• Bulletin of the Korean Chemical Society
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• 제12권6호
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• pp.662-665
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• 1991

In order to prepare new chiral borohydrides (4) possessing chirality on dialkyl moieties, a series of B-alkoxydiisopinocampheylborinates (3) were synthesized by treatment of diisopinocampheylborane ($Ipc_2BH$) with alcohols (R in ROH: Me, Et, i-Pr, t-Bu) and reacted with excess of potassium hydride. Of these chiral borinic esters, only B-methoxydiisopinocampheyl borinate (3a) was converted into the corresponding dialkylmonoalkoxyborohydride (4a). For the other borinic esters, hydride uptake reactions were very slow at room temperature, accompanying disproportionation products at $65^{\circ}C$. The hydride (4a) formed is stable at $0^{\circ}C$ and can be stored over potassium hydride for few months. In the asymmetric reduction of the selected ketones, 4a provided the corresponding alcohols, such as 21% ee for 3-methyl-2-butanone, 11% ee for 2,2-dimethylcyclopentanone, 24% ee for acetophenone, 32% ee for 3-acetylpyridine, 30% for methyl benzoylformate, 31% ee for 4-phenyl-3-butyn-2-one, 39% ee for 3-butyn-2-one, and 34% ee for 3-hexyn-2-one.

• 대한바이러스학회지
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• 제26권2호
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• pp.191-204
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• 1996

The characterization of the 5 Korean isolates (K96P10, K94P05, K91P55, K87P39, and K82P01) of Japanese encephalitis virus (JEV) was compared with JE virus prototype Nakayama-NIH (NKY-NIH) using prM/M and envelope gene sequences of the JEV genome and phylogenetic analysis. The antigenic analysis of these viruses were done by the cross-hamagglutination inhibition (HI) test using polyclonal antibodies against Korean isolates and NKY-NIH. The sequence homology of the Korean isolates and NKY-NIH ranged between 87.4 % - 95.6 % at the nucleotide level and between 98.2 % - 97.2 % at the amino acid level over the E nucleotides compared. Alignment of E protein amino acid sequences revealed that residue positions E89, E129, E221, E244, E327, E366, E459, and E477 characterized the Korean strains. According to phylogenetic analysis bases on the E nucleotide, there are at least 2 genetic types of JEV existing in Korea and Korean strains were distinct from NKY-NIH. However, the cross HI test results of all the Korean isolates were serologically no different from NKY-NIH strain.

• 보건행정학회지
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• 제27권2호
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• pp.149-156
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• 2017

Background: This study was conducted to evaluate the performance of the Hierarchical Condition Category (HCC) model, identify potentially high-cost patients, and examine the effects of adding prior utilization to the risk model using Korean claims data. Methods: We incorporated 2 years of data from the National Health Insurance Services-National Sample Cohort. Five risk models were used to predict health expenditures: model 1 (age/sex groups), model 2 (the Center for Medicare and Medicaid Services-HCC with age/sex groups), model 3 (selected 54 HCCs with age/sex groups), model 4 (bed-days of care plus model 3), and model 5 (medication-days plus model 3). We evaluated model performance using $R^2$ at individual level, predictive positive value (PPV) of the top 5% of high-cost patients, and predictive ratio (PR) within subgroups. Results: The suitability of the model, including prior use, bed-days, and medication-days, was better than other models. $R^2$ values were 8%, 39%, 37%, 43%, and 57% with model 1, 2, 3, 4, and 5, respectively. After being removed the extreme values, the corresponding $R^2$ values were slightly improved in all models. PPVs were 16.4%, 25.2%, 25.1%, 33.8%, and 53.8%. Total expenditure was underpredicted for the highest expenditure group and overpredicted for the four other groups. PR had a tendency to decrease from younger group to older group in both female and male. Conclusion: The risk adjustment models are important in plan payment, reimbursement, profiling, and research. Combined prior use and diagnostic data are more powerful to predict health costs and to identify high-cost patients.

• 한국토양비료학회지
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• 제46권5호
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• pp.379-385
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• 2013

Although sorghum residue production was estimated to be $8{\sim}10Mg\;ha^{-1}$, most sorghum straw was used to be burnt or removed after harvest. This experiment was conducted to evaluate the effect of the incorporation of manured sorghum residues on soil physical properties from 2010 to 2012 in the converted paddy field. Five treatment with 3 replication consisted of control, inorganic fertilizer (NPK), manured residues, sorghum stover and sawdust manure. The incorporation level of organic source was $10Mg\;ha^{-1}$ without inorganic fertilizer NPK. The investigated physical parameters were bulk density (BD), porosity, water stability aggregate (WSA), water infiltration rater (WIR), penetration resistance (PR) and soil water retention characteristics (WRC) with soil depth. The incorporation of manured sorghum residues improved WIR significantly over inorganic fertilizer (NPK), sorghum residues and sawdust manure. The BD by incorporating with manured residues on sorghum was reduced significantly with crop residue over plot of NPK and sawdust. Significant increase in WSA was observed with stubble incorporation alone or manured sorghum residues. Soil WRC were significantly enhanced with manured sorghum residue incorporated without NPK. The average PR at 0~15 cm was 0.54 MPa for manured sorghum residues. For sawdust manure plot it was 0.42 MPa, for Sawdust manure plot 0.39 MPa and for NPK plot 0.54 MPa.

• Journal of Ginseng Research
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• 제39권3호
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• pp.213-220
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• 2015

Background: Korean ginseng (Panax ginseng Meyer) is a perennial herb prone to various root diseases, with Phytophthora cactorum being considered one of the most dreaded pathogens. P. cactorum causes foliar blight and root rot. Although chemical pesticides are available for disease control, attention has been shifted to viable, eco-friendly, and cost-effective biological means such as plant growth-promoting rhizobacteria (PGPR) for control of diseases. Methods: Native Bacillus amyloliquefaciens strain HK34 was isolated from wild ginseng and assessed as a biological control agent for ginseng. Leaves from plants treated with HK34 were analyzed for induced systemic resistance (ISR) against P. cactorum in square plate assay. Treated plants were verified for differential expression of defense-related marker genes using quantitative reverse transcription polymerase chain reaction. Results: A total of 78 native rhizosphere bacilli from wild P. ginseng were isolated. One of the root-associated bacteria identified as B. amyloliquefaciens strain HK34 effectively induced resistance against P. cactorum when applied as soil drench once (99.1% disease control) and as a priming treatment two times in the early stages (83.9% disease control). A similar result was observed in the leaf samples of plants under field conditions, where the percentage of disease control was 85.6%. Significant upregulation of the genes PgPR10, PgPR5, and PgCAT in the leaves of plants treated with HK34 was observed against P. cactorum compared with untreated controls and only pathogen-treated plants. Conclusion: The results of this study indicate HK34 as a potential biocontrol agent eliciting ISR in ginseng against P. cactorum.

• Asian Pacific Journal of Cancer Prevention
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• 제15권22호
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• pp.9801-9804
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• 2014

Background: Colorectal cancer is currently the third most common cancer in Indonesia, yet colonoscopy - the most accepted mode of screening to date - is not done routinely and national data are still lacking. Objective: To determine the detection rate of colorectal cancers and adenomas in unselected patients undergoing colonoscopy for various large bowel symptoms at the Digestive Disease and GI Oncology Centre, Medistra Hospital in Jakarta, Indonesia. Materials and Methods: Colonoscopy data from January 2009 to December 2012 were reviewed. New patients referred for colonoscopy were included. Data collected were patient demographic and significant colonoscopy findings such as the presence of hemorrhoids, colonic polyps, colonic diverticula, inflammation, and tumor mass. Histopathological data were obtained for specimens taken by biopsy. Associations between categorical variables were analyzed using chi-square test, while mean differences were tested using the t-test. Results: A total of, 1659 cases were included in this study, 889 (53.6%) of them being men. Polyps or masses were found in 495 (29.8%) patients while malignancy was confirmed in 74 (4.5%). Patients with a polyp or mass were significantly older (60.2 vs 50.8 years; p<0.001; t-test) and their presence was significantly associated with male gender (35.0% vs 23.9%; prevalent ratio [PR] 1.71; 95% confidence interval [CI] 1.38-2.12; p<0.001) and age >50 years (39.6% vs 16.6%; PR 3.29; 95% CI 2.59-4.12; p<0.001). Neoplastic lesions was found in 257 (16.1%), comprising 180 (11.3%) adenomas, 10 (0.6%) in situ carcinomas, and 67 (4.2%) carcinomas. Conclusions: Polyps or masses were found in 30% of colonoscopy patients and malignancies in 16.1%. These figures do not represent the nation-wide demographic status of colorectal cancer, but may reflect a potentially increasing major health problem with colorectal cancer in Indonesia.

• Clinical and Experimental Reproductive Medicine
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• 제42권4호
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• pp.169-174
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• 2015

Objective: To assess compliance with Korean guidelines for embryo transfer, the possible reasons for non-compliance, and multiple pregnancies according to each specific condition in compliant cycles. Methods: A single-institution, retrospective study was conducted of 256 fresh in vitro fertilization cycles during 2012-2014. To assess compliance with Korean guidelines, the maximum recommended number of embryos transferred (according to criteria of age, transfer day, and presence of favorable conditions) was compared with the actual number of embryos transferred. Clinical pregnancy rate (PR) was assessed as the percentage of pregnant women resulting from each set of transfer conditions, including the number of embryos transferred. The multiple pregnancy rate (MPR) was calculated as the percentage of pregnant women with a multifetal pregnancy. Results: The compliance rate with the Korean guidelines was 96.5% (247/256). Non-compliance occurred in nine cycles owing to poor embryo quality, repeated implantation failure, or hostile endometrium. In compliant cycles, the PR was 31.2% (77/247), and the MPR was 27.3% (21/77; 20 twins and one triplet). Higher MPR was noted in two types of transfer conditions: transfer of three cleavage embryos in women aged 35-39 years with favorable conditions (66.7%; primarily from those aged 35-37 years) and transfer of two blastocysts in women aged ${\geq}40$ years with favorable conditions (50%). Conclusion: Under the Korean guidelines, compliance rate was high in our center. Multiple pregnancies occurred primarily in group with favorable conditions. In high-risk groups for multiple pregnancies, reducing number of embryos transferred should be considered than suggested in the guideline.

• 한국식품조리과학회지
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• 제31권2호
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• pp.193-199
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• 2015

According to the definition of 'native local food', Jeju has combined its regional specialty products with its own cooking method. It has almost four-hundred kinds, which reflects regional specialty and diversity, yet it is not very well-known. Thus, this present study provides basic research information through the investigation of tourist awareness, intention to consume, drawbacks, development necessity and direction of development of Jeju local foods. The survey was conducted with 295 domestic tourists who had visited Jeju in the last 10 years. In response to a question asked about the consciousness of Jeju local foods, 67.8% of respondents chose average, indicating a relatively high cause for concern. Intention to consume averaged 3.26, which was higher than tourist awareness, having an average of 2.60. Furthermore, local food interest and demographic characteristics of respondents were found to have an influence on tourist awareness and intention to consume. 87.8% of respondents answered above average with respect to the drawbacks of Jeju's local foods and development necessity and direction, with the main drawbacks being lack of PR (43.1%) and high price (39.0%). The priority of most respondents was the quality and taste of the food (50.8%). Based on the results of this study, if tourist awareness can be effectively increased, an escalation in intent to consume will follow, naturally promoting the consumption of Jeju's local foods. Consequentially, for tourism commercialization, the quality and taste of the foods have to be improved in addition to the gain in popularity through efficient PR methods.

• 대한전자공학회논문지TC
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• 제39권6호
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• pp.10-10
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• 2002

본 논문은 기지국들로부터 단말기로의 TDOA(Time Difference of Arrival) 성분을 기반으로 한 무선측위 기법의 성능향상에 영향을 미치는 다중경로의 최초 도착 시간 지연 성분을 정밀하게 취득하기 위한 고해상 채널 추정 기법을 소개한다. 제안된 고해상 채널 추정 기법은 3GPP에서 공용 파일럿 신호의 수신 자기 상관 함수 특성을 주파수 영역상에서 샘플링하고 Hermitian Toeplitz 성질을 만족하는 행렬을 구성하여 이에 대한 벡터 영역상의 분석을 거쳐 시간 지연 성분들을 정밀 추정하게 된다. 본 논문에서 시뮬레이션을 통하여 제안된 고해상 채널 추정 기법을 수정 CODIT 모델을 바탕으로 3GPP에서 고려되는 PR-IPDL(Pseudo Random-Idle Period Downlink)과 TA-lPDL(Time Aligned-Idle Period Down-link) 무선 측위 기법에 적용하여 무선 측위 성능을 체계적으로 분석한다.

• 대한전자공학회논문지SD
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• 제39권6호
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• pp.59-68
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• 2002

본 논문에서는 블록 효과(blocking effect)가 없고, 압축성능 또한 높아 영상압축을 포함한 여러 응용 분야에서 널리 사용되고 있는 2차원 이산 웨이블렛 변환(DWT, Discrete Wavelet Transform) 필터를 설계하였다. 필터로는 4개의 필터 탭을 갖는 Two-channel QMF(Quadrature Mirror Filter) PR(Perfect Reconstruction) Lattice 필터를 사용하였다. 제안된 DWT 아키텍쳐는 단순하지만 효과적인 스케줄링 기법을 이용하여 설계되어 최소의 하드웨어(곱셈기, 덧셈기, 레지스터 등)로 구성되었고, 이 아키텍쳐에 두 개의 연속적인 입력이 동시에 제공되면 효율적으로 2차원 DWT를 수행함을 보였다. 제안된 아키텍쳐는 RTL 레벨 시뮬레이션을 통해 검증되었고, 100% 하드웨어 이용도(utilization)를 나타낸다. 다른 연구 결과들과 비교하였을 때 최소의 하드웨어를 사용하여 상대적으로 높은 수행능력을 보였다. 효과적인 메모리 매핑 방법과 그를 위한 주소 발생 방법이 제안되었으며, 고정 소수점 연산 시에 발생하는 에러를 분석하여 적절한 양자화 비트를 결정하기 위한 다양한 시뮬레이션과 성능이 분석되었다.