 단독 또는 복합 처리에 의한 amylogram 특성은 최고점도의 경우 대조구, PG, polyphosphate, pyrophosphate, metaphosphate, PG+poly., PG+pyro. 및 PG+meta. 첨가구에서 273, 269, 274, 260, 272, 295, 269 RVU이었고 setback 값은 대조구, PG, polyphosphate, pyrophosphate, metaphosphate, PG+poly., PG+pyro. 및 PG+meta. 첨가구에서 104, 97, 92, 99, 99, 95, 102 RVU이었다. (중략)

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