• 한국가축번식학회지
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• 제22권2호
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• pp.177-186
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• 1998

While tubal pregnancy is frequently observed in human, it has been reported to rarely occur in other mammals. To investigate the reason of the absence of tubal pregnancy in other mammals, the ability of bovine tubal(oviductal) fluid to su, pp.rt the outgrowth of mouse embryos waw examined by using an in vitro model system wherein the trophoblast cells of hatched mouse blastocysts attach to and outgrow on tissue culture plates coated with FBS. When mouse blastocysts grwon in vitro from 2-cell embryos were cultrued in the dishes coated with FBS, human follicular fluid(hFF) and bovine follicular fluid(bFF), respectively, underwent outgrowth by spreading onto the plastic dishes during 48 hr. In contrast, none of the embryos cultured in the dishes coated with BSA or bovine obiductal fluid(bOF) did outgrow but remained as late blastocysts. Since addition of bOF at 5mg/ml or higher conc. to the culture medium resulted in degeneration of all embryos during 48 hr culture, 10mM conc. of glutathione(GSH) was added to the bOF-containing medium to circumvent the toxicity of bOF. In addition, bOF was heated $65^{\circ}C$ for 30 min(hbOF) to get rid of its precipitating properties and then added to the culture medium. When blastocysts were cultured in the presence of both hbOF and GSH 45.4% of embryos attached to the culture dishes. However, none of these embryos underwent outgrowth. Fially embryos were cultured in the presence of both hbOF and GSH but in the dishes coated with FBS. When they were examined after 48 hr, all of the blastocysts exhibited well-developed outgrwoth. Based upon these results, it is concluded that bovine oviductal fluid is capable of su, pp.rting the attchment of mouse blastocysts onto the culture plaste whereas it cannot promote the outgrwoth of mouse blastocysts in vitro, probably due to the lack of outgrwoth factor.

• The Korean Journal of Physiology and Pharmacology
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• 제7권4호
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• pp.211-215
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• 2003

To examine the localization pattern of phospholipase D2 (PLD2) in the pancreatic islet (the islet of Langerhans) depending on species, we conducted a morphological experiment in the rat and guinea pig. Since individual islets display a typical topography with a central core of B cell mass and a peripheral boundary of A, D, and PP cells, double immunofluorescent staining with a panel of antibodies was performed to identify PLD2-immunoreactive cells in the islets PLD2 immunoreactivity was mainly present in A and PP cells of the rat pancreatic islets. And yet, in the guinea pig, PLD2 immunoreactivity was exclusively localized in A cells, and not in PP cells. These findings suggest a possibility that PLD2 is mainly located in A cells of rodent pancreatic islets, and that the existence of PLD2 in PP cells is not universal in all species. Based on these results, it is suggested that PLD2 may play a significant role in the function of A and/or PP cells via a PLD-mediated signaling pathway.

• 한국식품영양과학회지
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• 제40권4호
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• pp.570-574
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• 2011

본 연구에서는 버섯을 이용한 다양한 가공제품의 개발 및 버섯의 활용성 증대의 일환으로 새송이버섯 분말 첨가에 따른 만두피의 품질특성에 대하여 알아보았다. 새송이버섯 분말을 2%, 4%, 6%로 함량을 달리하여 만두피를 제조하여 품질특성을 조사한 결과, 조리 후의 중량 및 만두피의 부피는 새송이버섯 분말 첨가 시 증가하였다. 수분흡수율은 유의적인 차이는 없었으며, 조리후의 탁도는 유의적으로 증가하였다. 분말첨가량이 증가할수록 L값은 감소하였으며 a값은 증가하였고, b값은 6% 첨가구가 가장 높게 나타났다. 조직감을 조사한 결과, 경도는 분말 첨가구에 비해 대조구가 높게 나타났다. 부착성은 분말첨가구가 대조구에 비해 증가하는 경향을 보였으며, 탄력성은 대조구와 비교하여 분말 2% 첨가 시까지는 차이를 나타내지 않다가 4% 이상 첨가 시탄력성이 낮아지는 것으로 나타났다. 씹힙성과 검성은 분말 첨가량이 증가할수록 감소하는 것으로 나타났으며, 응집성은 2%, 4% 첨가구는 대조구와 차이를 나타내지 않았으나 새송이버섯 분말 6% 첨가 시 유의적으로 감소하였다. 관능적 특성 조사결과 분말 6% 이상 첨가 시 색깔 특성이 저하되는 것으로 나타났으며, 만두피의 향미, 맛, 매끄러운 정도, 촉촉한 정도, 치아에 달라붙는 정도는 새송이 분말 첨가에 의해 차이를 나타내지 않았다. 씹힙성은 대조구에 비해 분말 첨가구에서 기호도가 높게 나타났으나 첨가량에 따른 유의적인 차이는 없었다. 새송이버섯 분말을 이용한 만두피의 제조 시에는 새송이 버섯 분말의 첨가량을 4%까지 첨가할 경우 만두피의 품질에 크게 영향을 미치지 않으면서 전반적인 기호도 면에서 우수한 만두피를 제조할 수 있을 것으로 생각된다.

• Bulletin of the Korean Chemical Society
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• 제22권6호
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• pp.587-592
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• 2001

The potential anticancer agents new anthracycline derivatives (2~9) have been synthesized from daunomycin (1a) and doxorubicin (1b) ad starting materials. Compounds 2 and 6 were prepared by the nucleophilic displacement type esterification of a 14-bromodaunomycin (1c) with a acetylsalicylic and palmitic acid in triethylamine, respectively. Compound 3 and 7 were obtained from daunomycin (1a) by direct amidation with the corresponding acids in the presence of EDCI and PP as esterification regents. Whereas 4 and 8 were prepared by reaction of doxorubicin (1b) with one equivalent of acetylsalicylic and palmitic acid using DCC/DMAP, respectively, 5 and 9 were obtained from 1b by acylation with two equivalents of the corresponding acids using EDCI/PP reagents.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2004년도 Asia Display / IMID 04
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• pp.41-43
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• 2004

Plasma polymerized para-xylene ($PP_PX$) deposited by plasma-enhanced chemical vapor deposition (PECVD) was used as the barrier layer on the polyethylene terephthalate (PET) substrate to improve lifetime of the flexible organic light-emitting diodes (FOLEDs). The $PP_PX$ barrier layer deposited on top of the PET substrate with plasma power of 30 W at deposition pressure of 0.2 torr showed transmittance spectra good enough to be applied in FOLED on PET substrates. FOLEDs with the $PP_PX$ barrier layer (barrier-FOLEDs) showed similar I-V and B-V characteristics to FOLEDs without the $PP_PX$ layer (control-FOLEDs). The lifetime of barrier-FOLED was two times longer than that of the control-FOLED. With $PP_PX$ passivation layers, lifetimes of both control and barrier-FOLEDs were improved by more than 4 times. These results show that PECVD deposited $PP_PX$ layers can be used as barrier layers for FOLEDs on plastic substrates as well as passivation layers for general OLEDs.

• 한국음향학회지
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• 제43권1호
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• pp.60-71
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• 2024

본 연구는 일반적인 평평한 에틸렌 비닐 아세테이트(Ethylen Vinyl Acetate, EVA) 완충재의 형상을 변화시켜 다양한 차음소재와 조합하여 복합구조의 바닥충격음 변화를 조사하는 데에 목적이 있다. 바닥충격음 저감에 효과적인 완충재를 선정하기 위해 Flat, Deck, Cavity type의 EVA, EPS, PET 흡음재, PP판넬, 고무발판 등 다양한 완충재를 조합하여 뱅머신을 이용한 1차 실험을 진행하였다. 1차 실험 데이터에 대해 통계분석한 결과 완충재 두께가 40 mm에 가까울수록 바닥충격음 저감효과가 증가하였으며 PET 흡음재, PP시트, 고무발판 등을 조합한 복합완충재에서 바닥충격음 효과가 증가하는 것을 알 수 있었다. 이에따라 2차 실험에서 모든 복합완충재의 두께는 40 mm로 통일하였으며, 1차 실험에 사용된 Flat, Deck, Cavity type 및 EVA를 발판형태로 가공한 Mount type 등 4가지 형태의 복합완충재를 설계하였다. 또한, Mount type을 제외한 3가지 기본 형태에서 각각 PET 흡음재(7 mm)를 추가했을 시 바닥충격음 변화를 살펴보았으며, Mount type의 경우 EVA발판 개수에 따른 바닥충격음 변화에 대해 고무공 충격원을 이용한 2차 실험을 진행하였다. 모든 실험은 공인인증시험기관의 목업실험실에서 진행하였다. 실험 결과, 기본형태의 Flat, Deck, Cavity type에서 PET를 추가할 경우 통계적으로 경량 5 dB ~ 9 dB, 중량 1 dB ~ 5 dB의 저감효과가 나타난 것을 알 수 있었다. 특히, Mount type의 경우 발판 수가 36개 이상일 때 경량 및 중량충격음에서 우수한 것으로 나타났다. 또한, 4가지 기본형태에 따라 동탄성계수가 높아질수록 바닥충격음의 저감이 증가하는 것으로 나타났다.

• 대한의생명과학회지
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• 제23권3호
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• pp.175-184
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• 2017

Cholera toxin (CT) is an ADP-ribosylating bacterial exotoxin that has been used as an adjuvant in animal studies of oral immunization. The mechanisms of mucosal immunogenicity and adjuvanticity of CT remain to be established. In this study, we investigated the role of indoleamine 2,3-dioxygenase (IDO), which participates in the induction of immune tolerance, in CT-mediated breakdown of oral tolerance. When IDO-deficient ($IDO^{-/-}$) mice and their littermates were given oral ovalbumin, significant changes in antibody responses, footpad swelling and $CD4^+$ T cell proliferation were not observed in $IDO^{-/-}$ mice. Feeding of CT decreased IDO expression in mesenteric lymph nodes (MLN) and Peyer's patch (PP). CT-induced downregulation of IDO expression was reversed by inhibitors of nuclear factor-kappa B (NF-${\kappa}B$), pyrrolidine dithiocarbamate and p50 small interfering RNA. IDO expression was downregulated by the NF-${\kappa}B$ inducers lipopolysaccharide and tumor necrosis factor-${\alpha}$. CT dampened IDO activity and mRNA expression in dendritic cells from MLN and PP. These data indicate that CT disrupts oral tolerance by activating NF-${\kappa}B$, which in turn downregulates IDO expression. This study betters the understanding of the molecular mechanism underlying CT-mediated abrogation of oral tolerance.

• 대한수학회보
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• 제24권1호
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• pp.13-17
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• 1987

Let S denote the class of nivalent functions normalized so that f(0)=f'(0)-1=0 in vertical bar z vertical bar <1. Let $S_{\alpha}$$^{*}$, -.pi./2<.alpha.<.pi./2, denote the subclass of S that satisfies Re $e^{i{\alpha}}$zf'(z)/f(z).geq.0 in vertical bar z vertical bar <1; then f is called .alpha.-spiral-like and the case .alpha.=0 is the class of normalized starlike functions [6, pp.52]. Let T denote the class of functions f normalized as above and satisfying Im z[Im f(z)]..geq.0 in vertical bar z vertical bar <1; then f is called typically real and T contains those functions of S whose coefficients are real [6, pp.55]. Also, in view of [6, pp.231], let B(.lambda.) be the class of function normalized as above and map vertical bar z vertical bar <1 onto the complement of an arc with radial angle .lambda.(0<.lambda.<.pi./2). The radial angle is meant to be the angle between the tangent and radial vectors to the arc. This note includes a sharp version for Corollary 1 of [2] when f.mem. $S_{\alpha}$$^{*}$ as well as a logarithmic coefficient estimate.nt estimate.

• 한국가축번식학회지
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• 제21권2호
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• pp.197-205
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• 1997

Improved hypophysectomy technique and the efficacy of bGH in hypophysectomized female rats were studied as a basis for the function of endocrine gland and hormones. 1. With improved sublaryngeal a, pp.oach by hypophysectomy, 34 rats out of 40 were successfully hypophysectomized(more than 80% of success). The surgical time for hypophysectomy per rat was taken about 3.0$\pm$1.0 min. 2. For the effect of hypophysectomy and bGH on body weight gain among the 5 gruops of A, B, C, D, and E, the weight gains for A, B, C, D, and E, were 93g, 9.2g, 10.7g, 25.1g and 36.2g, respectively, which implied that hypophysectomy had a major effect on body weight. And also, the effect of bGH was paralleled with the level of bGH. There were significant difference between control and hypophysectomized groups, and between the bGH treated and bGH non-treated groups after hypophysectomy(p<0.01). 3. For the effect of hypophysectomy and bGH on the length of femur, tibia, humerus, and anterbrachi, longest was for A, shortest for B, and longer in order of C, D, and E. The A group was significantly longer than B, C, D, and E groups. The B group was shorter than C, D, and E groups(p<0.01). 4. For the effect of hypophysectomy and bGH on the weight of femur, tibia, humerus, and antebrachi, heaviest was for A, lightest for B, and heavier in order of C, D, and E. The A group was significantly heavier than B, C, D, and E groups. The B group was lighter than C, D, and E groups(p<0.01). 5. In changes of body length, and weights of liver and heart, A group was most drastically increased. Among the hypophysectomized groups, the change was increased in order of B, C, D, and E. Especially, the change of A group was significantly greater than B, C, D and E gruops. However, no significant differences were found among B, C, D, and E groups. 6. The hypophysectomy in rat had a significant effect on body growth. The effect of hormone was remarkably different depending upon the level of hormone. It was found that 300$\mu\textrm{g}$ of bGH/kg of body wt/day was slightly lower for normal growth.

• 한국식품과학회지
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• 제31권1호
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• pp.158-163
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• 1999

흑미(흑진주벼)를 PE와 PP 그리고 PE와 PP를 적층한 필름을 이용하여 포장한 후 $20^{\circ}C$에 저장하면서 흑미의 품질변화를 측정하였다. 품질 측정은 수분활성도, 지방산도, 저장 중 무게변화, 색도변화, 경도변화, Hexanal 생성량, 지방산의 변화등을 측정하였다. 수분활성도는 초기 0.642이였는데 저장 8개월까지 거의 변화가 없었다. 지방산도는 포장재가 두꺼울수록 적게 변하였고, PE보다는 PP가 적게 변했지만 PE/PP 접착필름이 가장 적게 변하였다. 색도의 경우 초기 L, a, b값이 각각 15.6, 5.2, -1.6이였는데 저장 8개월까지 L값이 약간 증가했으나 포장재간의 차이는 거의 없었으며 초기 색도와도 거의 차이가 없었다. 경도도 초기 값보다 약간 증가했으며 PE와 PP를 적층한 포장재로 포장된 시료가 저장 8개월 후에 가장 변화가 적었으며 0.05 mm PE가 가장 많이 변하였다. Hexanal의 생성량은 PE와 PP를 적층한 것이 가장 적었으며 0.05 mm PE가 가장 많았다. 또한 지방산중 linoleic acid의 변화량도 PE와 PP를 접착한 필름이 가장 적었으며 0.05 mm PE가 가장 많았다. 전반적으로 가장 양호한 포장재는 PE와 PP를 적층한 필름이었으나 포장재간의 차이는 적었다.