• 제목/요약/키워드: PICK1

검색결과 370건 처리시간 0.034초

Functional Regulation of Dopamine D3 Receptor through Interaction with PICK1

  • Zheng, Mei;Zhang, Xiaohan;Min, Chengchun;Choi, Bo-Gil;Oh, In-Joon;Kim, Kyeong-Man
    • Biomolecules & Therapeutics
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    • 제24권5호
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    • pp.475-481
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    • 2016
  • PICK1, a PDZ domain-containing protein, is known to increase the reuptake activities of dopamine transporters by increasing their expressions on the cell surface. Here, we report a direct and functional interaction between PICK1 and dopamine $D_3$ receptors ($D_3R$), which act as autoreceptors to negatively regulate dopaminergic neurons. PICK1 colocalized with both dopamine $D_2$ receptor ($D_2R$) and $D_3R$ in clusters but exerted different functional influences on them. The cell surface expression, agonist affinity, endocytosis, and signaling of $D_2R$ were unaffected by the coexpression of PICK1. On the other hand, the surface expression and tolerance of $D_3R$ were inhibited by the coexpression of PICK1. These findings show that PICK1 exerts multiple effects on $D_3R$ functions.

Design and Construction of a Pick-up Type Pulse Crop Harvester

  • Lee, Ki Yong;Yoo, Soonam;Han, Byung Hee;Choi, Yong;Choi, Il Su
    • Journal of Biosystems Engineering
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    • 제42권1호
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    • pp.12-22
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    • 2017
  • Purpose: This aim of this study was to develop a pick-up type pulse crop harvester for harvesting cut and dried pulse crop. Methods: The pick-up type pulse crop harvester was designed and constructed. Its specifications and operating performance were investigated. Results: Compared with conventional bean harvesters, the pick-up type pulse crop harvester adopted seven rows of chains with tines to pick-up the cut and dried pulse crop on a flat or ridged field, two transverse threshing drums with steel wire teeth to reduce the threshing speed, and a tilt plate and plastic bucket elevator for conveying clean grain to reduce damage. The threshing speed and the oscillating frequency of the separating and cleaning parts according to crop type and condition could be varied easily to efficiently use engine power and to improve harvesting performance. The harvester showed forward speed ranges of 0 ~ 1.5 m/s during harvesting operation, and 0 ~ 2.5 m/s during road travelling. The pick-up width of the harvester was about 1 m. Conclusions: The pick-up type self-propelled 51.5 kW harvester was designed and constructed to harvest cut and dried pulse crop. The effective field capacity of the harvester was predicted as above 40 a/h.

Effect of hardfacing on wear reduction of pick cutters under mixed rock conditions

  • Chang, Soo-Ho;Lee, Chulho;Kang, Tae-Ho;Ha, Taewook;Choi, Soon-Wook
    • Geomechanics and Engineering
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    • 제13권1호
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    • pp.141-159
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    • 2017
  • A pick cutter is a rock-cutting tool used in partial-face excavation machines such as roadheaders, and its quality is a key element influencing the excavation performance and efficiency of such machines. In this study, pick cutters with hardfacing deposits applied to a tungsten carbide insert were made with aim of increasing their durability and wear resistance. They were field-tested by being installed in a roadheader and compared with conventional pick cutters under the same excavation conditions for 24 hours. The hardfaced pick cutters showed much smaller weight loss after excavation, and therefore better excavation performance, than the conventional pick cutters. In particular, the damage to and detachment (loss) of tungsten carbide inserts was minimal in the hardfaced pick cutters. A detailed inspection using scanning electron microscope-energy dispersive X-ray spectrometry and three-dimensional X-ray computed tomography scanning revealed no macro- or micro-cracks in the pick cutters. The reason for the absence of cracks may be that the heads of pick cutters are mechanically worn after the tungsten carbide inserts have been worn and damaged. However, scanning revealed the presence of voids between tungsten carbide inserts and pick cutter heads. This discovery of voids indicates the need to improve production processes in order to guarantee a higher quality of pick cutters.

지속되는 신생아 담즙 정체증과 간비비대를 주소로 내원하여 유전자분석으로 확진된 C형 Niemann-Pick병 (Molecular diagnosis of Niemann-Pick type C presenting with neonatal cholestasis and hepatosplenomegaly)

  • 정민희;고정민;김구환;유한욱
    • Journal of Genetic Medicine
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    • 제4권2호
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    • pp.200-203
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    • 2007
  • C형 Niemann-Pick병은 NPC1 및 NPC2 유전자의 돌연변이로 인해 발생하는 질환으로 상염색체 열성으로 유전되며 신생아 간염과 간비비대, 이후 안구의 수직운동 마비, 조화운동불능, 구음장애, 근육긴장이상, 경련 등 서서히 진행하는 신경학적 이상을 보이게 된다. 환아는 7개월 된 여아로 출생 후부터 황달과 간비비대가 지속되어 리소솜성 축적질환을 의심하였고 시행한 골수검사상 거품형태의 조직구가 관찰되어 Niemann-Pick병을 진단하였다. 신생아 황달, 간비비대 등 환아의 임상양상을 고려했을 때 C형 Nimann-Pick병이 의심되었고 확진을 위해 시행한 NPC1 유전자 검사에서 c.451_452del (p.Ser151TrpfsX18) 및 새로운 돌연변이인 c.1757+3_6del의 이형접합체임을 확인하여 질환을 확진 하였다.

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흘로그램 간섭계를 이용한 광픽업 베이스의 미소 열변형 측정 (Measurement of Micro Thermal Deformation of Optical Pick-up Base Using Holographic Interferometry)

  • 서영민;강신일
    • 한국정밀공학회:학술대회논문집
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    • 한국정밀공학회 2002년도 춘계학술대회 논문집
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    • pp.191-194
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    • 2002
  • In optical pick-up, optical components such as objective lens, collimator, mirror, laser diode and photo diode are mounted on the pick-up base. These components must keep their original position during operation for proper transmittance of information from laser diode to optical disk and back to photo diode. However, micro thermal deformation of pick-up base which is induced by thermal environment during operation can deteriorate the performance of optical pick-up. Therefore, it is important to measure and analyze the thermal deformation behavior of pick-up base under thermal environment. In the present study, a measurement system using holographic interferometry was designed to measure micro thermal deformation of pick up base. The measurement system was verified by using the deformation of cantilever with prescribed motion actuated by PZT with 1 nm resolution. Interferometric measurement was compared quantitatively with that induced by PZT actuator. Finally, micro thermal deformation of pick-up base under actual thermal environment was measured using the present holographic interferometry and the results were analysed.

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Embossed new dental pick이 치주염에 미치는 영향 (Effect of embossed new dental pick on periodontitis)

  • 석헌주;김종관
    • Journal of Periodontal and Implant Science
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    • 제34권3호
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    • pp.563-572
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    • 2004
  • Since bacterial plaque is known as the major cause of every oral disease, it is necessary to control plaque to maintain periodontal health. Although tooth brushing has been the typical method of plaque control, additional use of plaque control devices are necessary for cleansing interdental areas. Dental floss has been used for a long time as the additional plaque control device and proved to be effective. The newly developed embossed new dental pick is composed of elastic plastic material in form with its tip longer than other toothpick. In addition, as thickness of the tip gradually increases, it can be adapted easily with minimal trauma to interdental gingiva. The embossed tip can remove dental plaque easily, and the opposite end can approach lingual and palatal areas through triple angulation. Therefore, the authors studied the effect of embossed new dental pick and dental floss on periodontally involved 15 patient. The following results were obtained. 1. For embossed new dental pick, probing depth at baseline, 1 week, 4 weeks were $3.6{\pm}0.6mm$, $3.4{\pm}0.5mm$, $3.2{\pm}0.5mm$, respectively, and $4.2{\pm}0.9mm$, $4.1{\pm}0.9mm$, $4.0{\pm}0.9mm$, respectivly for clinical attachment level. 2. In case of embossed new dental pick, bleeding on probing at baseline, 1 week, 4 weeks were $43.0{\pm}4.4%$, $28.5{\pm}5.1%$, $22.2{\pm}5.6%$, respectively, and, at 1 week and 4 weeks, they were significantly different from that of dental floss. 3. Gingival index of toαhpick at baseline, 1 week, 4 weeks were $1.7{\pm}0.5$, $1.0{\pm}0.3$, $0.9{\pm}0.2$, respectively, and, $1.7{\pm}0.5$, $1.1{\pm}0.4$, $1.0{\pm}0.4$, respectively for plaque index, and $3.0{\pm}0.5$, $1.7{\pm}0.5$, $1.4{\pm}0.4$, respectively for proximal plaque index. proximal plaque index at 4 weeks was significantly different from that of dental floss. 4. The result of questionnaire showed that the two types of device were both satisfactory, however, embossed new dental pick had higher preference as well as satisfaction. As a result, embossed new dental pick is thought to be clinically effective for its simplicity and good accessibility.

A형 Niemann-Pick 병 1례 (A case of Niemann-Pick disease type A)

  • 유호연;오지은;박재선;김미향;김신동;정경순
    • Clinical and Experimental Pediatrics
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    • 제49권12호
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    • pp.1358-1362
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    • 2006
  • Niemann-Pick병은 lysosome내에 sphingomyelinase의 결핍으로 sphingomyelin이란 지질이 축적된 세포들이 간, 비장, 골수, 폐, 및 뇌 등에 침착되어 간, 비장 종대 및 신경증상을 나타내며, 상염색체 열성으로 유전되는 대사성 질환이다. 1914년 Niemann에 의해 처음 보고되어 Gaucher병의 한 변형으로 분류되어 있다가, 1927년 Pick에 의해 새로 분류되어 Niemann-Pick 병으로 명명되었다. 세계적으로도 희귀한 질환으로 국내에서는 1962년 정 등이 처음 보고한 이래 현재까지 저자가 조사한 바로 총 7례 정도가 보고되었다.저자들은 18개월 된 남아에서 임상증상 및 검사 소견으로 A 형 Niemann-Pick병으로 생각되는 1례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

광 픽업 성능 평가기 캘리브레이션 (Calibration of an Optical Pick-up Performance Evaluator)

  • 류정래;도태용
    • 제어로봇시스템학회논문지
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    • 제20권5호
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    • pp.578-583
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    • 2014
  • Optical pick-up is a core component for data read/write operations in optical disc drives, and an optical pick-up performance evaluator is an instrument used to analyze the overall performance of an optical pick-up. Due to inevitable errors in an analog measurement circuit, resultant evaluation data is not guaranteed to be accurate. In this paper, a calibration method for an optical pick-up performance evaluator is proposed to ensure evaluation accuracy. Measured data is corrected by a 1st order correction function, and a calibration process based on least-square method is utilized to obtain correction coefficients of the correction function. The proposed calibration method is applied to experiments, and enhanced accuracy is presented with resultant evaluation data.

전자기력을 이용한 진동형 자이로스코프의 가진 및 검출 기법 연구 (A Driving and Pick-Off Method of Vibratory Gyroscopes Using Electromagnetic Force)

  • 이정영;홍성경
    • 제어로봇시스템학회논문지
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    • 제9권1호
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    • pp.30-36
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    • 2003
  • Driving and pick-off using electromagnetic force for a cylindrical vibratory gyroscope is considered. A gyroscope consisting of thin cylindrical vibrating element and electromagnetic drive and pick-off element is designed, fabricated and tested. The results of the proposed pick-off method were compared with the results of the highly precise laser interferometer and eddy current sensor as it was used as the reference standard. Through the experiment, it is verified that the proposed electromagnetic driving and pick-off method can be an effective alternative to conventional electrostatic or piezo-electric methods.

이산요소법을 이용한 화강암의 선형절삭 시뮬레이션 (Linear Cutting Simulation for Granite using Discrete Element Method)

  • 전철웅;손정현;이재욱
    • 한국기계가공학회지
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    • 제15권4호
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    • pp.1-7
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    • 2016
  • The pick cutter, which directly contacts and crushes the rock, is the expendable part of a roadheader. The arrangement and angle of attachment of the pick cutter are important factors that determine excavator performance. It is necessary to numerically calculate the contact between the pick cutter and rock. The rock is defined as a set of particles using the discrete element method. The parallel bond model is used to define the bonds between particles. The properties of granite that are measured by the uniaxial compressive test are applied to the numerical rock model. The pick cutter is defined by the polygon elements. The linear cutting simulation is considered to simulate the contact between the pick cutter and rock. The results of the simulation show the rock breaking due to contact with the pick cutter.