• YAKHAK HOEJI
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• v.57 no.6
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• pp.432-441
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• 2013

It's been almost 20 years since the adoption of Good Manufacturing Practices (GMP) in Korea since 1994. There have been big progresses in the GMP regulations and its implementations. 'New GMP' in 2008 has adopted validation, pre-approval GMP evaluation, annual quality review, etc.. Upon the submission of PIC/S (Pharmaceutical Inspection Cooperation Scheme) application by Korea's Ministry of Food and Drug Safety in April, 2012, Korea is facing new opportunity to level up Korea GMP regulations. As such, this study suggested GMP revision points by comparing and analyzing the differences between PIC/S GMP and Korea GMP. Those areas which GMP is not required such as radiopharmaceuticals and medical gases should adopt GMP. And independent GMP regulation is needed for Active Pharmaceutical Ingredients and investigational medicinal products. Also, those regulations shall be implemented in the higher level of legal status. Finally, rather than pursuing GMP harmonization only for PIC/S membership, GMP improvement in the long term shall be taken into consideration by reflecting current quality issues such as ICH Q8 (Pharmaceutical development), Q9 (Quality Risk Management) and Q10 (Pharmaceutical Quality System).

• 제어로봇시스템학회:학술대회논문집
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• 2004.08a
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• pp.1962-1965
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• 2004

In this paper, the new algorithm for blind adaptive decorrelating parallel interference canceller detector in direct-sequence code division multiple access (DS-CDMA) synchronous communication systems is proposed. The goal of this paper is to improve the performance of the blind adaptive decorrelating parallel interference cancellation detector (BAD/PIC). The proposed blind adaptive decorrelating detector is using optimum step-size technique bootstrap algorithm as an initial stage of PIC, which does not require a training sequence. Therefore, this algorithm has a superior view of utilizing bandwidth and reduces the complexity of computation of inversion cross-correlation matrix. The computer simulation results show that the bit error rate performance of the proposed algorithm for the new structure of detector is better than that of the other detectors such as matched filters, the conventional PIC, and the blind adaptive decorrelating PIC detector.

• Biomolecules & Therapeutics
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• v.9 no.4
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• pp.277-281
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• 2001

Chromium is an essential nutrient and participates in glucose and lipid metabolism in human beings and animals. The present study was conducted to assess the effects of chromium picolinate (Cr-pic) on glucose tolerance and insulin sensitivity in type I and ll diabetic rats. The experimental groups were type I diabetic (streptozotocin-induced: 40 mg/kg, i.p.) and type II diabetic (Goto-Kakizaki rats) models. Each group was subdivided into control. low-dose and high-dose of Cr-pic treated groups. The Cr-pic was orally administered with Cr-pic (100 mg/kg for low dose group and 200 mg/kg for high dose group) for 4 weeks. And then we performed intraperitoneal glucose tolerance test (IPGTT) and insulin sensitivity test (ITT). The glucose tolerance test was carried out by inection of glucose (2 g/kg, i.p.). The peripheral insulin sensitivity test was con- ducted by injection of insulin (5 units/kg, s.c.) and glucose. We performed determining of blood glucose concentration at 0, 10, 30, 60, 90, and 120 min using automated glucose analyzer. The plasma insulin concentration was determined by rat insulin EIA kit. Administration of Cr-pic improved weight gain in all group s with higher significant in the low-dose group. There was no significance between the control and the Cr-pic treated groups in the area under the blood glucose curve and serum insulin concentration plots of IPGTT and peripheral ITT in type I diabetic rats. But Cr-pic treated groups showed significantly lower levels of the area under the blood glucose currie during IPGTT and ITT and the high-dose group showed less effects compared with the low-dose group in the type II diabetic rats. The plasma insulin concentration of both diabetic groups was not influenced by Cr-pic supplementation. We can conclude that chromium picolinate may improve the endogenous and exogenous insulin action and peripheral insulin sensitivity in type II diabetic rats.

• Journal of the Korean Society of Food Science and Nutrition
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• v.46 no.2
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• pp.267-272
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• 2017

Piceatannol (PIC) is a natural hydroxylated analog of resveratrol (RSV), which is a polyphenol known to extend lifespan by stimulating sirtuins. The aim of this study was to investigate the effects of PIC and RSV on the toll-like receptor 4 (TLR4)-nuclear factor kappa B ($NF-{\kappa}B$) pathway in mouse hepatocytes and an obese/diabetic KK/HlJ mouse model. AML12 mouse hepatocytes in the absence or presence of palmitic acids (PA) were treated with PIC ($50{\mu}M$) or RSV ($50{\mu}M$). Male KK/HlJ mice at 20 weeks of age were divided into three subgroups as follows: 1) obese and diabetic control (KK), 2) KK_PIC, and 3) KK_RSV. PIC and RSV were administered orally at a dose of 10 mg/kg/d for 4 weeks. Four weeks of PIC and RSV treatment did not affect body weight or food intake in KK mice. Serum fasting blood glucose was significantly reduced in KK_PIC, and 2 h oral glucose tolerance test area under the curve was significantly reduced by PIC and RSV treatment in KK mice. PIC tended to improve homeostasis model assessment of the insulin resistance index (HOMA-IR) and HOMA beta-cells in diabetic KK mice. TLR4 and $NF-{\kappa}B$ were down-regulated by PIC and RSV treatments in hepatocytes in the absence or presence of PA. Insulin receptor, AMP-activated protein kinase, peroxisome proliferator-activated receptor gamma, nucleotide oligomerization domain-like receptor family pyrin domain-containing 3, interleukin-1, and $NF-{\kappa}B$ were altered in PIC-treated livers. Collectively, PIC and RSV inhibited the $TLR4-NF-{\kappa}B$ pathway, and PIC seems to be more effective than RSV in the regulation of analyzed targets, which are involved in insulin signaling and inflammation in vivo.

• Journal of the Korean Society of Marine Environment & Safety
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• v.13 no.3
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• pp.235-240
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• 2007

Recently, energy saving buildings are interested in many parts and many types of thermal insulating materials have been developed. The temperature and brightness of inside and outside building are influenced by weather change and sun's brightness and location. The location of building considering the natural daylight is an important parameter to build a building. To modeling the natural daylight, we used 342 electric bulbs which mean artificial daylight. All these bulbs are installed on dome shape frame. Especially it is focused on the luminosity control of each bulb in this paper. The luminosity of bulbs is controlled by phase control using several PIC microprocessors and triacs.

• Composites Research
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• v.34 no.6
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• pp.394-399
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• 2021

Piecewise Integrated Composite (PIC) is a new concept to design composite structures of multiple stacking angles both for in-plane direction and through the thickness direction in order to improve stiffness and strength. In the present study, PIC beam was suggested based on 3D training data instead of 2D data, which did offer a limited behavior of beam characteristics, with enhancing the stiffness accompanied by reduced tip deformation. Generally training data were observed from the designated reference finite elements, and preliminary FE analysis was conducted with respect to regularly distributed reference elements. Also triaxiality values for each element were obtained in order to categorize the loading state, i.e. tensile, compressive or shear. The main FE analysis was conducted to predict the mechanical characteristics of the PIC beam.

• Composites Research
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• v.33 no.3
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• pp.108-114
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• 2020

Piecewise Integrated Composite (PIC) beam is composed of different stacking against loading type depending upon location. The aim of current study is to assign robust stacking sequences against external loading to every corresponding part of the PIC beam based on the value of stress triaxiality at generated reference points using the k-NN (k-Nearest Neighbor) classification, which is one of representative machine learning techniques, in order to excellent superior bending characteristics. The stress triaxiality at reference points is obtained by three-point bending analysis of the Al beam with training data categorizing the type of external loading, i.e., tension, compression or shear. Loading types of each plane of the beam were classified by independent plane scheme as well as total beam scheme. Also, loading fidelities were calibrated for each case with the variation of hyper-parameters. Most effective stacking sequences were mapped into the PIC beam based on the k-NN classification model with the highest loading fidelity. FE analysis result shows the PIC beam has superior external loading resistance and energy absorption compared to conventional beam.

• Composites Research
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• v.36 no.1
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• pp.53-58
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• 2023

The PIC design method is assigning different stacking sequences for each shell element through the preliminary FE analysis. In previous study, machine learning was applied to the PIC design method in order to assign the region efficiently, and the training data is labeled by dividing each region into tension, compression, and shear through the preliminary FE analysis results value. However, since buckling is not considered, when buckling occurs, it can't be divided into appropriate loading type. In the present study, it was proposed PIC-NTL (PIC design using novel technique for analyzing load type) which is method for applying a novel technique for analyzing load type considering buckling to the conventional PIC design. The stress triaxiality for each ply were analyzed for buckling analysis, and the representative loading type was designated through the determined loading type within decision area divided into two regions of the same size in the thickness direction of the elements. The input value of the training data and label consisted in coordination of element and representative loading type of each decision area, respectively. A machine learning model was trained through the training data, and the hyperparameters that affect the performance of the machine learning model were tuned to optimal values through Bayesian algorithm. Among the tuned machine learning models, the SVM model showed the highest performance. Most effective stacking sequence were mapped into PIC tube based on trained SVM model. FE analysis results show the design method proposed in this study has superior external loading resistance and energy absorption compared to previous study.

• Bulletin of the Korean Chemical Society
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• v.33 no.1
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• pp.48-54
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• 2012

The $[Fe_4S_4]^{2+}$ clusters with 2-, 3-, and 4-pyridinemethanethiolate (S2-Pic, S3-Pic, and S4-Pic, respectively) terminal ligands have been synthesized from the ligand substitution reaction of the $(^nBu_4N)_2[Fe_4S_4Cl_4]$ (I) cluster. The new $(^nBu_4N)_2[Fe_4S_4(SR)_4]$ (R = 2-Pic; II, 3-Pic; III, 4-Pic; IV) clusters were characterized by FTIR and UV-Vis spectroscopy. Cluster II was crystallized in the monoclinic space group C2/c with a = 24.530 (5) $\AA$, b = 24.636(4) $\AA$, c = 21.762(4) $\AA$, ${\beta}=103.253(3)^{\circ}$, and Z = 8. The X-ray structure of II showed two unique 2:2 site-differentiated $[Fe_4S_4]^{2+}$ clusters due to the bidentate-mode coordination by 2-pyridinemethanethiolate ligands. Cluster III was crystallized in the same monoclinic space group C2/c with a = 26.0740(18) $\AA$, b = 23.3195(16) $\AA$, c = 22.3720(15) $\AA$, ${\beta}=100.467(2)^{\circ}$, and Z = 8. The 3-pyridinemethanethiolate ligand of III was coordinated to the $[Fe_4S_4]^{2+}$ core as a terminal mode. Cluster IV with 4-pyridinemethanethiolate ligands was found to have a similar structure to the cluster III. Fully reversible $[Fe_4S_4]^{2+}/[Fe_4S_4]^+$ redox waves were observed from all three clusters by cyclic voltammetry measurement. The electrochemical potentials for the $[Fe_4S_4]^{2+}/[Fe_4S_4]^+$ transition decreased in the order of II, III and IV, and the reduction potential changes by the ligands were explained based on the structural differences among the complexes. The complex III was reacted with sulfonium salt of $[PhMeSCH_2-p-C_6H_4CN](BF_4)$ in MeCN to test possible radical-involving reaction as a functional model of the [$Fe_4S_4$]-SAM (S-adenosylmethionine) cofactor. However, the isolated reaction products of 3-pyridinemethanethiolate-p-cyanobenzylsulfide and thioanisole suggested that the reaction followed an ionic mechanism and the products formed from the terminal ligand attack to the sulfonium.

• Electronics and Telecommunications Trends
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• v.19 no.2 s.86
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• pp.117-126
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• 2004

본 논문에서는 인터넷 콘텐츠에 대한 내용선별 기술표준인 PICS의 동향을 살펴보고, 이것을 준용하여 무선인터넷 내용선별 기술을 표준화할 경우 고려사항을 검토하였다. 전 세계적으로 적용되는 업계표준인 PICS는 인터넷 내용물을 선별적으로 볼 수 있게 해주는 기반구조로서, 선별 소프트웨어와 등급서비스들 간에 잘 동작할 수 있게 도와주는 기술 규격이다. 이러한 PICS를 무선인터넷 환경에 적용하여 국내 현실에 알맞은 무선인터넷 내용선별 표준을 개발할 경우 추진하여야 할 연구분야 및 정책 지원분야를 검토하였다. 그리고 자율적인 운영을 기반으로 한 인터넷 내용등급제의 활성화, 내용선별 기술 표준화 및 소프트웨어 개발 연구 등에 정부의 정책적인 지원이 필요하다.