Toxicological Research
- Volume 14 Issue 3
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- Pages.357-363
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- 1998
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- 1976-8257(pISSN)
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- 2234-2753(eISSN)
Teratogenic Effects of Phenytoin on Rat Embryos in Culture
랫드에 있어서 배양배자에 대한 Phenytoin의 최기형성 효과
- Kim, Jong-Choon (Toxicology Research Center, Korea Research institute of Chemical Technology) ;
- Lim, Kwang-Hyeon (Toxicology Research Center, Korea Research institute of Chemical Technology) ;
- Chung, Moon-Koo (Toxicology Research Center, Korea Research institute of Chemical Technology) ;
- Roh, Jung-Koo (Toxicology Research Center, Korea Research institute of Chemical Technology)
- Published : 1998.09.01
Abstract
The teratogenic potential of the anticonvulsant drug phenytoin (PHT) has been well documented both in the human and in the experimental animals. However there are few reports on the effects of PHT on embryonic development in rats in vitro. The present study was performed to evaluate the teratogenic effects of PHT using whole-embryo culture system in rats. Sprague-Dawley rat embryos were explanted on gestational day (GD) 9.5 and cultured for 48 hrs in the immediately centrifuged and heat-inactivated rat serum containing 0,25,50, or