• Journal of Korean Ophthalmic Optics Society
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• v.18 no.2
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• pp.157-163
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• 2013

Purpose: This study was investigated weather watching 2D and 3D images effecting on accommodative function (AF), and differences between changes of AF by 2D and 3D. Methods: 50 subjects (male 30, female 20) aged 20's to 40's years old ($22.9{\pm}3.93$ years) who are available to watching 3D images were participated for this study. Accommodative amplitude (AA) by near point of accommodation (NPA), accommodative response (AR), positive and negative relative accommodation (PRA, NRA), accommodative facility (AF) were measured before, after watching 2D and 3D images at 1 m distance for 30 minutes respectively. Results: Accommodative amplitude after both watching 2D and 3D images decreased comparing to before watching images, and AA after watching 3D images was significantly lower than after watching 2D images. AR after both watching 2D and 3D images increased comparing to before watching images, but there was no difference between 2D and 3D. PRA and NRA were not significantly different between before, after watching 2D and 3D images. Accommodation speed by AF was increased for before watching ($13.52{\pm}3.32$ cpm) following by for after watching 2D images ($14.28{\pm}3.21$ cpm) and for watching 3D images ($14.90{\pm}3.27$ cpm). Conclusions: Watching images at close distance is effect to accommodation functions, and sequence of AA decrease of before watching images following by after watching 2D images and after watching 3D images may effect to asthenopia with same sequence as AA decrease. The results of increase of AF after watching images, specially 3D images show a possibility of vision therapy and further detail VT studies using 3D images are required in the future.

• Nuclear Engineering and Technology
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• v.49 no.2
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• pp.380-386
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• 2017

Fennovoima's nuclear power plant, Hanhikivi 1, $Pyh{\ddot{a}}joki$, Finland, is currently in design phase, and its construction is scheduled to begin in 2018 and electricity production in 2024. The objective of this paper is to produce a preliminary list of safety-significant external event combinations including preliminary probability estimates, to be used in the probabilistic risk assessment of Hanhikivi 1 plant. Starting from the list of relevant single events, the relevant event combinations are identified based on seasonal variation, preconditions related to different events, and dependencies (fundamental and cascade type) between events. Using this method yields 30 relevant event combinations of two events for the Hanhikivi site. The preliminary probability of each combination is evaluated, and event combinations with extremely low probability are excluded from further analysis. Event combinations of three or more events are identified by adding possible events to the remaining combinations of two events. Finally, 10 relevant combinations of two events and three relevant combinations of three events remain. The results shall be considered preliminary and will be updated after evaluating more detailed effects of different events on plant safety.

• The Korean Journal of Physiology
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• v.23 no.1
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• pp.43-49
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• 1989

Effects of atrial natriuretic peptide (ANP) on the development of hypertension in 2-kidney, 1-clip (2-K, 1-C) rats were examined. In one group of rats, ANP infusion (500 ng/hr, iv) started immediately after clipping the renal artery. Another group of rats with one kidney-clipped was without ANP infusion and served as a control. Blood pressure was measured on days 4, 7, and 10 following clipping the renal artery. Upon the last blood pressure measurement finished, blood sample was collected by decapitation to measure plasma renin activity (PRA), and both kidneys were taken to weigh and to measure renin content. The ANP-infused group showed an attenuation of increases in blood pressure compared to the non-infused control group. PRA was lower in the ANP-infused group than in the non-infused group. Cortical renal renin content (RRC) of the clipped kidneys was not different between ANP-infused and non-infused groups. The clipped kidneys showed a higher RRC and weighed less than the non-clipped contralateral kidneys within each group. In contrast, sham-clipped rats did not show significant changes in any of the parameters examined regardless of whether ANP was infused or not. These results demonstrate that chronic ANP infusion does not prevent but does attenuate the development of hypertension in 2-K, 1-C rats. It is suggested that ANP plays a role in the long-term regulation of blood pressure, at least in part, by antagonizing the renin-angiotensin-system.

• Journal of Veterinary Clinics
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• v.21 no.2
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• pp.140-142
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• 2004

Thirty four dogs presented with generalized progressive retinal atrophy(gPRA) from September 2002 to April 2004 were reviewed to characterize signalments and prevalence rate in Korea. Mean age was 6.3$\pm$2.7 years-old and 59% was less than six years old. The most prevalent breed was Miniature Schnauzer (50%) and the affected mean age was slightly earlier (4.4$\pm$1.1 years-old). However, there was no sex predisposition. Cataract was confirmed in 15 dogs (44%) and 67% was bilateral.

• Proceedings of KOSOMES biannual meeting
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• 2002.10a
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• pp.163-175
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• 2002

가상현실 기법(virtual reality technologies)를 해양안전사고 가시화 시스템 개발에 적용하기 위한 개발론에 대해서 기술하였다. ‘목포해심’ 재결서 700여가지 사건에 대한 분류표와 수령화 표를 작성하여 질적 데이터를 양적 데이터로 변환하였다. 개발론에 대한 검토결과, 과거 10년 간의 해양사고 사건사례를 압축하여 저차원 데이터를 획득하기 위해서는 다변량해석기법(multivariate analysis)을 적용해야하고, 위기관리를 종합적으로 수행하기 위해서는 기존에 제시되고 있는 PRA, QRA, SPE 등의 기법 중 적합한 것을 적용할 필요가 있으며, 통계 데이터의 가시화를 위해서는 MATLAB의 Simulink 와 VR Toolkit을 이용하면 가능함을 분석할 수 있었다.

• Journal of Korean Ophthalmic Optics Society
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• v.20 no.2
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• pp.117-124
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• 2015

Purpose: The purpose of this study was to compare the accommodative function of young adult in their 20s wearing monovision, modified monovision, and aspheric multifocal contact lenses at near task. Methods: Thirty young adults ($23.53{\pm}2.37years$) were fitted with monovision, modified monovision (the application of single vision contact lenses and center-near low addition aspheric multifocal contact lenses), and aspheric center-near multifocal contact lenses. After wearing these modalities during a week for adaption, and after watching visual display at computer for inducing accommodative pressure for 1 hour. The following assessments of accommodative function were made: contrast visual acuity (VA) at distance and near; accommodative response; near accommodative facility; and negative relative accommodation (NRA)/positive relative accommodation (PRA). All measurements were carried out binocularly. Results: In binocular distance VA with contrast of 10%, monovision was the worst among the four modalities (p=0.005). In accommodative response at 1 m (1.00 D), monovision was the lowest (p<0.05) and accommodative response at 40 cm (2.50 D) with monovision was lower than that of modified monovision and multifocal contact lens (p<0.05). We also found that there were no significant differences in accommodative facility and NRA/PRA among the four modalities. Conclusions: In young adult (20s), monovision with low add reduced the accommodative response at near task, however, modified monovision and multifocal lens with center-near type did not affect accommodative relaxation.

• Nuclear Engineering and Technology
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• v.28 no.3
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• pp.247-256
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• 1996

This paper presents a new approach for assessing accident management strategies using containment event trees (CETs) developed during an individual plant examination (IPE) for a reference plant (CE type, 950 MWe PWR). Various accident management strategies to reduce risk have been proposed through IPE. Three strategies for the station blackout sequence are used as an example : 1) reactor cavity flooding only, 2) primary system depressurization only, and 3) doing both. These strategies are assumed to be initiated at about the time of core uncovery. The station blackout (SBO) sequence is selected in this paper since it is identified as one of the most threatening sequences to safety of the reference plant. The effectiveness and adverse effects of each accident management strategy are considered synthetically in the CETs. A best estimate assessment for the developed CETs using data obtained from NUREG-1150, other PRA results, and the MAAP code calculations is performed. The strategies are ranked with respect to minimizing the frequencies of Various containment failure modes. The proposed approach is demonstrated to be very flexible in that it can be applied to any kind of accident management strategy for any sequence.

• 한국균학회소식:학술대회논문집
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• 2015.05a
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• pp.60-60
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• 2015

Hybrid histidine kinase is a part of two-component system that is required for various stress responses and pathogenesis of pathogenic fungi. In the present study, Tco1, a homologue of human pathogen Cryptococcus neoformans Tco1 encoding a hybrid histidine kinase, was identified in corn smut pathogen Ustilago maydis by bioinformatic analysis. To explore the role of Tco1 in the virulence of U. maydis, mutants in which the tco1 gene was partially deleted were constructed by allelic exchange. The U. maydis tco1 mutants did show unaltered growth rate on axenic medium but were unable to produce conjugation tubes and develop fuzzy filaments, resulting in impaired mating of compatible strains. The expression levels of prf1, pra1, and mfa1 which are involved in the pheromone pathway significantly decreased in the tco1 mutants. In inoculation tests to host, the tco1 mutants showed significantly reduced ability in the production of anthocyanin pigments and tumor development on maize leaves. Overall, the combined results indicated that Tco1 plays important roles in sexual development and virulence of U. maydis by regulating the expression of the genes involved in the pheromone pathway.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1997.04a
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• pp.81-81
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• 1997

We previously demonstrated an enhancer-like positive regulatory element within a 259-bp sequence (-2352 to-2094 bp) of the human CYP1A2 gene in HepG2 cells. Three protein binding sites were identified by DNase I footprint analyses within the 259-bp sequence: protected region A PRA ( -2283 to-2243 bp), PRB (-2218 to-2187 bp), and PRC (-2124 to-2098 bp) (I. Chung and E. Bresnick, Mol. Pharmacol. 47, 677-685, 1995). In the present study, the functional significance of those protected regions was examined. Transfection experiments with deletion and substitution mutants defined the PRB and PRC as containing positive and negative regulatory elements, respectively. Human breast carcinoma MCF-7 cells were cotransfected with a hepatocyte nuclear factor-1 (HNF-1) expression vector and CYP1A2 promoter-or thymidine kinase promoter-luciferase remoter gene constructs. HNF-1, which contributes to the liver specificity of genes, enhanced reporter gene activity in a PRC sequence-dependent manner. These results suggested that PRC could exist bound to a repressor which was displaceable by other transcription factors such as HNF-1. Results obtained by transfection of HepG2 hepatoma cells with various PRB substitution mutant-luciferase gene fusion constructs indicated that the entire sequence of PRB was necessary for promoter activity. Consequently, the regulation of CYP1A3 expression is very complex, requiring a number of both positive and negative regulatory factors.

• Progress in Medical Physics
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• v.18 no.3
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• pp.144-148
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• 2007

Current digital radiography systems are rapidly glowing in clinical applications. The purpose of this study was to evaluate the characteristics of a mobile digital radiographic system. The performance of the mobile DR system was evaluated by measuring the modulation transfer function (MTF), noise power spectrum (NPS), and detective quantum efficiency (DQE). Measurements were made on a LISTEM Mobix-1000 generator and a Teleoptic PRA Alpha-R4000 detector. Imaging characteristics were measured for these two systems using the IEC-61267 defined RQA5 (kVp: 74, additional filtration: 21 mmAl) radiographic condition. The MTF at 10% was measured as 2.4 cycles/mm and the DQE(0) values for radiation exposure 0.19, 0.5, and 1.3 mR were measured as 54%, 55%, and 76%, respectively. The NPS curves gradually decreased at high spatial frequencies. This high DQE at low frequencies, may be useful for low frequency information. The results suggested that mobile DR system could be integrated with emergency ambulance system in teleradiologic imaging applications.