• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.12 no.7
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• pp.1167-1174
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• 2001

Antenna PIM(Passive Intermodulation) level measurement results are rarely credited due to the external signal receiving characteristics of antenna, and seriously affected by the external PIM sources such as anechoic chamber absorber and antenna tower. In this paper, antenna PIM model for the Reflect PIM measurement method is presented. Through the null point phenomena of the PIM level obtained by antenna PIM model simulations and experimental results, we concluded that antenna PIM level measurements are greatly affected by the PIM level generated on the anechoic chamber absorber and the path differences of PIM signal reflected to the antenna.

• ETRI Journal
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• v.24 no.6
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• pp.435-442
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• 2002

Antenna Passive Intermodulation (PIM) level measurement results are rarely credited to be due to external signal receiving characteristics of the antennas or serious effects from external PIM sources, such as the anechoic chamber absorber and antenna tower. This paper presents an antenna PIM model for a reflected PIM measurement method. Based on the findings of null point generation and the behavior of the third order PIM values obtained by theoretical predictions and experimental results, we concluded that the results of the antenna PIM level test were influenced by the external PIM sources generated by the anechoic chamber absorber and the path differences of PIM signals coming into the antenna.

• Quantitative Bio-Science
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• v.37 no.2
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• pp.113-124
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• 2018

Pim kinases are important targets for cancer therapies because they are mainly responsible for cancer metastasis and overall therapeutic treatment responses. Because of their unusual structural feature in the hinge region of the ATP-binding site, new binding motifs have been discovered and used for the development of Pim kinases inhibitors. The results of a screening of 5-membered heteroaromatic compounds and the effects of structural modifications on the inhibition of Pim kinases' activities showed the potential scaffold for Pim inhibitors. 1,3,4-Oxadiazole-2(3H)-thione was found as a new scaffold for Pim kinase inhibitors.

• Membrane Journal
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• v.33 no.6
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• pp.362-368
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• 2023

This research article explores the application of Polymer of Intrinsic Microporosity (PIM-1) as a cutting-edge material for CO₂ gas separation membranes in response to the escalating global concern over climate change and the imperative to reduce greenhouse gas emissions. The study delves into the synthesis, molecular weight control, and fabrication of PIM-1 membranes, providing comprehensive insights through various characterization techniques. The intrinsic microporosity of PIM-1, arising from its unique crosslinked and rigid structure, is harnessed for selective gas permeation, particularly of carbon dioxide. The article emphasizes the tunable chemical properties of PIM-1, allowing for customization and optimization of gas separation membranes. By controlling the molecular weight, higher molecular weight (H-PIM-1) membranes are demonstrated to exhibit superior CO₂ permeability and selectivity compared to lower molecular weight counterparts (L-PIM-1). The study's findings highlight the critical role of molecular weight in tailoring PIM-1 membrane properties, contributing to the advancement of next-generation membrane technologies for efficient and selective CO₂ capture-an essential step in addressing the pressing global challenge of climate change.

• Korean Journal of Clinical Pharmacy
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• v.25 no.4
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• pp.254-263
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• 2015

Objectives: The present study assessed the prevalence of the potentially inappropriate medication (PIM) use in Korean elderly patients with Parkinson's disease. In addition, this study examined risk factors that affect PIM use. Method: A retrospective, observational study was conducted using Korean National Health Insurance claims database of 2009. PIM use in Parkinson's disease patients aged 65 years or older was examined based on 2012 Beers Criteria. Multivariable logistic regression was conducted to identify risk factors for PIM use. Results: Among 5,277 elderly patients with Parkinson's disease, 88.9% of patients used PIM(s) at least once. The average number of PIM items used per patient was 4.2. PIM use ratio, the proportion of total amount of PIMs to all medications per patient, was 12.6%. Frequently used PIM therapeutic classes were benzodiazepines (32.7%), first-generation antihistamines (19.2%), and prokinetics (17.5%). Individual PIMs most commonly used included chlorpheniramine (11.4%), levosulpiride (10.9%), diazepam (9.0%), and alprazolam (7.6%). Women (odds ratio [OR] 1.14, 95% confidence interval [CI] 1.11-1.16), medical aid (OR 1.18, 95% CI 1.15-1.21), and long-term facilities (OR 2.43, 95% CI 2.22-2.65) were shown to be risk factors associated with PIM use. Of particular, wide variation in PIM use was associated with the types of healthcare facility. Conclusion: The PIM prevalence was very high in elderly Parkinson's disease patients. Nationally effective and systematic efforts to identify and prevent PIM use should be made to ensure patient safety and to improve quality of care in the elderly.

• The Journal of the Acoustical Society of Korea
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• v.28 no.8
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• pp.796-805
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• 2009

In this paper, a fabrication process for PZT preform of 1-3 type piezo-composite were studied using powder injection molding (PIM). The viscosity and the Pressure-Volume-Temperature (PVT) characteristics of the fabricated PZT feedstock were analyzed. The filling patterns, pressure, temperature distributions, and forming defects of the preform were analyzed with 3D TIMON commercial packages during PIM process. Also the fabrication conditions and the delivery system of the preform were optimized during the entire PIM process. Based on the simulated results, the preform having uniform distributions of the PZT rod was fabricated with the PIM process.

• Bulletin of the Korean Chemical Society
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• v.35 no.7
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• pp.2123-2129
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• 2014

Pim kinases are promising targets in the treatment of hematopoietic and solid cancers. Meridianin C was chosen as a starting point to discover novel pim kinase inhibitors. Using known pim kinase's structural information, aminopyrimidine was introduced to provide the hydrogen-bonding interactions with the conserved lysine residue in the ATP binding pocket of all three Pim kinases. Synthesized 3,5-bis(aminopyrimidinyl)indole derivatives showed pan-pim inhibitory activity. Aminoalkyl substituent was attached on the aminopyrimidine to further enhance the potency and physicochemical properties of compound. The research reveals a significative way of designing compounds with high potency and kinase selectivity for pan-pim kinases.

• Proceedings of the Korean Powder Metallurgy Institute Conference
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• 2002.04b
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• pp.13-13
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• 2002

분말사출성형(PIM, Powder Injection Molding) 기술은 금속, 초경 또는 세라믹 등과 같은 소결 가능한 분말을 유기결합체와 혼압하고 이를 기존의 사출성형법을 이용하여 일정한 형상으로 성형한 다음 결합제 제거정 공정을 거처 최종 고온 소결함으로써 3차원의 복잡한 형상의 부품을 후가공 없이 정밀하게 대량 생산 할 수 있는 신분말 성형 기술이다.기계 , 항공,전자정보,반도체,의료 등의 제반 분야에서 산업 및 생활기기들이 초소형화, 초정밀, 및 고기능호 되어 감에 따라 부품 또한 일반 공정에서 제조하기 힘든 크기로 초소형화 되고, 형상이 더욱 복잡화 되며 우수한 기계적 특성 또한 요구되고 있다. 세계 분말 사출성 ; 산업은 이러한 산업적 요구에 맞춰 급격히 발전함과 동싱에 시장 또한 급격히 성장되고 있다. 그러나 국내의 PIM 산업은 88년 기술이 도입된 이후 세계 PIM 산업의 성장 속도를 따라가지 못하고 있는 실정이다. 이번 발표에서 국내의 PIM 산업 현황을 조사하여 국내 시장 규모. 성장 속도, 주요 PIM업체의 소개할 예정이다. 그리고 국내 PIM 산업의 상대적인 저성장 요인을 분석하고 향후 국내 PIM 업계의 발전 방안을 제시할 예정이다. 예정이다.

• Membrane Journal
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• v.30 no.6
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• pp.420-432
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• 2020

Random copolymers made of both 'polymer of intrinsic microporosity (PIM-1)' and Ellagic acid were prepared for the first time by a facile one-step polycondensation reaction. By combining the highly porous and contorted structure of PIM (polymers with intrinsic microporosity) and flat-type hydrophilic ellagic acid, the membranes obtained from these random copolymers [(PIM-co-EA)-x] showed high CO2 permeability (> 4516 Barrer) with high CO2/N2 (> 23~26) and CO2/CH4 (> 18~19) selectivity, that surpassed the Robeson upper bound (2008) for both pairs of the gas mixture. Incorporation of flat-type ellagic acid into the PIM-1 not only enhances the gas permeability by disturbing the kinked structure of PIM-1 but also increases the selectivity of CO2 over N2 and CH4, due to an increase of rigidity and polarity in the resultant copolymer membranes.

• Journal of Integrative Natural Science
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• v.10 no.2
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• pp.95-104
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• 2017

Proviral Integration site of Moloney (Pim) murine Leukemia virus kinases is a serine/threonine specific protein kinase. It is largely involved in cell survival and proliferation. Pim-1 phosphorylates multiple cellular substrates to inhibit apoptosis and promote cell cycle progression. Over expression of Pim-1 kinase is observed in a range of malignancies and various solid cancers. High level of Pim-1 expression is seen in myeloma, acute myeloid leukemia, prostate cancer and liver carcinomas. Hence, Pim-1 is considered as an interesting cancer target. In the present study, we have performed region-focused CoMFA study on a series of imidazopyridazine derivatives as Pim-1 kinase inhibitors. A statistically acceptable region-focused CoMFA model ($q^2=0.571$; ONC=3; $r^2=0.909$) was developed. The model was then validated using Bootsrapping and progressive sampling. The contour map highlighted the regions favorable to increase the activity. Bulky substitutions in $R^2$ position of the phenyl ring could increase the activity. Similarly, small negative substitution in the $R^1$ position of the Pyridine ring could increase the activity considerably. Our results will be useful to design novel Pim-1 kinase inhibitors of this series.