• 공업화학
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• 제2권3호
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• pp.246-252
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• 1991

Poly (ethylene terephthalate) (PET)와 Poly (1, 4-phenylene terephthalate) (PHT)의 copolyester (PEHT)를 PHT 반복단위의 함량이 30mo1% 미만인 범위에서 용액중합으로 합성하고 이들의 물성을 조사하였다. PEHT 중 PHT의 함량이 증가함에 따라 유리전이 온도, 결정화 속도, 내열성은 증가하고, 녹는점은 감소하였다. PHT 반복단위 함량이 16.5, 24.9 mol %인 경우 액정성을 관찰할 수 있었으며, PET 반복단위와 PHT 반복단위에 의한 결정이 혼재함을 광각 X-선 회절로부터 관찰하였다.

• Toxicological Research
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• 제8권2호
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• pp.273-284
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• 1992

It is well known that phenytoin (PHT), a commonly prescribed anticonvulsant, has teratogenicity in experimental animals and human. The major malformation induced by PHT in mouse is cleft palate. The mechanisms of the embryotoxic effects of PHT are unknown. However, PHT and synthetic glucocorticoids share several features with respect to their teratogenicity, and it was known that PHT increased maternal corticosterone level. Therefore PHT-induced cleft palate may be mediated indirectly by elevated maternal corticosterone. Recently it was reported that secalonic acid Dinduced cleft palate and elevated endogenous corticosterone level, and that such effects were antagonized by DMSO. The purpose of this work was to investigate whether the elevated maternal corticosterone is associated with the teratogenicity of PHT in the ICR mouse fetuses by treatment with PHT or PHT plus DMSO. PHT (74mg/kg, BW) was daily administered intraperitoneally on day 10~12 of gestation with and without DMSO(2ml/kg, BW), and the fetal malformation was observed on day 18. Maternal serum corticosterone and fetal PHT levels were determined by HPLC. The results are summarized as follows. 1)The percentage of cleft palate incidense in fetuses following treatment with PHT on day 10~12 of gestation was 51.7%. 2)There was a significant decrement in the cleft palate incidence in fetuses to 30.8% in the group treated with PHT plus DMSO compared with 51.7% in that with PHT alone. 3) Maternal serum corticosterone levels following treatment with PHT on day 10~12 of gestation increased by 116~343% compared with that of vehicle control. Such effect was antagonized by DMSO. 4)PHT concentration in the fetuses was not affected by DMSO. These results suggest that PHT-induced cleft-palate in fetuses seems to be closely associated with the elevation of maternal corticosterone level.

• 한방재활의학과학회지
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• 제30권4호
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• pp.1-16
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• 2020

Objectives The main purpose of this study was to evaluate the bone healing effect of Pahyeolsandong-tang (PHT)(Poxiesanteng-tang) extract in tibia fracture-induced mice. Methods PHT was extracted using a solution of 35% ethanol in 60℃ for 8 hours. Mice were randomly divided into 4 groups (normal, control, PHT 50 and PHT 100). Mice of experimental groups were medicated with PHT 50 or 100 mg/kg for 7 to 21 days. To clarify the effect of bone fracture healing, relative messenger RNA (mRNA) expressions of osteocalcin (OCN), runt-related transcription factor 2 (Runx2), osterix (OSX), Sox9, collagen type II alpha 1 chain (Col2a1), receptor activator of nuclear factor kappa-B ligand (RANKL), osteoprotegerin (OPG) were examined. Results In in vitro experiment, relative mRNA expression of OCN, Runx2, Col2a1 was significantly increased in PHT treated group to compare with control differentiation group. In in vivo experiment, relative mRNA expression of OCN, Runx2, OSX, Sox9, Col2a1, RANKL, OPG was significantly increased in PHT treated group. Conclusions This study showed that PHT accelerates bone fracture healing through the activation of osteoclasts and osteoblasts. It was showed that PHT significantly promotes osteoblasts differentiation by osteoblast differentiation markers such as OCN, Runx2, Col1a2. Also it was investigated that PHT had stimulatory effect on osteoblasts function through enhancing OCN, Runx2, OSX, Sox9, Col2a1 and, osteoclasts function through enhancing RANKL and OPG markers. PHT effectively promotes bone fracture healing process through activation of osteoblasts and osteoclasts.

• 정보처리학회논문지A
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• 제14A권6호
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• pp.347-356
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• 2007

프로세서의 파이프라인 길이가 점차 길어지고 한 사이클에 이슈되는 명령어의 수가 증가함에 따라, 분기 예측기의 정확도는 프로세서의 성능에 상당한 영향을 미치게 되었다. 또한, 내장형 프로세서를 설계하는데 있어서는 전력 효율성이 가장 중요한 설계 고려 사항 중 하나가 되었다. 그러므로, 내장형 프로세서의 분기 예측기를 설계할 때에는 성능과 전력 효율성이 함께 고려되어야 한다. 본 논문에서는 gshare 분기 예측기가 적용된 내장형 프로세서에서 선택적인 BTB (Branch Target Buffer) 접근을 가능하게 하는 저전력 분기 예측기를 제안하고자 한다. 제안하는 분기 예측기 내에서 BTB는 직전 명령어가 테이큰 (Taken) 분기로 예측되지 않는 경우에는, PHT (Pattern History Table)의 예측 결과가 테이큰인 경우에만 접근된다. PHT의 예측 결과가 테이큰인 분기 명령어의 경우에만 다음에 인출될 명령어의 주소를 BTB 접근을 통해 얻은 주소로 결정하기 때문이다. 물론, 이와 같은 선택적인 BTB 접근으로 인하여 성능 저하가 발생하는 것을 방지하기 위해 직전 명령어가 테이큰분기로 예측된 경우에는 PHT의 예측 결과에 관계없이 BTB는 항상 접근된다. 선택적인 BTB 접근을 하기 위해, 제안하는 분기 예측기 내의 PHT는 기존 분기 예측기의 PHT와 비교하여 1 사이클 일찍 접근되도록 구현한다. 1 사이클 빠른 접근을 위해 제안하는 PHT는 한 번의 접근을 통해 두 개의 예측 결과를 동시에 얻어오게 구현하고, 이를 통해 PHT의 접근 횟수도 줄임으로써 분기 예측기의 전력 소모를 줄이는 효과 또한 얻게 된다. 제안하는 분기 예측기는 하드웨어 오버헤드나 예측 정확도의 감소 없이 전력 소모를 줄일 수 있다는 장점을 가진다. 실험 결과에 따르면, 제안하는 분기 예측기는 기존의 분기 예측기와 비교하여 $35{\sim}48%$의 전력 소모를 줄이는 결과를 보인다.

• 대한수의학회지
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• 제34권4호
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• pp.821-831
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• 1994

Phenytoin(PHT), a commonly prescribed anticonvulsant, has been known as a teratogen in experimental animals and human. However, PHT has strain-specific teratogenic effects for mice and human. Dimethyl sulfoxids(DMSO) has been known to antagonize the teratogenic effects of secalonic acid D, a toxic mold metabolite that has similar teratogenic effects to PHT. Therefore, this study was performed to examine the embryopathic effects of PHT in terms of treatment period and the antiteratogenic effect of DMSO in ICR mice. PHT(75mg/kg, BW) was administered intrapetitoneally on day 10, 10-11 and 10-12 of gestation with or without DMSO(2ml/kg, BW), and the fetal malformation was observed on day 18. Major malformation of fetuses treated with PHT on day 10, 10-11 and 10-12 of gestation was cleft palate, and the percentages of fetus with cleft palate were 14.5%, 31.7% and 51.7%, respectively. Also, there was a significant decrease of cleft palate from 51.7% in PHT alone group to 30.8% in PHT plus DMSO group. Our findings suggest that cleft palate is one of major malformation by PHT treatment in ICR mouse and DMSO has strong antiteratogenic effect.

• 대한금속재료학회지
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• 제48권2호
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• pp.180-186
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• 2010

For the application of field emission display (FED), it is essential to develop a carbon nanotube (CNT) cathode with high emission current density. In this study, we developed and demonstrated a post-heat treatment (PHT) process to improve field emission properties of CNT cathodes. Since the PHT is intended to burn out organic materials covering the CNTs, the PHT was carried out by heating samples at a high temperature in an atmosphere. The PHT process is applied for samples processed by surface treatment with an adhesive tape. Compared to samples prior to the PHT, samples after the PHT at $360^{\circ}C$ showed about 17% improvement in emission current density. The major reason for the increased current density is mainly the increased aspect ratio of the CNTs because of the removal of the adhesive organic residues covering the CNTs, which were attached on the CNT surfaces during the surface treatment using the adhesive taping method.

• Asian Pacific Journal of Cancer Prevention
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• 제15권4호
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• pp.1649-1654
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• 2014

Background: Clinically significant portal hypertension (PHT) is considered as a contraindication for hepatectomy according to the guidelines of the European Association for Study of Liver and the American Association for Study of Liver Diseases. However, this issue remains controversial. Here we performed a metaanalysis to evaluate the impact of PHT on the results of hepatectomy for hepatocellular carcinoma (HCC). Methods: Cohort studies evaluating the impact of clinically significant PHT, defined as oesophageal varices and/or splenomegaly associated with thrombocytopenia, on the results of hepatectomy for HCC were identified using a predefined search strategy. Summary risk ratios (RRs) and 95% confidence intervals (95% CIs) for PHT and outcomes after hepatectomy for HCC were calculated. Results: Seven cohort studies which including 574 cases with PHT and 1,354 cases without PHT were considered eligible for inclusion. The meta-analysis showed that, in all patients, pooled RRs of post-operative liver failure, post-operative ascites, peri-operative blood transfusion, operative mortality, 3- and 5-year overall survival associated with PHT were 2.23 (95% CI: 1.48-3.34, P=0.0001), 1.77 (95% CI: 1.19-2.64, P=0.005), 1.23 (95% CI: 1.03-1.49, P=0.03), 2.58 (95% CI: 1.12-5.96, P=0.03), 0.82 (95% CI: 0.75-0.88, P<0.00001) and 0.76 (95% CI: 0.69-0.85, P<0.00001), respectively. In subgroup analysis, similar results were found in Child-Pugh class A patients. Conclusion: This meta-analysis suggests that presence of oesophageal varices and/or splenomegaly associated with thrombocytopenia is associated with higher rates of post-operative complications and poor long-term survival after hepatectomy for HCC.

• Toxicological Research
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• 제14권3호
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• pp.357-363
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• 1998

The teratogenic potential of the anticonvulsant drug phenytoin (PHT) has been well documented both in the human and in the experimental animals. However there are few reports on the effects of PHT on embryonic development in rats in vitro. The present study was performed to evaluate the teratogenic effects of PHT using whole-embryo culture system in rats. Sprague-Dawley rat embryos were explanted on gestational day (GD) 9.5 and cultured for 48 hrs in the immediately centrifuged and heat-inactivated rat serum containing 0,25,50, or $100{\mu}g$ PHT/mL. At the end of culture period the embryos were scored for morphological development according to the procedure of Van Maele-Fabry, and their total protein contents were determined. At 100 ${\mu}$g/mL of culture medium. PHT caused significant reduction in developmental score and protein content of embryos and a high incidence morphological abnormalities (100%). Characteristic malformations included altered yolk and embryonic circulation, craniofacial hypoplasia, neural tube schisis, branchial arch defects, abnormal ratation, and limb bud hypoplasia, among others. There were no adverse effects on embryonic growth and development at concentrations of 25 and 50 ${\mu}$g /mL of culture medium. The results indicated that the dysmorphogenic effect of PHT on cultured embryos is due to a direct interference with embryonic development.

• 한국정보과학회논문지:컴퓨팅의 실제 및 레터
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• 제14권6호
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• pp.619-623
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• 2008

차선검출시스템은 지능형 차량 시스템의 중요한 요소이다. 차선검출 시, 주변 환경과 날씨의 변화 때문에 차선검출은 다양한 어려움에 직면하게 된다. 본 논문에서는 차선검출 및 추적을 위해 다양한 환경에서도 안정적으로 동작하는 간단하면서 효율적인 방법을 제안한다. 제안된 방법에서는 차선을 추적하고 차선의 기울기를 수정하기 위해 확률적 허프 변환(Probabilistic Hough Transform, PHT)과 최소자승법(Least-square method, LSM)를 이용한다. 일반적으로 차량의 내부에 설치된 카메라로부터 획득된 영상은 영상의 하단부분에서 차선이 비교적 뚜렷이 나타나고, 주변의 간섭을 적게 받는다는 가정 하에 제안된 방법에서는 차선검출 및 추적의 효율성을 증대시키기 위해 영상의 하단부분에 관심의 대상이 되는 두 개의 영역을 설정한다. 제안된 방법의 효율성을 입증하기 위해 정지영상과 비디오영상을 사용하여 실험하였고, 실험결과 제안된 방법이 강건하고, 신뢰성있는 결과를 얻었음을 보였다.

• Nuclear Engineering and Technology
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• 제53권10호
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• pp.3236-3246
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• 2021

Lessons learned from the Fukushima Daiichi nuclear power plant accident directed that multiple failures should be considered more seriously rather than single failure in the licensing bases and safety cases because attempts to take accident management measures could be unsuccessful under the high radiation environment aggravated by multiple failures, such as complete loss of electric power, uncontrollable loss of coolant inventory, failure of essential safety function recovery. In the case of the complete loss of electric power called station blackout (SBO), if there is no mitigation action for recovering safety functions, the reactor core would be overheated, and severe fuel damage could be anticipated due to the failure of the active heat sink. In such a transient condition at CANDU-6 plants, the seal failure of the primary heat transport (PHT) pumps can facilitate a consequent increase in the fuel sheath temperature and eventually lead to degradation of the fuel integrity. Therefore, it is necessary to specify the regulatory guidelines for multiple failures on a licensing basis so that licensees should prepare the accident management measures to prevent or mitigate accident conditions. In order to explore the efficiency of implementing accident management strategies for CANDU-6 plants, this study proposed a realistic accident analysis approach on the SBO transient with multiple-failure sequences such as seal failure of PHT pumps without operator's recovery actions. In this regard, a comparative study for two PHT pump seal failure modes with and without coolant seal leakage was conducted using a best-estimate code to precisely investigate the behaviors of thermal-hydraulic parameters during transient conditions. Moreover, a sensitivity analysis for different PHT pump seal leakage rates was also carried out to examine the effect of leakage rate on the system responses. This study is expected to provide the technical bases to the accident management strategy for unmitigated transient conditions with multiple failures.