• Journal of Institute of Control, Robotics and Systems
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• v.8 no.4
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• pp.333-337
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• 2002

A content-based image retrieval method using color, texture, and shape features is proposed in this paper. A region segmentation technique using PIM(Picture Information Measure) entropy is used for similarity indexing. For segmentation, a color image is first transformed to a gray image and it is divided into n$\times$n non-overlapping blocks. Entropy using PIM is obtained from each block. Adequate variance to perform good segmentation of images in the database is obtained heuristically. As variance increases up to some bound, objects within the image can be easily segmented from the background. Therefore, variance is a good indication for adequate image segmentation. For high variance image, the image is segmented into two regions-high and low entropy regions. In high entropy region, hue-saturation-intensity and canny edge histograms are used for image similarity calculation. For image having lower variance is well represented by global texture information. Experiments show that the proposed method displayed similar images at the average of 4th rank for top-10 retrieval case.

• Journal of Surface Science and Engineering
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• v.51 no.2
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• pp.104-109
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• 2018

Fe-2 wt.%Ni alloys were fabricated by metal powder injection molding, and their oxidation behavior at $600-700^{\circ}C$ for 30 h in air was studied in order to find the effect of the small addition of Ni in the iron matrix on the high-temperature oxidation. Oxide scales that formed after oxidation consisted primarily of $Fe_2O_3$, where microscopic voids were scattered. Nickel was segregated initially at the scale/matrix interface, and later at the lower part of the $Fe_2O_3$ scale. At $600^{\circ}C$, Fe-2wt.%Ni alloys oxidized parabolically initially, and linearly after 15 h. At $650-700^{\circ}C$, they oxidized linearly from the initial period. Although Fe-2wt.%Ni alloys oxidized slower than pure iron, their oxidation rates were relatively fast.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.25 no.1A
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• pp.114-121
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• 2000

The problem of an input-buffered switch is the HOL(head-of-line) blocking which limits the maximum throughput but it is easy to implement in hardware. However, HOL blocking can be eliminated using aVOQ(virtual-output-queueing) technique. 0 this paper, we propose a new cell-scheduling algorithm for aninput-buffered ATM switch. The proposed algorithm, called PPIM(Probabilistic Parallel Iterative Matching), imposesa weight to every request based on the reserved bandwidth. It is shown that the input-buffered ATM switch withthe proposed PPIM algorithm not only provides high throughput and low delay but it also reduces the jitter,compared with the existing WPIM(Weighted PIM).

• Design & Manufacturing
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• v.11 no.3
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• pp.1-7
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• 2017

The fabrication process of micro pattern structure with high precision and high aspect ratio using powder injection molding (PIM) is developed. In the PIM process, the metal powder is mixed with the binder systems and the mixture is injected into the metal mold. The injection molded green parts are debinded and sintered to reach final shape and properties. In this method, the optimization of physical properties such as fluidity and strength of the binder system is essential for perfect filling the high aspect ratio micro-pattern. For this purpose, the correlation between the properties of the binder system and feedstock and ${\mu}-PIM$ process was investigated, and a binder system with low viscosity at low temperature(about $110^{\circ}C$) and high strength after cooling was investigated and applied. Employing this process, high precision parts with line type micro pattern structure which has pattern size $160{\mu}m$ and aspect ratio more than 2 can be manufactured.

• Molecules and Cells
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• v.44 no.7
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• pp.444-457
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• 2021

Although the mechanism of chronic myeloid leukemia (CML) initiation through BCR/ABL oncogene has been well characterized, CML cell differentiation into erythroid lineage cells remains poorly understood. Using CRISPR-Cas9 screening, we identify Chromobox 8 (CBX8) as a negative regulator of K562 cell differentiation into erythrocytes. CBX8 is degraded via proteasomal pathway during K562 cell differentiation, which activates the expression of erythroid differentiation-related genes that are repressed by CBX8 in the complex of PRC1. During the differentiation process, the serine/threonine-protein kinase PIM1 phosphorylates serine 196 on CBX8, which contributes to CBX8 reduction. When CD235A expression levels are analyzed, the result reveals that the knockdown of PIM1 inhibits K562 cell differentiation. We also identify TRIM28 as another interaction partner of CBX8 by proteomic analysis. Intriguingly, TRIM28 maintains protein stability of CBX8 and TRIM28 loss significantly induces proteasomal degradation of CBX8, resulting in an acceleration of erythroid differentiation. Here, we demonstrate the involvement of the CBX8-TRIM28 axis during CML cell differentiation, suggesting that CBX8 and TRIM28 are promising novel targets for CML research.

• International Journal of Knowledge Content Development & Technology
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• v.9 no.1
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• pp.19-42
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• 2019

This study examined activities involving the finding, organizing, managing, and re-finding of information by knowledge workers in Kuwait. This research also conducted a review of the tools needed for effective personal information management (PIM) and assessed perceptions about improving PIM through Internet use. Data were collected through semi-structured interviews conducted among 26 graduates of the Department of Information Studies at Kuwait University. These participants are currently employed in different sectors engaged in a variety of information-related activities. This study's findings indicated that participants gathered different types of information from a variety of sources. This information was stored using several devices and services, including desktop computers, shared drives, clouds, bookmarked websites, e-mail correspondence, and favorites lists. Participants organized information in personal folders according to categories such as subject/topic, time, project, document type, and geographical region. Preferred methods for information re-finding included searching by keyword and browsing through folders. Interviewees reported problems of information overload, fragmentation, and anxiety. Most were active in social media via mobile device, while some of them used Siri or Ask Google to retrieve information. Tools used for PIM included calendars, tasks, schedules, e-mail management tools, clouds, and social networking tools. Participants reported that the Internet helped with personal information management practices, but that some privacy issues arose in this context.

• Korean Journal of Soil Science and Fertilizer
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• v.45 no.6
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• pp.1032-1036
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• 2012

A bulking agent is an essential material for composting of high-moisture livestock manure such as pig slurry. Sawdust has been used as the most popular bulking agent but resources are limited in Korea. In this study, the feasibility of rice hull as a bulking agent was examined for composting of solid pig manure. The solid pig manure was mixed with 15% sawdust (PM+SD15), 15% rice hull (PM+RH15), 10% sawdust and 5% rice hull (PM+SD10+RH5), and 5% sawdust and 10% rice hull (PM+SD5+RH10) based on fresh weight. These mixtures were composted for 35 days. The average temperature of the composting file for 35 days was higher in PM+SD10+RH5 and PM+SD5+RH10 than in PM+SD15 and PM+RH15. The mass loss of PM+SD10+RH5 and PM+SD5+RH10 were 36.7 and 36.4%, respectively, which were higher than that of PM+SD15 and PM+RH15. After composting, organic matter content and organic matter/nitrogen ratio in all treatments met the official standards of commercial fertilizers. We concluded that rice hull may be a good bulking agent for pig manure composting when it is used in mixture with sawdust.

• Journal of the Korean Data and Information Science Society
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• v.24 no.1
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• pp.117-124
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• 2013

Association rule of data mining techniques is the method to quantify the relationship between a set of items in a huge database, andhas been applied in various fields like internet shopping mall, healthcare, insurance, and education. There are three primary interestingness measures for association rule, support and confidence and lift. Confidence is the most important measure of these measures, and we generate some association rules using confidence. But it is an asymmetric measure and has only positive value. So we can face with difficult problems in generation of association rules. In this paper we apply the similarity measures by probabilistic interestingness measure (PIM) with all marginal proportions (AMP) to solve this problem. The comparative studies with support, confidences, lift, chi-square statistics, and some similarity measures by PIM with AMPare shown by numerical example. As the result, we knew that the similarity measures by PIM with AMP could be seen the degree of association same as confidence. And we could confirm the direction of association because they had the sign of their values, and select the best similarity measure by PIM with AMP.

• The KIPS Transactions:PartD
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• v.15D no.2
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• pp.187-196
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• 2008

The system development approach method of the new paradigm, as being standardizing MDA(Model Driven Architecture) in OMG(Object Management Group), the core technique of MDA definite technique structure for system materialization focusing on Model, is to build the design and the statement for system in PIM(Platform Independent Model), Materialization technique, and to build PSM(Platform Specific Model) adapt to materialization environment, and then to be the technique transforming into language Platform suitable to materialization environment. It includes MOF(Meta-Object Facility), UML, XMI(XML Metadata Interchange), CWM(Common Warehouse Metamodel), the core of MDA. Though these operations MDA support automatic tools product the practicable system after carrying out transform operation with the above information. In this thesis, it will be approached how to design and materialize the Bachelor management system based on MDA and the importance of modeling should be emphasized by applying to the approach method based on MDA. It should be suggested how to develop software efficiently, written it out in PIM, and suggested the process transforming PSM into EJB by J2EE Platform. The system is designed and implemented using automatic tool, edit machine(Together Architect 2006 for Eclipse, Edit plus2) supporting MDA and Database Modeling tool(ER/WIN 4.1). In conclusion, it should be suggested the efficiency analysis result for development process of traditional and based on MDA.

• International Journal of Oncology
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• v.56 no.1
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• pp.368-378
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• 2020

Meridianin C is a marine natural product with anticancer activity. Several meridianin C derivatives (compounds 7a-j) were recently synthesized, and their inhibitory effects on pro-viral integration site for Moloney murine leukemia virus (PIM) kinases, as well as their antiproliferative effects on human leukemia cells, were reported. However, the anti-leukemic effects and mechanisms of action of meridianin C and its derivatives remain largely unknown. The aim of the present study was to investigate the effects of meridianin C and its derivatives on MV4-11 human acute myeloid leukemia cell growth. The parent compound meridianin C did not markedly affect the viability and survival of MV4-11 cells. By contrast, MV4-11 cell viability and survival were reduced by meridianin C derivatives, with compound 7a achieving the most prominent reduction. Compound 7a notably inhibited the expression and activity of PIM kinases, as evidenced by reduced B-cell lymphoma-2 (Bcl-2)-associated death promoter phosphorylation at Ser112. However, meridianin C also suppressed PIM kinase expression and activity, and the pan-PIM kinase inhibitor AZD1208 only slightly suppressed the survival of MV4-11 cells. Thus, the anti-survival effect of compound 7a on MV4-11 cells was unrelated to PIM kinase inhibition. Moreover, compound 7a induced apoptosis, caspase-9 and -3 activation and poly(ADP-ribose) polymerase (PARP) cleavage, but did not affect death receptor (DR)-4 or DR-5 expression in MV4-11 cells. Compound 7a also induced the generation of cleaved Bcl-2, and the downregulation of myeloid cell leukemia (Mcl)-1 and X-linked inhibitor of apoptosis (XIAP) in MV4-11 cells. Furthermore, compound 7a increased eukaryotic initiation factor (eIF)-2α phosphorylation and decreased S6 phosphorylation, whereas GRP-78 expression was unaffected. Importantly, treatment with a pan-caspase inhibitor (z-VAD-fmk) significantly attenuated compound 7a-induced apoptosis, caspase-9 and -3 activation, PARP cleavage, generation of cleaved Bcl-2 and downregulation of Mcl-1 and XIAP in MV4-11 cells. Collectively, these findings demonstrated the strong anti-survival and pro-apoptotic effects of compound 7a on MV4-11 cells through regulation of caspase-9 and -3, Bcl-2, Mcl-1, XIAP, eIF-2α and S6 molecules.